https://wiki.oroboros.at/api.php?action=feedcontributions&user=Gnaiger+Erich&feedformat=atomBioblast - User contributions [en]2024-03-28T23:48:40ZUser contributionsMediaWiki 1.36.1https://wiki.oroboros.at/index.php?title=Talk:High-resolution_respirometry&diff=246685Talk:High-resolution respirometry2024-03-28T18:12:55Z<p>Gnaiger Erich: </p>
<hr />
<div>[[Image:BB-Bioblast.jpg|left|30px|link=http://www.bioblast.at/index.php/Bioblast:About|Bioblast wiki]]<br />
<br />
[[File:O2k-Core to FluoRespirometer.jpg|right|400px |O2k-Core to FluoRespirometer]]<br />
<br />
== Popular Bioblast page ==<br />
::: [[High-resolution respirometry]] has been accessed more than <br />
::::* 40,000 times (2019-07-22)<br />
::::* 35,000 times (2019-03-13)<br />
::::* 30,000 times (2017-04-05)<br />
::::* 25,000 times (2016-09-18)<br />
::::* 20,000 times (2016-02-27)<br />
::::* 15,000 times (2015-08-11)<br />
::::* 10,000 times (2014-11-22)<br />
::::* 5,000 times (2013-08-25)</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=High-resolution_respirometry&diff=246684High-resolution respirometry2024-03-28T18:12:20Z<p>Gnaiger Erich: </p>
<hr />
<div>{{MitoPedia<br />
|abbr=HRR<br />
|description=[[Image:O2k-Fluorometer.jpg|200px|left|O2k-FluoRespirometer]] '''High-resolution respirometry, HRR''', is the state-of-the-art approach in mitochondria and cell research to measure respiration in various types of [[mitochondrial preparations]] and [[living cells]] combined with MultiSensor modules. <br />
<br />
Mitochondrial function and dysfunction have gained increasing interest, reflecting growing awareness of the fact that mitochondria play a pivotal role in human health and disease. HRR combines instrumental accuracy and reliability with the versatility of applicable protocols, allowing practically unlimited addition and combination of substrates, inhibitors, and uncouplers in the [[Oroboros O2k]]. Substrate-uncoupler-inhibitor titration (SUIT) protocols allow the interrogation of numerous mitochondrial pathway and coupling states in a single respirometric assay. Mitochondrial respiratory pathways may be analyzed in detail to evaluate even minor alterations in respiratory coupling and pathway control patterns. <br />
<br />
The O2k is a sole source technology, with no other available instrument meeting its specifications for high-resolution respirometry. Technologically, HRR is based on the Oroboros O2k, combining optimized chamber design, application of oxygen-tight materials, electrochemical sensors, Peltier-temperature control, and specially developed software features (DatLab) to obtain the unique sensitive and quantitative resolution of oxygen concentration and oxygen flux, with both, a closed-chamber or open-chamber mode of operation ([[TIP2k-Module|TIP2k]]). Standardized calibration of the polarographic oxygen sensor (static sensor calibration), calibration of the sensor response time (dynamic sensor calibration), and evaluation of instrumental background oxygen flux (systemic flux compensation) provide the experimental basis for high accuracy of quantitative results and quality control in HRR. HRR can be extended for MultiSensor analysis by using the [[O2k-Fluo Smart-Module]]. [[Smart Fluo-Sensor]]s are integrated into the O2k to measure simultaneously fluorometric signals using specific fluorophores. Potentiometric modules are available with ion-selective electrodes (pH, TPP<sup>+)</sup>. The [[PB-Module]] extends HRR to PhotoBiology with accurate control of the light intensity and measurement of photosynthesis. The O2k-J and the NextGen-O2k support all these O2k-Modules. The [[NextGen-O2k]] all-in-one, however, is unique in supporting Q-Redox and NADH-Redox Modules.<br />
|info=[[Oroboros O2k]]<br />
}}<br />
<br />
::::* <big>'''Power O2k''':</big> Several O2k units are operated simultaneously ('''P'''1, '''P'''2, ..) to combine high-resolution respirometry with [[Power O2k-Respirometer |high-output]].<br />
<br />
<br />
== MitoPedia: O2k and high-resolution respirometry ==<br />
::::» [[MitoPedia: O2k hardware]]<br />
::::» [[MitoPedia: DatLab]]<br />
::::» [[MitoPedia: SUIT]]<br />
<br />
<br />
== Links ==<br />
::::'''»''' [[MitoPedia: Respiratory states]] [[Image:P.jpg|link=OXPHOS capacity|OXPHOS]] [[Image:R.jpg|link=ROUTINE respiration|ROUTINE]] [[Image:E.jpg|link=ET capacity|ET capacity]] [[Image:L.jpg|link=LEAK respiration|LEAK]] - [[Image:ROX.jpg|link=Residual oxygen consumption|ROX]]<br />
::::» [[Respirometry]]<br />
::::» [[MitoPedia: Respirometry]]<br />
::::» [http://en.wikipedia.org/wiki/Respirometry Wikipedia: Respirometry]<br />
::::» [[O2k Applications]]<br />
<br />
<br /><br />
[[File:Expand.png|right|45px |Click to expand or collaps]]<br />
<div class="toccolours mw-collapsible mw-collapsed"><br />
:::[[File:Questions.jpg|left|24px |Explanation of terms]] '''» Keywords'''<br />
<div class="mw-collapsible-content"><br />
::: '''Instrument'''<br />
::::» [[DatLab]]; » [[MitoPedia: DatLab]]<br />
::::» Instrumental background oxygen flux »» [[MiPNet14.06 Instrumental O2 background]]<br />
::::» [[Oroboros O2k-Core (O2k-Series D - G)]]<br />
::::» [[O2k-FluoRespirometer]]<br />
::::» [[O2k-MultiSensor]]<br />
::::» [[Oroboros O2k]]; » [[MitoPedia: O2k hardware]]<br />
::::» [[Power O2k-Respirometer]]<br />
::::» [[MiPNet06.03 POS-calibration-SOP |Static sensor calibration]]<br />
::::» [[TIP2k-Module|TIP2k]]<br />
<br />
::: '''Concept'''<br />
::::» [[Concentration]]<br />
::::» [[Coupling-control state]] <br />
::::» [[High-resolution respirometry]]<br />
::::» [[Mitochondrial preparations]]<br />
::::» [[Oxidative phosphorylation]]<br />
::::» [[Oxygen |Oxygen, dioxygen, O<sub>2</sub>]]<br />
::::» [[Oxygen flux]]<br />
::::» [[Electron-transfer-pathway state]]<br />
::::» [[Respiration]]<br />
::::» [[Respirometry]]; » [[MitoPedia: Respirometry]]<br />
::::» [[SUIT| Substrate-uncoupler-inhibitor titration (SUIT) protocols]]; » [[MitoPedia: SUIT]]<br />
</div><br />
</div><br />
<br /><br />
<br />
[[Image:O2k-Publications.jpg|left|116px|link=O2k-Publications: Topics|O2k-Publications in the MiPMap]]<br />
<br /><br />
[[File:Expand.png|right|45px |Click to expand or collaps]]<br />
<div class="toccolours mw-collapsible mw-collapsed"><br />
::: <span style="font-size:105%; color:##424242">'''» References'''</span><br />
<div class="mw-collapsible-content"><br />
::: '''O2k-Publications'''<br />
::::* [[O2k-Publications |O2k-Publications: Chronological]]<br />
::::* [[O2k-Publications: Topics]]<br />
<br />
<br />
== Keywords: Oxygen signal ==<br />
{{Template:Keywords: Oxygen signal}}<br />
<br />
<br />
::: '''Selected references'''<br />
::::* [[Gnaiger 1995 J Bioenerg Biomembr]]<br />
::::* [[Gnaiger 2001 Respir Physiol]]<br />
::::* [[Gnaiger 2008 POS]]<br />
::::* [[Gnaiger 2020 BEC MitoPathways]]<br />
</div><br />
</div><br />
<br /><br />
<br />
{{MitoPedia methods<br />
|mitopedia method=Respirometry, Fluorometry, Spectrophotometry<br />
}}<br />
{{MitoPedia O2k and high-resolution respirometry<br />
|mitopedia O2k and high-resolution respirometry=O2k hardware, O2k-Respirometry, O2k-FluoRespirometry<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=High-resolution_respirometry&diff=246672High-resolution respirometry2024-03-28T09:02:51Z<p>Gnaiger Erich: </p>
<hr />
<div>{{MitoPedia<br />
|abbr=HRR<br />
|description=[[Image:O2k-Fluorometer.jpg|200px|left|O2k-FluoRespirometer]] '''High-resolution respirometry, HRR''', is the state-of-the-art approach in mitochondria and cell research to measure respiration in various types of [[mitochondrial preparations]] and [[living cells]] combined with MultiSensor modules. Mitochondrial function and dysfunction have gained increasing interest, reflecting growing awareness of the fact that mitochondria play a pivotal role in human health and disease. HRR combines instrumental accuracy and reliability with the versatility of applicable protocols, allowing practically unlimited addition and combination of substrates, inhibitors, and uncouplers in the [[Oroboros O2k]]. Substrate-uncoupler-inhibitor titration (SUIT) protocols allow the interrogation of numerous mitochondrial pathway and coupling states in a single respirometric assay. Mitochondrial respiratory pathways may be analyzed in detail to evaluate even minor alterations in respiratory coupling and pathway control patterns. <br />
<br />
The O2k is a sole source technology, with no other available instrument meeting its specifications for high-resolution respirometry. Technologically, HRR is based on the Oroboros O2k, combining optimized chamber design, application of oxygen-tight materials, electrochemical sensors, Peltier-temperature control, and specially developed software features (DatLab) to obtain the unique sensitive and quantitative resolution of oxygen concentration and oxygen flux, with both, a closed-chamber or open-chamber mode of operation ([[TIP2k-Module|TIP2k]]). Standardized calibration of the polarographic oxygen sensor (static sensor calibration), calibration of the sensor response time (dynamic sensor calibration), and evaluation of instrumental background oxygen flux (systemic flux compensation) provide the experimental basis for high accuracy of quantitative results and quality control in HRR. HRR can be extended for MultiSensor analysis by using the [[O2k-Fluo Smart-Module]]. [[Smart Fluo-Sensor]]s are integrated into the O2k to measure simultaneously fluorometric signals using specific fluorophores. Potentiometric modules are available with ion-selective electrodes (pH, TPP<sup>+)</sup>. The [[PB-Module]] extends HRR to PhotoBiology with accurate control of the light intensity and measurement of photosynthesis. The O2k-J and the NextGen-O2k support all these O2k-Modules. The [[NextGen-O2k]] all-in-one, however, is unique in supporting Q-Redox and NADH-Redox Modules.<br />
|info=[[Oroboros O2k]]<br />
}}<br />
[[File:O2k-Core to FluoRespirometer.jpg|right|400px |O2k-Core to FluoRespirometer]]<br />
<br />
<br />
::::* <big>'''Power O2k-Respirometer''':</big> Several O2k units are operated simultaneously ('''P'''1, '''P'''2, ..) to combine high-resolution respirometry with [[Power O2k-Respirometer |high-output]].<br />
<br />
<br />
== MitoPedia: O2k and high-resolution respirometry ==<br />
::::» [[MitoPedia: O2k hardware]]<br />
::::» [[MitoPedia: DatLab]]<br />
::::» [[MitoPedia: SUIT]]<br />
<br />
<br />
== Links ==<br />
::::'''»''' [[MitoPedia: Respiratory states]] [[Image:P.jpg|link=OXPHOS capacity|OXPHOS]] [[Image:R.jpg|link=ROUTINE respiration|ROUTINE]] [[Image:E.jpg|link=ET capacity|ET capacity]] [[Image:L.jpg|link=LEAK respiration|LEAK]] - [[Image:ROX.jpg|link=Residual oxygen consumption|ROX]]<br />
::::» [[Respirometry]]<br />
::::» [[MitoPedia: Respirometry]]<br />
::::» [http://en.wikipedia.org/wiki/Respirometry Wikipedia: Respirometry]<br />
::::» [[O2k Applications]]<br />
<br />
<br /><br />
[[File:Expand.png|right|45px |Click to expand or collaps]]<br />
<div class="toccolours mw-collapsible mw-collapsed"><br />
:::[[File:Questions.jpg|left|24px |Explanation of terms]] '''» Keywords'''<br />
<div class="mw-collapsible-content"><br />
::: '''Instrument'''<br />
::::» [[DatLab]]; » [[MitoPedia: DatLab]]<br />
::::» Instrumental background oxygen flux »» [[MiPNet14.06 Instrumental O2 background]]<br />
::::» [[Oroboros O2k-Core (O2k-Series D - G)]]<br />
::::» [[O2k-FluoRespirometer]]<br />
::::» [[O2k-MultiSensor]]<br />
::::» [[Oroboros O2k]]; » [[MitoPedia: O2k hardware]]<br />
::::» [[Power O2k-Respirometer]]<br />
::::» [[MiPNet06.03 POS-calibration-SOP |Static sensor calibration]]<br />
::::» [[TIP2k-Module|TIP2k]]<br />
<br />
::: '''Concept'''<br />
::::» [[Concentration]]<br />
::::» [[Coupling-control state]] <br />
::::» [[High-resolution respirometry]]<br />
::::» [[Mitochondrial preparations]]<br />
::::» [[Oxidative phosphorylation]]<br />
::::» [[Oxygen |Oxygen, dioxygen, O<sub>2</sub>]]<br />
::::» [[Oxygen flux]]<br />
::::» [[Electron-transfer-pathway state]]<br />
::::» [[Respiration]]<br />
::::» [[Respirometry]]; » [[MitoPedia: Respirometry]]<br />
::::» [[SUIT| Substrate-uncoupler-inhibitor titration (SUIT) protocols]]; » [[MitoPedia: SUIT]]<br />
</div><br />
</div><br />
<br /><br />
<br />
[[Image:O2k-Publications.jpg|left|116px|link=O2k-Publications: Topics|O2k-Publications in the MiPMap]]<br />
<br /><br />
[[File:Expand.png|right|45px |Click to expand or collaps]]<br />
<div class="toccolours mw-collapsible mw-collapsed"><br />
::: <span style="font-size:105%; color:##424242">'''» References'''</span><br />
<div class="mw-collapsible-content"><br />
::: '''O2k-Publications'''<br />
::::* [[O2k-Publications |O2k-Publications: Chronological]]<br />
::::* [[O2k-Publications: Topics]]<br />
<br />
<br />
== Keywords: Oxygen signal ==<br />
{{Template:Keywords: Oxygen signal}}<br />
<br />
<br />
::: '''Selected references'''<br />
::::* [[Gnaiger 1995 J Bioenerg Biomembr]]<br />
::::* [[Gnaiger 2001 Respir Physiol]]<br />
::::* [[Gnaiger 2008 POS]]<br />
::::* [[Gnaiger 2020 BEC MitoPathways]]<br />
</div><br />
</div><br />
<br /><br />
<br />
{{MitoPedia methods<br />
|mitopedia method=Respirometry, Fluorometry, Spectrophotometry<br />
}}<br />
{{MitoPedia O2k and high-resolution respirometry<br />
|mitopedia O2k and high-resolution respirometry=O2k hardware, O2k-Respirometry, O2k-FluoRespirometry<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Template:Next_oroboros_ecosystem_agenda&diff=246663Template:Next oroboros ecosystem agenda2024-03-27T08:40:12Z<p>Gnaiger Erich: </p>
<hr />
<div><br />
2024 Week 15<br />
<br />
* '''Apr-08 Mo'''<br />
:{|<br />
| width="110" align="center" | [[File:MitoPedia.jpg|left|80px|MitoPedia|link=MitoPedia]]<br />
|''' Is fatty acid oxidation (FAO) considered as CI- or CII-driven respiration? '''<br><br />
Neither. There is simultaneous electron transfer from FAO into the Q-junction through the electron transferring flavoprotein dehydrogenase complex (CETFDH) and Complex I. <br><br />
- »'''[[Fatty acid oxidation]]'''«, »'''[[Gnaiger 2020 BEC MitoPathways]]'''«, »'''[[Gnaiger 2024 J Biol Chem]]'''« <br><br />
- communicated by »[[Timon-Gomez Alba]]« and »[[Willis Jaime R]]« <br />
|}<br />
----<br />
* '''Apr-09 Tu''' <br />
:::: 10:00 '''[[Gnaiger Erich|Erich Gnaiger]] presenting at [[MOSBRI Consensus Meeting 2024 Rome IT]]''' - ''Quality-controlled high-resolution respirometry: bacterial and clinical applications''<br />
----<br />
* '''Apr-10 We''' <br />
----<br />
* '''Apr-11 Th''' <br />
World Parkinson's Disease Day<br />
:{|<br />
| width="100" align="center" |[[Image:O2k-Publications.jpg|70px|link=http://wiki.oroboros.at/index.php/O2k-Publications:_Topics |O2k-Publications in the MiPMap]]<br />
|'''"The markers of mitochondrial biogenesis were consistently affected in PD [Parkinson’s disease] patients group."''' <br><br />
* Kamienieva I, Charzyńska A, Duszyński J, Malińska D, Szczepanowska J (2023) In search for mitochondrial biomarkers of Parkinson's disease: Findings in parkin-mutant human fibroblasts. [[Kamienieva 2023 Biochim Biophys Acta Mol Basis Dis|»Bioblast link«]]<br />
:from the O2k-Network »[[PL Warsaw Szewczyk A]]«<br />
|}<br />
----<br />
* '''Apr-12 Fr'''<br />
<br />
2024 Week 16<br />
<br />
* '''Apr-15 Mo''' <br />
----<br />
* '''Apr-16 Tu''' <br />
----<br />
* '''Apr-17 We''' <br />
----<br />
* '''Apr-18 Th''' <br />
----<br />
* '''Apr-19 Fr'''<br />
<br />
2024 Week 17<br />
<br />
* '''Apr-22 Mo'''<br />
----<br />
* '''Apr-23 Tu''' <br />
----<br />
* '''Apr-24 We''' <br />
----<br />
* '''Apr-25 Th''' <br />
----<br />
* '''Apr-26 Fr'''<br />
<br />
2024 Week 18<br />
<br />
* '''Apr-29 Mo'''<br />
----<br />
* '''Apr-30 Tu''' <br />
----<br />
* '''May-01 We''' <br />
----<br />
* '''May-02 Th''' <br />
----<br />
* '''May-03 Fr'''<br />
<br />
2024 Week 19<br />
<br />
* '''May-06 Mo'''<br />
----<br />
* '''May-07 Tu''' <br />
----<br />
* '''May-08 We''' <br />
----<br />
* '''May-09 Th''' <br />
----<br />
* '''May-10 Fr'''<br />
<br />
2024 Week 20<br />
<br />
* '''May-13 Mo'''<br />
----<br />
* '''May-14 Tu''' <br />
----<br />
* '''May-15 We''' <br />
----<br />
* '''May-16 Th''' <br />
----<br />
* '''May-17 Fr'''<br />
<br />
2024 Week 21<br />
<br />
* '''May-20 Mo''' <br />
----<br />
* ''May-21 Tu''' <br />
----<br />
* '''May-22 We''' <br />
----<br />
* '''May-23 Th''' <br />
----<br />
* '''May-24 Fr'''<br />
<br />
2024 Week 22<br />
<br />
* '''May-27 Mo'''<br />
----<br />
* '''May-28 Tu''' <br />
----<br />
* '''May-29 We''' <br />
----<br />
* '''May-30 Th''' <br />
----<br />
* '''May-31 Fr'''<br />
<br />
2024 Week 23<br />
<br />
* '''Jun-03 Mo'''<br />
----<br />
* '''Jun-04 Tu''' <br />
----<br />
* '''Jun-05 We''' <br />
----<br />
* '''Jun-06 Th''' <br />
----<br />
* '''Jun-07 Fr'''<br />
<br />
2024 Week 24<br />
<br />
* '''Jun-10 Mo'''<br />
----<br />
* '''Jun-11 Tu''' <br />
----<br />
* '''Jun-12 We''' <br />
----<br />
* '''Jun-13 Th''' <br />
----<br />
* '''Jun-14 Fr'''<br />
<br />
2024 Week 25<br />
<br />
* '''Jun-17 Mo'''<br />
:::: [[Image:O2k-Workshops.png|60px|link=MiPNet28.02 IOC162 Schroecken AT]] <big> '''[[MiPNet28.11 IOC163 Schroecken AT]]'''</big> Jun 17-22<br />
<br />
----<br />
* '''Jun-18 Tu''' <br />
:::: [[Image:O2k-Workshops.png|60px|link=MiPNet28.02 IOC162 Schroecken AT]] <big> '''[[MiPNet28.11 IOC163 Schroecken AT]]'''</big> Jun 17-22<br />
----<br />
* '''Jun-19 We''' <br />
:::: [[Image:O2k-Workshops.png|60px|link=MiPNet28.02 IOC162 Schroecken AT]] <big> '''[[MiPNet28.11 IOC163 Schroecken AT]]'''</big> Jun 17-22<br />
----<br />
* '''Jun-20 Th''' <br />
:::: [[Image:O2k-Workshops.png|60px|link=MiPNet28.02 IOC162 Schroecken AT]] <big> '''[[MiPNet28.11 IOC163 Schroecken AT]]'''</big> Jun 17-22<br />
----<br />
* '''Jun-21 Fr'''<br />
:::: [[Image:O2k-Workshops.png|60px|link=MiPNet28.02 IOC162 Schroecken AT]] <big> '''[[MiPNet28.11 IOC163 Schroecken AT]]'''</big> Jun 17-22<br />
<br />
2024 Week 26<br />
<br />
* '''Jun-24 Mo'''<br />
----<br />
* '''Jun-25 Tu''' <br />
----<br />
* '''Jun-26 We''' <br />
----<br />
* '''Jun-27 Th''' <br />
----<br />
* '''Jun-28 Fr'''<br />
<br />
<br />
2024 Week 27<br />
<br />
* '''Jul-01 Mo'''<br />
----<br />
* '''Jul-02 Tu''' <br />
----<br />
* '''Jul-03 We''' <br />
----<br />
* '''Jul-04 Th''' <br />
----<br />
* '''Jul-05 Fr'''<br />
<br />
2024 Week 28<br />
<br />
* '''Jul-08 Mo'''<br />
----<br />
* '''Jul-09 Tu''' <br />
----<br />
* '''Jul-10 We''' <br />
----<br />
* '''Jul-11 Th''' <br />
----<br />
* '''Jul-12 Fr'''<br />
<br />
2024 Week 29<br />
<br />
* '''Jul-15 Mo'''<br />
----<br />
* '''Jul-16 Tu''' <br />
----<br />
* '''Jul-17 We''' <br />
----<br />
* '''Jul-18 Th''' <br />
----<br />
* '''Jul-19 Fr'''<br />
<br />
2024 Week 30<br />
<br />
* '''Jul-22 Mo'''<br />
----<br />
* '''Jul-23 Tu''' <br />
----<br />
* '''Jul-24 We''' <br />
----<br />
* '''Jul-25 Th''' <br />
----<br />
* '''Jul-26 Fr'''<br />
<br />
2024 Week 31<br />
<br />
* '''Jul-29 Mo'''<br />
----<br />
* '''Jul-30 Tu''' <br />
----<br />
* '''Jul-31 We''' <br />
----<br />
* '''Aug-01 Th''' <br />
----<br />
* '''Aug-02 Fr'''<br />
<br />
2024 Week 32<br />
<br />
* '''Aug-05 Mo'''<br />
----<br />
* '''Aug-06 Tu''' <br />
----<br />
* '''Aug-07 We''' <br />
----<br />
* '''Aug-08 Th''' <br />
----<br />
* '''Aug-09 Fr'''<br />
<br />
2024 Week 33<br />
<br />
* '''Aug-12 Mo'''<br />
----<br />
* '''Aug-13 Tu''' <br />
----<br />
* '''Aug-14 We''' <br />
----<br />
* '''Aug-15 Th''' <br />
----<br />
* '''Aug-16 Fr'''<br />
<br />
2024 Week 34<br />
<br />
* '''Aug-19 Mo'''<br />
----<br />
* '''Aug-20 Tu''' <br />
----<br />
* '''Aug-21 We''' <br />
----<br />
* '''Aug-22 Th''' <br />
----<br />
* '''Aug-23 Fr'''<br />
<br />
2024 Week 35<br />
<br />
* '''Aug-26 Mo'''<br />
----<br />
* '''Aug-27 Tu''' <br />
----<br />
* '''Aug-28 We''' <br />
----<br />
* '''Aug-29 Th''' <br />
----<br />
* '''Aug-30 Fr'''<br />
<br />
2024 Week 36<br />
<br />
* '''Sep-02 Mo'''<br />
----<br />
* '''Sep-03 Tu''' <br />
----<br />
* '''Sep-04 We''' <br />
----<br />
* '''Sep-05 Th''' <br />
----<br />
* '''Sep-06 Fr'''<br />
<br />
2024 Week 37<br />
<br />
* '''Sep-09 Mo'''<br />
----<br />
* '''Sep-10 Tu''' <br />
----<br />
* '''Sep-11 We''' <br />
----<br />
* '''Sep-12 Th''' <br />
----<br />
* '''Sep-13 Fr'''<br />
<br />
2024 Week 38<br />
<br />
* '''Sep-16 Mo'''<br />
----<br />
* '''Sep-17 Tu''' <br />
----<br />
* '''Sep-18 We''' <br />
----<br />
* '''Sep-19 Th''' <br />
----<br />
* '''Sep-20 Fr'''<br />
<br />
2024 Week 39<br />
<br />
* '''Sep-22 Su'''<br />
::::: <big> '''[[EMC2024 Ljubljana SI]]'''</big> 2024 Sep 22-26 <br />
* '''Sep-23 Mo'''<br />
::::: <big> '''[[EMC2024 Ljubljana SI]]'''</big> 2024 Sep 22-26 <br />
----<br />
* '''Sep-24 Tu''' <br />
::::: <big> '''[[EMC2024 Ljubljana SI]]'''</big> 2024 Sep 22-26 <br />
----<br />
* '''Sep-25 We''' <br />
::::: <big> '''[[EMC2024 Ljubljana SI]]'''</big> 2024 Sep 22-26 <br />
----<br />
* '''Sep-26 Th''' <br />
::::: <big> '''[[EMC2024 Ljubljana SI]]'''</big> 2024 Sep 22-26 <br />
----<br />
* '''Sep-27 Fr'''<br />
<br />
<br />
2024 Week 40<br />
<br />
* '''Sep-30 Mo'''<br />
:::: [[Image:O2k-Workshops.png|60px|link=MiPNet28.02 IOC164 Schroecken AT]] <big> '''[[MiPNet28.12 IOC164 Schroecken AT]]'''</big> Sep 30-Okt 05<br />
----<br />
* '''Okt-01 Tu''' <br />
:::: [[Image:O2k-Workshops.png|60px|link=MiPNet28.02 IOC164 Schroecken AT]] <big> '''[[MiPNet28.12 IOC164 Schroecken AT]]'''</big> Sep 30-Okt 05<br />
----<br />
* '''Okt-02 We''' <br />
:::: [[Image:O2k-Workshops.png|60px|link=MiPNet28.02 IOC164 Schroecken AT]] <big> '''[[MiPNet28.12 IOC164 Schroecken AT]]'''</big> Sep 30-Okt 05<br />
----<br />
* '''Okt-03 Th''' <br />
:::: [[Image:O2k-Workshops.png|60px|link=MiPNet28.02 IOC164 Schroecken AT]] <big> '''[[MiPNet28.12 IOC164 Schroecken AT]]'''</big> Sep 30-Okt 05<br />
----<br />
* '''Okt-04 Fr'''<br />
:::: [[Image:O2k-Workshops.png|60px|link=MiPNet28.02 IOC164 Schroecken AT]] <big> '''[[MiPNet28.12 IOC164 Schroecken AT]]'''</big> Sep 30-Okt 05<br />
<br />
2024 Week 41<br />
<br />
* '''Okt-07 Mo'''<br />
----<br />
* '''Okt-08 Tu''' <br />
----<br />
* '''Okt-09 We''' <br />
----<br />
* '''Okt-10 Th''' <br />
----<br />
* '''Okt-11 Fr'''<br />
<br />
2024 Week 42<br />
<br />
* '''Okt-14 Mo'''<br />
----<br />
* '''Okt-15 Tu''' <br />
----<br />
* '''Okt-16 We''' <br />
----<br />
* '''Okt-17 Th''' <br />
----<br />
* '''Okt-18 Fr'''<br />
<br />
2024 Week 43<br />
<br />
* '''Okt-21 Mo'''<br />
----<br />
* '''Okt-22 Tu''' <br />
----<br />
* '''Okt-23 We''' <br />
----<br />
* '''Okt-24 Th''' <br />
----<br />
* '''Okt-25 Fr'''<br />
::::: <big> '''[[14th Mitochondrial Disease Conference 2024 Padova IT]]'''</big> 2024 Oct 25-27<br />
<br />
2024 Week 44<br />
<br />
* '''Okt-28 Mo'''<br />
----<br />
* '''Okt-29 Tu''' <br />
----<br />
* '''Okt-30 We''' <br />
----<br />
* '''Okt-31 Th''' <br />
----<br />
* '''Nov-01 Fr''' <br />
<br />
2024 Week 45<br />
<br />
* '''Nov-04 Mo'''<br />
----<br />
* '''Nov-05 Tu''' <br />
----<br />
* '''Nov-06 We''' <br />
----<br />
* '''Nov-07 Th''' <br />
----<br />
* '''Nov-08 Fr'''<br />
<br />
2024 Week 46<br />
<br />
* '''Nov-11 Mo'''<br />
----<br />
* '''Nov-12 Tu''' <br />
----<br />
* '''Nov-13 We''' <br />
----<br />
* '''Nov-14 Th''' <br />
----<br />
* '''Nov-15 Fr'''<br />
<br />
<br />
2024 Week 47<br />
<br />
* '''Nov-18 Mo'''<br />
----<br />
* '''Nov-19 Tu''' <br />
----<br />
* '''Nov-20 We''' <br />
----<br />
* '''Nov-21 Th''' <br />
----<br />
* '''Nov-22 Fr'''<br />
<br />
2024 Week 48<br />
<br />
* '''Nov-25 Mo'''<br />
----<br />
* '''Nov-26 Tu''' <br />
----<br />
* '''Nov-27 We''' <br />
----<br />
* '''Nov-28 Th''' <br />
----<br />
* '''Nov-29 Fr'''<br />
<br />
2024 Week 49<br />
<br />
* '''Dez-02 Mo'''<br />
----<br />
* '''Dez-03 Tu''' <br />
----<br />
* '''Dez-04 We''' <br />
----<br />
* '''Dez-05 Th''' <br />
----<br />
* '''Dez-06 Fr'''<br />
<br />
2024 Week 50<br />
<br />
* '''Dez-09 Mo'''<br />
----<br />
* '''Dez-10 Tu''' <br />
----<br />
* '''Dez-11 We''' <br />
----<br />
* '''Dez-12 Th''' <br />
----<br />
* '''Dez-13 Fr'''<br />
<br />
2024 Week 51<br />
<br />
* '''Dez-16 Mo'''<br />
----<br />
* '''Dez-17 Tu''' <br />
----<br />
* '''Dez-18 We''' <br />
----<br />
* '''Dez-19 Th''' <br />
----<br />
* '''Dez-20 Fr'''<br />
<br />
2024 Week 52<br />
<br />
* '''Dez-23 Mo'''<br />
----<br />
* '''Dez-24 Tu''' <br />
----<br />
* '''Dez-25 We''' <br />
----<br />
* '''Dez-26 Th''' <br />
----<br />
* '''Dez-27 Fr'''</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Steininger_2002_J_Antimicrob_Chemother&diff=246661Steininger 2002 J Antimicrob Chemother2024-03-27T07:45:33Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=Steininger C, Allerberger F, Gnaiger E (2002) Clinical significance of inhibition kinetics in ''Streptococcus pyogenes'' in response to penicillin. J Antimicrob Chemother 50:517-23. https://doi.org/10.1093/jac/dkf174<br />
|info=[http://www.ncbi.nlm.nih.gov/pubmed/12356796 PMID: 12356796 Open Access]<br />
|authors=Steininger C, Allerberger F, Gnaiger Erich<br />
|year=2002<br />
|journal=J Antimicrob Chemother<br />
|abstract=Objectives: The antibiotic mode of action against clinical isolates of ''Streptococcus pyogenes'' and physiological factors involved in modifying the inhibitory response to the antibiotic were investigated.<br />
Methods: We developed high-resolution respirometry for continuous monitoring of bacterial growth and inhibition kinetics. One hundred and ten clinical isolates from 90 paediatric patients were tested, including 48 isolates obtained from 28 patients with eradication failure. Respirometric inhibition curves were monitored at 4 mg/L penicillin G over a short 30 min period, corresponding to the drug’s serum half-life.<br />
<br />
Results: None of the clinical isolates exhibited penicillin tolerance. Latency in the respirometric response of ''S. pyogenes'' to penicillin increased significantly with decreasing strain-specific respirometric growth rate. No difference in inhibition kinetics was found in vitro for isolates from patients with or without bacteriological treatment failure.<br />
Conclusions: In streptococcal pharyngotonsillitis, tolerance is not a relevant concept to explain bacteriological treatment failure. Definitions of tolerance should be reconsidered in the framework of growth-dependent antibiotic susceptibility.<br />
|mipnetlab=AT Innsbruck Gnaiger E, AT Innsbruck Oroboros <br />
}}<br />
== Cited by ==<br />
::* 2 articles in PubMed (2021-12-27) https://pubmed.ncbi.nlm.nih.gov/12356796/<br />
<br />
{{Labeling<br />
|area=Respiration, mt-Biogenesis;mt-density, mt-Medicine, Pharmacology;toxicology<br />
|diseases=Infectious<br />
|organism=Eubacteria<br />
|preparations=Intact cells<br />
|couplingstates=ROUTINE<br />
|instruments=Oxygraph-2k<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Donnelly_2023_MitoFit&diff=246660Donnelly 2023 MitoFit2024-03-27T07:13:56Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=Donnelly C, Komlódi T, Cecatto C, Cardoso LHD, Compagnion AC, Matera A, Tavernari D, Zanou N, Kayser B, Gnaiger E, Place N (2023) Functional hypoxia reduces mitochondrial calcium uptake. MitoFit Preprints 2023.2. https://doi.org/10.26124/mitofit:2023-0002 — ''2024-11-17 published in [[Donnelly 2024 Redox Biol |'''Redox Biol''']].''<br />
|info=MitoFit Preprints 2023.2. [[File:MitoFit Preprints pdf.png|left|160px|link=https://wiki.oroboros.at/images/b/b4/Donnelly_2023_MitoFit.pdf|MitoFit pdf]] [https://wiki.oroboros.at/images/b/b4/Donnelly_2023_MitoFit.pdf Functional hypoxia reduces mitochondrial calcium uptake.]<br/><br />
|authors=MitoFit Preprints<br />
|year=2023<br />
|journal=MitoFit Prep<br />
|abstract=Mitochondrial respiration extends beyond ATP generation, with the organelle participating in many cellular and physiological processes. Parallel changes in components of the mitochondrial electron transfer system with respiration render it an appropriate hub for coordinating cellular adaption to changes in oxygen levels. How changes in respiration under functional hypoxia (i.e., when intracellular O<sub>2</sub> levels limit mitochondrial respiration) are relayed by the electron transfer system to impact mitochondrial adaption and remodeling after hypoxic exposure remains poorly defined. This is largely due to challenges integrating findings under controlled and defined O<sub>2</sub> levels in studies connecting functions of isolated mitochondria to humans during physical exercise. Here we present experiments under conditions of hypoxia in isolated mitochondria, myotubes and exercising humans. Performing steady-state respirometry with isolated mitochondria we found that oxygen limitation of respiration reduced electron flow and oxidative phosphorylation, lowered the mitochondrial membrane potential difference, and decreased mitochondrial calcium influx. Similarly, in myotubes under functional hypoxia mitochondrial calcium uptake decreased in response to sarcoplasmic reticulum calcium release for contraction. In both myotubes and human skeletal muscle this blunted mitochondrial adaptive responses and remodeling upon contractions. Our results suggest that by regulating calcium uptake the mitochondrial electron transfer system is a hub for coordinating cellular adaption under functional hypoxia.<br><br />
|keywords=respirometry; membrane potential; skeletal muscle; exercise; coenzyme Q<br />
|editor=[[Tindle-Solomon L]]<br />
|mipnetlab=AT Innsbruck Oroboros, CH Lausanne Place N, HU Budapest Tretter L<br />
}}<br />
<br />
ORC'''ID''': [[File:ORCID.png|20px|link=https://orcid.org/0000-0002-5392-7876]] Donnelly Chris, [[File:ORCID.png|20px|link=https://orcid.org/0000-0001-9876-1411]] Komlodi Timea, [[File:ORCID.png|20px|link=https://orcid.org/0000-0001-7068-6165]] Cecatto Cristiane, [[File:ORCID.png|20px|link=https://orcid.org/0000-0001-6392-9229]] Cardoso Luiza HD, [[File:ORCID.png|20px|link=https://orcid.org/0000-0002-9776-7501]] Kayser Bengt, [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-3647-5895]] Gnaiger Erich,[[File:ORCID.png|20px|link=https://orcid.org/0000-0001-9044-0621]] Place Nicolas<br />
{{Labeling<br />
|area=Respiration, Exercise physiology;nutrition;life style<br />
|injuries=Hypoxia<br />
|organism=Human, Mouse<br />
|tissues=Heart, Skeletal muscle, Nervous system, Other cell lines<br />
|preparations=Isolated mitochondria<br />
|topics=Calcium, mt-Membrane potential, Redox state<br />
|instruments=Oxygraph-2k, TIP2k, O2k-Fluorometer, Ca, NextGen-O2k<br />
|additional=Steady state<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Donnelly_2023_MitoFit&diff=246659Donnelly 2023 MitoFit2024-03-27T07:13:16Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=Donnelly C, Komlódi T, Cecatto C, Cardoso LHD, Compagnion AC, Matera A, Tavernari D, Zanou N, Kayser B, Gnaiger E, Place N (2023) Functional hypoxia reduces mitochondrial calcium uptake. MitoFit Preprints 2023.2. https://doi.org/10.26124/mitofit:2023-0002 — ''2024-11-17 published in [[Donnelly 2024 Redox Biol |'''Redox Biol'''].''<br />
|info=MitoFit Preprints 2023.2. [[File:MitoFit Preprints pdf.png|left|160px|link=https://wiki.oroboros.at/images/b/b4/Donnelly_2023_MitoFit.pdf|MitoFit pdf]] [https://wiki.oroboros.at/images/b/b4/Donnelly_2023_MitoFit.pdf Functional hypoxia reduces mitochondrial calcium uptake.]<br/><br />
|authors=MitoFit Preprints<br />
|year=2023<br />
|journal=MitoFit Prep<br />
|abstract=Mitochondrial respiration extends beyond ATP generation, with the organelle participating in many cellular and physiological processes. Parallel changes in components of the mitochondrial electron transfer system with respiration render it an appropriate hub for coordinating cellular adaption to changes in oxygen levels. How changes in respiration under functional hypoxia (i.e., when intracellular O<sub>2</sub> levels limit mitochondrial respiration) are relayed by the electron transfer system to impact mitochondrial adaption and remodeling after hypoxic exposure remains poorly defined. This is largely due to challenges integrating findings under controlled and defined O<sub>2</sub> levels in studies connecting functions of isolated mitochondria to humans during physical exercise. Here we present experiments under conditions of hypoxia in isolated mitochondria, myotubes and exercising humans. Performing steady-state respirometry with isolated mitochondria we found that oxygen limitation of respiration reduced electron flow and oxidative phosphorylation, lowered the mitochondrial membrane potential difference, and decreased mitochondrial calcium influx. Similarly, in myotubes under functional hypoxia mitochondrial calcium uptake decreased in response to sarcoplasmic reticulum calcium release for contraction. In both myotubes and human skeletal muscle this blunted mitochondrial adaptive responses and remodeling upon contractions. Our results suggest that by regulating calcium uptake the mitochondrial electron transfer system is a hub for coordinating cellular adaption under functional hypoxia.<br><br />
|keywords=respirometry; membrane potential; skeletal muscle; exercise; coenzyme Q<br />
|editor=[[Tindle-Solomon L]]<br />
|mipnetlab=AT Innsbruck Oroboros, CH Lausanne Place N, HU Budapest Tretter L<br />
}}<br />
<br />
ORC'''ID''': [[File:ORCID.png|20px|link=https://orcid.org/0000-0002-5392-7876]] Donnelly Chris, [[File:ORCID.png|20px|link=https://orcid.org/0000-0001-9876-1411]] Komlodi Timea, [[File:ORCID.png|20px|link=https://orcid.org/0000-0001-7068-6165]] Cecatto Cristiane, [[File:ORCID.png|20px|link=https://orcid.org/0000-0001-6392-9229]] Cardoso Luiza HD, [[File:ORCID.png|20px|link=https://orcid.org/0000-0002-9776-7501]] Kayser Bengt, [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-3647-5895]] Gnaiger Erich,[[File:ORCID.png|20px|link=https://orcid.org/0000-0001-9044-0621]] Place Nicolas<br />
{{Labeling<br />
|area=Respiration, Exercise physiology;nutrition;life style<br />
|injuries=Hypoxia<br />
|organism=Human, Mouse<br />
|tissues=Heart, Skeletal muscle, Nervous system, Other cell lines<br />
|preparations=Isolated mitochondria<br />
|topics=Calcium, mt-Membrane potential, Redox state<br />
|instruments=Oxygraph-2k, TIP2k, O2k-Fluorometer, Ca, NextGen-O2k<br />
|additional=Steady state<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Baglivo_2022_MitoFit-QC&diff=246658Baglivo 2022 MitoFit-QC2024-03-27T07:12:54Z<p>Gnaiger Erich: </p>
<hr />
<div>[[File:Bioblast2022 banner.jpg|link=Bioblast_2022]]<br />
{{MitoFit page name}}<br />
{{Publication<br />
|title=Baglivo E, Cardoso LHD, Cecatto C, Gnaiger E (2022) Statistical analysis of instrumental reproducibility as internal quality control in high-resolution respirometry. https://doi.org/10.26124/mitofit:2022-0018.v2 — ''2022-08-04 published in [https://doi.org//10.26124/bec:2022-0008 '''Bioenerg Commun 2022.8.''']''<br />
|info=MitoFit Preprints 2022.18. [[File:MitoFit Preprints pdf.png|left|160px|link=https://wiki.oroboros.at/images/c/c8/Baglivo_2022_MitoFit-QC.pdf|MitoFit pdf]] [https://wiki.oroboros.at/images/c/c8/Baglivo_2022_MitoFit-QC.pdf Statistical analysis of instrumental reproducibility as internal quality control in high-resolution respirometry] [[File:WatchThePresentationYoutube_icon.jpg|200px|link=https://www.youtube.com/watch?v=mNSu-hY3hUg&t=15s|»''Watch the presentation''«]]<br />
|authors=MitoFit Preprints<br />
|year=2022<br />
|journal=MitoFit Prep<br />
|abstract=::: <small>Version 2 ('''v2''') '''2022-05-09''' [https://wiki.oroboros.at/images/c/c8/Baglivo_2022_MitoFit-QC.pdf doi:10.26124/mitofit:2022-0018.v2]</small><br />
::: <small>Version 1 (v1) 2022-05-05 [https://wiki.oroboros.at/images/archive/c/c8/20220506062726%21Baglivo_2022_MitoFit-QC.pdf doi:10.26124/mitofit:2022-0018.v1] - [https://wiki.oroboros.at/index.php/File:Baglivo_2022_MitoFit-QC.pdf »Link to all versions«]</small><br />
<br />
[[File:Baglivo 2022 MitoFit QC graphical-abstract.png|right|300px|Graphical abstract]]<br />
<br />
[[Baglivo 2022 Abstract Bioblast]]: Evaluation of instrumental reproducibility is a primary component of quality control to quantify the precision and limit of detection of analytical procedures. A pre-analytical instrumental standard operating procedure (SOP) is implemented in high-resolution respirometry consisting of: (''1'') a daily SOP-POS for air calibration of the polarographic oxygen sensor (POS) in terms of oxygen concentration ''c''<sub>O<sub>2</sub></sub> [µM]. This is part of the ''sensor test'' to evaluate POS performance; (''2'') a monthly SOP-BG starting with the SOP-POS followed by the ''chamber test'' quantifying the instrumental O<sub>2</sub> background. The chamber test focuses on the slope d''c''<sub>O<sub>2</sub></sub>/d''t'' [pmol∙s<sup>−1</sup>∙mL<sup>−1</sup>] to determine O<sub>2</sub> consumption by the POS and O<sub>2</sub> backdiffusion into the chamber as a function of ''c''<sub>O<sub>2</sub></sub> in the absence of sample. Finally, zero O<sub>2</sub> calibration completes the sensor test. <br />
<br />
We applied this SOP in a 3-year study using 48 Oroboros O2k chambers. Stability of air and zero O<sub>2</sub> calibration signals was monitored throughout intervals of up to 8 months without sensor service. Maximum drift over 1 to 3 days was 0.06 pmol∙s<sup>−1</sup>∙mL<sup>−1</sup>, without persistence over time since drift was <0.004 pmol∙s<sup>−1</sup>∙mL<sup>−1</sup> for time intervals of one month, corresponding to a drift per day of 0.2 % of the signal at air saturation. Instrumental O<sub>2</sub> background -d''c''<sub>O<sub>2</sub></sub>/d''t'' was stable within ±1 pmol∙s<sup>−1</sup>∙mL<sup>−1</sup> when measured at monthly intervals. These results confirm the instrumental limit of detection of volume-specific O<sub>2</sub> flux at ±1 pmol∙s<sup>−1</sup>∙mL<sup>−1</sup>. The instrumental SOP applied in the present study contributes to the generally applicable internal quality control management ensuring the unique reproducibility in high-resolution respirometry.<br />
|mipnetlab=AT Innsbruck Oroboros<br />
}}<br />
ORC'''ID''':[[File:ORCID.png|20px|link= https://orcid.org/0000-0002-5507-9663]] Baglivo Eleonora [[File:ORCID.png|20px|link=https://orcid.org/0000-0001-6392-9229]] Cardoso Luiza HD, [[File:ORCID.png|20px|link=https://orcid.org/0000-0001-7068-6165]] Cecatto Cristiane, [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-3647-5895]] Gnaiger Erich<br />
__TOC__<br />
== Data availability ==<br />
:::: Original files are available Open Access at Zenodo repository: https://doi.org/10.26124/mitofit:2022-0018<br />
<br />
== References ==<br />
<br />
{{#ask:[[Additional label::MitoFit2022QC]]<br />
| mainlabel=Link<br />
|?Has title=Reference<br />
|?Was published in year=Year<br />
|?Has info=View<br />
|format=broadtable<br />
|limit=5000<br />
|offset=0<br />
|sort=Has title<br />
|order=ascending<br />
}}<br />
<br />
== Support ==<br />
<br />
:::: This work was part of the Oroboros [[NextGen-O2k]] project, with funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement nº 859770.<br />
<br />
{{Labeling<br />
|area=Respiration, Instruments;methods<br />
|tissues=HEK<br />
|instruments=Oxygraph-2k, O2k-Protocol<br />
|additional=Bioblast 2022, SUIT-001 O2 ce-pce D003<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=MitoPedia:_DatLab&diff=246647MitoPedia: DatLab2024-03-26T09:27:49Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Technical support}}{{MitoPedia_navigation_line}}<br />
::: '''Welcome at MitoPedia: DatLab'''. Here you find [[O2k-Open Support|'''Oroboros support''']] for DatLab and the '''[[MitoPedia: O2k hardware |O2k]]'''.<br />
<br />
<br />
<big><big>'''List of DatLab menus'''</big></big><br />
__TOC__<br />
<br />
[[File:DatLab-bar.jpg|460px|link=DatLab]]<br />
[[Image:Logo OROBOROS-DatLab.jpg|left|60px||link=http://wiki.oroboros.at/index.php/DatLab |DatLab]]<br />
<big><big>'''[[DatLab installation]]'''</big></big><br />
::::* 2024-03-21 On the calendar date of the beginning of spring, the Oroboros DatLab team proudly announced that '''the new DatLab 8.1 version was finally released'''.<br />
::::» <big> [[MiPNet21.16 DatLab 7 Innovations]]</big><br />
::::» <big> [[MiPNet26.06 DatLab 7: Guide]]</big><br />
<br />
[[File:File-menu.png|right|150px]]<br />
=== File ===<br />
::::» [[Open DLD file|Open]]<br />
::::» [[Close - DatLab| Close]]<br />
::::» [[Save - DatLab | Save]]<br />
::::» [[Save and Disconnect | Save and disconnect]]<br />
::::» [[Save as - DatLab | Save as]]<br />
::::» [[File search - DatLab| File search]]<br />
::::» [[Delete - DatLab | Delete]]<br />
::::» Import DatLab templates [[DatLab templates]]<br />
::::» Export<br />
:::::* [[Export DL-Protocol User (*.DLPU)]]<br />
:::::* Data to text file: [[Text file - DatLab | Text file]]<br />
:::::* Export - Events to text file: [[Text file - DatLab | Text file]]<br />
:::::* Export - One channel to DatLab 2 analysis: [[DatLab 2]]<br />
::::» Change user: [[User code - DatLab | User]]<br />
::::» Manage users: [[User code - DatLab | User]]<br />
<br />
[[File:O2k-menu.png|right|150px]]<br />
=== Oroboros O2k ===<br />
::::» [[O2k configuration]]<br />
::::» [[O2k channel labels]]<br />
::::» [[O2k control]]<br />
::::» [[Stirrer A on/off]]<br />
::::» [[Stirrer B on/off]]<br />
::::» [[Stirrer test]]<br />
::::» [[Illumination on/off]]<br />
::::» Manage setups: [[Manage setups and templates - DatLab |Manage setups and templates]]<br />
<br />
[[File:TIP2k-menu.png|right|150px]]<br />
=== TIP2k ===<br />
::::» TIP2k control: [[MiPNet12.10 TIP2k-manual|Titration-Injection microPump]]<br />
::::» Manage setups: [[Manage setups and templates - DatLab |Manage setups and templates]]<br />
<br />
[[File:Protocol-menu.png|right|200px]]<br />
=== Protocols ===<br />
<br />
::::» [[Run DL-Protocol/Set O2 limit]]<br />
::::» [[Run_DL-Protocol/Set_O2_limit#Protocol_menu |Show DL-Protocol and Synchronous DL-Protocol events]]<br />
::::» [[Instrumental: Browse DL-Protocols and templates]]<br />
::::» [[SUIT: Browse DL-Protocols and templates]]<br />
::::» [[Install Oroboros protocol package]]<br />
::::» [[MitoPedia: SUIT |Browse www.bioblast.at/index.php./MitoPedia: SUIT]]<br />
::::» [[Enable DL-Protocol editing]]<br />
<br />
[[File:Experiment-menu.png|right|150px]]<br />
=== Experiment ===<br />
::::» [[Sample - DatLab |Sample]]<br />
::::» [[Experimental log - DatLab |Experimental log]]<br />
::::» Add event: [[Events - DatLab |Events]]<br />
<br />
[[File:Calibration-menu.png|right|150px]]<br />
=== Calibration ===<br />
::::» O2: [[O2 calibration - DatLab|O2 calibration]]<br />
::::» Amp: [[Amp calibration - DatLab|Amp calibration]] <br />
::::» pX: [[PX calibration - DatLab|pX calibration]]<br />
<br />
[[File:Flux-Slope-menu.png|right|130px]]<br />
=== Flux / Slope ===<br />
::::» O2: [[Flux / Slope]]<br />
::::» Amp: [[Flux / Slope]]<br />
::::» pX: [[Flux / Slope]]<br />
::::» Proton [[Flux / Slope]]<br />
<br />
[[File:Graph-menu.png|right|150px]]<br />
=== Graph ===<br />
::::» Add graph/Delete bottom graph: [[Add Graph/Delete bottom graph|Add/Delete]]<br />
::::» Select plots: [[Select plots - DatLab]]<br />
::::» Scaling: [[Scaling - DatLab]]<br />
::::» Info: [[Layout_for_DatLab_graphs#Graph / Info|Graph / Info]]<br />
::::» [[Synchronous time axes]]<br />
::::» [[Autoscale]]<br />
:::::* [[Autoscale time axis]]<br />
:::::* [[Autoscale Y1 (Y2) axes]]<br />
:::::* [[Automatic pan]]<br />
::::» Mouse control: [[Mouse control: Mark|Mark]] and [[Mouse control: Zoom|Zoom]]<br />
::::» [[Full screen]]<br />
::::» [[Display numerical value]]<br />
::::» [[Display Power-O2k]]<br />
::::» Options: [[Graph options - DatLab |Graph options]]<br />
::::» [[Copy to clipboard]]<br />
<br />
<br />
[[File:Layout-menu.png|right|150px]]<br />
=== Layout ===<br />
::::» Info / Load / Save: [[Layout_for_DatLab_graphs#Layout: Info/ Load/ Safe| Layout: Info/ Load/ Safe]]<br />
::::» Standard layouts - O2k-FluoRespirometer: [[Layout_for_DatLab_graphs#Standard layouts - O2k-FluoRespirometer |Standard layouts - O2k-FluoRespirometer]]<br />
::::» Lab layouts: [[Layout_for_DatLab_graphs#Lab layouts| Lab layouts]]<br />
::::» User: Name: [[Layout_for_DatLab_graphs#User: Name| User: Name]]<br />
<br />
[[File:Marks-menu.png|right|150px]]<br />
=== Marks ===<br />
::::» Edit mark information: [[Marks - DatLab|Marks]]<br />
::::» Statistics: [[Mark statistics - DatLab|Mark statistics]]<br />
::::» Manage mark stat. templates: [[Manage setups and templates - DatLab |Manage setups and templates]]<br />
::::» Specifications: [[Mark specifications - DatLab |Mark specifications]]<br />
::::» Manage mark specifications templates: [[Manage setups and templates - DatLab |Manage setups and templates]]<br />
::::» [[Copy marks]]<br />
<br />
<br />
== DatLab glossary ==<br />
<br />
{{#ask:[[MitoPedia O2k and high-resolution respirometry::DatLab]]<br />
| mainlabel=Term<br />
|?Has abbr=Abbreviation<br />
|?Description=Description<br />
|format=broadtable<br />
|limit=1000<br />
|order=ascending<br />
}}<br />
<br />
<br />
<br />
== Further links ==<br />
<br />
::::» [[O2k-Manual#DatLab_manuals |O2k-Manual: DatLab]]<br />
::::» [[O2k-Demo experiments]]<br />
::::» [[DatLab |O2k-Catalogue: DatLab]]<br />
<br />
<br />
::: Related topics<br />
::::» [[MitoPedia: Respirometry|Respirometry]]<br />
::::» [[MitoPedia: Fluorometry|Fluorometry]]<br />
::::» [[MitoPedia: Spectrophotometry|Spectrophotometry]]</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Select_O2k_-_DatLab&diff=246645Select O2k - DatLab2024-03-26T08:26:46Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Technical support}}<br />
{{MitoPedia without banner<br />
|description='''Select O2k - DatLab''' <br />
|info=<br />
}}<br />
<br />
__TOC__<br />
== DatLab 8 ==<br />
<br />
:::* 2024-03-21 On the calendar date of the beginning of spring, the Oroboros DatLab team proudly announced that '''the new DatLab 8.1 version was finally released'''.<br />
<br />
<br />
{{Labeling<br />
|area=Instruments;methods<br />
|additional=DatLab, DL8, DatLab 8<br />
}}<br />
{{MitoPedia methods<br />
|mitopedia method=Respirometry<br />
}}<br />
{{MitoPedia O2k and high-resolution respirometry<br />
|mitopedia O2k and high-resolution respirometry=DatLab<br />
}}<br />
[[Category:DatLab 8]]</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=DatLab&diff=246644DatLab2024-03-26T08:19:41Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Technical support}}<br />
__TOC__<br />
{{MitoPedia without banner<br />
|abbr=<br />
|description=[[Image:Logo OROBOROS-DatLab.jpg|200px|right|DatLab]]'''DatLab''' is the O2k-Software for Data Acquisition & Analysis, specifically developed for [[high-resolution respirometry]] with the O2k.<br />
The newest DatLab version is '''DatLab 8''', included in the O2k-Packages. NextGen-O2k and O2k-Series J* and higher come with DatLab 8 installed on the integrated PC (Linux). DatLab 8 is required for the NextGen-O2k. DatLab 8.1 is compatible with O2k-Series (E and higher).<br />
<br />
The DatLab software is designed for 64-bit versions of Windows operating systems and does not run on MAC devices.<br />
<br />
The minimum computer requirements are Intel-Core-2 or equivalent CPU, 2GB RAM and Windows XP (64-bit version). However, we recommend Intel i5 or equivalent CPU, 4GB RAM, Windows 10 (64-bit version) and SSD. For the proper display of DatLab on your computer, please make sure the “Language settings” are set to English.<br />
<br />
&#42;Optionally available without integrated PC.<br />
<br />
|info=[[Image:MitoPedia.jpg|left|60px|link=http://www.bioblast.at/index.php/MitoPedia:_DatLab |MitoPedia: DatLab]] [[MitoPedia: DatLab]]<br />
}}<br />
<br><br />
[[File:Expand.png|right|45px |Click to expand or collaps]]<br />
<div class="toccolours mw-collapsible mw-collapsed" style="background:#F7F8FF"><br />
<span style="font-size:105%; color:#424242">[[File:Questions.jpg|left|18px |Asking]]'''Does [[DatLab]] software run on MAC devices?'''</span><br />
<div class="mw-collapsible-content"> No. The [[DatLab]] software is designed for Windows operating systems.<br />
</div><br />
</div><br />
<br><br />
{{Labeling<br />
|area=Instruments;methods<br />
|instruments=Oxygraph-2k, O2k-Fluorometer<br />
|additional=DatLab<br />
}}<br />
<br />
<br />
{{MitoPedia O2k and high-resolution respirometry<br />
|mitopedia O2k and high-resolution respirometry=O2k hardware, DatLab, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Feero_2024_JAMA&diff=246639Feero 2024 JAMA2024-03-25T09:04:38Z<p>Gnaiger Erich: Created page with "{{Publication |title=Feero WG, Steiner RD, Slavotinek A, Faial T, Bamshad MJ, Austin J, Korf BR, Flanagin A, Bibbins-Domingo K (2024) Guidance on use of race, ethnicity, and g..."</p>
<hr />
<div>{{Publication<br />
|title=Feero WG, Steiner RD, Slavotinek A, Faial T, Bamshad MJ, Austin J, Korf BR, Flanagin A, Bibbins-Domingo K (2024) Guidance on use of race, ethnicity, and geographic origin as proxies for genetic ancestry groups in biomedical publications. JAMA https://doi.org/10.1001/jama.2024.3737.<br />
|info=[https://jamanetwork.com/journals/jama/fullarticle/2816403 Open Access]<br />
|authors=Feero WG, Steiner RD, Slavotinek A, Faial T, Bamshad MJ, Austin J, Korf BR, Flanagin A, Bibbins-Domingo K<br />
|year=2024<br />
|journal=JAMA<br />
|abstract=In March 2023, the National Academies of Sciences, Engineering, and Medicine (NASEM) released a consensus study report titled Using Population Descriptors in Genetics and Genomics Research.1 Sponsored by the US National Institutes of Health, the report is more than a discussion of the use of terminology; the authors of the NASEM report suggest a tectonic shift away from current models that use race, ethnicity, and geographic origin as proxies for genetic ancestry groups (ie, a set of individuals who share more similar genetic ancestries) in genetic and genomic science. The recommendations are rooted in evidence that genetic variation in individuals falls, in general, on a continuum of variation not captured well by existing population descriptors and that the ongoing use of such descriptors as analytical variables jeopardizes the scientific validity of research.2 Furthermore, the authors of the NASEM report point out that current scientific practices can sometimes perpetuate harmful typological thinking about individuals, including racism.<br />
|editor=Gnaiger E<br />
}}<br />
{{Labeling<br />
|additional=BEC<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Talk:Metformin&diff=246638Talk:Metformin2024-03-25T08:09:41Z<p>Gnaiger Erich: </p>
<hr />
<div>::::* https://pubmed.ncbi.nlm.nih.gov/28500767/<br />
::::* https://www.frontiersin.org/articles/10.3389/fphys.2022.867244/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1846266_a0P58000000G0YjEAK_Physio_20220407_arts_A<br />
<br />
::::* Xiao S, Li V, Lyu X et al. Lac-Phe mediates the effects of metformin on food intake and body weight. Nat. Metab. doi:10.1038/s42255-024-00999-9 (2024)</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Talk:Communication_-_mitochondria_and_the_patient&diff=246630Talk:Communication - mitochondria and the patient2024-03-24T19:09:55Z<p>Gnaiger Erich: Created page with "== Links == ::::* World Health Organization (2001) International classification of functioning, disability and health (ICF). World Health Organization, Geneva. https://iris.w..."</p>
<hr />
<div>== Links ==<br />
<br />
::::* World Health Organization (2001) International classification of functioning, disability and health (ICF). World Health Organization, Geneva. https://iris.who.int/bitstream/handle/10665/42407/9241545429.pdf?sequence=1 - [https://wiki.oroboros.at/index.php/World_Health_Organization_2001_ICF »Bioblast link«]<br />
::::* World Health Organization (2010) Framework for Action on Interprofessional Education & Collaborative Practice (IPECP). World Health Organization, Geneva. http://www.who.int/hrh/nursing_midwifery/en/ - [https://wiki.oroboros.at/index.php/World_Health_Organization_2010_IPECP »Bioblast link«] - [https://interprofessional.global/about/interprofessional-education-collaborative-practice/ Interprofessional education and interprofessional collaborative practice IPECP]<br />
::::* https://www.inproproject.eu/</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Communication_-_mitochondria_and_the_patient&diff=246629Communication - mitochondria and the patient2024-03-24T19:09:37Z<p>Gnaiger Erich: </p>
<hr />
<div>{{MitoPedia<br />
|description=Mitochondria and the patient: communication between patients, medical professionals, scientists, and the public<br />
}}<br />
<br />
{{MitoPedia topics<br />
|mitopedia topic=MitoGlobal Organizations<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Communication_-_mitochondria_and_the_patient&diff=246628Communication - mitochondria and the patient2024-03-24T19:08:33Z<p>Gnaiger Erich: Created page with "{{MitoPedia |description=Mitochondria and the patient: communication between patients, medical professionals, scientists, and the public }} {{MitoPedia concepts}} {{MitoPedia..."</p>
<hr />
<div>{{MitoPedia<br />
|description=Mitochondria and the patient: communication between patients, medical professionals, scientists, and the public<br />
}}<br />
{{MitoPedia concepts}}<br />
{{MitoPedia methods}}<br />
{{MitoPedia O2k and high-resolution respirometry}}<br />
{{MitoPedia topics<br />
|mitopedia topic=MitoGlobal Organizations<br />
}}<br />
== Links ==<br />
::::* World Health Organization (2001) International classification of functioning, disability and health (ICF). World Health Organization, Geneva. https://iris.who.int/bitstream/handle/10665/42407/9241545429.pdf?sequence=1 - [https://wiki.oroboros.at/index.php/World_Health_Organization_2001_ICF »Bioblast link«]<br />
::::* World Health Organization (2010) Framework for Action on Interprofessional Education & Collaborative Practice (IPECP). World Health Organization, Geneva. http://www.who.int/hrh/nursing_midwifery/en/ - [https://wiki.oroboros.at/index.php/World_Health_Organization_2010_IPECP »Bioblast link«] - [https://interprofessional.global/about/interprofessional-education-collaborative-practice/ Interprofessional education and interprofessional collaborative practice IPECP]<br />
::::* https://www.inproproject.eu/</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=World_Health_Organization_2010_IPECP&diff=246627World Health Organization 2010 IPECP2024-03-24T18:57:47Z<p>Gnaiger Erich: Created page with "{{Publication |title=World Health Organization (2010) Framework for Action on Interprofessional Education & Collaborative Practice (IPECP). World Health Organization, Geneva...."</p>
<hr />
<div>{{Publication<br />
|title=World Health Organization (2010) Framework for Action on Interprofessional Education & Collaborative Practice (IPECP). World Health Organization, Geneva. http://www.who.int/hrh/nursing_midwifery/en/<br />
|info=[https://interprofessional.global/wp-content/uploads/2018/11/WHO-2010-WHO-framework-for-action-on-interprofessional-education-collaborative-practice.pdf Open Access]<br />
|authors=World Health Organization<br />
|year=2010<br />
|journal=World Health Organization Geneva<br />
|abstract=At a time when the world is facing a shortage of health workers, policy-makers are looking for innovative strategies that can help them develop policy and programmes to bolster the global health workforce. The ''Framework for Action on Interprofessional Education and Collaborative Practice'' highlights the current status of interprofessional collaboration around the world, identifies the mechanisms that shape successful collaborative teamwork and outlines a series of action items that policy-makers can apply within their local health system (Figure 1). The goal of the Framework is to provide strategies and ideas that will help health policy-makers implement the elements of interprofessional education and collaborative practice that will be most beneficial in their own jurisdiction.<br />
<br />
* The World Health Organization (WHO) and its partners recognize interprofessional collaboration in education and practice as an innovative strategy that will play an important role in mitigating the global health workforce crisis.<br />
<br />
* Interprofessional education occurs when students from two or more professions learn about, from and with each other to enable effective collaboration and improve health outcomes.<br />
<br />
* Interprofessional education is a necessary step in preparing a “collaborative practice-ready” health workforce that is better prepared to respond to local health needs.<br />
<br />
* A collaborative practice-ready health worker is someone who has learned how to work in an interprofessional team and is competent to do so.<br />
<br />
* Collaborative practice happens when multiple health workers from different professional backgrounds work together with patients, families, carers and communities to deliver the highest quality of care. It allows health workers to engage any individual whose skills can help achieve local health goals.<br />
<br />
* After almost 50 years of enquiry, the World Health Organization and its partners acknowledge that there is sufficient evidence to indicate that effective interprofessional education enables effective collaborative practice.<br />
<br />
* Collaborative practice strengthens health systems and improves health outcomes.<br />
<br />
* Integrated health and education policies can promote effective interprofessional education and collaborative practice.<br />
<br />
* A range of mechanisms shape effective interprofessional education and collaborative practice. These include: <br />
:- supportive management practices <br />
:- identifying and supporting champions <br />
:- the resolve to change the culture and attitudes of health workers<br />
:- a willingness to update, renew and revise existing curricula <br />
:- appropriate legislation that eliminates barriers to collaborative practice.<br />
<br />
* Mechanisms that shape interprofessional education and collaborative practice are not the same in all health systems. Health policy-makers should utilize the mechanisms that are most applicable and appropriate to their own local or regional context.<br />
<br />
* Health leaders who choose to contextualize, commit and champion interprofessional education and collaborative practice position their health system to facilitate achievement of the health-related Millennium Development Goals (MDGs).<br />
<br />
* The ''Framework for Action on Interprofessional Education and Collaborative Practice'' provides policy-makers with ideas on how to implement interprofessional education and collaborative practice within their current context.<br />
<br><br />
<br />
|editor=Gnaiger E<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=World_Health_Organization_2001_ICF&diff=246626World Health Organization 2001 ICF2024-03-24T16:47:00Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=World Health Organization (2001) International classification of functioning, disability and health (ICF). World Health Organization, Geneva. https://iris.who.int/bitstream/handle/10665/42407/9241545429.pdf?sequence=1<br />
|info=[https://iris.who.int/bitstream/handle/10665/42407/9241545429.pdf?sequence=1 Open Access]<br />
|authors=World Health Organization<br />
|year=2001<br />
|journal=World Health Organization Geneva<br />
|abstract=This volume contains the ''International Classification of Functioning, Disability and Health'', known as ICF. The overall aim of the ICF classification is to provide a unified and standard language and framework for the description of health and health-related states. It defines components of health and some health-related components of well-being (such as education and labour). The domains contained in ICF can, therefore, be seen as ''health domains'' and ''health-related domains''. These domains are described from the perspective of the body, the individual and society in two basic lists: (1) Body Functions and Structures; and (2) Activities and Participation.<sup>2</sup> As a classification, ICF systematically groups different domains<sup>3</sup> for a person in a given health condition (e.g. what a person with a disease or disorder does do or can do). Functioning is an umbrella term encompassing all body functions, activities and participation; similarly, disability serves as an umbrella term for impairments, activity limitations or participation restrictions. ICF also lists environmental factors that interact with all these constructs. In this way, it enables the user to record useful profiles of individuals’ functioning, disability and health in various domains.<br />
<br />
<sup>2</sup> These terms, which replace the formerly used terms “impairment”, “disability” and “handicap”, extend the scope of the classification to allow positive experiences to be described. The new terms are further defined in this Introduction and are detailed within the classification. It should be noted that these terms are used with specific meanings that may differ from their everyday usage.<br />
<br />
<sup>3</sup> A domain is a practical and meaningful set of related physiological functions, anatomical structures, actions, tasks, or areas of life.<br />
|editor=Gnaiger E<br />
}}<br />
== ICF ==<br />
<br />
:::* Towards a common language for functioning, disability and health ICF (2002) WHO/EIP/GPE/CAS/01.3 - [https://cdn.who.int/media/docs/default-source/classification/icf/icfbeginnersguide.pdf Open Access]<br />
<br />
:::: ICF: "It is the conceptual basis for the definition, measurement and policy formulations for health and disability. It is a universal classification of disability and health for use in health and health-related sectors."<br />
<br />
:::: "ICF is named as it is because of its stress is on health and functioning, rather than on disability. Previously, disability began where health ended; once you were disabled, you where in a separate category. We want to get away from this kind of thinking. We want to make ICF a tool for measuring functioning in society, no matter what the reason for one's impairments. So it becomes a much more versatile tool with a much broader area of use than a traditional classification of health and disability. .. This is a radical shift. From emphasizing people's disabilities, we now focus on their level of health."</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=World_Health_Organization_2001_ICF&diff=246625World Health Organization 2001 ICF2024-03-24T16:27:00Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=World Health Organization (2001) International classification of functioning, disability and health. World Health Organization Geneva. https://iris.who.int/bitstream/handle/10665/42407/9241545429.pdf?sequence=1<br />
|info=[https://iris.who.int/bitstream/handle/10665/42407/9241545429.pdf?sequence=1 Open Access]<br />
|authors=World Health Organization<br />
|year=2001<br />
|journal=World Health Organization Geneva<br />
|abstract=This volume contains the ''International Classification of Functioning, Disability and Health'', known as ICF. The overall aim of the ICF classification is to provide a unified and standard language and framework for the description of health and health-related states. It defines components of health and some health-related components of well-being (such as education and labour). The domains contained in ICF can, therefore, be seen as ''health domains'' and ''health-related domains''. These domains are described from the perspective of the body, the individual and society in two basic lists: (1) Body Functions and Structures; and (2) Activities and Participation.<sup>2</sup> As a classification, ICF systematically groups different domains<sup>3</sup> for a person in a given health condition (e.g. what a person with a disease or disorder does do or can do). Functioning is an umbrella term encompassing all body functions, activities and participation; similarly, disability serves as an umbrella term for impairments, activity limitations or participation restrictions. ICF also lists environmental factors that interact with all these constructs. In this way, it enables the user to record useful profiles of individuals’ functioning, disability and health in various domains.<br />
<br />
<sup>2</sup> These terms, which replace the formerly used terms “impairment”, “disability” and “handicap”, extend the scope of the classification to allow positive experiences to be described. The new terms are further defined in this Introduction and are detailed within the classification. It should be noted that these terms are used with specific meanings that may differ from their everyday usage.<br />
<br />
<sup>3</sup> A domain is a practical and meaningful set of related physiological functions, anatomical structures, actions, tasks, or areas of life.<br />
|editor=Gnaiger E<br />
}}<br />
== ICF ==<br />
<br />
:::* Towards a common language for functioning, disability and health ICF (2002) WHO/EIP/GPE/CAS/01.3 - [https://cdn.who.int/media/docs/default-source/classification/icf/icfbeginnersguide.pdf Open Access]<br />
<br />
:::: ICF: "It is the conceptual basis for the definition, measurement and policy formulations for health and disability. It is a universal classification of disability and health for use in health and health-related sectors."<br />
<br />
:::: "ICF is named as it is because of its stress is on health and functioning, rather than on disability. Previously, disability began where health ended; once you were disabled, you where in a separate category. We want to get away from this kind of thinking. We want to make ICF a tool for measuring functioning in society, no matter what the reason for one's impairments. So it becomes a much more versatile tool with a much broader area of use than a traditional classification of health and disability. .. This is a radical shift. From emphasizing people's disabilities, we now focus on their level of health."</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=World_Health_Organization_2001_ICF&diff=246624World Health Organization 2001 ICF2024-03-24T16:17:41Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=World Health Organization (2001) International classification of functioning, disability and health. World Health Organization Geneva. https://iris.who.int/bitstream/handle/10665/42407/9241545429.pdf?sequence=1<br />
|info=[https://iris.who.int/bitstream/handle/10665/42407/9241545429.pdf?sequence=1 Open Access]<br />
|authors=World Health Organization<br />
|year=2001<br />
|journal=World Health Organization Geneva<br />
|abstract=This volume contains the ''International Classification of Functioning, Disability and Health'', known as ICF. The overall aim of the ICF classification is to provide a unified and standard language and framework for the description of health and health-related states. It defines components of health and some health-related components of well-being (such as education and labour). The domains contained in ICF can, therefore, be seen as ''health domains'' and ''health-related domains''. These domains are described from the perspective of the body, the individual and society in two basic lists: (1) Body Functions and Structures; and (2) Activities and Participation.<sup>2</sup> As a classification, ICF systematically groups different domains<sup>3</sup> for a person in a given health condition (e.g. what a person with a disease or disorder does do or can do). Functioning is an umbrella term encompassing all body functions, activities and participation; similarly, disability serves as an umbrella term for impairments, activity limitations or participation restrictions. ICF also lists environmental factors that interact with all these constructs. In this way, it enables the user to record useful profiles of individuals’ functioning, disability and health in various domains.<br />
<br />
<sup>2</sup> These terms, which replace the formerly used terms “impairment”, “disability” and “handicap”, extend the scope of the classification to allow positive experiences to be described. The new terms are further defined in this Introduction and are detailed within the classification. It should be noted that these terms are used with specific meanings that may differ from their everyday usage.<br />
<br />
<sup>3</sup> A domain is a practical and meaningful set of related physiological functions, anatomical structures, actions, tasks, or areas of life.<br />
|editor=Gnaiger E<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=World_Health_Organization_2001_ICF&diff=246623World Health Organization 2001 ICF2024-03-24T16:15:36Z<p>Gnaiger Erich: Created page with "{{Publication |title=World Health Organization (2001) International classification of functioning, disability and health. World Health Organization Geneva. https://iris.who.in..."</p>
<hr />
<div>{{Publication<br />
|title=World Health Organization (2001) International classification of functioning, disability and health. World Health Organization Geneva. https://iris.who.int/bitstream/handle/10665/42407/9241545429.pdf?sequence=1<br />
|info=[https://iris.who.int/bitstream/handle/10665/42407/9241545429.pdf?sequence=1 Open Access]<br />
|authors=World Health Organization<br />
|year=2001<br />
|journal=World Health Organization Geneva<br />
|abstract=This volume contains the ''International Classification of Functioning, Disability and Health'', known as ICF. The overall aim of the ICF classification is to provide a unified and standard language and framework for the description of health and health-related states. It defines components of health and some health-related components of well-being (such as education and labour). The domains contained in ICF can, therefore, be seen as ''health domains'' and ''health-related domains''. These domains are described from the perspective of the body, the individual and society in two basic lists: (1) Body Functions and Structures; and (2) Activities and Participation.2 As a classification, ICF systematically groups different domains3 for a person in a given health condition (e.g. what a person with a disease or disorder does do or can do). Functioning is an umbrella term encompassing all body functions, activities and participation; similarly, disability serves as an umbrella term for impairments, activity limitations or participation restrictions. ICF also lists environmental factors that interact with all these constructs. In this way, it enables the user to record useful profiles of individuals’ functioning, disability and health in various domains.<br />
<br />
2. These terms, which replace the formerly used terms “impairment”, “disability” and “handicap”, extend the scope of the classification to allow positive experiences to be described. The new terms are further defined in this Introduction and are detailed within the classification. It should be noted that these terms are used with specific meanings that may differ from their everyday usage.<br />
<br />
3. A domain is a practical and meaningful set of related physiological functions, anatomical structures, actions, tasks, or areas of life.<br />
|editor=Gnaiger E<br />
}}<br />
{{Labeling}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Help:Formatting&diff=246622Help:Formatting2024-03-24T08:58:29Z<p>Gnaiger Erich: </p>
<hr />
<div>__TOC__<br />
::::» Cheatsheet: https://en.wikipedia.org/wiki/Help:Cheatsheet<br />
<br />
== General text formatting ==<br />
<br />
* The general text indent should comprise four colons (::::). Make a space after the double points and before the text. Try to divide the text into passages.<br />
* If you create a list with bullets, use three preceding colons (:::*) <br />
* If you create a list with numeration, use four preceding colons (::::#) <br />
<br />
* If you do not want headers to get listed in the table of contents, use big and/ or bold font without any indent. <br />
* Use » before links, when they are not integrated into the text<br />
<br />
== General formatting ==<br />
=== Style ===<br />
:::: ''italic''<br />
:::: '''bold''' => when an article name is first mentioned<br />
<br />
=== Headings ===<br />
`== Main Heading Example ==´<br />
<br />
`=== Sub heading Example ===´<br />
<br />
=== Indent ===<br />
: Left<br />
:: more left<br />
::: even more left<br />
<br />
=== Numbering ===<br />
::::# Numbered list<br />
::::# two<br />
::::# three<br />
<br />
=== Bullet list ===<br />
:::* Bullet list<br />
:::* two<br />
:::* three<br />
<br />
=== Subscript and Superscript ===<br />
:::: ''p''<sub>O<sub>2</sub></sub><br />
:::: Ca<sup>2+</sup><br />
<br />
=== Hyperlinks ===<br />
::::» '''[https://en.wikipedia.org/wiki/Help:Link Formatting: Links]'''<br />
<br />
:::* Do not put a link in the heading text, with few exceptions.<br />
<br />
:::* Internal link<br />
:::: Internal link: [[ATP]]<br />
:::: [[ATP|link to ATP but with different text than internal link]]<br />
<br />
:::* External link ===<br />
:::: External link: [http://en.wikipedia.org/wiki/EGTA_%28chemical%29 Wikipedia] ; there is a space between the weblink and the word, which is shown. Do not forget '''http://''' otherwise the link does not work.<br />
<br />
=== Files ===<br />
::::» ''' [https://en.wikipedia.org/wiki/Help:Files Formatting:Files]'''<br />
<br />
:::* You can upload the following file types on the Bioblast wiki: zip, dld, dlt, pdf, png, gif, jpg, jpeg, doc, docx, xls, xlsx <br />
:::: See above the guideline on how to implement files into the website<br />
<br />
== Tables ==<br />
<br />
::::» '''[https://en.wikipedia.org/wiki/Help:Table Formatting: Tables]'''<br />
<br />
<br />
{|border="1"<br />
|+<br />
!Obst<br />
!Gemüse<br />
|-<br />
|align="right"|Banane<br />
|align="right"|Tomate<br />
|-<br />
|align="right"|Birne<br />
|align="right"|Gurke<br />
|-<br />
|}<br />
<br />
<br />
<br />
{|border="5"<br />
|- style="font-style:italic; color:green;"<br />
|align="right"|Banane || align="right"|Birne<br />
|- style="font-style:italic; color:red;"<br />
|align="right"|Tomate || align="right"|Gurke<br />
|-<br />
|}<br />
<br />
<br />
<br />
{|border="1" cellpadding="20" cellspacing="0"<br />
!Shopping list<br />
|-<br />
|<br />
*Milk<br />
*Bread<br />
*Juice<br />
|}<br />
<br />
== Automatic tables ==<br />
<br />
:::: If you want to create an automatic table you have to write down the next code (adapting it to your necessities), after the code you would find the explanation to each part. <br />
<br />
:::: <nowiki><br />
{{#ask:[[Category:O2k-Workshops]] [[Additional label::IOC]] |?Has title=Reference |format=broadtable |limit=500 |offset=0 |sort=Was written by |order=descending}} </nowiki><br />
<br />
::*'''<nowiki>#ask:[[Category:xxx]]</nowiki>''' will search on the category where the information is, you can search over more than one category, for that you have to write:'''<nowiki>#ask:[[Category:xxx]][[Category:xxx]]</nowiki>'''<br />
<br />
::*'''<nowiki>[[Additional label::xxx]]</nowiki>''' in this area you have to write what you want to search, in which field, for example those pages that in the keyword field contein O2k and are from year 2012 -->'''<nowiki>[[Keyword::O2k]][[Year::2012]]</nowiki>'''<br />
<br />
::*'''|?Has title=reference |?Was published in year |?Diseases''' With the question mark you selected the fields you want to appear in the table<br />
<br />
::*'''|format=broadtable |limit=500 |offset=0''' this line define the format of the table. it´s necessary to write limit 500 because if it´s too short it would not appear all of them. <br />
<br />
::*'''|sort= Was written by |sort=was published in year |sort=Has title |sort=Was submitted in year''' Here you selected the field from which the table will be sorted. <br />
<br />
::*'''|order=descending or ascending}}''' choose one of both options to order the table.<br />
<br />
:::: '''Attention-''' <br />
::::* For automatic publication tables '''sort by''' Was published in year / for automatic abstract tables '''sort by''' Was submitted in year<br />
::::* If in the pages where you are searching to create the automatic table, exist the label '''articletype''', this page WILL NOT appear in the table.<br />
<br />
== Figures, Pictures, Images ==<br />
::::» '''[https://www.mediawiki.org/wiki/Help:Images Formatting:Images]'''<br />
<br />
:::: Upload: Go to 'Upload file' in the 'Toolbox' or just click this link: [[Special:Upload]]<br />
:::: [http://en.wikipedia.org/wiki/Help:Wiki_markup#Images Figures, Images] Instructions to insert the picture on the page can be found on the 'Upload file' page.<br />
:::: [[Special:ListFiles]]<br />
<br />
::::* Uploaded pictures should not have more than 1200px on the longest side. Profile pictures of persons should have this ratio: 3:4.<br />
<br />
::::* Several figures do not change size when the zoom of the screen is modified, hence they change in proportion with the text. In many cases, a zoom of 125% is considered as a standard [Ctrl-O]. Therefore, formatting of such figures should be optimized at a zoom of 125%.<br />
<br />
== Side bar ==<br />
::::* [[MediaWiki:Sidebar]]<br />
<br />
== Startpage ==<br />
:::: Changing the startpage of the wiki/ the link of the logo in the navigation bar: Edit the page “MediaWiki:Mainpage”, write inside the name of the page you want to have as the startpage. Save.<br />
<br />
:::: Link: "skins/Vector.php"<br />
<br />
<br />
== Forms ==<br />
::::* [[Special:Forms]]<br />
::::* Linking in Forms<br />
::::# MitoPedia, Publications, MiPnetLabs<br />
:::: when, you work with the Form then the external links [ ] and internal links [[ ]] function as mentioned before<br />
<br />
::::# Products<br />
:::: here in the Info field ONLY internal links (for convenience) will work (since the form automatically adds the wikitag [[ ]] to the references.<br />
<br />
== Mathematical formula ==<br />
<br />
::::''More details:'' » [http://de.wikipedia.org/wiki/Hilfe:TeX Help with MathFormulas]<br />
<br />
== References/Footnotes ==<br />
::::* »[[Bioblast-references]]<br />
:::: Use the following comands within the text: <ref><br />
:::: Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002 [[Gnaiger 2020 BEC MitoPathways | »Bioblast link]]</ref>. Then a list of references is generated like this:<br />
<br />
=== References ===<br />
:::: <references/><br />
<br />
== Email ==<br />
<br />
[[Has mailaddress::{{{mailaddress|instruments@oroboros.at}}}]]<br />
<br />
<br />
<br />
[[Category:Help]]</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=National_Academies_of_Sciences,_Engineering,_and_Medicine_2023_BMI_and_beyond&diff=246621National Academies of Sciences, Engineering, and Medicine 2023 BMI and beyond2024-03-24T08:52:20Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=National Academies of Sciences, Engineering, and Medicine (2023) BMI and beyond: Considering context in measuring obesity and its applications: Proceedings of a workshop—in brief. The National Academies Press, Washington, DC. https://doi.org/10.17226/27185<br />
|info=[https://nap.nationalacademies.org/catalog/27185/bmi-and-beyond-considering-context-in-measuring-obesity-and-its?utm_source=NASEM+News+and+Publications&utm_campaign=cae440fb22-EMAIL_CAMPAIGN_2023_07_31_04_08&utm_medium=email&utm_term=0_-cae440fb22-%5BLIST_EMAIL_ID%5D&mc_cid=cae440fb22&mc_eid=50f76db947 Open Access]<br />
|authors=National Academies of Sciences, Engineering, and Medicine<br />
|year=2023<br />
|journal=National Academies Press<br />
|abstract=The Roundtable on Obesity Solutions of the Health and Medicine Division of the National Academies of Sciences, Engineering, and Medicine held a virtual public workshop, BMI and Beyond: Considering Context in Measuring Obesity and its Applications, on April 4, 2023. The workshop was the first in a two-part series to explore the current science on measures of body composition, body fat distribution, and obesity.<br />
|editor=Gnaiger E<br />
}}<br />
----<br />
{{BME_navigation_line}}<br />
__TOC__<br />
<br />
== From BMI to BME ==<br />
''Work in progress'' by [[Gnaiger E]] 2020-02-10 linked to a preprint in preparation on [[body mass excess |'''BME''']] and [[:Category:BME and mitObesity |'''mitObesity''']].<br />
<br />
{{Template:Publications: BME and body fat}}<br />
{{Template:Publications: BME and height}}<br />
<br />
{{MitoPedia: BME and mitObesity}}<br />
<br />
{{Labeling<br />
|area=Exercise physiology;nutrition;life style<br />
|diseases=Obesity<br />
|organism=Human<br />
|tissues=Fat<br />
|additional=BMI, BME, Fat<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=National_Academies_of_Sciences,_Engineering,_and_Medicine_2020_Advancing_Open_Science_practices&diff=246620National Academies of Sciences, Engineering, and Medicine 2020 Advancing Open Science practices2024-03-24T08:51:25Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=National Academies of Sciences, Engineering, and Medicine (2020) Advancing Open Science practices: stakeholder perspectives on incentives and disincentives. The National Academies Press, Washington DC https://doi.org/10.17226/25725.<br />
|info=[https://www.nap.edu/download/25725?utm_source=NASEM+News+and+Publications&utm_campaign=21d79e146e-NAP_mail_new_2020_03_02&utm_medium=email&utm_term=0_96101de015-21d79e146e-104786469&goal=0_96101de015-21d79e146e-104786469&mc_cid=21d79e146e&mc_eid=50f76db947 Open Access]<br />
|authors=National Academies of Sciences, Engineering, and Medicine<br />
|year=2020<br />
|journal=National Academies Press<br />
|abstract=Open science “aims to ensure the free availability and usability of scholarly publications, the data that result from scholarly research, and the methodologies, including code or algorithms that were used to generate those data."1 The actual and potential benefits of open science include strengthened rigor and reliability, the ability to address new questions, faster and more inclusive dissemination of knowledge, broader participation in research, effective use of resources, improved performance of research tasks, and open publication for public benefit.2<br />
<br />
Yet, achieving open science will require overcoming several significant barriers. For example, the structure of the scholarly publications market limits open access to articles. Other barriers include the cost and accessibility of open infrastructure and researcher incentives. In addition, access to some types of research data may continue to be restricted due to privacy, proprietary, or national security concerns. As one effort to increase the contributions of open science among many, the Board on Research Data and Information (BRDI) of the National Academies of Sciences, Engineering, and Medicine (the National Academies) established the Roundtable on Aligning Incentives for Open Science (see Box 1). On September 20, 2019, the Roundtable organized a public symposium in Washington, DC, to consider some of the barriers and challenges to open science, as well as ways to overcome them. Key external stakeholders—including researchers, librarians, learned societies, publishers and infrastructure developers—shared their insights on the current state of the research ecosystem, as well as their visions for how open science can function at scale.<br />
<br />
To open the symposium, Keith Yamamoto, Roundtable co-chair, noted the goals of open science to develop the best science, democratize information, and make discoveries and outcomes accessible to all. “We are far from these ideals,” he acknowledged, given the current system of hiring, funding, and promoting individual scientists. The Roundtable convened the symposium to listen to a broad range of stakeholders who, he said, “are not just talking about open science but are really working within their own contexts to make it the norm.” It is expected that these inputs will help the Roundtable further define immediate and longer term priorities.<br />
|editor=[[Gnaiger E]],<br />
}}<br />
== Comment: Preprints ==<br />
[[Gnaiger E]] 2020-03-03<br />
<br />
:::: Although the topic of Open Access publication has been well covered, the term 'Preprint' is mentioned only once in the entire publication, in the context of Open Access to posters at meetings of the American Geophysical Union (AGU): "Access is not open to non-attendees and even attendees have limited access. AGU has developed a preprint service that archives posters" (p 6). The concept of Preprint publication, however, plays a central role in Open Science [1].<br />
<br />
::::[1] Gnaiger E (2019) Editorial: A vision on preprints for mitochondrial physiology and bioenergetics. MitoFit Preprint Arch doi:10.26124/mitofit:190002.v2. - [[Gnaiger 2019 MitoFit Preprints Editorial |»Bioblast link«]]<br />
<br />
{{Labeling<br />
|additional=Gentle Science,<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=National_Academies_of_Sciences,_Engineering,_and_Medicine_2018_Science_data_infrastructure&diff=246619National Academies of Sciences, Engineering, and Medicine 2018 Science data infrastructure2024-03-24T08:50:59Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=National Academies of Sciences, Engineering, and Medicine (2018) International coordination for science data infrastructure: Proceedings of a workshop—in brief.. The National Academies Press, Washington DC doi: https://doi.org/10.17226/25015.<br />
|info=[https://doi.org/10.17226/25015 Open Access]<br />
|authors=National Academies of Sciences, Engineering, and Medicine<br />
|year=2018<br />
|journal=National Academies Press<br />
|abstract=Advances in science and technology have led to the creation of large amounts of data—data that could be harnessed to improve productivity, cure disease, and address many other critical issues. Consensus in the scientific community is growing that the transition to truly data-driven and open science is best achieved by the establishment of a globally interoperable research infrastructure.<br />
A number of projects are looking to establish this infrastructure and exploit data to its fullest potential. Several projects in the United States, Europe, and China have made significant strides toward this effort. The goal of these projects is to make research data findable, accessible, interoperable, and reusable, or FAIR (see Box 1). The expected impact and benefits of FAIR data are substantial. To realize these benefits, there is a need to examine critical success factors for implementation, including training of a new generation of data experts to provide the necessary capacity.<br />
<br />
On November 1, 2017, the Board on Research Data and Information (BRDI) of the National Academies of<br />
Sciences, Engineering, and Medicine organized a symposium to explore these issues. Invited experts from China, Europe, and the United States were asked to:<br />
* Review proposed science data infrastructure projects around the globe;<br />
* Highlight, compare, and contrast the plans and capabilities of these projects; and<br />
* Discuss the critical success factors for implementation and the role of international cooperation for scientific data management.<br />
|editor=[[Gnaiger E]],<br />
}}<br />
== The FAIR Data Principles ==<br />
<br />
:::: The FAIR Data Principles set out requirements for the sharing of scientific data<br />
<br />
::::* '''F'''indable: Easy to find by both humans and computer systems and based on mandatory description of the metadata that allows the discovery of interesting datasets.<br />
::::* '''A'''ccessible: Stored for long term such that they can be easily accessed and/or downloaded with well-defined license and access conditions (Open Access when possible), whether at the level of metadata, or at the level of the actual data content.<br />
::::* '''I'''nteroperable: Ready to be combined with other datasets by humans as well as computer systems.<br />
::::* '''R'''eusable: Ready to be used for future research and to be processed further using computational methods.<br />
:::: Source: Barend Mons, presentation, November 1, 2017, Washington, DC. Credit given to the Dutch Techcentre for Life Sciences.<br />
<br />
== H2020 ==<br />
::::* [http://ec.europa.eu/research/participants/data/ref/h2020/grants_manual/hi/oa_pilot/h2020-hi-oa-data-mgt_en.pdf H2020 Programme: Guidelines on FAIR Data Management in Horizon 2020]<br />
<br />
== Cited by ==<br />
{{Template:Cited by Gnaiger 2020 BEC MitoPhysiology}}<br />
<br />
{{Labeling<br />
|additional=Gentle Science, BEC 2020.1<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=National_Academies_of_Sciences,_Engineering,_and_Medicine_2017_Communicating_science_effectively&diff=246618National Academies of Sciences, Engineering, and Medicine 2017 Communicating science effectively2024-03-24T08:50:42Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=National Academies of Sciences, Engineering, and Medicine (2017) Communicating science effectively: A research agenda. The National Academies Press, Washington DC https://doi.org/10.17226/23674.<br />
|info=[https://doi.org/10.17226/23674 Open Access]<br />
|authors=National Academies of Sciences, Engineering, and Medicine<br />
|year=2017<br />
|journal=National Academies Press<br />
|abstract=Science and technology are embedded in virtually every aspect of modern life. As a result, people face an increasing need to integrate information from science with their personal values and other considerations as they make important life decisions about medical care, the safety of foods, what to do about climate change, and many other issues. Communicating science effectively, however, is a complex task and an acquired skill. Moreover, the approaches to communicating science that will be most effective for specific audiences and circumstances are not obvious. Fortunately, there is an expanding science base from diverse disciplines that can support science communicators in making these determinations.<br />
|editor=[[Gnaiger E]],<br />
}}<br />
{{Labeling}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=National_Academies_of_Sciences,_Engineering,_and_Medicine_2020_Addressing_the_underrepresentation_of_women&diff=246617National Academies of Sciences, Engineering, and Medicine 2020 Addressing the underrepresentation of women2024-03-24T08:50:22Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=National Academies of Sciences, Engineering, and Medicine (2020) Promising practices for addressing the underrepresentation of women in science, engineering, and medicine: opening doors. The National Academies Press, Washington DC https://doi.org/10.17226/25585.<br />
|info=[https://www.nap.edu/catalog/25585/promising-practices-for-addressing-the-underrepresentation-of-women-in-science-engineering-and-medicine Open Access]<br />
|authors=National Academies of Sciences, Engineering, and Medicine<br />
|year=2020<br />
|journal=National Academies Press<br />
|abstract=Careers in science, engineering, technology, mathematics, and medicine (STEMM) offer opportunities to advance knowledge, contribute to the well-being of communities, and support the security, prosperity, and health of the United States. Many women, however, do not pursue or persist in these careers or advance to leadership positions. The bulk of evidence indicates that underrepresentation of women in STEMM—including at leadership levels—is driven by a wide range of structural, cultural, and institutional patterns of bias, discrimination, and inequity that do not affect men of comparable ability and training. To date, there have been seven National Academies reports published over the past two decades that have addressed causes and consequences of the underrepresentation of women in science, engineering, and medicine. Among those consequences are:<br />
<br />
(1) A national labor shortage in many science, engineering, and medical professions, particularly in technical fields, that cannot be filled unless institutions and organizations recruit from a broad and diverse talent pool.<br />
<br />
(2) Lost opportunities for innovation and economic gain, particularly since research shows that more diverse teams generate more innovative solutions to problems, publish higher impact articles, and raise a company’s bottom line. In other words, there are opportunity costs to perpetuating a scientific workforce that lacks diversity.<br />
<br />
(3) Lost talent as a result of discrimination, unconscious bias, and sexual harassment, which often prevents women from pursuing careers in science, engineering, and medicine.<br />
<br />
In this report, which is based on an analysis of current research, the committee provides a range of stakeholders with actionable recommendations on how to take coordinated action to drive necessary changes to the system of science, engineering, and medical education, research, and employment. The committee’s recommendations are not aimed at “fixing the women,” but instead focus on changing the culture through systemic actions. To do so will require the men and women in Congress, the White House, federal funding agencies (particularly the National Institutes of Health and the National Science Foundation), colleges and universities, and professional societies to approach this issue armed with a heightened sense of urgency and an evidence-based strategy for action. This report aims to provide both.<br />
|editor=[[Gnaiger E]],<br />
}}<br />
== Conclusions ==<br />
<br />
:::: Conclusion 1: Although the absolute number of women earning degrees across science, engineering, and medical fields has increased in recent years, women—especially women of color—are underrepresented relative to their presence in the workforce and the U.S. population. National patterns of underrepresentation vary by career stage, race and ethnicity, and discipline.<br />
<br />
:::: Conclusion 2: Bias, discrimination, and harassment are major drivers of the underrepresentation of women in science, engineering, and medicine; they are often experienced more overtly and intensely by women of intersecting identities (e.g., women of color, women with disabilities, LGBTQIA women; Lesbian, Gay, Bisexual, Transgender, Queer, Intersex, and Asexual).<br />
<br />
:::: Conclusion 3: While some institutions have seen improvements in the representation of women in science, engineering, and medical education and careers, national patterns of underrepresentation are still prevalent at most institutions, especially for women of color.<br />
<br />
:::: Conclusion 4: There are numerous effective, evidence-based strategies and practices that institutions can adopt to improve the recruitment, retention, and advancement of White women across a broad range of scientific, engineering, and medical disciplines and multiple stages of the educational and career pathway. However, additional investigation is needed specifically to understand how to support more effectively the participation of women of color and women of other intersecting identities in science, engineering, and medicine.<br />
<br />
:::: Conclusion 5: Improving recruitment and retention of women in STEMM throughout their education and training is important, particularly in mathematics-intensive fields such as computer science and engineering. Educational strategies that challenge stereotypes about the essential attributes of a successful STEMM professional and about the nature of work in STEMM can increase interest, improve performance, and instill a sense of belonging in these fields among White women, women of color, and other underrepresented groups (e.g., first-generation college students and men of color).<br />
<br />
:::: Conclusion 6: Both research literature and the findings of focus groups that were carried out by the independent nonprofit research institute RTI International on behalf of this study point to a common set of conditions that support institutional adoption of practices to improve the recruitment, retention, and advancement of women, including:<br />
::::* Committed leadership at all levels, especially from those in positions of authority (such as policy makers, college and university presidents and deans, and individual faculty that manage training programs and large laboratories) who can implement, allocate resources toward, and monitor progress on new policies and strategies that close the gender gap.<br />
::::* Dedicated financial and human resources—including new or re-directed funds and appropriately compensated individuals in positions of power and authority whose work is dedicated toward opening doors to opportunity and success for women.<br />
::::* Accountability and data collection—especially when used as a tool to inform and incentivize progress.<br />
::::* Adoption of an intersectional approach that explicitly and concretely addresses the challenges faced by women of color and other groups who encounter multiple, cumulative forms of bias and discrimination.<br />
<br />
== Recommendations ==<br />
<br />
:::# '''Driving transparency and accountability'''. Institutions must articulate and deliver on measurable goals and benchmarks that are regularly monitored and publicly reported. Multiple studies have demonstrated that transparency and accountability can drive behavior change.<br />
:::# '''Adopting data-driven approaches to address underrepresentation of women in STEMM'''. The committee recommends a targeted data-driven approach to closing the gender gap in science, engineering, and medicine. Such an approach includes, for example, dissecting the barriers by discipline and career stage, recognizing explicitly that interventions and strategies that generally work well for White women may not work well for women of color and, in addition, using disaggregated data collection, analysis, and monitoring as the basis for constructing specific interventions within the unique context of each institution.<br />
:::# '''Rewarding, recognizing, and resourcing equity, diversity, and inclusion efforts'''. Equity, diversity, and inclusion efforts by institutions are often hindered by a lack of sufficient resources and by the expectation that individuals, particularly women and people of color, who are most affected by these issues, will assume a leadership role in promoting positive change without appropriate compensation, authority, or promise of reward or recognition.<br />
:::# '''Filling knowledge gaps'''. Although scholarly research on gender disparities in science, engineering, and medicine has yielded an abundance of information that can be applied toward reaching gender equity, there are critical knowledge gaps that require closer attention.<br />
<br />
::::* Leaders in academia and scientific societies should put policies and practices in place to prioritize, reward, recognize, and resource equity, diversity, and inclusion efforts appropriately.<br />
<br />
<br />
{{Labeling<br />
|area=Gender<br />
|additional=Gentle Science,<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=National_Academies_of_Sciences,_Engineering,_and_Medicine_2024_Body_composition_and_obesity&diff=246616National Academies of Sciences, Engineering, and Medicine 2024 Body composition and obesity2024-03-24T08:49:04Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=National Academies of Sciences, Engineering, and Medicine (2024) Exploring the science on measures of body composition, body fat distribution, and obesity. National Academies Press, Washington, DC https://doi.org/10.17226/27461.<br />
|info=[https://nap.nationalacademies.org/catalog/27461/exploring-the-science-on-measures-of-body-composition-body-fat-distribution-and-obesity?utm_source=NASEM+News+and+Publications&utm_campaign=ef8dee7bac-Final_Book_2024_03_22_27461&utm_medium=email&utm_term=0_-ef8dee7bac-%5BLIST_EMAIL_ID%5D&goal=0_96101de015-ef8dee7bac-104786469&mc_cid=ef8dee7bac&mc_eid=50f76db947 National Academies Press, Open Access]<br />
|authors=National Academies of Sciences, Engineering, and Medicine<br />
|year=2024<br />
|journal=National Academies Press<br />
|abstract=The National Academies Roundtable on Obesity Solutions hosted a public workshop series in April and June 2023 that explored the current science on measures of body composition and body fat distribution. Discussions focused on the strengths and limitations, and clinical and anthropological perspectives of body mass index (BMI) as a measure of adiposity and health. Presentations also shed light on the connection between misinformation and bias and stigma, as well as challenged current communication strategies to improve messaging about obesity.<br />
|editor=Gnaiger E<br />
}}<br />
----<br />
{{BME_navigation_line}}<br />
__TOC__<br />
<br />
== From BMI to BME ==<br />
''Work in progress'' by [[Gnaiger E]] 2020-02-10 linked to a preprint in preparation on [[body mass excess |'''BME''']] and [[:Category:BME and mitObesity |'''mitObesity''']].<br />
<br />
{{Template:Publications: BME and body fat}}<br />
{{Template:Publications: BME and height}}<br />
<br />
{{MitoPedia: BME and mitObesity}}<br />
<br />
{{Labeling<br />
|area=Exercise physiology;nutrition;life style<br />
|diseases=Obesity<br />
|organism=Human<br />
|tissues=Fat<br />
|additional=BMI, BME, Fat<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=National_Academies_of_Sciences,_Engineering,_and_Medicine_2024_Body_composition_and_obesity&diff=246615National Academies of Sciences, Engineering, and Medicine 2024 Body composition and obesity2024-03-24T08:48:30Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=National Academies of Sciences, Engineering, and Medicine (2024) Exploring the science on measures of body composition, body fat distribution, and obesity. National Academies Press, Washington, DC https://doi.org/10.17226/27461.<br />
|info=[https://nap.nationalacademies.org/catalog/27461/exploring-the-science-on-measures-of-body-composition-body-fat-distribution-and-obesity?utm_source=NASEM+News+and+Publications&utm_campaign=ef8dee7bac-Final_Book_2024_03_22_27461&utm_medium=email&utm_term=0_-ef8dee7bac-%5BLIST_EMAIL_ID%5D&goal=0_96101de015-ef8dee7bac-104786469&mc_cid=ef8dee7bac&mc_eid=50f76db947 National Academies Press, Open Access]<br />
|authors=National Academies of Sciences, Engineering, and Medicine<br />
|year=2024<br />
|journal=National Academies Press<br />
|abstract=The National Academies Roundtable on Obesity Solutions hosted a public workshop series in April and June 2023 that explored the current science on measures of body composition and body fat distribution. Discussions focused on the strengths and limitations, and clinical and anthropological perspectives of body mass index (BMI) as a measure of adiposity and health. Presentations also shed light on the connection between misinformation and bias and stigma, as well as challenged current communication strategies to improve messaging about obesity.<br />
|editor=Gnaiger E<br />
}}<br />
{{Labeling<br />
|diseases=Obesity<br />
|organism=Human<br />
|additional=BME<br />
}}<br />
----<br />
{{BME_navigation_line}}<br />
__TOC__<br />
<br />
== From BMI to BME ==<br />
''Work in progress'' by [[Gnaiger E]] 2020-02-10 linked to a preprint in preparation on [[body mass excess |'''BME''']] and [[:Category:BME and mitObesity |'''mitObesity''']].<br />
<br />
{{Template:Publications: BME and body fat}}<br />
{{Template:Publications: BME and height}}<br />
<br />
{{MitoPedia: BME and mitObesity}}<br />
<br />
{{Labeling<br />
|area=Exercise physiology;nutrition;life style<br />
|diseases=Obesity<br />
|organism=Human<br />
|tissues=Fat<br />
|additional=BMI, BME, Fat<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=National_Academies_of_Sciences,_Engineering,_and_Medicine_2023_Quantum_information&diff=246614National Academies of Sciences, Engineering, and Medicine 2023 Quantum information2024-03-24T08:46:44Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=National Academies of Sciences, Engineering, and Medicine (2023) Advancing chemistry and quantum information science: an assessment of research opportunities at the interface of chemistry and quantum information science in the United States. National Academies Press, Washington, DC. https://doi.org/10.17226/26850<br />
|info=[https://doi.org/10.17226/26850 National Academies Press Open Access]<br />
|authors=National Academies of Sciences, Engineering, and Medicine<br />
|year=2023<br />
|journal=National Academies Press<br />
|abstract=Quantum information science (QIS) investigates how to exploit quantum behavior and its ability to encode, <br />
sense, process, and transmit information. This emerging field has developed ideas that may one day revolutionize <br />
such technological areas as communications, sensing, computing, navigation, and measurement. More recently, <br />
scientists and engineers have initiated new ideas that will significantly impact chemistry and biology. Quantum <br />
technologies follow a divergent set of operational rules beyond classical physics, which implies that these devices <br />
may surpass conventional capabilities. For example, developments in QIS could generate a faster and more secure <br />
internet, install financial systems backed by unique cryptographic codes and hardware, equip submarines with <br />
state-of-the-art surveillance systems, upgrade medical imaging machines, and generate other technologies to unparalleled levels compared to their classical counterparts. Overall, such advancements will impact U.S. economic <br />
prosperity, national security, medicine, and global research, development, and innovation competitiveness. This <br />
point becomes increasingly clear when one includes the involvement of chemistry approaches to QIS. The chemical industry as well as the development of new methods and materials could undergo a major shift in direction <br />
resulting in fruitful achievements if further developments of chemistry approaches to QIS were to be pursued. <br />
To achieve this long-term vision and sustain U.S. leadership in science and innovation, a robust QIS research <br />
enterprise needs to be established. While the physics community has enabled the field to move closer to creating <br />
QIS technologies by shedding light on the fundamental behavior of quantum properties, more details are necessary to bring these concepts into practical applications. The field of QIS is now at an inflection point, where the <br />
need for developing and measuring quantum molecular materials that are operational, practical, and efficient is <br />
paramount. Because chemistry is the study of manipulating properties and behaviors across different length scales, <br />
from subatomic to macromolecular levels, this discipline will certainly play a central role in guiding QIS toward <br />
future designs and measurements.<br />
<br />
Chair of the Committee: Theodore G Goodson, III, University of Michigan - [https://www.ebec2024.org/index.php/topics/#topic01 EBEC2024 Topic 1]<br />
<br />
|editor=Gnaiger E<br />
}}<br />
{{Labeling<br />
|area=Instruments;methods<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=National_Academies_of_Sciences,_Engineering,_and_Medicine_2018_Sexual_harassment&diff=246613National Academies of Sciences, Engineering, and Medicine 2018 Sexual harassment2024-03-24T08:45:17Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=National Academies of Sciences, Engineering, and Medicine (2018) Sexual harassment of women: climate, culture, and consequences in academic sciences, engineering, and medicine. The National Academies Press, Washington DC. doi: https://doi.org/10.17226/24994.<br />
|info=[https://www.nap.edu/catalog/24994/sexual-harassment-of-women-climate-culture-and-consequences-in-academic Open Access]<br />
|authors=National Academies of Sciences, Engineering, and Medicine<br />
|year=2018<br />
|journal=National Academies Press<br />
|abstract=Important gains have been made in the past two decades in the participation of women in science, engineering, and biomedical disciplines at the undergraduate and graduate levels of the United States. However, more rapid and sustained progress in closing the gender gap in science, engineering, and medicine is jeopardized by the persistence of sexual harassment and its adverse impact on women's careers in our nation's colleges and universities.<br />
|editor=[[Gnaiger E]]<br />
}}<br />
== Selected quotes ==<br />
<br />
::::* Leadership training programs for those in Academia should include training on how to recognize and handle harassment issues, and how to take explicit steps to create a culture and climate to reduce and prevent sexual harassment-and not just protect the institution against liability.<br />
<br />
::::* State legislature and Congress should consider new and additional legislation with the following goals:<br />
::::::: a. Better protecting sexual harassment claimants from retaliation.<br />
::::::: b. Prohibiting confidentiality in settlement agreements that currently enable harassers to move to another institution and conceal past adjucations.<br />
<br />
::::* In addition to these risk factors, there are also conditions on campus that are exacerbating the problem, including the following:<br />
::::::* Insufficient attention to this topic among campus leaders-including presidents, provosts, deans, and department chairs.<br />
::::::* Lack of clear policies and procedures on campus, and within departments, that make clear that all forms of sexual harassment, including gender harassment, will not be tolerated; that investigations will be taken seriously; and that there are meaningful punishments for violating the policies.<br />
<br />
{{Labeling<br />
|additional=Gentle Science,<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=National_Academies_of_Sciences,_Engineering,_and_Medicine_2017_Fostering_integrity_in_research&diff=246612National Academies of Sciences, Engineering, and Medicine 2017 Fostering integrity in research2024-03-24T08:41:42Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=The National Academies of Sciences, Engineering, and Medicine (2017) Fostering integrity in research. The National Academies Press, Washington, DC doi:https://doi.org/10.17226/21896.<br />
|info=[https://www.nap.edu/catalog/21896/fostering-integrity-in-research National Academy of Sciences - Open Access]<br />
|authors=The National Academies of Sciences, Engineering, and Medicine<br />
|year=2017<br />
|journal=National Academies Press<br />
|abstract=The integrity of knowledge that emerges from research is based on individual and collective adherence to core values of objectivity, honesty, openness, fairness, accountability, and stewardship. Integrity in science means that the organizations in which research is conducted encourage those involved to exemplify these values in every step of the research process. Understanding the dynamics that support – or distort – practices that uphold the integrity of research by all participants ensures that the research enterprise advances knowledge.<br />
<br />
The scientific research enterprise is a cornerstone of modern society. In the United States<br />
alone, the public and private sectors invest hundreds of billions of dollars and countless hours of<br />
highly skilled labor into the generation, validation, and dissemination of new knowledge every<br />
year. This investment delivers enormous benefits to society in the form of better health,<br />
enhanced understanding of the natural world, and new technologies that boost economic growth<br />
and improve life in myriad ways.<br />
<br />
The integrity of knowledge that emerges from research is based on individual and<br />
collective adherence to core values of objectivity, honesty, openness, fairness, accountability,<br />
and stewardship.<br />
|editor=[[Gnaiger E]]<br />
}}<br />
__TOC__<br />
== Selected quotes ==<br />
<br />
=== Recommendations ===<br />
::::* 1. To better align the realities of research with its values and ideals, all stakeholders in the research enterprise — researchers, research institutions, research sponsors, journals, and societies — should significantly improve and update their practices and policies to respond to the threats to research integrity identified in this report.<br />
::::* 3. Research institutions and federal agencies should work to ensure that good-faith whistleblowers are protected and that their concerns are assessed and addressed in a fair, thorough, and timely manner.<br />
::::* 4. Societies and journals should develop clear disciplinary authorship standards. Standards should be based on the principle that those who have made a significant intellectual contribution are authors. Significant intellectual contributions can be made in the design or conceptualization of a study, the conduct of research, the analysis or interpretation of data, or the drafting or revising of a manuscript for intellectual content. Those who engage in these activities should be designated as authors of the reported work, and all authors should approve the final manuscript. In addition to specifying all authors, standards should (1) provide for the identification of one or more authors who assume responsibility for the entire work, (2) require disclosure of all author roles and contributions, and (3) specify that gift or honorary authorship, coercive authorship, ghost authorship, and omitting authors who have met the articulated standards are always unacceptable.<br />
::::* 6. Through their policies and through the development of supporting infrastructure, research sponsors and science, engineering, technology, and medical journal and book publishers should ensure that information sufficient for a person knowledgeable about the field and its techniques to reproduce reported results is made available at the time of publication or as soon as possible after publication.<br />
::::* 7. Federal funding agencies and other research sponsors should allocate sufficient funds to enable the long-term storage, archiving, and access of datasets and code necessary for the replication of published findings.<br />
::::* 8. To avoid unproductive duplication of research and to permit effective judgments on the statistical significance of findings, researchers should routinely disclose all statistical tests carried out, including negative findings. Research sponsors, research institutions, and journals should support and encourage this level of transparency.<br />
::::* 11. Researchers, research institutions, and research sponsors that participate in and support international collaborations should leverage these partnerships to foster research integrity through mutual learning and sharing of best practices, including collaborative international research on research integrity.<br />
<br />
=== A changing environment ===<br />
::::* Increasing pressure on both junior and senior researchers to publish in prominent journals has created a bias to produce the kinds of novel, newsworthy, and paradigm-shifting results favored by these journals. Similarly, the difficulty in securing government grants and contracts along with explicit federal requirements to do so have increased the pressure on researchers to emphasize the significance and relevance of proposed research. The importance of publications in establishing the reputation of researchers and as the basis for hiring and promotion decisions has increased the potential for disputes over authorship and distorts the publication process—for example, by heightening the temptation to publish multiple papers on just one experiment or dataset.<br />
::::* New forms of scientific publication pose challenges to traditional peer review systems.1 Examples include non-peer-reviewed web publications that are widely available, “publication” on personal web pages, and rapid publication with continuously updated reviews. The emergence of research based on computer analyses of massive datasets raises questions about access to both the data and the computer code used to analyze the data and about the allocation of credit to those who collect, curate, and disseminate data and to those who create software and programs that perform scientific analysis on the datasets. Computational science also raises questions regarding appropriate stewardship and persistence of datasets and code.<br />
<br />
:::* '''Objectivity'''<br />
::::* Human judgment and decisions are prone to a variety of cognitive biases and systematic errors in reasoning. Even the best scientific intentions are not always sufficient to ensure scientific objectivity. Scientific objectivity can be compromised accidentally or without recognition by individuals. .. A primary purpose of scientific replication is to minimize the extent to which experimental findings are distorted by biases and errors.<br />
::::* Objectivity can be compromised when institutional expectations, laboratory culture, the regulatory environment, or funding needs put pressure on the scientist to produce positive results or to produce them under time pressure. Scientists and researchers operate in social contexts, and the incentives and pressures of those contexts can have a profound effect on the exercise of scientific methodology and a researcher’s commitment to scientific objectivity.<br />
<br />
:::* '''Honesty'''<br />
::::* Being honest is not always straightforward. It may not be easy to decide what to do with outlier data .. A single outlier data point may be legitimately interpreted as a malfunctioning instrument or a contaminated sample. However, true scientific integrity requires the disclosure of the exclusion of a data point and the effect of that exclusion unless the contamination or malfunction is documented, not merely conjectured. There are accepted statistical methods and standards for dealing with outlier data ..<br />
::::* Honest work includes accurate reporting of what was done, including the methods used to do that work.<br />
::::* The “file drawer” effect was first discussed almost 40 years ago; Robert Rosenthal (1979) presented the extreme view that “journals are filled with the 5 percent of the studies that show Type I errors, while the file drawers are filled with the 95 percent of the studies that show nonsignificant results.”<br />
<br />
:::* '''Openness'''<br />
::::* ''Openness'' is not the same as honesty, but it is predicated on honesty. In the scientific enterprise, openness refers to the value of being transparent and presenting all the information relevant to a decision or conclusion. This is essential so that others in the web of the research enterprise can understand why a decision or conclusion was reached. Openness also means making the data on which a result is based available to others so that they may reproduce and verify results or build on them.<br />
<br />
:::* '''Accountability'''<br />
::::* At its core, accountability implies an obligation to explain and/or justify one’s behavior. Accountability requires that individuals be willing and able to demonstrate the validity of their work or the reasons for their actions. .. Mutual accountability therefore builds trust ..<br />
::::* .. research supervisors are also accountable for being attentive to the educational and career development needs of students, postdoctoral fellows, and other junior researchers whom they oversee.<br />
<br />
:::* '''Fairness'''<br />
::::* Fairness is a particularly important consideration in the list of authors for a publication and in the citations included in reports of research results. Investigators may be tempted to claim that senior or well-known authors played a larger role than they actually did so that their names may help carry the paper to publication and readership.<br />
::::* Upholding fairness also requires researchers to acknowledge those whose work contributed to their advances. This is usually done through citing relevant work in reporting results.<br />
<br />
:::* '''Stewardship'''<br />
::::* One area where individual researchers exercise stewardship is by performing service for their institution, discipline, or the broader research enterprise that may not necessarily be recognized or rewarded. .. Senior researchers may also serve as mentors to younger researchers whom they are not directly supervising or formally responsible for.<br />
<br />
=== Complexity of collaboration===<br />
::::* Collaborative science requires that researchers focus at least some attention on coordination and interaction, which in theory might detract from the time and effort devoted to research.<br />
<br />
=== Framing best practices for research integrity ===<br />
:::* '''Researchers'''<br />
::::# Research Integrity. Uphold research integrity with vigilance, professionalism, and collegiality.<br />
::::# Data Handling. Manage research data effectively, responsibly, and transparently throughout the research process. This includes providing free and open access to research data, models, and code underlying reported results to the extent possible ..<br />
::::# Authorship and Communication. Follow general and disciplinary authorship standards when communicating through formal publications. Describe the roles and contributions of all authors.<br />
::::# Mentoring and Supervision. Know your responsibilities as a mentor and supervisor. Be a helpful, effective mentor and supervisor to early-career researchers.<br />
::::# Peer Review. Strive to be a fair and effective peer reviewer who provides careful reviews, maintains confidentiality, and recognizes and discloses conflicts of interest.<br />
::::# Research Compliance. Understand and comply with relevant institutional and governmental regulations governing research, including those specific to a given discipline or field.<br />
<br />
:::* '''Institutions'''<br />
::::# Management. Integrate research integrity considerations into overall approaches to research, education, and institutional management.<br />
::::# Assessment. Perform regular assessments of the climate for research integrity at the institutional and department levels and address weaknesses that are identified.<br />
::::# Performing Research Misconduct Investigations. Perform regular inventories of institutional policies, procedures, and capabilities for investigating and addressing research misconduct and address weaknesses that are identified.<br />
::::# Training and Education. Strive for continuous improvement in RCR* training and education.<br />
<br />
<br />
:::::: <small>'''Footnote''': RCR = [http://www.apa.org/research/responsible/ responsible conduct of research]</small><br />
<br />
{{Labeling<br />
|additional=Gentle Science,<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Talk:Body_mass_excess&diff=246611Talk:Body mass excess2024-03-24T08:41:14Z<p>Gnaiger Erich: </p>
<hr />
<div>References<br />
<br />
::::* https://hal.archives-ouvertes.fr/hal-01561605/document<br />
::::* https://jamanetwork.com/journals/jama/fullarticle/2778234?guestAccessKey=0a2822f9-c344-4122-bf17-45cbe664e1b3&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_term=mostread&utm_content=olf-widget_04082021<br />
::::* https://pubmed.ncbi.nlm.nih.gov/33436528/<br />
::::* https://pubmed.ncbi.nlm.nih.gov/31095428/<br />
::::* https://www.mdpi.com/2227-9059/9/3/258<br />
::::* https://jamanetwork.com/journals/jama/fullarticle/2783690?guestAccessKey=c7e25160-01d1-4115-bd00-ec44097f7a8d&utm_source=silverchair&utm_campaign=altmetric&utm_content=2021_year-end&cmp=1&utm_medium=email<br />
::::* https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2777737?utm_source=silverchair&utm_campaign=altmetric&utm_content=2021_year-end&cmp=1&utm_medium=email<br />
::::* https://jamanetwork.com/journals/jama/fullarticle/2787551?guestAccessKey=c0420c99-99a1-4b35-928d-1e53d902de98<br />
::::* https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2787246?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetworkopen&utm_content=mthlyforyou&utm_term=010222<br />
::::* https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038834<br />
::::* Shi Q, Wang Y, Hao Q, Vandvik PO, Guyatt G, Li J, Chen Z, Xu S, Shen Y, Ge L, Sun F, Li L, Yu J, Nong K, Zou X, Zhu S, Wang C, Zhang S, Qiao Z, Jian Z, Li Y, Zhang X, Chen K, Qu F, Wu Y, He Y, Tian H, Li S. Pharmacotherapy for adults with overweight and obesity: a systematic review and network meta-analysis of randomised controlled trials. Lancet. 2021 Dec 8:S0140-6736(21)01640-8. doi: 10.1016/S0140-6736(21)01640-8. Epub ahead of print. PMID: 34895470 - https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01640-8/fulltext?dgcid=raven_jbs_etoc_email<br />
::::* https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01919-X/fulltext?dgcid=raven_jbs_etoc_email<br />
::::* https://onlinelibrary.wiley.com/action/doSearch?field1=Contrib&text1=Chabot+D&field2=AllField&text2=&field3=AllField&text3=&Ppub=<br />
::::* https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789169?guestAccessKey=5560b202-f036-4162-8403-aa9e31f31035&utm_source=silverchair&utm_campaign=jama_network&utm_content=car_weekly_highlights&cmp=1&utm_medium=email<br />
::::* https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788555?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetworkopen&utm_content=mthlyforyou&utm_term=030622<br />
::::* https://www.nap.edu/download/26498<br />
::::* https://www.frontiersin.org/articles/10.3389/fphys.2022.924649/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1914357_a0P58000000G0YjEAK_Physio_20220728_arts_A&id_mc=312850737&utm_source=sfmc&utm_medium=email&utm_campaign=Article+Alerts+V4.1-Frontiers&utm_id=1914357<br />
::::* https://gmed-una-storage.s3.amazonaws.com/bx_posts_files/5/5w/5w9/5w99egarfgpxur6k8bj3vcfkk7ysbya2.pdf<br />
::::* https://nap.nationalacademies.org/catalog/26681/targeting-structures-communications-and-beliefs-to-advance-practical-strategies-for-obesity-solutions?utm_source=NASEM+News+and+Publications&utm_campaign=4f373bfa21-EMAIL_CAMPAIGN_2022_08_19_02_40&utm_medium=email&utm_term=0_96101de015-4f373bfa21-104786469&mc_cid=4f373bfa21&mc_eid=50f76db947<br />
::::* https://nap.nationalacademies.org/catalog/26437/addressing-structural-racism-bias-and-health-communication-as-foundational-drivers-of-obesity?utm_source=NASEM+News+and+Publications&utm_campaign=0dcf1bc9b3-EMAIL_CAMPAIGN_2022_08_29_01_45&utm_medium=email&utm_term=0_96101de015-0dcf1bc9b3-104786469&mc_cid=0dcf1bc9b3&mc_eid=50f76db947<br />
::::* [[Legaki 2022 Curr Obes Rep]]<br />
::::* https://journals.physiology.org/ajplung/The-Physiology-of-Obesity?utm_source=AJPLung&utm_medium=email&utm_campaign=newsletter-feb2023&_zs=XShbW&_zl=K0aS3<br />
<br />
::::* Pontzer H, Yamada Y, Sagayama H, Ainslie PN, Andersen LF, Anderson LJ, Arab L, Baddou I, Bedu-Addo K, Blaak EE, Blanc S, Bonomi AG, Bouten CVC, Bovet P, Buchowski MS, Butte NF, Camps SG, Close GL, Cooper JA, Cooper R, Das SK, Dugas LR, Ekelund U, Entringer S, Forrester T, Fudge BW, Goris AH, Gurven M, Hambly C, El Hamdouchi A, Hoos MB, Hu S, Joonas N, Joosen AM, Katzmarzyk P, Kempen KP, Kimura M, Kraus WE, Kushner RF, Lambert EV, Leonard WR, Lessan N, Martin C, Medin AC, Meijer EP, Morehen JC, Morton JP, Neuhouser ML, Nicklas TA, Ojiambo RM, Pietiläinen KH, Pitsiladis YP, Plange-Rhule J, Plasqui G, Prentice RL, Rabinovich RA, Racette SB, Raichlen DA, Ravussin E, Reynolds RM, Roberts SB, Schuit AJ, Sjödin AM, Stice E, Urlacher SS, Valenti G, Van Etten LM, Van Mil EA, Wells JCK, Wilson G, Wood BM, Yanovski J, Yoshida T, Zhang X, Murphy-Alford AJ, Loechl C, Luke AH, Rood J, Schoeller DA, Westerterp KR, Wong WW, Speakman JR; IAEA DLW Database Consortium. Daily energy expenditure through the human life course. Science. 2021 Aug 13;373(6556):808-812. doi: 10.1126/science.abe5017. PMID: 34385400<br />
<br />
::::* Careau V, Halsey LG, Pontzer H, Ainslie PN, Andersen LF, Anderson LJ, Arab L, Baddou I, Bedu-Addo K, Blaak EE, Blanc S, Bonomi AG, Bouten CVC, Buchowski MS, Butte NF, Camps SGJA, Close GL, Cooper JA, Das SK, Cooper R, Dugas LR, Eaton SD, Ekelund U, Entringer S, Forrester T, Fudge BW, Goris AH, Gurven M, Hambly C, El Hamdouchi A, Hoos MB, Hu S, Joonas N, Joosen AM, Katzmarzyk P, Kempen KP, Kimura M, Kraus WE, Kushner RF, Lambert EV, Leonard WR, Lessan N, Martin CK, Medin AC, Meijer EP, Morehen JC, Morton JP, Neuhouser ML, Nicklas TA, Ojiambo RM, Pietiläinen KH, Pitsiladis YP, Plange-Rhule J, Plasqui G, Prentice RL, Rabinovich RA, Racette SB, Raichlen DA, Ravussin E, Reilly JJ, Reynolds RM, Roberts SB, Schuit AJ, Sjödin AM, Stice E, Urlacher SS, Valenti G, Van Etten LM, Van Mil EA, Wells JCK, Wilson G, Wood BM, Yanovski J, Yoshida T, Zhang X, Murphy-Alford AJ, Loechl CU, Luke AH, Rood J, Sagayama H, Schoeller DA, Wong WW, Yamada Y, Speakman JR; IAEA DLW database group. Energy compensation and adiposity in humans. Curr Biol. 2021 Oct 25;31(20):4659-4666.e2. doi: 10.1016/j.cub.2021.08.016. Epub 2021 Aug 27. PMID: 34453886<br />
<br />
::::* Halsey LG, Careau V, Pontzer H, Ainslie PN, Andersen LF, Anderson LJ, Arab L, Baddou I, Bedu-Addo K, Blaak EE, Blanc S, Bonomi AG, Bouten CVC, Bovet P, Buchowski MS, Butte NF, Camps SGJA, Close GL, Cooper JA, Das SK, Cooper R, Dugas LR, Ekelund U, Entringer S, Forrester T, Fudge BW, Goris AH, Gurven M, Hambly C, Hamdouchi AE, Hoos MB, Hu S, Joonas N, Joosen AM, Katzmarzyk P, Kempen KP, Kimura M, Kraus WE, Kushner RF, Lambert EV, Leonard WR, Lessan N, Martin CK, Medin AC, Meijer EP, Morehen JC, Morton JP, Neuhouser ML, Nicklas TA, Ojiambo RM, Pietiläinen KH, Pitsiladis YP, Plange-Rhule J, Plasqui G, Prentice RL, Rabinovich RA, Racette SB, Raichlen DA, Ravussin E, Reynolds RM, Roberts SB, Schuit AJ, Sjödin AM, Stice E, Urlacher SS, Valenti G, Van Etten LM, Van Mil EA, Wilson G, Wood BM, Yanovski J, Yoshida T, Zhang X, Murphy-Alford AJ, Loechl CU, Luke AH, Rood J, Sagayama H, Schoeller DA, Westerterp KR, Wong WW, Yamada Y, Speakman JR. Variability in energy expenditure is much greater in males than females. J Hum Evol. 2022 Oct;171:103229. doi: 10.1016/j.jhevol.2022.103229. Epub 2022 Sep 15. PMID: 36115145<br />
<br />
::::* Higgins S, Pomeroy A, Bates LC, Paterson C, Barone Gibbs B, Pontzer H, Stoner L. Sedentary behavior and cardiovascular disease risk: An evolutionary perspective. Front Physiol. 2022 Jul 27;13:962791. doi: 10.3389/fphys.2022.962791. PMID: 35965885<br />
<br />
::::* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050949/<br />
<br />
::::* https://www.nature.com/articles/s42255-023-00829-4<br />
<br />
::::* https://www.nature.com/articles/s42255-023-00822-x<br />
<br />
::::* https://www.nature.com/articles/s42255-023-00790-2<br />
::::* https://www.nature.com/articles/s42255-023-00782-2<br />
<br />
::::* https://www.nature.com/articles/s42255-022-00733-3<br />
<br />
::::* https://www.nature.com/articles/s42255-022-00731-5 Open Access<br />
<br />
::::* https://www.nature.com/articles/s42255-022-00629-2 Open Access<br />
<br />
::::* https://journals.physiology.org/doi/full/10.1152/physrev.00022.2022?utm_source=journal-newsletter&utm_medium=email&utm_campaign=PRV-sept2023&_zs=XShbW&_zl=VThl3<br />
<br />
::::* From muscle to brain - https://www.frontiersin.org/articles/10.3389/fphys.2023.1273981/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_2234071_a0P58000000G0YjEAK_Physio_20231019_arts_A&id_mc=312850737&utm_source=sfmc&utm_medium=email&utm_campaign=Article+Alerts+V4.1-Frontiers&utm_id=2234071&Business_Goal=%%__AdditionalEmailAttribute1%%&Audience=%%__AdditionalEmailAttribute2%%&Email_Category=%%__AdditionalEmailAttribute3%%&Channel=%%__AdditionalEmailAttribute4%%&BusinessGoal_Audience_EmailCategory_Channel=%%__AdditionalEmailAttribute5%%<br />
<br />
::::* https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.15115?utm_source=APS&utm_medium=email&utm_campaign=journal-newsletter-dec2023<br />
<br />
::::* https://www.jlr.org/article/S0022-2275(24)00024-5/fulltext</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=National_Academies_of_Sciences,_Engineering,_and_Medicine_2023_BMI_and_beyond&diff=246610National Academies of Sciences, Engineering, and Medicine 2023 BMI and beyond2024-03-24T08:40:38Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=National Academies of Sciences, Engineering, and Medicine (2023) BMI and beyond: Considering context in measuring obesity and its applications: Proceedings of a workshop—in brief. The National Academies Press, Washington, DC https://doi.org/10.17226/27185<br />
|info=[https://nap.nationalacademies.org/catalog/27185/bmi-and-beyond-considering-context-in-measuring-obesity-and-its?utm_source=NASEM+News+and+Publications&utm_campaign=cae440fb22-EMAIL_CAMPAIGN_2023_07_31_04_08&utm_medium=email&utm_term=0_-cae440fb22-%5BLIST_EMAIL_ID%5D&mc_cid=cae440fb22&mc_eid=50f76db947 Open Access]<br />
|authors=National Academies of Sciences, Engineering, and Medicine<br />
|year=2023<br />
|journal=National Academies Press<br />
|abstract=The Roundtable on Obesity Solutions of the Health and Medicine Division of the National Academies of Sciences, Engineering, and Medicine held a virtual public workshop, BMI and Beyond: Considering Context in Measuring Obesity and its Applications, on April 4, 2023. The workshop was the first in a two-part series to explore the current science on measures of body composition, body fat distribution, and obesity.<br />
|editor=Gnaiger E<br />
}}<br />
----<br />
{{BME_navigation_line}}<br />
__TOC__<br />
<br />
== From BMI to BME ==<br />
''Work in progress'' by [[Gnaiger E]] 2020-02-10 linked to a preprint in preparation on [[body mass excess |'''BME''']] and [[:Category:BME and mitObesity |'''mitObesity''']].<br />
<br />
{{Template:Publications: BME and body fat}}<br />
{{Template:Publications: BME and height}}<br />
<br />
{{MitoPedia: BME and mitObesity}}<br />
<br />
{{Labeling<br />
|area=Exercise physiology;nutrition;life style<br />
|diseases=Obesity<br />
|organism=Human<br />
|tissues=Fat<br />
|additional=BMI, BME, Fat<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=National_Academies_of_Sciences,_Engineering,_and_Medicine_2023_Navigating_infodemics&diff=246609National Academies of Sciences, Engineering, and Medicine 2023 Navigating infodemics2024-03-24T08:39:36Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=National Academies of Sciences, Engineering, and Medicine (2023) Navigating infodemics and building trust during public health emergencies: proceedings of a workshop in brief. National Academies Press, Washington, DC. https://doi.org/10.17226/27188<br />
|info=[http://nap.nationalacademies.org/27188 National Academies Press, Open Access]<br />
|authors=National Academies of Sciences, Engineering, and Medicine<br />
|year=2023<br />
|journal=National Academies Press<br />
|abstract=At the request of the Centers for Disease Control and Prevention (CDC), the National Academies of Sciences, Engineering, and Medicine hosted a two-day public workshop on April 10-11, 2023 to examine the history of public health infodemics, the impact of infodemics on trust in the public health enterprise, and tools and practices used to address infodemics.<br />
<br />
At the outset of the workshop, Howard Koh, Harvard T.H. Chan School of Public Health, described the term “infodemic” as the rapid spread of large amounts of sometimes conflicting or inaccurate information that can impede the ability of individuals, communities, and authorities to protect health and effectively respond in a crisis. Even a deluge of accurate information can overwhelm the public. In times of emergency, there may also be situations in which people do not have access to the information they need. <br />
<br />
In his closing remarks, Griffis called for increased understanding of how to resource institutions at all levels to reduce the harmful effects of mis- and disinformation. To this end, CDC conducts regular meetings with other federal agencies to coordinate responses to emerging misinformation. Furthermore, CDC is working to: (1) build improved misinformation monitoring and alert systems; (2) develop a more systematic approach to misinformation through the agency; (3) create, in collaboration with academic institutions, a system to increase sentinel data collection and social listening; (4) establish rapid response infrastructure to provide the public with accurate information from trusted community sources; and (5) develop tools for public health to predict the virality of vaccine misinformation. CDC continually strives to disseminate accurate information as it is needed through appropriate channels in order to empower the public to make decisions that support their health and wellbeing.<br />
<br />
|editor=Gnaiger E<br />
}}<br />
{{Labeling<br />
|additional=Gentle Science, Ambiguity crisis<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=The_National_Academies_Press,_Washington,_DC&diff=246608The National Academies Press, Washington, DC2024-03-24T08:38:02Z<p>Gnaiger Erich: Gnaiger Erich moved page The National Academies Press, Washington, DC to National Academies Press</p>
<hr />
<div>#REDIRECT [[National Academies Press]]</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=National_Academies_Press&diff=246607National Academies Press2024-03-24T08:38:01Z<p>Gnaiger Erich: Gnaiger Erich moved page The National Academies Press, Washington, DC to National Academies Press</p>
<hr />
<div>{{Journal<br />
|Title=[https://nap.nationalacademies.org/ National Academies Press]<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=National_Academies_Press&diff=246606National Academies Press2024-03-24T08:37:14Z<p>Gnaiger Erich: Created page with "{{Journal |Title=[https://nap.nationalacademies.org/ National Academies Press] }}"</p>
<hr />
<div>{{Journal<br />
|Title=[https://nap.nationalacademies.org/ National Academies Press]<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=National_Academies_of_Sciences,_Engineering,_and_Medicine_2024_Body_composition_and_obesity&diff=246605National Academies of Sciences, Engineering, and Medicine 2024 Body composition and obesity2024-03-24T08:32:37Z<p>Gnaiger Erich: Created page with "{{Publication |title=National Academies of Sciences, Engineering, and Medicine (2024) Exploring the science on measures of body composition, body fat distribution, and obesit..."</p>
<hr />
<div>{{Publication<br />
|title=National Academies of Sciences, Engineering, and Medicine (2024) Exploring the science on measures of body composition, body fat distribution, and obesity. National Academies Press, Washington, DC https://doi.org/10.17226/27461.<br />
|info=[https://nap.nationalacademies.org/catalog/27461/exploring-the-science-on-measures-of-body-composition-body-fat-distribution-and-obesity?utm_source=NASEM+News+and+Publications&utm_campaign=ef8dee7bac-Final_Book_2024_03_22_27461&utm_medium=email&utm_term=0_-ef8dee7bac-%5BLIST_EMAIL_ID%5D&goal=0_96101de015-ef8dee7bac-104786469&mc_cid=ef8dee7bac&mc_eid=50f76db947 National Academies Press, Open Access]<br />
|authors=National Academies of Sciences, Engineering, and Medicine<br />
|year=2024<br />
|journal=National Academies Press, Washington, DC<br />
|abstract=The National Academies Roundtable on Obesity Solutions hosted a public workshop series in April and June 2023 that explored the current science on measures of body composition and body fat distribution. Discussions focused on the strengths and limitations, and clinical and anthropological perspectives of body mass index (BMI) as a measure of adiposity and health. Presentations also shed light on the connection between misinformation and bias and stigma, as well as challenged current communication strategies to improve messaging about obesity.<br />
|editor=Gnaiger E<br />
}}<br />
{{Labeling<br />
|diseases=Obesity<br />
|organism=Human<br />
|additional=BME<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Talk:Body_mass_excess&diff=246604Talk:Body mass excess2024-03-24T08:10:05Z<p>Gnaiger Erich: </p>
<hr />
<div>References<br />
<br />
::::* https://hal.archives-ouvertes.fr/hal-01561605/document<br />
::::* https://jamanetwork.com/journals/jama/fullarticle/2778234?guestAccessKey=0a2822f9-c344-4122-bf17-45cbe664e1b3&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_term=mostread&utm_content=olf-widget_04082021<br />
::::* https://pubmed.ncbi.nlm.nih.gov/33436528/<br />
::::* https://pubmed.ncbi.nlm.nih.gov/31095428/<br />
::::* https://www.mdpi.com/2227-9059/9/3/258<br />
::::* https://jamanetwork.com/journals/jama/fullarticle/2783690?guestAccessKey=c7e25160-01d1-4115-bd00-ec44097f7a8d&utm_source=silverchair&utm_campaign=altmetric&utm_content=2021_year-end&cmp=1&utm_medium=email<br />
::::* https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2777737?utm_source=silverchair&utm_campaign=altmetric&utm_content=2021_year-end&cmp=1&utm_medium=email<br />
::::* https://jamanetwork.com/journals/jama/fullarticle/2787551?guestAccessKey=c0420c99-99a1-4b35-928d-1e53d902de98<br />
::::* https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2787246?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetworkopen&utm_content=mthlyforyou&utm_term=010222<br />
::::* https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038834<br />
::::* Shi Q, Wang Y, Hao Q, Vandvik PO, Guyatt G, Li J, Chen Z, Xu S, Shen Y, Ge L, Sun F, Li L, Yu J, Nong K, Zou X, Zhu S, Wang C, Zhang S, Qiao Z, Jian Z, Li Y, Zhang X, Chen K, Qu F, Wu Y, He Y, Tian H, Li S. Pharmacotherapy for adults with overweight and obesity: a systematic review and network meta-analysis of randomised controlled trials. Lancet. 2021 Dec 8:S0140-6736(21)01640-8. doi: 10.1016/S0140-6736(21)01640-8. Epub ahead of print. PMID: 34895470 - https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01640-8/fulltext?dgcid=raven_jbs_etoc_email<br />
::::* https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01919-X/fulltext?dgcid=raven_jbs_etoc_email<br />
::::* https://onlinelibrary.wiley.com/action/doSearch?field1=Contrib&text1=Chabot+D&field2=AllField&text2=&field3=AllField&text3=&Ppub=<br />
::::* https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789169?guestAccessKey=5560b202-f036-4162-8403-aa9e31f31035&utm_source=silverchair&utm_campaign=jama_network&utm_content=car_weekly_highlights&cmp=1&utm_medium=email<br />
::::* https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788555?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetworkopen&utm_content=mthlyforyou&utm_term=030622<br />
::::* https://www.nap.edu/download/26498<br />
::::* https://www.frontiersin.org/articles/10.3389/fphys.2022.924649/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1914357_a0P58000000G0YjEAK_Physio_20220728_arts_A&id_mc=312850737&utm_source=sfmc&utm_medium=email&utm_campaign=Article+Alerts+V4.1-Frontiers&utm_id=1914357<br />
::::* https://gmed-una-storage.s3.amazonaws.com/bx_posts_files/5/5w/5w9/5w99egarfgpxur6k8bj3vcfkk7ysbya2.pdf<br />
::::* https://nap.nationalacademies.org/catalog/26681/targeting-structures-communications-and-beliefs-to-advance-practical-strategies-for-obesity-solutions?utm_source=NASEM+News+and+Publications&utm_campaign=4f373bfa21-EMAIL_CAMPAIGN_2022_08_19_02_40&utm_medium=email&utm_term=0_96101de015-4f373bfa21-104786469&mc_cid=4f373bfa21&mc_eid=50f76db947<br />
::::* https://nap.nationalacademies.org/catalog/26437/addressing-structural-racism-bias-and-health-communication-as-foundational-drivers-of-obesity?utm_source=NASEM+News+and+Publications&utm_campaign=0dcf1bc9b3-EMAIL_CAMPAIGN_2022_08_29_01_45&utm_medium=email&utm_term=0_96101de015-0dcf1bc9b3-104786469&mc_cid=0dcf1bc9b3&mc_eid=50f76db947<br />
::::* [[Legaki 2022 Curr Obes Rep]]<br />
::::* https://journals.physiology.org/ajplung/The-Physiology-of-Obesity?utm_source=AJPLung&utm_medium=email&utm_campaign=newsletter-feb2023&_zs=XShbW&_zl=K0aS3<br />
<br />
::::* Pontzer H, Yamada Y, Sagayama H, Ainslie PN, Andersen LF, Anderson LJ, Arab L, Baddou I, Bedu-Addo K, Blaak EE, Blanc S, Bonomi AG, Bouten CVC, Bovet P, Buchowski MS, Butte NF, Camps SG, Close GL, Cooper JA, Cooper R, Das SK, Dugas LR, Ekelund U, Entringer S, Forrester T, Fudge BW, Goris AH, Gurven M, Hambly C, El Hamdouchi A, Hoos MB, Hu S, Joonas N, Joosen AM, Katzmarzyk P, Kempen KP, Kimura M, Kraus WE, Kushner RF, Lambert EV, Leonard WR, Lessan N, Martin C, Medin AC, Meijer EP, Morehen JC, Morton JP, Neuhouser ML, Nicklas TA, Ojiambo RM, Pietiläinen KH, Pitsiladis YP, Plange-Rhule J, Plasqui G, Prentice RL, Rabinovich RA, Racette SB, Raichlen DA, Ravussin E, Reynolds RM, Roberts SB, Schuit AJ, Sjödin AM, Stice E, Urlacher SS, Valenti G, Van Etten LM, Van Mil EA, Wells JCK, Wilson G, Wood BM, Yanovski J, Yoshida T, Zhang X, Murphy-Alford AJ, Loechl C, Luke AH, Rood J, Schoeller DA, Westerterp KR, Wong WW, Speakman JR; IAEA DLW Database Consortium. Daily energy expenditure through the human life course. Science. 2021 Aug 13;373(6556):808-812. doi: 10.1126/science.abe5017. PMID: 34385400<br />
<br />
::::* Careau V, Halsey LG, Pontzer H, Ainslie PN, Andersen LF, Anderson LJ, Arab L, Baddou I, Bedu-Addo K, Blaak EE, Blanc S, Bonomi AG, Bouten CVC, Buchowski MS, Butte NF, Camps SGJA, Close GL, Cooper JA, Das SK, Cooper R, Dugas LR, Eaton SD, Ekelund U, Entringer S, Forrester T, Fudge BW, Goris AH, Gurven M, Hambly C, El Hamdouchi A, Hoos MB, Hu S, Joonas N, Joosen AM, Katzmarzyk P, Kempen KP, Kimura M, Kraus WE, Kushner RF, Lambert EV, Leonard WR, Lessan N, Martin CK, Medin AC, Meijer EP, Morehen JC, Morton JP, Neuhouser ML, Nicklas TA, Ojiambo RM, Pietiläinen KH, Pitsiladis YP, Plange-Rhule J, Plasqui G, Prentice RL, Rabinovich RA, Racette SB, Raichlen DA, Ravussin E, Reilly JJ, Reynolds RM, Roberts SB, Schuit AJ, Sjödin AM, Stice E, Urlacher SS, Valenti G, Van Etten LM, Van Mil EA, Wells JCK, Wilson G, Wood BM, Yanovski J, Yoshida T, Zhang X, Murphy-Alford AJ, Loechl CU, Luke AH, Rood J, Sagayama H, Schoeller DA, Wong WW, Yamada Y, Speakman JR; IAEA DLW database group. Energy compensation and adiposity in humans. Curr Biol. 2021 Oct 25;31(20):4659-4666.e2. doi: 10.1016/j.cub.2021.08.016. Epub 2021 Aug 27. PMID: 34453886<br />
<br />
::::* Halsey LG, Careau V, Pontzer H, Ainslie PN, Andersen LF, Anderson LJ, Arab L, Baddou I, Bedu-Addo K, Blaak EE, Blanc S, Bonomi AG, Bouten CVC, Bovet P, Buchowski MS, Butte NF, Camps SGJA, Close GL, Cooper JA, Das SK, Cooper R, Dugas LR, Ekelund U, Entringer S, Forrester T, Fudge BW, Goris AH, Gurven M, Hambly C, Hamdouchi AE, Hoos MB, Hu S, Joonas N, Joosen AM, Katzmarzyk P, Kempen KP, Kimura M, Kraus WE, Kushner RF, Lambert EV, Leonard WR, Lessan N, Martin CK, Medin AC, Meijer EP, Morehen JC, Morton JP, Neuhouser ML, Nicklas TA, Ojiambo RM, Pietiläinen KH, Pitsiladis YP, Plange-Rhule J, Plasqui G, Prentice RL, Rabinovich RA, Racette SB, Raichlen DA, Ravussin E, Reynolds RM, Roberts SB, Schuit AJ, Sjödin AM, Stice E, Urlacher SS, Valenti G, Van Etten LM, Van Mil EA, Wilson G, Wood BM, Yanovski J, Yoshida T, Zhang X, Murphy-Alford AJ, Loechl CU, Luke AH, Rood J, Sagayama H, Schoeller DA, Westerterp KR, Wong WW, Yamada Y, Speakman JR. Variability in energy expenditure is much greater in males than females. J Hum Evol. 2022 Oct;171:103229. doi: 10.1016/j.jhevol.2022.103229. Epub 2022 Sep 15. PMID: 36115145<br />
<br />
::::* Higgins S, Pomeroy A, Bates LC, Paterson C, Barone Gibbs B, Pontzer H, Stoner L. Sedentary behavior and cardiovascular disease risk: An evolutionary perspective. Front Physiol. 2022 Jul 27;13:962791. doi: 10.3389/fphys.2022.962791. PMID: 35965885<br />
<br />
::::* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050949/<br />
<br />
::::* https://www.nature.com/articles/s42255-023-00829-4<br />
<br />
::::* https://www.nature.com/articles/s42255-023-00822-x<br />
<br />
::::* https://www.nature.com/articles/s42255-023-00790-2<br />
::::* https://www.nature.com/articles/s42255-023-00782-2<br />
<br />
::::* https://www.nature.com/articles/s42255-022-00733-3<br />
<br />
::::* https://www.nature.com/articles/s42255-022-00731-5 Open Access<br />
<br />
::::* https://www.nature.com/articles/s42255-022-00629-2 Open Access<br />
<br />
::::* https://journals.physiology.org/doi/full/10.1152/physrev.00022.2022?utm_source=journal-newsletter&utm_medium=email&utm_campaign=PRV-sept2023&_zs=XShbW&_zl=VThl3<br />
<br />
::::* From muscle to brain - https://www.frontiersin.org/articles/10.3389/fphys.2023.1273981/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_2234071_a0P58000000G0YjEAK_Physio_20231019_arts_A&id_mc=312850737&utm_source=sfmc&utm_medium=email&utm_campaign=Article+Alerts+V4.1-Frontiers&utm_id=2234071&Business_Goal=%%__AdditionalEmailAttribute1%%&Audience=%%__AdditionalEmailAttribute2%%&Email_Category=%%__AdditionalEmailAttribute3%%&Channel=%%__AdditionalEmailAttribute4%%&BusinessGoal_Audience_EmailCategory_Channel=%%__AdditionalEmailAttribute5%%<br />
<br />
::::* https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.15115?utm_source=APS&utm_medium=email&utm_campaign=journal-newsletter-dec2023<br />
<br />
::::* https://www.jlr.org/article/S0022-2275(24)00024-5/fulltext<br />
<br />
::::* Exploring the science on measures of body composition, body fat distribution, and obesity https://nap.nationalacademies.org/catalog/27461/exploring-the-science-on-measures-of-body-composition-body-fat-distribution-and-obesity?utm_source=NASEM+News+and+Publications&utm_campaign=ef8dee7bac-Final_Book_2024_03_22_27461&utm_medium=email&utm_term=0_-ef8dee7bac-%5BLIST_EMAIL_ID%5D&goal=0_96101de015-ef8dee7bac-104786469&mc_cid=ef8dee7bac&mc_eid=50f76db947</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Complex_II_ambiguities&diff=246594Complex II ambiguities2024-03-22T06:21:30Z<p>Gnaiger Erich: </p>
<hr />
<div>{{MitoPedia<br />
|abbr=CII ambiguities<br />
|description=[[File:CII-ambiguities Graphical abstract.png|300px|left|link=Gnaiger 2023 MitoFit CII]]The current narrative that the reduced coenzymes NADH and FADH2 feed electrons from the tricarboxylic acid (TCA) cycle into the mitochondrial electron transfer system can create ambiguities around respiratory Complex CII. Succinate dehydrogenase or CII reduces FAD to FADH2 in the canonical forward TCA cycle. However, some graphical representations of the membrane-bound electron transfer system (ETS) depict CII as the site of oxidation of FADH2. This leads to the false believe that FADH2 generated by electron transferring flavoprotein (CETF) in fatty acid oxidation and mitochondrial glycerophosphate dehydrogenase (CGpDH) feeds electrons into the ETS through CII. In reality, NADH and succinate produced in the TCA cycle are the substrates of Complexes CI and CII, respectively, and the reduced flavin groups FMNH2 and FADH2 are downstream products of CI and CII, respectively, carrying electrons from CI and CII into the Q-junction. Similarly, CETF and CGpDH feed electrons into the Q-junction but not through CII. The ambiguities surrounding Complex II in the literature call for quality control, to secure scientific standards in current communications on bioenergetics and support adequate clinical applications.<br />
|info=Gnaiger E (2024) Complex II ambiguities ― FADH<sub>2</sub> in the electron transfer system. J Biol Chem 300: 105470. https://doi.org/10.1016/j.jbc.2023.105470<br />
}}<br />
'''» ''Links:''''' [[Ambiguity crisis]], [[:Category:Ambiguity crisis - NAD and H+ |Complex I and hydrogen ion ambiguities in the electron transfer system]]<br />
<br />
__TOC__<br />
== A game of cards ==<br />
<br />
:::: 33 copies or variations of a CII ambiguity theme<br />
<br />
:::::: [[File:Martell 2023 Nat Commun CORRECTION.png|400px|link=Martell 2023 Nat Commun]]<br />
:::: '''1.''' Martell E, Kuzmychova H, Kaul E, Senthil H, Chowdhury SR, Morrison LC, Fresnoza A, Zagozewski J, Venugopal C, Anderson CM, Singh SK, Banerji V, Werbowetski-Ogilvie TE, Sharif T (2023) Metabolism-based targeting of MYC via MPC-SOD2 axis-mediated oxidation promotes cellular differentiation in group 3 medulloblastoma. '''Nat Commun''' 14:2502. - [[Martell 2023 Nat Commun |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Solhaug 2023 Cytotechnology CORRECTION.png|400px|link=Solhaug 2023 Cytotechnology]]<br />
:::: '''2.''' Solhaug A, Gjessing M, Sandvik M, Eriksen GS (2023) The gill epithelial cell lines RTgill-W1, from Rainbow trout and ASG-10, from Atlantic salmon, exert different toxicity profiles towards rotenone. '''Cytotechnology''' 75:63-75. - [[Solhaug 2023 Cytotechnology |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Fahimi 2022 Trends in Chemistry CORRECTION.png|400px|link=Fahimi 2022 Trends in Chemistry]]<br />
:::: '''3.''' Fahimi P, Matta CF (2022) The hot mitochondrion paradox: reconciling theory and experiment. '''Trends in Chemistry''' 4:4-20. - [[Fahimi 2022 Trends in Chemistry |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Foo 2022 Trends Microbiol CORRECTION.png|400px|link=Foo 2022 Trends Microbiol]]<br />
:::: '''4.''' Foo J, Bellot G, Pervaiz S, Alonso S (2022) Mitochondria-mediated oxidative stress during viral infection. '''Trends Microbiol''' 30:679-92. - [[Foo 2022 Trends Microbiol |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Joshi 2022 Biomolecules CORRECTION.png|400px|link=Joshi 2022 Biomolecules]]<br />
:::: '''5.''' Joshi A, Ito T, Picard D, Neckers L (2022) The mitochondrial HSP90 paralog TRAP1: structural dynamics, interactome, role in metabolic regulation, and inhibitors. '''Biomolecules''' 12:880. - [[Joshi 2022 Biomolecules |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Manickam 2022 J Control Release CORRECTION.png|400px|link=Manickam 2022 J Control Release]]<br />
:::: '''6.''' Manickam DS (2022) Delivery of mitochondria via extracellular vesicles - a new horizon in drug delivery. '''J Control Release''' 343:400-7. - [[Manickam 2022 J Control Release |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Wu 2022 Neuromolecular Med CORRECTION.png|400px|link=Wu 2022 Neuromolecular Med]]<br />
:::: '''7.''' Wu Z, Ho WS, Lu R (2022) Targeting mitochondrial oxidative phosphorylation in glioblastoma therapy. '''Neuromolecular Med''' 24:18-22. - [[Wu 2022 Neuromolecular Med |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Yang 2022 J Cleaner Production CORRECTION.png|400px|link=Yang 2022 J Cleaner Production]]<br />
:::: '''8.''' Yang Y, Zhang X, Hu X, Zhao J, Chen X, Wei X, Yu X (2022) Analysis of the differential metabolic pathway of cultured ''Chlorococcum humicola'' with hydroquinone toxic sludge extract. '''J Cleaner Production''' 370:133486. - [[Yang 2022 J Cleaner Production |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Ignatieva 2021 Int J Mol Sci CORRECTION.png|400px|link=Ignatieva 2021 Int J Mol Sci]]<br />
:::: '''9.''' Ignatieva E, Smolina N, Kostareva A, Dmitrieva R (2021) Skeletal muscle mitochondria dysfunction in genetic neuromuscular disorders with cardiac phenotype. '''Int J Mol Sci''' 22:7349. - [[Ignatieva 2021 Int J Mol Sci |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Anoar 2021 Front Neurosci CORRECTION.jpg|400px|link=Anoar 2021 Front Neurosci]]<br />
:::: '''10.''' Anoar S, Woodling NS, Niccoli T (2021) Mitochondria dysfunction in frontotemporal dementia/amyotrophic lateral sclerosis: lessons from ''Drosophila'' models. '''Front Neurosci''' 15:786076. - [[Anoar 2021 Front Neurosci |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Shields 2021 Front Cell Dev Biol CORRECTION.png|400px|link=Shields 2021 Front Cell Dev Biol]]<br />
:::: '''11.''' Shields HJ, Traa A, Van Raamsdonk JM (2021) Beneficial and detrimental effects of reactive oxygen species on lifespan: a comprehensive review of comparative and experimental studies. '''Front Cell Dev Biol''' 9:628157. - [[Shields 2021 Front Cell Dev Biol |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Vesga 2021 Med Chem Res CORRECTION.png|400px|link=Vesga 2021 Med Chem Res]]<br />
:::: '''12.''' Vesga LC, Silva AMP, Bernal CC, Mendez-Sánchez SC, Bohórquez ARR (2021) Tetrahydroquinoline/4,5-dihydroisoxazole hybrids with a remarkable effect over mitochondrial bioenergetic metabolism on melanoma cell line B16F10. '''Med Chem Res''' 30:2127–43. - [[Vesga 2021 Med Chem Res |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Gopalakrishnan 2020 Sci Rep CORRECTION.png|400px|link=Gopalakrishnan 2020 Sci Rep]]<br />
:::: '''13.''' Gopalakrishnan S, Mehrvar S, Maleki S, Schmitt H, Summerfelt P, Dubis AM, Abroe B, Connor TB Jr, Carroll J, Huddleston W, Ranji M, Eells JT (2020) Photobiomodulation preserves mitochondrial redox state and is retinoprotective in a rodent model of retinitis pigmentosa. '''Sci Rep''' 10:20382. - [[Gopalakrishnan 2020 Sci Rep |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Aye 2022 Am J Obstet Gynecol CORRECTION.png|400px|link=Aye 2022 Am J Obstet Gynecol]]<br />
:::: '''14.''' Aye ILMH, Aiken CE, Charnock-Jones DS, Smith GCS (2022) Placental energy metabolism in health and disease-significance of development and implications for preeclampsia. '''Am J Obstet Gynecol''' 226:S928-44. - [[Aye 2022 Am J Obstet Gynecol |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Lu 2023 Explor Res Hypothesis Med CORRECTION.png|400px|link=Lu 2023 Explor Res Hypothesis Med]]<br />
:::: '''15.''' Lu F (2023) Hypothetical hydrogenase activity of human mitochondrial Complex I and its role in preventing cancer transformation. '''Explor Res Hypothesis Med''' 8:280-5. - [[Lu 2023 Explor Res Hypothesis Med |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Cojocaru 2023 Antioxidants (Basel) CORRECTION.png|400px|link=Cojocaru 2023 Antioxidants (Basel)]]<br />
:::: '''16.''' Cojocaru KA, Luchian I, Goriuc A, Antoci LM, Ciobanu CG, Popescu R, Vlad CE, Blaj M, Foia LG (2023) Mitochondrial dysfunction, oxidative stress, and therapeutic strategies in diabetes, obesity, and cardiovascular disease. '''Antioxidants (Basel)''' 12:658. - [[Cojocaru 2023 Antioxidants (Basel) |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Faria 2023 Pharmaceutics CORRECTION.png|400px|link=Faria 2023 Pharmaceutics]]<br />
:::: '''17.''' Faria R, Boisguérin P, Sousa Â, Costa D (2023) Delivery systems for mitochondrial gene therapy: a review. '''Pharmaceutics''' 15:572. - [[Faria 2023 Pharmaceutics |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:George 2023 Platelets CORRECTION.png|400px|link=George 2023 Platelets]]<br />
:::: '''18.''' George CE, Saunders CV, Morrison A, Scorer T, Jones S, Dempsey NC (2023) Cold stored platelets in the management of bleeding: is it about bioenergetics? '''Platelets''' 34:2188969 - [[George 2023 Platelets |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Narine 2022 Front Cell Neurosci CORRECTION.png|400px|link=Narine 2022 Front Cell Neurosci]]<br />
:::: '''19.''' Narine M, Colognato H (2022) Current insights into oligodendrocyte metabolism and its power to sculpt the myelin landscape. '''Front Cell Neurosci''' 16:892968. - [[Narine 2022 Front Cell Neurosci |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Sainero-Alcolado 2022 Cell Death Differ CORRECTION.png|400px|link=Sainero-Alcolado 2022 Cell Death Differ]]<br />
:::: '''20.''' Sainero-Alcolado L, Liaño-Pons J, Ruiz-Pérez MV, Arsenian-Henriksson M (2022) Targeting mitochondrial metabolism for precision medicine in cancer. '''Cell Death Differ''' 29:1304-17. - [[Sainero-Alcolado 2022 Cell Death Differ |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Nguyen 2021 Brief Bioinform CORRECTION.png|400px|link=Nguyen 2021 Brief Bioinform]]<br />
:::: '''21.''' Nguyen TT, Nguyen DK, Ou YY (2021) Addressing data imbalance problems in ligand-binding site prediction using a variational autoencoder and a convolutional neural network. '''Brief Bioinform''' 22:bbab277. - [[Nguyen 2021 Brief Bioinform |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Prasuhn 2021 Front Cell Dev Biol CORRECTION.png|400px|link=Prasuhn 2021 Front Cell Dev Biol]]<br />
:::: '''22.''' Prasuhn J, Davis RL, Kumar KR (2021) Targeting mitochondrial impairment in Parkinson's disease: challenges and opportunities. '''Front Cell Dev Biol''' 8:615461. - [[Prasuhn 2021 Front Cell Dev Biol |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Gallinat 2022 Int J Mol Sci CORRECTION.png|400px|link=Gallinat 2022 Int J Mol Sci]]<br />
:::: '''23.''' Gallinat A, Vilahur G, Padró T, Badimon L (2022) Network-assisted systems biology analysis of the mitochondrial proteome in a pre-clinical model of ischemia, revascularization and post-conditioning. '''Int J Mol Sci''' 23:2087. - [[Gallinat 2022 Int J Mol Sci |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Turton 2021 Expert Opinion Orphan Drugs CORRECTION.png|400px|link=Turton 2021 Expert Opinion Orphan Drugs]]<br />
:::: '''24.''' Turton N, Bowers N, Khajeh S, Hargreaves IP, Heaton RA (2021) Coenzyme Q10 and the exclusive club of diseases that show a limited response to treatment. '''Expert Opinion Orphan Drugs''' 9:151-60. - [[Turton 2021 Expert Opinion Orphan Drugs |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Keidar 2023 Front Physiol CORRECTION.png|400px|link=Keidar 2023 Front Physiol]]<br />
:::: '''25.''' Keidar N, Peretz NK, Yaniv Y (2023) Ca<sup>2+</sup> pushes and pulls energetics to maintain ATP balance in atrial cells: computational insights. '''Front Physiol''' 14:1231259. - [[Keidar 2023 Front Physiol |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Chakrabarty 2021 Cell Stem Cell 3 CORRECTION.png|400px|link=Chakrabarty 2021 Cell Stem Cell]]<br />
:::: '''26.''' Chakrabarty RP, Chandel NS (2021) Mitochondria as signaling organelles control mammalian stem cell fate. '''Cell Stem Cell''' 28:394-408. - [[Chakrabarty 2021 Cell Stem Cell |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Vargas-Mendoza 2021 Life (Basel) CORRECTION.png|400px|link=Vargas-Mendoza 2021 Life (Basel)]]<br />
:::: '''27.''' Vargas-Mendoza N, Angeles-Valencia M, Morales-González Á, Madrigal-Santillán EO, Morales-Martínez M, Madrigal-Bujaidar E, Álvarez-González I, Gutiérrez-Salinas J, Esquivel-Chirino C, Chamorro-Cevallos G, Cristóbal-Luna JM, Morales-González JA (2021) Oxidative stress, mitochondrial function and adaptation to exercise: new perspectives in nutrition. '''Life (Basel)''' 11:1269. - [[Vargas-Mendoza 2021 Life (Basel) |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Egan 2023 Physiol Rev CORRECTION.png|400px|link=Egan 2023 Physiol Rev]]<br />
:::: '''28.''' Egan B, Sharples AP (2023) Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training. '''Physiol Rev''' 103:2057-2170. - [[Egan 2023 Physiol Rev |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Han 2021 Am J Respir Cell Mol Biol CORRECTION.png|400px|link=Han 2021 Am J Respir Cell Mol Biol]]<br />
:::: '''29.''' Han S, Chandel NS (2021) Lessons from cancer metabolism for pulmonary arterial hypertension and fibrosis. '''Am J Respir Cell Mol Biol''' 65:134-45. - [[Han 2021 Am J Respir Cell Mol Biol |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Lakovou 2022 Front Aging Neurosci CORRECTION.png|400px|link=Iakovou 2022 Front Aging Neurosci]]<br />
:::: '''30.''' Iakovou E, Kourti M (2022) A comprehensive overview of the complex role of oxidative stress in aging, the contributing environmental stressors and emerging antioxidant therapeutic interventions. '''Front Aging Neurosci''' 14:827900. - [[Iakovou 2022 Front Aging Neurosci |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Jayasankar 2022 ACS Omega CORRECTION.png|400px|link=Jayasankar 2022 ACS Omega]]<br />
:::: '''31.''' Jayasankar V, Vrdoljak N, Roma A, Ahmed N, Tcheng M, Minden MD, Spagnuolo PA (2022) Novel mango ginger bioactive (2,4,6-trihydroxy-3,5-diprenyldihydrochalcone) inhibits mitochondrial metabolism in combination with Avocatin B. '''ACS Omega''' 7:1682-93. - [[Jayasankar 2022 ACS Omega |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Yuan 2022 Oxid Med Cell Longev CORRECTION.png|400px|link=Yuan 2022 Oxid Med Cell Longev]]<br />
:::: '''32.''' Yuan Q, Zeng ZL, Yang S, Li A, Zu X, Liu J (2022) Mitochondrial stress in metabolic inflammation: modest benefits and full losses. '''Oxid Med Cell Longev''' 2022:8803404. - [[Yuan 2022 Oxid Med Cell Longev |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Yin 2021 FASEB J CORRECTION.png|400px|link=Yin 2021 FASEB J]]<br />
:::: '''33.''' Yin M, O'Neill LAJ (2021) The role of the electron transport chain in immunity. '''FASEB J''' 35:e21974. - [[Yin 2021 FASEB J |»Bioblast link«]]<br />
<br><br />
<br />
<br />
== Doubles ==<br />
<br />
:::::: [[File:Chen 2014 Circ Res CORRECTION.png|400px|link=Chen 2014 Circ Res]]<br />
:::: '''1.''' Chen YR, Zweier JL (2014) Cardiac mitochondria and reactive oxygen species generation. '''Circ Res''' 114:524-37. - [[Chen 2014 Circ Res |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Chen 2022 Am J Physiol Cell Physiol CORRECTION.png|400px|link=Chen 2022 Am J Physiol Cell Physiol]]<br />
:::: '''2.''' Chen CL, Zhang L, Jin Z, Kasumov T, Chen YR (2022) Mitochondrial redox regulation and myocardial ischemia-reperfusion injury. '''Am J Physiol Cell Physiol''' 322:C12-23. - [[Chen 2022 Am J Physiol Cell Physiol |»Bioblast link«]]<br />
<br><br />
<br><br />
<br />
:::::: [[File:Chen 2022 Int J Mol Sci CORRECTION.png|400px|link=Chen 2022 Int J Mol Sci]]<br />
:::: '''1.''' Chen TH, Koh KY, Lin KM, Chou CK (2022) Mitochondrial dysfunction as an underlying cause of skeletal muscle disorders. '''Int J Mol Sci''' 23:12926. - [[Chen 2022 Int J Mol Sci |»Bioblast link«]]<br />
<br><br />
<br />
:::::: [[File:Schniertshauer 2023 Curr Issues Mol Biol CORRECTION.jpg.png|400px|link=Schniertshauer 2023 Curr Issues Mol Biol]]<br />
:::: '''2.''' Schniertshauer D, Wespel S, Bergemann J (2023) Natural mitochondria targeting substances and their effect on cellular antioxidant system as a potential benefit in mitochondrial medicine for prevention and remediation of mitochondrial dysfunctions. '''Curr Issues Mol Biol''' 45:3911-32. - [[Schniertshauer 2023 Curr Issues Mol Biol |»Bioblast link«]]<br />
<br><br />
<br />
<br />
:::: [[Gnaiger_2023_MitoFit_CII#Beyond_version_6 |'''and more ..''']]<br />
<br />
<br />
{{MitoPedia concepts<br />
|mitopedia concept=MiP concept<br />
}}<br />
{{MitoPedia methods}}<br />
{{MitoPedia O2k and high-resolution respirometry}}<br />
{{MitoPedia topics<br />
|mitopedia topic=Enzyme, Substrate and metabolite<br />
}}<br />
{{Labeling<br />
|additional=MitoPedia:FAT4BRAIN<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=EU-METAHEART_MC2_Meeting_2024_Antalya_TR&diff=246535EU-METAHEART MC2 Meeting 2024 Antalya TR2024-03-17T06:36:45Z<p>Gnaiger Erich: </p>
<hr />
<div>{{MitoGlobal header page name}}<br />
<br />
{{Publication<br />
|title=[[File:COST Logo.jpg|left|120px|COST Action]][[File:EU-METAHEART logo.jpg|right|70px|EU-METAHEART]]'''Antalya TR''', 2024 Mar 18-21. EU-METAHEART MC2 Meeting<br />
|info= [[EU-METAHEART]]<br />
|authors= [[EU-METAHEART]]<br />
|year=2024-03-18<br />
|journal=MitoGlobal<br />
|abstract= COST CA22169 METAHEART Management Committee meeting MC2, Antalya, Turkey, 2024<br />
}}<br />
<br />
== Venue ==<br />
:::: Miracle Resort Hotel https://www.miraclehotel.com/<br />
<br />
== Organizers ==<br />
:::: COST Association - European Cooperation in Science and Technology<br />
:::: Action Contact: [[Maack C|Prof Christoph Maack]], University Clinic Würzburg, DE<br />
:::: [[Gnaiger Erich |Erich Gnaiger]] is part of the Management Committee of CA22169 - EUropean network to tackle METAbolic alterations in HEART failure (EU-METAHEART)<br />
<br />
== Program ==<br />
:::: Program available [[Media:EU-METAHEART_MC2_Meeting_Antalya_03-2024_programme.pdf|here]]<br />
<br />
== Oroboros at EU-METAHEART MC2 Meeting ==<br />
:::: [[Gnaiger Erich]]: [[Donnelly_2024_EU-METAHEART_MC2_Meeting |Impact of hypoxia on mitochondrial function: effects on oxidative phosphorylation, mitochondrial membrane potential, redox state of coenzyme Q, and calcium uptake]], ''Mar 19, 15:05-15:20''<br />
<br />
== Support ==<br />
:::: [[File:Flag yellow low.jpg|left|100px]] Funded by the European Union.<br />
<br/><br />
<br/><br />
:::: [[Image:COST Logo.jpg|left|140pxE]] COST (European Cooperation in Science and Technology) is a funding organisation for research and innovation networks. Our Actions help connect research initiatives across Europe and beyond and enable researchers and innovators to grow their ideas in any science and technology field by sharing them with their peers. COST Actions are bottom-up networks with a duration of four years that boost research, innovation and careers. - [http://www.cost.eu/ www.cost.eu]<br />
<br />
<br />
{{Labeling<br />
|additional=2024, MitoGlobal, ORO, Next, EU-METAHEART events<br />
}}<br />
<br />
<br />
[[Image:MitoGlobal.jpg|right|80px|link=http://www.bioblast.at/index.php/MitoGlobal|MitoGlobal]] <br />
Listed under [[MitoGlobal Events]].</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Donnelly_2022_BEC&diff=246534Donnelly 2022 BEC2024-03-16T09:31:02Z<p>Gnaiger Erich: </p>
<hr />
<div>[[File:Bioblast2022 banner.jpg|link=Bioblast_2022]]<br />
{{BEC}}<br />
[[File:BEC-exlibris.png|right|290px|Bioenergetics Communications|link=https://www.bioenergetics-communications.org/index.php/bec/index]]<br />
{{Publication<br />
|title=Donnelly C, Schmitt S, Cecatto C, Cardoso LHD, Komlódi T, Place N, Kayser B, Gnaiger E (2022) The ABC of hypoxia – what is the norm. Bioenerg Commun 2022.12.v2. https://doi.org/10.26124/bec:2022-0012.v2<br />
|info=Bioenerg Commun 2022.12.v2. [[File:OpenAccess-downloadPDF.png|200px||link=https://www.bioenergetics-communications.org/index.php/bec/article/view/donnelly_2022/166 |Open Access pdf]]<br /> ''published online'' 2022-12-22 v2; 2022-11-14 v1 [[File:WatchThePresentationYoutube_icon.jpg|200px|link=https://www.youtube.com/watch?v=EEo3rMa_r30&t=945s|»''Watch the presentation''«]]<br />
<br /><br /><br />
|authors=Donnelly Chris, Schmitt Sabine, Cecatto Cristiane, Cardoso Luiza HD, Komlodi Timea, Place Nicolas, Kayser Bengt, Gnaiger Erich<br />
<br />
|year=2022<br />
<br />
|journal=Bioenerg Commun<br />
|abstract=[[File:BEC.png|25px|link=https://doi.org/10.26124/bec:2022-0012]] https://doi.org/10.26124/bec:2022-0012.v2<br />
<br />
[[File:Oxia terms.png|right|300px]]<br />
Hypoxia is a condition of oxygen levels below normoxia and opposite to hyperoxia. We here define the normoxic reference state by three complementary precepts: (A) ''ambient'' normoxia at sea level in the contemporary atmosphere and corresponding dissolved O<sub>2</sub> concentrations at air saturation of aqueous environments; (B) ''biological'' compartmental O<sub>2</sub> levels at ambient normoxia under physiological activity of healthy organisms in the absence of environmental stress (e.g. stress in a diving human, a stranded whale, a thermally stressed fish); and (C) O<sub>2</sub> levels above the respiratory oxygen ''control'' region. In the oxygen control region, the capacity for O<sub>2</sub> consumption is compromised by hypoxic partial O<sub>2</sub> pressure as evaluated by O<sub>2</sub> kinetics of respiration or other critical functions. The ABC of hypoxia distinguishes deviations from these reference points caused by different mechanisms: (∆A) ''ambient'' alterations of oxygen levels; (∆B) ''biological'' O<sub>2</sub> demand exceeding O<sub>2</sub> supply under pathological or experimental limitations of convective O<sub>2</sub> transport or O<sub>2</sub> diffusion; and (∆C) ''critical'' oxygen pressure in oxygen kinetics shifted by pathological and toxicological effects or environmental stress. The ABC of hypoxia may be of help in the design and interpretation of ''in vitro'' and ''in vivo'' experimental studies.<br />
<br><br />
<br />
|keywords=ambient, anoxia, critical O<sub>2</sub> pressure ''p''<sub>c</sub>, functional hypoxia, hyperoxia, hypoxia, limiting O<sub>2</sub> pressure ''p''<sub>l</sub>, normoxia, oxygen O<sub>2</sub>, O<sub>2</sub> concentration ''c''<sub>O<sub>2</sub></sub> [µM], O<sub>2</sub> pressure ''p''<sub>O<sub>2</sub></sub> [kPa]<br />
<br />
<br />
|editor=Tindle-Solomon L<br />
|mipnetlab=AT Innsbruck Oroboros, CH Lausanne Place N<br />
}}<br />
ORC'''ID''': [[File:ORCID.png|20px|link=https://orcid.org/0000-0002-5392-7876]] Donnelly Chris, [[File:ORCID.png|20px|link=https://orcid.org/0000-0002-8111-6819]] Schmitt Sabine, [[File:ORCID.png|20px|link=https://orcid.org/0000-0001-7068-6165]] Cecatto Cristiane, [[File:ORCID.png|20px|link=https://orcid.org/0000-0001-6392-9229]] Cardoso Luiza HD, [[File:ORCID.png|20px|link=https://orcid.org/0000-0001-9876-1411]] Komlodi Timea, [[File:ORCID.png|20px|link=https://orcid.org/0000-0001-9044-0621]] Place Nicolas, [[File:ORCID.png|20px|link=https://orcid.org/0000-0002-9776-7501]] Kayser Bengt, [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-3647-5895]] Gnaiger Erich<br />
__TOC__<br />
== From version v1 to v2 ==<br />
:::: The concept of updated '''versions''' of publications in BEC is promoted, to quickly add corrections and minor updates without return to peer review. Another round of peer review is mandatory for a new '''edition''' of ''[[Living Communications]]''.<br />
<br />
:::: Language does not have the rigorous structure of mathematics to avoid ambiguities. We have two interesting cases in our ABC abstract ('''[https://www.bioenergetics-communications.org/index.php/bec/article/view/donnelly_2022/111 v1]'''): <br />
<br />
:::: '''Case 1'''<br />
:::::: <span style="background:#ffff00">Reader Type L</span>:<br />
<br />
:::::::: (B) biological compartmental O<sub>2</sub> levels at ambient normoxia under physiological activity of healthy organisms in the <span style="background:#ffff00">absence of environmental stress</span> (e.g. in a diving human, a stranded whale, a thermally stressed animal); ..<br />
<br />
:::::: <span style="background:#00ffff >Reader Type T</span>:<br />
<br />
:::::::: (B) biological compartmental O<sub>2</sub> levels at ambient normoxia under physiological activity of healthy organisms in the absence of environmental <span style="background:#00ffff >stress</span> (e.g. in a diving human, a stranded whale, a thermally stressed animal); ..<br />
<br />
:::: '''Case 2'''<br />
:::::: <span style="background:#ffff00">Reader Type L</span>:<br />
<br />
:::::::: (C) control of respiration i.e., O<sub>2</sub> levels <span style="background:#ffff00">above the region</span>, where the capacity for O<sub>2</sub> consumption is not compromised by partial O<sub>2</sub> pressure as evaluated by its kinetics.<br />
<br />
:::::: <span style="background:#00ffff >Reader Type T</span>:<br />
<br />
:::::::: (C) control of respiration i.e., O<sub>2</sub> levels above the <span style="background:#00ffff">region</span>, where the capacity for O<sub>2</sub> consumption is not compromised by partial O<sub>2</sub> pressure as evaluated by its kinetics.<br />
<br />
:::: Reader Type L is correct in case 2 where Reader Type T gets it wrong, but Reader Type L fails to get it right in case 1 where Reader Type T gets the intended message. Science relies on 'correct' reading — considering context —, which should be helped by 'correct' writing. Find out in '''v2''' if you are Reader <span style="background:#ffff00">Type L</span> (reading the linked phrase) or Reader <span style="background:#00ffff >Type T</span> (reading the final term), or if you are the 'correcting' reader in both cases. Here is the update with emphasized corrections ('''v2'''):<br />
<br />
:::::::: (B) ''biological'' compartmental O<sub>2</sub> levels at ambient normoxia under physiological activity of healthy organisms in the absence of environmental <span style="background:#00ffff >stress</span> (e.g. <span style="background:#00ffff >stress</span> in a diving human, a stranded whale, a thermally stressed fish); <br />
<br />
:::::::: (C) O<sub>2</sub> levels <span style="background:#ffff00">above the respiratory oxygen ''control'' region</span>. '''In the oxygen control region, the capacity for O<sub>2</sub> consumption is compromised''' by hypoxic partial O<sub>2</sub> pressure as evaluated by O<sub>2</sub> kinetics of respiration or other critical functions. <br />
<br />
== Abstract v1 ==<br />
:::: Hypoxia is a condition of oxygen levels below normoxia and opposite to hyperoxia. We here define the normoxic reference state by three complementary precepts: (A) ambient normoxia at sea level in the contemporary atmosphere and corresponding dissolved O<sub>2</sub> concentration at air saturation of aqueous environments; (B) biological compartmental O<sub>2</sub> levels at ambient normoxia under physiological activity of healthy organisms in the absence of environmental stress (e.g. in a diving human, a stranded whale, a thermally stressed animal); and (C) control of respiration i.e., O<sub>2</sub> levels above the region, where the capacity for O<sub>2</sub> consumption is not compromised by partial O<sub>2</sub> pressure as evaluated by its kinetics. The concept of the ABC of hypoxia is extended by addressing deviations from these reference points caused by different mechanisms: ∆A: ambient alterations of oxygen levels; ∆B: biological O<sub>2</sub> demand exceeding O<sub>2</sub> supply under pathological or experimental limitations of convective O<sub>2</sub> transport or O<sub>2</sub> diffusion; and ∆C: critical oxygen pressure in oxygen kinetics shifted by pathological and toxicological effects or environmental stress. The ABC of hypoxia may be of help in the design and interpretation of in vitro and in vivo experimental studies.<br />
<br />
== On definitions ==<br />
<br />
::::* ''Definitions always leak at the margins, where experts delight in posing counterexamples for their peers to ponder. Fortunately, the typical cases are clear enough that a little fuzziness around the edges does not interfere with the larger picture'' ([[Miller 1991 Scientific American Library]]).<br />
<br />
::::* ''A lexicographer tries, not always successfully, to steer a course between incomprehension and miscomprehension. .. writing definitions is a difficult and little-appreciated art'' ([[Miller 1991 Scientific American Library]]).<br />
<br />
::::* ''Full standardisation of definitions and analytical procedures could be feasible for new research efforts. .. For existing datasets and studies, harmonisation attempts to achieve some, but not necessarily perfect, homogeneity of definitions might need substantial effort and coordination. .. Large consortia and collaborations can allow the use of a common language among investigators for clinical definitions, laboratory measurements, and statistical analyses'' ([[Ioannidis 2014 Lancet]]).<br />
<br />
<br />
== Further reading ==<br />
::::* Alva R, Gardner GL, Liang P, Stuart JA (2022) Supraphysiological oxygen levels in mammalian cell culture: current state and future perspectives. Cells 11:3123. https://doi.org/10.3390/cells11193123. PMID: 36231085<br />
<br />
::::* Mori MP, Penjweini R, Ma J, Alspaugh G, Andreoni A, Kim YC, Wang PY, Knutson JR, Hwang PM (2023) Mitochondrial respiration reduces exposure of the nucleus to oxygen. https://doi.org/10.1016/j.jbc.2023.103018<br />
<br />
::::* Stuart JA, Fonseca J, Moradi F, Cunningham C, Seliman B, Worsfold CR, Dolan S, Abando J, Maddalena LA (2018) How supraphysiological oxygen levels in standard cell culture affect oxygen-consuming reactions. Oxid Med Cell Longev 2018:8238459. https://doi.org/10.1155/2018/8238459. PMID: 30363917<br />
<br />
::::* Wefers BM, Arbous M, Raat N, Mik E (2019) Mind the mitochondria! J Emergency Critical Care Med 3. https://jeccm.amegroups.org/article/view/5352<br />
<br />
<br />
== Preprint ==<br />
::::» [[Donnelly 2022 MitoFit Hypoxia]]<br />
<br />
<br />
{{Labeling<br />
|area=Respiration, Comparative MiP;environmental MiP, Exercise physiology;nutrition;life style<br />
|injuries=Oxidative stress;RONS, Hypoxia<br />
|topics=Aerobic glycolysis, Flux control, Temperature<br />
|couplingstates=ROUTINE<br />
|instruments=Oxygraph-2k<br />
|additional=Ambiguity crisis, Tissue normoxia, BEC<br />
}}<br />
[[Category:BEC]]</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Wefers_2019_J_Emergency_Critical_Care_Med&diff=246533Wefers 2019 J Emergency Critical Care Med2024-03-16T09:30:39Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=Wefers BM, Arbous M, Raat N, Mik E (2019) Mind the mitochondria! J Emergency Critical Care Med 3. https://jeccm.amegroups.org/article/view/5352<br />
|info=[https://jeccm.amegroups.org/article/view/5352 Open Access]<br />
|authors=Wefers BM, Arbous M, Raat N, Mik E<br />
|year=2019<br />
|journal=J Emergency Critical Care Med<br />
|abstract=Safeguarding an adequate oxygen transport to organs and tissues is a prime goal in the care for critically ill patients. Over the last two decades it has become clear that in certain pathophysiological circumstances macrocirculatory derailment is followed, or accompanied, by microcirculatory dysfunction. Resuscitation strategies to restore and optimize blood flow to organs are based on the idea that restoring oxygen supply will re-establish aerobic metabolism and lead to “healthy parenchymal cells”. However, mitochondrial damage and subsequent dysfunction, or cellular adaptation to hypoxia, might attenuate or even counterbalance the positive effects of resuscitation on the cellular level. In this short review we will address mitochondrial function and adaptation, causes of mitochondrial dysfunction, the concept of cytopathic hypoxia, (loss of) hemodynamic coherence and ways to assess aspects of mitochondrial function in patients. Mitochondria are the primary consumers of oxygen and the ultimate destination of approximately 98% of oxygen reaching our tissue cells. Most of the oxygen is used for energy production by oxidative phosphorylation, but a small amount is used for generating reactive oxygen species and heat generation. While adenosine triphosphate (ATP) production is the best-known function of mitochondria, they also play key roles in calcium homeostasis and cell-death mechanisms. Oxidative phosphorylation has a very high affinity for oxygen and functions well at very low oxygen levels. However, cellular respiration does adapt to changes in oxygen availability at physiological levels, a mechanism known as “oxygen conformance”. Oxygen conformance, mitochondrial damage by certain hits (e.g., toxins and medication), mitochondrial dysfunction and autonomic metabolic reprogramming are factors that could contribute to what is known as “cytopathic hypoxia”. This concept describes insufficient oxygen metabolism in cells despite sufficient oxygen delivery in sepsis. Altered cellular oxygen utilization and thus reduced oxygen demand could in itself cause decreased microcirculatory blood flow, making microcirculatory dysfunction in sepsis under some circumstances a possible epiphenomenon. Resuscitation and forced restoration of microcirculatory flow could lead to relative hyperoxia, and be counterproductive by increasing reactive oxygen production and intervening with protective adaptation mechanisms. The complex pathophysiology of a critically ill patient, especially in severe sepsis and septic shock, requires a multilevel approach. In understanding the interplay between macrocirculation, microcirculation, and parenchymal cells the mitochondria are key players that should not be overlooked. Progress is being made in technologies to assess aspects of mitochondrial function at the bedside, for example direct measurement of mitochondrial oxygen tension and oxygen consumption.<br />
|editor=Gnaiger E<br />
}}<br />
{{Labeling<br />
|area=mt-Medicine<br />
|diseases=Sepsis<br />
|injuries=Hypoxia<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Wefers_2019_J_Emergency_Critical_Care_Med&diff=246532Wefers 2019 J Emergency Critical Care Med2024-03-16T09:30:17Z<p>Gnaiger Erich: Created page with "{{Publication |title=Wefers BM, Arbous M, Raat N, Mik E (2019) Mind the mitochondria!. J Emergency Critical Care Med 3. https://jeccm.amegroups.org/article/view/5352. |info=[h..."</p>
<hr />
<div>{{Publication<br />
|title=Wefers BM, Arbous M, Raat N, Mik E (2019) Mind the mitochondria!. J Emergency Critical Care Med 3. https://jeccm.amegroups.org/article/view/5352.<br />
|info=[https://jeccm.amegroups.org/article/view/5352 Open Access]<br />
|authors=Wefers BM, Arbous M, Raat N, Mik E<br />
|year=2019<br />
|journal=J Emergency Critical Care Med<br />
|abstract=Safeguarding an adequate oxygen transport to organs and tissues is a prime goal in the care for critically ill patients. Over the last two decades it has become clear that in certain pathophysiological circumstances macrocirculatory derailment is followed, or accompanied, by microcirculatory dysfunction. Resuscitation strategies to restore and optimize blood flow to organs are based on the idea that restoring oxygen supply will re-establish aerobic metabolism and lead to “healthy parenchymal cells”. However, mitochondrial damage and subsequent dysfunction, or cellular adaptation to hypoxia, might attenuate or even counterbalance the positive effects of resuscitation on the cellular level. In this short review we will address mitochondrial function and adaptation, causes of mitochondrial dysfunction, the concept of cytopathic hypoxia, (loss of) hemodynamic coherence and ways to assess aspects of mitochondrial function in patients. Mitochondria are the primary consumers of oxygen and the ultimate destination of approximately 98% of oxygen reaching our tissue cells. Most of the oxygen is used for energy production by oxidative phosphorylation, but a small amount is used for generating reactive oxygen species and heat generation. While adenosine triphosphate (ATP) production is the best-known function of mitochondria, they also play key roles in calcium homeostasis and cell-death mechanisms. Oxidative phosphorylation has a very high affinity for oxygen and functions well at very low oxygen levels. However, cellular respiration does adapt to changes in oxygen availability at physiological levels, a mechanism known as “oxygen conformance”. Oxygen conformance, mitochondrial damage by certain hits (e.g., toxins and medication), mitochondrial dysfunction and autonomic metabolic reprogramming are factors that could contribute to what is known as “cytopathic hypoxia”. This concept describes insufficient oxygen metabolism in cells despite sufficient oxygen delivery in sepsis. Altered cellular oxygen utilization and thus reduced oxygen demand could in itself cause decreased microcirculatory blood flow, making microcirculatory dysfunction in sepsis under some circumstances a possible epiphenomenon. Resuscitation and forced restoration of microcirculatory flow could lead to relative hyperoxia, and be counterproductive by increasing reactive oxygen production and intervening with protective adaptation mechanisms. The complex pathophysiology of a critically ill patient, especially in severe sepsis and septic shock, requires a multilevel approach. In understanding the interplay between macrocirculation, microcirculation, and parenchymal cells the mitochondria are key players that should not be overlooked. Progress is being made in technologies to assess aspects of mitochondrial function at the bedside, for example direct measurement of mitochondrial oxygen tension and oxygen consumption.<br />
|editor=Gnaiger E<br />
}}<br />
{{Labeling<br />
|area=mt-Medicine<br />
|diseases=Sepsis<br />
|injuries=Hypoxia<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=San-Millan_2023_Antioxidants_(Basel)&diff=246531San-Millan 2023 Antioxidants (Basel)2024-03-16T09:00:13Z<p>Gnaiger Erich: Created page with "{{Publication |title=San-Millán I (2023) The key role of mitochondrial function in health and disease. Antioxidants (Basel) 12:782. https://doi.org/10.3390/antiox12040782 |in..."</p>
<hr />
<div>{{Publication<br />
|title=San-Millán I (2023) The key role of mitochondrial function in health and disease. Antioxidants (Basel) 12:782. https://doi.org/10.3390/antiox12040782<br />
|info=[https://pubmed.ncbi.nlm.nih.gov/37107158/ PMID: 37107158 Open Access]<br />
|authors=San-Millan I<br />
|year=2023<br />
|journal=Antioxidants (Basel)<br />
|abstract=The role of mitochondrial function in health and disease has become increasingly recognized, particularly in the last two decades. Mitochondrial dysfunction as well as disruptions of cellular bioenergetics have been shown to be ubiquitous in some of the most prevalent diseases in our society, such as type 2 diabetes, cardiovascular disease, metabolic syndrome, cancer, and Alzheimer's disease. However, the etiology and pathogenesis of mitochondrial dysfunction in multiple diseases have yet to be elucidated, making it one of the most significant medical challenges in our history. However, the rapid advances in our knowledge of cellular metabolism coupled with the novel understanding at the molecular and genetic levels show tremendous promise to one day elucidate the mysteries of this ancient organelle in order to treat it therapeutically when needed. Mitochondrial DNA mutations, infections, aging, and a lack of physical activity have been identified to be major players in mitochondrial dysfunction in multiple diseases. This review examines the complexities of mitochondrial function, whose ancient incorporation into eukaryotic cells for energy purposes was key for the survival and creation of new species. Among these complexities, the tightly intertwined bioenergetics derived from the combustion of alimentary substrates and oxygen are necessary for cellular homeostasis, including the production of reactive oxygen species. This review discusses different etiological mechanisms by which mitochondria could become dysregulated, determining the fate of multiple tissues and organs and being a protagonist in the pathogenesis of many non-communicable diseases. Finally, physical activity is a canonical evolutionary characteristic of humans that remains embedded in our genes. The normalization of a lack of physical activity in our modern society has led to the perception that exercise is an "intervention". However, physical activity remains the modus vivendi engrained in our genes and being sedentary has been the real intervention and collateral effect of modern societies. It is well known that a lack of physical activity leads to mitochondrial dysfunction and, hence, it probably becomes a major etiological factor of many non-communicable diseases affecting modern societies. Since physical activity remains the only stimulus we know that can improve and maintain mitochondrial function, a significant emphasis on exercise promotion should be imperative in order to prevent multiple diseases. Finally, in populations with chronic diseases where mitochondrial dysfunction is involved, an individualized exercise prescription should be crucial for the "metabolic rehabilitation" of many patients. From lessons learned from elite athletes (the perfect human machines), it is possible to translate and apply multiple concepts to the betterment of populations with chronic diseases.<br />
|editor=Gnaiger E<br />
}}<br />
{{Labeling<br />
|area=Respiration, Exercise physiology;nutrition;life style, mt-Medicine<br />
|diseases=Aging;senescence, Cancer, Cardiovascular, Diabetes, Obesity<br />
|organism=Human<br />
}}</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Talk:Body_mass_excess&diff=246521Talk:Body mass excess2024-03-15T08:04:56Z<p>Gnaiger Erich: </p>
<hr />
<div>References<br />
<br />
::::* https://hal.archives-ouvertes.fr/hal-01561605/document<br />
::::* https://jamanetwork.com/journals/jama/fullarticle/2778234?guestAccessKey=0a2822f9-c344-4122-bf17-45cbe664e1b3&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_term=mostread&utm_content=olf-widget_04082021<br />
::::* https://pubmed.ncbi.nlm.nih.gov/33436528/<br />
::::* https://pubmed.ncbi.nlm.nih.gov/31095428/<br />
::::* https://www.mdpi.com/2227-9059/9/3/258<br />
::::* https://jamanetwork.com/journals/jama/fullarticle/2783690?guestAccessKey=c7e25160-01d1-4115-bd00-ec44097f7a8d&utm_source=silverchair&utm_campaign=altmetric&utm_content=2021_year-end&cmp=1&utm_medium=email<br />
::::* https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2777737?utm_source=silverchair&utm_campaign=altmetric&utm_content=2021_year-end&cmp=1&utm_medium=email<br />
::::* https://jamanetwork.com/journals/jama/fullarticle/2787551?guestAccessKey=c0420c99-99a1-4b35-928d-1e53d902de98<br />
::::* https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2787246?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetworkopen&utm_content=mthlyforyou&utm_term=010222<br />
::::* https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038834<br />
::::* Shi Q, Wang Y, Hao Q, Vandvik PO, Guyatt G, Li J, Chen Z, Xu S, Shen Y, Ge L, Sun F, Li L, Yu J, Nong K, Zou X, Zhu S, Wang C, Zhang S, Qiao Z, Jian Z, Li Y, Zhang X, Chen K, Qu F, Wu Y, He Y, Tian H, Li S. Pharmacotherapy for adults with overweight and obesity: a systematic review and network meta-analysis of randomised controlled trials. Lancet. 2021 Dec 8:S0140-6736(21)01640-8. doi: 10.1016/S0140-6736(21)01640-8. Epub ahead of print. PMID: 34895470 - https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01640-8/fulltext?dgcid=raven_jbs_etoc_email<br />
::::* https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01919-X/fulltext?dgcid=raven_jbs_etoc_email<br />
::::* https://onlinelibrary.wiley.com/action/doSearch?field1=Contrib&text1=Chabot+D&field2=AllField&text2=&field3=AllField&text3=&Ppub=<br />
::::* https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789169?guestAccessKey=5560b202-f036-4162-8403-aa9e31f31035&utm_source=silverchair&utm_campaign=jama_network&utm_content=car_weekly_highlights&cmp=1&utm_medium=email<br />
::::* https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788555?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetworkopen&utm_content=mthlyforyou&utm_term=030622<br />
::::* https://www.nap.edu/download/26498<br />
::::* https://www.frontiersin.org/articles/10.3389/fphys.2022.924649/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_1914357_a0P58000000G0YjEAK_Physio_20220728_arts_A&id_mc=312850737&utm_source=sfmc&utm_medium=email&utm_campaign=Article+Alerts+V4.1-Frontiers&utm_id=1914357<br />
::::* https://gmed-una-storage.s3.amazonaws.com/bx_posts_files/5/5w/5w9/5w99egarfgpxur6k8bj3vcfkk7ysbya2.pdf<br />
::::* https://nap.nationalacademies.org/catalog/26681/targeting-structures-communications-and-beliefs-to-advance-practical-strategies-for-obesity-solutions?utm_source=NASEM+News+and+Publications&utm_campaign=4f373bfa21-EMAIL_CAMPAIGN_2022_08_19_02_40&utm_medium=email&utm_term=0_96101de015-4f373bfa21-104786469&mc_cid=4f373bfa21&mc_eid=50f76db947<br />
::::* https://nap.nationalacademies.org/catalog/26437/addressing-structural-racism-bias-and-health-communication-as-foundational-drivers-of-obesity?utm_source=NASEM+News+and+Publications&utm_campaign=0dcf1bc9b3-EMAIL_CAMPAIGN_2022_08_29_01_45&utm_medium=email&utm_term=0_96101de015-0dcf1bc9b3-104786469&mc_cid=0dcf1bc9b3&mc_eid=50f76db947<br />
::::* [[Legaki 2022 Curr Obes Rep]]<br />
::::* https://journals.physiology.org/ajplung/The-Physiology-of-Obesity?utm_source=AJPLung&utm_medium=email&utm_campaign=newsletter-feb2023&_zs=XShbW&_zl=K0aS3<br />
<br />
::::* Pontzer H, Yamada Y, Sagayama H, Ainslie PN, Andersen LF, Anderson LJ, Arab L, Baddou I, Bedu-Addo K, Blaak EE, Blanc S, Bonomi AG, Bouten CVC, Bovet P, Buchowski MS, Butte NF, Camps SG, Close GL, Cooper JA, Cooper R, Das SK, Dugas LR, Ekelund U, Entringer S, Forrester T, Fudge BW, Goris AH, Gurven M, Hambly C, El Hamdouchi A, Hoos MB, Hu S, Joonas N, Joosen AM, Katzmarzyk P, Kempen KP, Kimura M, Kraus WE, Kushner RF, Lambert EV, Leonard WR, Lessan N, Martin C, Medin AC, Meijer EP, Morehen JC, Morton JP, Neuhouser ML, Nicklas TA, Ojiambo RM, Pietiläinen KH, Pitsiladis YP, Plange-Rhule J, Plasqui G, Prentice RL, Rabinovich RA, Racette SB, Raichlen DA, Ravussin E, Reynolds RM, Roberts SB, Schuit AJ, Sjödin AM, Stice E, Urlacher SS, Valenti G, Van Etten LM, Van Mil EA, Wells JCK, Wilson G, Wood BM, Yanovski J, Yoshida T, Zhang X, Murphy-Alford AJ, Loechl C, Luke AH, Rood J, Schoeller DA, Westerterp KR, Wong WW, Speakman JR; IAEA DLW Database Consortium. Daily energy expenditure through the human life course. Science. 2021 Aug 13;373(6556):808-812. doi: 10.1126/science.abe5017. PMID: 34385400<br />
<br />
::::* Careau V, Halsey LG, Pontzer H, Ainslie PN, Andersen LF, Anderson LJ, Arab L, Baddou I, Bedu-Addo K, Blaak EE, Blanc S, Bonomi AG, Bouten CVC, Buchowski MS, Butte NF, Camps SGJA, Close GL, Cooper JA, Das SK, Cooper R, Dugas LR, Eaton SD, Ekelund U, Entringer S, Forrester T, Fudge BW, Goris AH, Gurven M, Hambly C, El Hamdouchi A, Hoos MB, Hu S, Joonas N, Joosen AM, Katzmarzyk P, Kempen KP, Kimura M, Kraus WE, Kushner RF, Lambert EV, Leonard WR, Lessan N, Martin CK, Medin AC, Meijer EP, Morehen JC, Morton JP, Neuhouser ML, Nicklas TA, Ojiambo RM, Pietiläinen KH, Pitsiladis YP, Plange-Rhule J, Plasqui G, Prentice RL, Rabinovich RA, Racette SB, Raichlen DA, Ravussin E, Reilly JJ, Reynolds RM, Roberts SB, Schuit AJ, Sjödin AM, Stice E, Urlacher SS, Valenti G, Van Etten LM, Van Mil EA, Wells JCK, Wilson G, Wood BM, Yanovski J, Yoshida T, Zhang X, Murphy-Alford AJ, Loechl CU, Luke AH, Rood J, Sagayama H, Schoeller DA, Wong WW, Yamada Y, Speakman JR; IAEA DLW database group. Energy compensation and adiposity in humans. Curr Biol. 2021 Oct 25;31(20):4659-4666.e2. doi: 10.1016/j.cub.2021.08.016. Epub 2021 Aug 27. PMID: 34453886<br />
<br />
::::* Halsey LG, Careau V, Pontzer H, Ainslie PN, Andersen LF, Anderson LJ, Arab L, Baddou I, Bedu-Addo K, Blaak EE, Blanc S, Bonomi AG, Bouten CVC, Bovet P, Buchowski MS, Butte NF, Camps SGJA, Close GL, Cooper JA, Das SK, Cooper R, Dugas LR, Ekelund U, Entringer S, Forrester T, Fudge BW, Goris AH, Gurven M, Hambly C, Hamdouchi AE, Hoos MB, Hu S, Joonas N, Joosen AM, Katzmarzyk P, Kempen KP, Kimura M, Kraus WE, Kushner RF, Lambert EV, Leonard WR, Lessan N, Martin CK, Medin AC, Meijer EP, Morehen JC, Morton JP, Neuhouser ML, Nicklas TA, Ojiambo RM, Pietiläinen KH, Pitsiladis YP, Plange-Rhule J, Plasqui G, Prentice RL, Rabinovich RA, Racette SB, Raichlen DA, Ravussin E, Reynolds RM, Roberts SB, Schuit AJ, Sjödin AM, Stice E, Urlacher SS, Valenti G, Van Etten LM, Van Mil EA, Wilson G, Wood BM, Yanovski J, Yoshida T, Zhang X, Murphy-Alford AJ, Loechl CU, Luke AH, Rood J, Sagayama H, Schoeller DA, Westerterp KR, Wong WW, Yamada Y, Speakman JR. Variability in energy expenditure is much greater in males than females. J Hum Evol. 2022 Oct;171:103229. doi: 10.1016/j.jhevol.2022.103229. Epub 2022 Sep 15. PMID: 36115145<br />
<br />
::::* Higgins S, Pomeroy A, Bates LC, Paterson C, Barone Gibbs B, Pontzer H, Stoner L. Sedentary behavior and cardiovascular disease risk: An evolutionary perspective. Front Physiol. 2022 Jul 27;13:962791. doi: 10.3389/fphys.2022.962791. PMID: 35965885<br />
<br />
::::* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050949/<br />
<br />
::::* https://www.nature.com/articles/s42255-023-00829-4<br />
<br />
::::* https://www.nature.com/articles/s42255-023-00822-x<br />
<br />
::::* https://www.nature.com/articles/s42255-023-00790-2<br />
::::* https://www.nature.com/articles/s42255-023-00782-2<br />
<br />
::::* https://www.nature.com/articles/s42255-022-00733-3<br />
<br />
::::* https://www.nature.com/articles/s42255-022-00731-5 Open Access<br />
<br />
::::* https://www.nature.com/articles/s42255-022-00629-2 Open Access<br />
<br />
::::* https://journals.physiology.org/doi/full/10.1152/physrev.00022.2022?utm_source=journal-newsletter&utm_medium=email&utm_campaign=PRV-sept2023&_zs=XShbW&_zl=VThl3<br />
<br />
::::* From muscle to brain - https://www.frontiersin.org/articles/10.3389/fphys.2023.1273981/full?utm_source=F-AAE&utm_medium=EMLF&utm_campaign=MRK_2234071_a0P58000000G0YjEAK_Physio_20231019_arts_A&id_mc=312850737&utm_source=sfmc&utm_medium=email&utm_campaign=Article+Alerts+V4.1-Frontiers&utm_id=2234071&Business_Goal=%%__AdditionalEmailAttribute1%%&Audience=%%__AdditionalEmailAttribute2%%&Email_Category=%%__AdditionalEmailAttribute3%%&Channel=%%__AdditionalEmailAttribute4%%&BusinessGoal_Audience_EmailCategory_Channel=%%__AdditionalEmailAttribute5%%<br />
<br />
::::* https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.15115?utm_source=APS&utm_medium=email&utm_campaign=journal-newsletter-dec2023<br />
<br />
::::* https://www.jlr.org/article/S0022-2275(24)00024-5/fulltext</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Talk:Complex_II_ambiguities&diff=246520Talk:Complex II ambiguities2024-03-15T08:02:09Z<p>Gnaiger Erich: /* Further links to FADH2→CII misconceptions */</p>
<hr />
<div>== Further links to FADH<sub>2</sub>→CII misconceptions ==<br />
<br />
::::* https://www.auctoresonline.org/article/methodological-approaches-to-the-study-of-mitochondrial-respiration<br />
::::* http://www.aginganddisease.org/EN/10.14336/AD.2013.0400364<br />
::::* https://www.google.com/imgres?imgurl=https%3A%2F%2Fstatic.cambridge.org%2Fbinary%2Fversion%2Fid%2Furn%3Acambridge.org%3Aid%3Abinary%3A64932%3A20160714063155119-0381%3A00643fig4_6.gif%3Fpub-status%3Dlive&imgrefurl=https%3A%2F%2Fwww.cambridge.org%2Fcore%2Fbooks%2Fplasma-medicine%2Fbasic-cell-biology%2F8D148F68F74BE0856439779344D026F7&tbnid=fhBbkpnX8i9PeM&vet=10CIIBEDMoowFqFwoTCJjZ-6a9tP0CFQAAAAAdAAAAABAC..i&docid=ZNvKqpw-3bPu_M&w=630&h=386&q=FADH2%20is%20the%20substrates%20of%20Complex%20II&client=firefox-b-d&ved=0CIIBEDMoowFqFwoTCJjZ-6a9tP0CFQAAAAAdAAAAABAC - https://www.cambridge.org/core/books/abs/plasma-medicine/basic-cell-biology/8D148F68F74BE0856439779344D026F7<br />
<br />
::::* https://www.mcponline.org/article/S1535-9476(24)00036-7/fulltext</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=MiPNet28.13_IOC165_Innsbruck_AT&diff=246519MiPNet28.13 IOC165 Innsbruck AT2024-03-15T06:18:12Z<p>Gnaiger Erich: </p>
<hr />
<div>{{OROBOROS header page name}}<br />
{{Publication<br />
|title=[[Image:O2k-Workshops.png|right|80px|link=O2k-Workshops]]'''Innsbruck AT''', 2024 Sep 02-04. EBEC2024 Satellite Oroboros O2k-Workshop: Mito&Chlora High-Resolution Respirometry and PhotoBiology, '''IOC165'''.<br />
|authors=Oroboros<br />
|year=2024-09-02<br />
|journal=Mitochondr Physiol Network<br />
|abstract='''EBEC2024 Satellite Oroboros O2k-Workshop: Mito&Chlora High-Resolution Respirometry and PhotoBiology'''. Innsbruck, Austria (2024 Sep 02-04).<br><br />
|mipnetlab=AT_Innsbruck_Oroboros<br />
}}<br />
<br />
__TOC__<br />
== General information ==<br />
:::: This 2.5-day training course provides an introduction the Oroboros [[O2k-FluoRespirometer]] including the [[PB-Module|O2k-PB-Module]], [[DatLab]] 8 and applications of the [[TIP2k-Module|TIP2k]]. Hands-on experiments illustrate the principle and show the unique advantages and limitations of simultaneous monitoring of oxygen concentration, mitochondrial respiration and hydrogen peroxide production. Many optimized [[SUIT protocols]] are available as DL-Protocols. The [[SUITbrowser]] helps you find the best SUIT protocol for your specific research questions. Furthermore, this workshop covers interpretation as well as calibration and instrumental service.<br />
<br />
<br />
== Venue ==<br />
::::» Oroboros O2k-Laboratory and ''MiPArt''<br />
::::: Schoepfstrasse 18, 6020 Innsbruck<br />
::::» Information on travel and venue: '''[[IOC Innsbruck]]'''<br />
<br />
<br />
== Registration ==<br />
:::: Registration will open soon.<br />
<br />
== Program ==<br />
:::: A new program is being created and will be uploaded when finalized. <br />
<br><br />
<br />
=== Tutors and lecturers ===<br />
<gallery mode=default perrow=6 widths="140px" heights="150px"><br />
File:Erich Gnaiger.jpg|'''[[Gnaiger E |Erich Gnaiger]]''', PhD, Oroboros Instruments - CEO, ''Innovation Alchemist''<br />
</gallery><br />
<br />
=== Participants ===<br />
<br />
{| class="wikitable"<br />
|-<br />
!<br />
!<br />
! Participant<br />
! Institution<br />
|-<br />
|1.<br />
|-<br />
|}<br />
<br />
<br />
<br />
<br />
<br />
<br />
== Contact ==<br />
:::: [mailto:instruments@oroboros.at| instruments@oroboros.at]<br />
<br />
:::: '''Oroboros Instruments'''<br />
:::: High-Resolution Respirometry <br />
:::: Schoepfstrasse 18<br />
:::: A-6020 Innsbruck, Austria<br />
:::: Tel: +43 677 647 929 17<br />
:::: Fax: +43 512 566796 20 <br />
<br />
:::: '''Mitochondria and Cell Research'''<br />
<br />
<br />
== IOC recommended reading ==<br />
::::» '''[[IOC recommended reading]]'''<br />
::::» '''[[MitoPedia: Respiratory states]]'''<br />
:::: [[Image:P.jpg|link=OXPHOS capacity|35px|OXPHOS]] [[Image:R.jpg|link=ROUTINE respiration|35px|ROUTINE]] [[Image:E.jpg|link=ET capacity|35px|ETS]] [[Image:L.jpg|link=LEAK respiration|35px|LEAK]] [[Image:ROX.jpg|link=Residual oxygen consumption|65px|ROX]]<br />
<br />
<br />
[[Image:MitoGlobal.jpg|right|80px|link=MitoGlobal|MitoGlobal]] <br />
O2k-Workshops are listed as [[MitoGlobal Events]].<br />
<br />
<br />
{{Labeling<br />
|additional=ORO, IOC, MitoFit, 2024, MitoGlobal, NextGen-O2k, Next, O2k-Network Award,<br />
}}<br />
<br />
[[Category:O2k-Workshops]]</div>Gnaiger Erichhttps://wiki.oroboros.at/index.php?title=Menditto_2006_Accred_Qual_Asur&diff=246461Menditto 2006 Accred Qual Asur2024-03-12T10:06:55Z<p>Gnaiger Erich: </p>
<hr />
<div>{{Publication<br />
|title=Menditto A, Patriarca M, Magnusson B (2006) Understanding the meaning of accuracy, trueness and precision. Accred Qual Asur 12:45-47.<br />
|info=[https://link.springer.com/article/10.1007/s00769-006-0191-z Springer Link]<br />
|authors=Menditto A, Patriarca M, Magnusson B<br />
|year=2006<br />
|journal=Accred Qual Asur<br />
|abstract=Clear definitions of basic terms, used to describe the quality of measurements, is essential for communication among scientists as well as when reporting measurement results to clients. Even if appropriate definitions are given in international standards and guidelines, the understanding of some basic terms sometimes proves difficult. The reasons for this are various, e.g., the same words being defined rather differently in encyclopaedias and in international standards as well as concepts, well established in some languages, that may be relatively new in other national communities and at large in the international one. Here we present a matrix intended to clarify the relationships between the type of error affecting an analytical measurement, the respective qualitative concepts (performance characteristics) and their quantitative expression.<br />
}}<br />
{{Labeling<br />
|additional=QM<br />
}}</div>Gnaiger Erich