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Additive effect of convergent electron flow
Description
Additivity describes the princple of substrate control of mitochondrial respiration with convergent electron flow. The additive effect of convergent electron flow is a consequence of electron flow converging at the Q-junction from respiratory Complexes I and II (NS or CI&II e-input). Further additivity may be observed by convergent electron flow through glycerophosphate dehydrogenase and electron-transferring flavoprotein complex. Convergent electron flow corresponds to the operation of the TCA cycle and mitochondrial substrate supply in vivo. Physiological substrate combinations supporting convergent NS e-input are required for reconstitution of intracellular TCA cycle function. Convergent electron flow simultaneously through Complexes I and II into the Q-junction supports higher OXPHOS capacity and ET capacity than separate electron flow through either CI or CII. The convergent NS effect may be completely or partially additive, suggesting that conventional bioenergetic protocols with mt-preparations have underestimated cellular OXPHOS-capacities, due to the gating effect through a single branch. Complete additivity is defined as the condition when the sum of separatly measured respiratory capacities, N + S, is identical to the capacity measured in the state with combined substrates, NS (CI&II). This condition of complete additivity, NS=N+S, would be obtained if electron channeling through supercomplex CI, CIII and CIV does not interact with the pool of redox intermediates in the pathway from CII to CIII and CIV, and if the capacity of the phosphorylation system (≈P) does not limit OXPHOS capacity (excess E-P capacity factor is zero). In most cases, however, additivity is incomplete, NS < N+S.
Abbreviation: Aα&β
Reference: Gnaiger 2020 MitoPathways, Gnaiger_2009_Int J Biochem Cell Biol
Contents
- More details » Respiratory complexes - more than five
List of publications: N and S and NS (CI and CII and CI&II)
| Year | Reference | Mammal and model | Tissue and cell | Stress | Diseases | |
|---|---|---|---|---|---|---|
| MiPNet21.17 BloodCellsIsolation | 2020-10-22 |  | Human | Blood cells Platelet | ||
| Hassan 2020 MitoFit Preprint Arch | 2020-04-30 | Hassan Hazirah, Gnaiger Erich, Zakaria Fazaine, Makpol Suzana, Abdul Karim Norwahidah (2020) Alterations in mitochondrial respiratory capacity and membrane potential: a link between mitochondrial dysregulation and autism. MitoFit Preprint Arch 2020.3 doi:10.26124/mitofit:200003. | Human | Mitochondrial disease | Autism | |
| Briones-Herrera 2020 Free Radic Biol Med | 2020 | Briones-Herrera A, Ramírez-Camacho I, Zazueta C, Tapia E, Pedraza-Chaverri J (2020) Altered proximal tubule fatty acid utilization, mitophagy, fission and supercomplexes arrangement in experimental Fanconi syndrome are ameliorated by sulforaphane-induced mitochondrial biogenesis. Free Radic Biol Med 153:54-70. | Rat | Kidney | ||
| Keppner 2020 Thesis | 2020 | Keppner G (2020) Impact of gut microbiota composition, liver metabolism and respiratory capacity of peripheral blood mononuclear cells on resting metabolic rate. PhD Thesis 100. | Human | Blood cells | Obesity | |
| Szibor 2020 J Biol Chem | 2020 | Szibor Marten, Gizatullina Zemfira, Gainutdinov Timur, Endres Thomas, Debska-Vielhaber Grazyna, Kunz Matthias, Karavasili Niki, Hallmann Kerstin, Schreiber Frank, Bamberger Alexandra, Schwarzer Michael, Doenst Torsten, Heinze Hans-Jochen, Leßmann Volkmar, Vielhaber Stefan, Kunz Wolfram S, Gellerich Frank Norbert (2020) Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply. J Biol Chem 295:4383-97. | Mouse | Nervous system | ||
| Wei 2020 Cell Rep | 2020 | Wei X, Lu Z, Li L, Zhang H, Sun F, Ma H, Wang L, Hu Y, Yan Z, Zheng H, Yang G, Liu D, Tepel M, Gao P, Zhu Z (2020) Reducing NADPH synthesis counteracts diabetic nephropathy through restoration of AMPK activity in type 1 diabetic rats. Cell Rep 32:108207. | Rat | Kidney | Diabetes | |
| Woessner 2020 J Appl Physiol (1985) | 2020 | Woessner MN, Neil C, Saner NJ, Goodman CA, McIlvenna LC, Ortiz de Zevallos J, Garnham AP, Levinger I, Allen JD (2020) Effect of inorganic nitrate on exercise capacity, mitochondria respiration and vascular function in heart failure reduced ejection fraction. J Appl Physiol (1985) 128:1355-64. | Human | Skeletal muscle | Cardiovascular | |
| BEC 2020.1 doi10.26124bec2020-0001.v1 | 2020 | Gnaiger Erich et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. doi:10.26124/bec:2020-0001.v1. | ||||
| Oellermann 2020 Sci Rep | 2020 | Oellermann M, Hickey AJR, Fitzgibbon QP, Smith G (2020) Thermal sensitivity links to cellular cardiac decline in three spiny lobsters. Sci Rep 10:202. | Crustaceans | Heart | Temperature | |
| Parker 2020 Thesis | 2020 | Parker EP (2020) The effect of isoleucine supplementation of peripheral blood mononuclear cell metabolism in subjects with type 2 diabetes. URS Thesis 31. | Human | Blood cells | Diabetes | |
| Doig 2020 Skelet Muscle | 2020 | Doig CL, Zielinska AE, Fletcher RS, Oakey LA, Elhassan YS, Garten A, Cartwright D, Heising S, Alsheri A, Watson DG, Prehn C, Adamski J, Tennant DA, Lavery GG (2020) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction. Skelet Muscle 10:5. | Mouse | Skeletal muscle | ||
| Musi 2020 Aging Cell | 2020 | Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME (2020) Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell 17:e12840. | Mouse | Nervous system | Aging;senescence Neurodegenerative | |
| Baggio 2020 Neurotoxicology | 2020 | Baggio S, Zenki K, Martins Silva A, Dos Santos TG, Rech G, Lazzarotto G, Dias RD, Mussulini BH, Rico EP, de Oliveira DL (2020) Fetal alcohol spectrum disorders model alters the functionality of glutamatergic neurotransmission in adult zebrafish. Neurotoxicology 78:152-160. | Zebrafish | Nervous system | Other | |
| Maddison 2020 PLoS Genet | 2020 | Maddison DC, Alfonso-Núñez M, Swaih AM, Breda C, Campesan S, Allcock N, Straatman-Iwanowska A, Kyriacou CP, Giorgini F (2020) A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics. PLoS Genet 16:e1009129. | Drosophila | |||
| Hraoui 2020 J Exp Biol | 2020 | Hraoui G, Bettinazzi S, Gendron AD, Boisclair D, Breton S (2020) Mitochondrial thermo-sensitivity in invasive and native freshwater mussels. J Exp Biol 223:jeb215921. | Molluscs | Lung;gill | Temperature | |
| Jespersen 2020 Sci Rep | 2020 | Jespersen NR, Hjortbak MV, Lassen TR, Støttrup NB, Johnsen J, Tonnesen PT, Larsen S, Kimose HH, Bøtker HE (2020) Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus. Sci Rep 10:10344. | Rat | Heart | Ischemia-reperfusion | Diabetes |
| Ehrlicher 2020 FASEB J | 2020 | Ehrlicher SE, Stierwalt HD, Miller BF, Newsom SA, Robinson MM (2020) Mitochondrial adaptations to exercise do not require Bcl2-mediated autophagy but occur with BNIP3/Parkin activation. FASEB J 34:4602-18. | Mouse | Skeletal muscle | ||
| Abid 2020 FASEB J | 2020 | Abid H, Ryan ZC, Delmotte P, Sieck GC, Lanza IR (2020) Extramyocellular interleukin-6 influences skeletal muscle mitochondrial physiology through canonical JAK/STAT signaling pathways. FASEB J 34:14458-72. | Mouse | Skeletal muscle | Oxidative stress;RONS | |
| Cassereau 2020 Exp Neurol | 2020 | Cassereau J, Chevrollier A, Codron P, Goizet C, Gueguen N, Verny C, Reynier P, Bonneau D, Lenaers G, Procaccio V (2020) Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K. Exp Neurol 323:113069. | Human | Fibroblast | Oxidative stress;RONS | Neurodegenerative |
| Ulgherait 2020 Nat Commun | 2020 | Ulgherait Matt, Chen Anna, McAllister Sophie F, Kim Han X, Delventhal Rebecca, Wayne Charlotte R, Garcia Christian J, Recinos Yocelyn, Oliva Miles, Canman Julie C, Picard Martin, Owusu-Ansah Edward, Shirasu-Hiza Mimi (2020) Circadian regulation of mitochondrial uncoupling and lifespan. Nat Commun 11:1927. | Drosophila | Aging;senescence | ||
| Gnaiger 2020 MitoPathways | 2020 | Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2 (in prep). | Human Mouse | Heart Skeletal muscle Fibroblast | ||
| Vaccari 2020 Eur J Appl Physiol | 2020 | Vaccari F, Passaro A, D'Amuri A, Sanz JM, Di Vece F, Capatti E, Magnesa B, Comelli M, Mavelli I, Grassi B, Fiori F, Bravo G, Avancini A, Parpinel M, Lazzer S (2020) Effects of 3-month high-intensity interval training vs. moderate endurance training and 4-month follow-up on fat metabolism, cardiorespiratory function and mitochondrial respiration in obese adults. Eur J Appl Physiol 120:1787-803. | Human | Skeletal muscle | Obesity | |
| Nascimento-Dos-Santos 2020 Biochim Biophys Acta Mol Basis Dis | 2020 | Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linden R, Galina A, Petrs-Silva H (2020) Neuroprotection from optic nerve injury and modulation of oxidative metabolism by transplantation of active mitochondria to the retina. Biochim Biophys Acta Mol Basis Dis 1866:165686. | Rat | Liver Nervous system | Neurodegenerative | |
| Visavadiya 2020 Mol Cell Biochem | 2020 | Visavadiya NP, Pena GS, Khamoui AV (2020) Mitochondrial dynamics and quality control are altered in a hepatic cell culture model of cancer cachexia. Mol Cell Biochem [Epub ahead of print]. | Mouse | Liver | Cancer | |
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| He 2020 Clin Transl Med | 2020 | He C, Gao P, Cui Y, Li Q, Li Y, Lu Z, Ma H, Zhao Y, Li L, Sun F, Chen, X, Jia H, Liu D, Yang G, Zheng H, Zhu Z (2020) Low‐glucose‐sensitive TRPC6 dysfunction drives hypoglycemia‐induced cognitive impairment in diabetes. Clin Transl Med 10:e205. | Mouse | Nervous system | Diabetes Alzheimer's | |
| Xiong 2020 Biomed Pharmacother | 2020 | Xiong Xiaowei, Lu Weihang, Qin Xuan, Luo Qingyu, Zhou Weimin (2020) Downregulation of the GLP-1/CREB/adiponectin pathway is partially responsible for diabetes-induced dysregulated vascular tone and VSMC dysfunction. Biomed Pharmacother 127:110218. | Human Rat | Endothelial;epithelial;mesothelial cell | Oxidative stress;RONS | Diabetes |
| Pelster 2020 PLoS One | 2020 | Pelster B, Wood CM, Campos DF, Val AL (2020) Cellular oxygen consumption, ROS production and ROS defense in two different size-classes of an Amazonian obligate air-breathing fish (Arapaima gigas). PLoS One 15:e0236507. | Fishes | Kidney Lung;gill | Hypoxia | |
| Schneider 2020 PLoS One | 2020 | Schneider J, Han WH, Matthew R, Sauve Y, Lemieux H (2020) Age and sex as confounding factors in the relationship between cardiac mitochondrial function and type 2 diabetes in the Nile Grass rat. PLoS One 15:e0228710. | Rat | Heart | Diabetes Aging;senescence | |
| Weaver 2020 Biol Lett | 2020 | Weaver RJ, Carrion G, Nix R, Maeda GP, Rabinowitz S, Iverson ENK, Thueson K, Havird JC (2020) High mitochondrial mutation rates in Silene are associated with nuclear-mediated changes in mitochondrial physiology. Biol Lett 16:20200450. | Plants | |||
| Tichanek 2020 Sci Rep | 2020 | Tichanek F, Salomova M, Jedlicka J, Kuncova J, Pitule P, Macanova T, Petrankova Z, Tuma Z, Cendelin J (2020) Hippocampal mitochondrial dysfunction and psychiatric-relevant behavioral deficits in spinocerebellar ataxia 1 mouse model. Sci Rep 10:5418. | Mouse | Nervous system | Neurodegenerative | |
| McCommis 2020 Nat Metab | 2020 | McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Kamm DR, Pyles KD, King MT, Veech RL, DeBosch BJ, Muoio DM, Gross RW, Finck BN (2020) Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice. Nat Metab 2:1232-47. | Mouse | Heart | Cardiovascular | |
| Krajcova 2020 PLOS ONE | 2020 | Krajčová A, Urban T, Megvinet D, Waldauf P, Balík M, Hlavička J, Budera P, Janoušek L, Pokorná E, Duška F (2020) High resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle. PLOS ONE 15:e0226142. | Human | Heart | Cryopreservation | |
| Macasoi 2020 Oncol Rep | 2020 | Macașoi I, Pavel IZ, Moacă AE, Avram S, David LV, Coricovac D, Mioc A, Spandidos DA, Tsatsakis A, Șoica C, Dumitrașcu V, Dehelean C (2020) Mechanistic investigations of antitumor activity of a Rhodamine B‑oleanolic acid derivative bioconjugate. Oncol Rep 44:1169-83. | Human | Endothelial;epithelial;mesothelial cell | Cancer | |
| Stankova 2020 Int J Mol Sci | 2020 | Staňková P, Kučera O, Peterová E, Lotková H, Maseko TE, Nožičková K, Červinková Z (2020) Adaptation of mitochondrial substrate flux in a mouse model of nonalcoholic fatty liver disease. Int J Mol Sci 21:E1101. | Mouse | Liver | Other | |
| Mahalingam 2020 J Physiol | 2020 | Mahalingam S, Cheviron ZA, Storz JF, McClelland GB, Scott GR (2020) Chronic cold exposure induces mitochondrial plasticity in deer mice native to high altitudes. J Physiol [Epub ahead of print]. | Mouse | Skeletal muscle | Temperature Hypoxia | |
| Lensu 2020 Nutrients | 2020 | Lensu S, Pariyani R, Mäkinen E, Yang B, Saleem W, Munukka E, Lehti M, Driuchina A, Lindén J, Tiirola M, Lahti L, Pekkala S (2020) Prebiotic xylo-oligosaccharides ameliorate high-fat-diet-induced hepatic steatosis in rats . Nutrients 12:E3225. | Rat | Liver | Other | |
| Remie 2020 Am J Clin Nutr | 2020 | Remie CME, Roumans KHM, Moonen MPB, Connell NJ, Havekes B, Mevenkamp J, Lindeboom L, de Wit VHW, van de Weijer T, Aarts SABM, Lutgens E, Schomakers BV, Elfrink HL, Zapata-Pérez R, Houtkooper RH, Auwerx J, Hoeks J, Schrauwen-Hinderling VB, Phielix E, Schrauwen P (2020) Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr 112:413-26. | Human | Skeletal muscle | Obesity | |
| Rondot 2020 Thesis | 2020 | Rondot A (2020) Fuels for winter: the role of proline in overwintering bumblebee queens (Bombus impatiens). Master's Thesis 41. | Hexapods | Skeletal muscle | ||
| Tepp 2020 Biochim Biophys Acta Gen Subj | 2020 | Tepp K, Puurand M, Timohhina N, Aid-Vanakova J, Reile I, Shevchuk I, Chekulayev V, Eimre M, Peet N, Kadaja L, Paju K, Kaambre T (2020) Adaptation of striated muscles to Wolframin deficiency in mice: Alterations in cellular bioenergetics. Biochim Biophys Acta Gen Subj 1864:129523. | Mouse | Heart Skeletal muscle | Inherited Neurodegenerative | |
| Souza da Silva 2020 Mol Neurobiol | 2020 | Souza da Silva J, Nonose Y, Rohden F, Lukasewicz Ferreira PC, Fontella FU, Rocha A, Wigner Brochier A, Vieira Apel R, de Lima TM, Seminotti B, Amaral AU, Galina A, Souza DO (2020) Guanosine neuroprotection of presynaptic mitochondrial calcium homeostasis in a mouse study with amyloid-β oligomers. Mol Neurobiol 57:4790-809. | Mouse | Nervous system | Alzheimer's | |
| Jayakumari 2020 J Diabetes | 2020 | Jayakumari NR, Rajendran RS, Sivasailam A, Vimala SS, Nanda S, Manjunatha S, Pillai VV, Karunakaran J, Gopala S (2020) Impaired substrate-mediated cardiac mitochondrial complex I respiration with unaltered regulation of fatty acid metabolism and oxidative stress status in type 2 diabetic Asian Indians. J Diabetes 12:542-55. | Human | Heart | Diabetes | |
| Piel 2020 PLoS One | 2020 | Piel S, Chamkha I, Dehlin AK, Ehinger JK, Sjövall F, Elmér E, Hansson MJ (2020) Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose. PLoS One 15:e0231173. | Human | Liver Platelet | ||
| Makrecka-Kuka 2020 Cardiovasc Drugs Ther | 2020 | Makrecka-Kuka Marina, Korzh Stanislava, Videja Melita, Vilks Karlis, Cirule Helena, Kuka Janis, Dambrova Maija, Liepinsh Edgars (2020) Empagliflozin protects cardiac mitochondrial fatty acid metabolism in a mouse model of diet-induced lipid overload. Cardiovasc Drugs Ther [Epub ahead of print]. | Mouse | Heart | Cardiovascular Diabetes | |
| Baxter 2020 Elife | 2020 | Baxter M, Voronkov M, Poolman T, Galli G, Pinali C, Goosey L, Knight A, Krakowiak K, Maidstone R, Iqbal M, Zi M, Prehar S, Cartwright EJ, Gibbs J, Matthews LC, Adamson AD, Humphreys NE, Rebelo-Guiomar P, Minczuk M, Bechtold DA, Loudon A, Ray D (2020) Cardiac mitochondrial function depends on BUD23 mediated ribosome programming. Elife 9:e50705. | Mouse | Heart | ||
| Lin 2020 Preprints | 2020 | Lin M, Fu T, Hsu C, Huang S, Lin Y, Wang J (2020) Cycling exercise training enhances mitochondrial bioenergetics of platelets in patients with peripheral arterial disease: a randomized controlled trial. Preprints 2020070567. | Human | Platelet | Other | |
| Pajuelo-Reguera 2020 Cells | 2020 | Pajuelo Reguera David, Čunátová Kristýna, Vrbacký Marek, Pecinová Alena, Houštěk Josef, Mráček Tomáš, Pecina Petr (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:E443. | Human | HEK | ||
| Hingst 2020 Mol Metab | 2020 | Hingst JR, Kjøbsted R, Birk JB, Jørgensen NO, Larsen MR, Kido K, Larsen JK, Kjeldsen SAS, Fentz J, Frøsig C, Holm S, Fritzen AM, Dohlmann TL, Larsen S, Foretz M, Viollet B, Schjerling P, Overby P, Halling JF, Pilegaard H, Hellsten Y, Wojtaszewski JFP (2020) Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise. Mol Metab 40:101028. | Mouse | Skeletal muscle | ||
| Cubizolle 2020 J Cell Mol Med | 2020 | Cubizolle A, Cia D, Moine E, Jacquemot N, Guillou L, Rosell M, Angebault-Prouteau C, Lenaers G, Meunier I, Vercauteren J, Durand T, Crauste C, Brabet P (2020) Isopropyl-phloroglucinol-DHA protects outer retinal cells against lethal dose of all-trans-retinal. J Cell Mol Med 24:5057-69. | Rat | Endothelial;epithelial;mesothelial cell | ||
| Kunz 2020 J Biol Chem | 2020 | Kunz HE, Dorschner JM, Berent TE, Meyer T, Wang X, Jatoi A, Kumar R, Lanza IR (2020) Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting. J Biol Chem [Epub ahead of print]. | Mouse | Skeletal muscle | Cancer | |
| Close 2020 Cells | 2020 | Close AF, Dadheech N, Lemieux H, Wang Q, Buteau J (2020) Disruption of beta-cell mitochondrial networks by the orphan nuclear receptor Nor1/Nr4a3. Cells 9:E168. | Rat | Islet cell;pancreas;thymus | Diabetes | |
| Le 2020 J Biol Chem | 2020 | Le CH, Benage LG, Specht KS, Li Puma LC, Mulligan CM, Heuberger AL, Prenni JE, Claypool SM, Chatfield KC, Sparagna GC, Chicco AJ (2020) Tafazzin deficiency impairs CoA-dependent oxidative metabolism in cardiac mitochondria . J Biol Chem 295:12485-97. | Human | Heart | Aging;senescence | |
| Janowska 2020 Toxicol In Vitro | 2020 | Janowska JI, Piel S, Saliba N, Kim CD, Jang DH, Karlsson M, Kilbaugh TJ, Ehinger JK (2020) Mitochondrial respiratory chain Complex I dysfunction induced by N-methyl carbamate ex vivo can be alleviated with a cell-permeable succinate prodrug carbamate toxicity and treatment. Toxicol In Vitro 65:104794. | Human | Platelet Blood cells | ||
| Bhaskaran 2020 Aging Cell | 2020 | Bhaskaran S, Pollock N, C Macpherson P, Ahn B, Piekarz KM, Staunton CA, Brown JL, Qaisar R, Vasilaki A, Richardson A, McArdle A, Jackson MJ, Brooks SV, Van Remmen H (2020) Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice. Aging Cell 19:e13225. | Mouse | Skeletal muscle | Aging;senescence | |
| Weger 2020 Sci Rep | 2020 | Weger M, Alpern D, Cherix A, Ghosal S, Grosse J, Russeil J, Gruetter R, de Kloet ER, Deplancke B, Sandi C (2020) Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress. Sci Rep 10:18308. | Mouse | Nervous system | ||
| Zussman 2020 J Autoimmun | 2020 | Zussman R, Xu LY, Damani T, Groom KM, Chen Q, Seers B, Viall CA, Chamley LW, Hickey A (2020) Antiphospholipid antibodies can specifically target placental mitochondria and induce ROS production. J Autoimmun 111:102437. | Human | Genital | Oxidative stress;RONS | |
| Severo 2020 Life Sci | 2020 | Severo L, Godinho D, Machado F, Hartmann D, Fighera MR, Soares FA, Furian AF, Oliveira MS, Royes LF (2020) The role of mitochondrial bioenergetics and oxidative stress in depressive behavior in recurrent concussion model in mice. Life Sci 257:117991. | Mouse | Nervous system | Other | |
| Hoffmann 2020 J Clin Endocrinol Metab | 2020 | Hoffmann C, Schneeweiss P, Randrianarisoa E, Schnauder G, Kappler L, Machann J, Schick F, Fritsche A, Heni M, Birkenfeld A, Niess AM, Häring HU, Weigert C, Moller A (2020) Response of mitochondrial respiration in adipose tissue and muscle to 8 weeks of endurance exercise in obese subjects. J Clin Endocrinol Metab 105:dgaa571. | Human | Skeletal muscle | Obesity | |
| Xia 2020 Biomed Res Int | 2020 | Xia W, Wang Q, Lu Y, Hu Y, Zhang X, Zhang J, Liu D, Song J, Zhu Z, Liu D, Zhang H (2020) Transient receptor potential channel canonical type 3 deficiency antagonizes myofibroblast transdifferentiation in vivo. Biomed Res Int 2020:1202189. | Human | Fibroblast | Oxidative stress;RONS | |
| Almoiliqy 2020 Acta Pharmacol Sin | 2020 | Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y (2020) Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53. Acta Pharmacol Sin 41:1208-22. | Rat | Endothelial;epithelial;mesothelial cell | Ischemia-reperfusion | |
| Pajuelo 2020 Cells | 2020 | Pajuelo Reguera D, Čunátová K, Vrbacký M, Pecinová A, Houštěk J, Mráček T, Pecina P (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:443. | Human | HEK | ||
| Lensu 2020 Preprints | 2020 | Lensu S, Pariyani R, Mäkinen E, Yang B, Saleem W, Munukka E, Lehti M, Driuchina A, Linden J, Tiirola M, Lahti L, Pekkala S (2020) Prebiotic xylo-oligosaccharides targeting Faecalibacterium prausnitzii prevent high fat diet-induced hepatic steatosis in rats. Preprints 2020:2020090241. | Rat | Liver | ||
| Gvozdjakova 2020 Diagnostics (Basel) | 2020 | Gvozdjakova Anna, Sumbalova Zuzana, Kucharska Jarmila, Komlosi Maria, Rausova Zuzana, Vancova Olga, Szamosova Monika, Mojto Viliam(2020) Platelet mitochondrial respiration, endogenous coenzyme Q10 and oxidative stress in patients with chronic kidney disease. Diagnostics (Basel) 10:E176. | Human | Platelet | Other | |
| Kupats 2020 Oxid Med Cell Longev | 2020 | Kupats E, Stelfa G, Zvejniece B, Grinberga S, Vavers E, Makrecka-Kuka M, Svalbe B, Zvejniece L, Dambrova M (2020) Mitochondrial-protective effects of R-phenibut after experimental traumatic brain injury. Oxid Med Cell Longev 2020:9364598. | Mouse | Nervous system | Other | |
| Coppin 2020 Cell Death Dis | 2020 | Coppin L, Jannin A, Ait Yahya E, Thuillier C, Villenet C, Tardivel M, Bongiovanni A, Gaston C, de Beco S, Barois N, van Seuningen I, Durand E, Bonnefond A, Vienne JC, Vamecq J, Figeac M, Vincent A, Delacour D, Porchet N, Pigny P (2020) Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface. Cell Death Dis 11:360. | Human | Islet cell;pancreas;thymus Endothelial;epithelial;mesothelial cell | Cancer | |
| Roginski 2020 Biochim Biophys Acta Mol Basis Dis | 2020 | Roginski AC, Wajner A, Cecatto C, Wajner SM, Castilho RF, Wajner M, Amaral AU (2020) Disturbance of bioenergetics and calcium homeostasis provoked by metabolites accumulating in propionic acidemia in heart mitochondria of developing rats. Biochim Biophys Acta Mol Basis Dis 1866:165682. | Rat | Heart Other cell lines | Permeability transition | Inherited |
| Courtes 2020 Brain Res Bull | 2020 | Courtes AA, Gonçalves DF, Hartmann DD, da Rosa PC, Cassol G, Royes LFF, de Carvalho NR, Soares FAA (2020) Guanosine protects against behavioural and mitochondrial bioenergetic alterations after mild traumatic brain injury. Brain Res Bull 163:31-39. | Rat | Nervous system | Other | |
| Grewal 2020 Exp Neurol | 2020 | Grewal R, Reutzel M, Dilberger B, Hein H, Zotzel J, Marx S, Tretzel J, Sarafeddinov A, Fuchs C, Eckert GP (2020) Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing. Exp Neurol 328:113248. | Human | Neuroblastoma | Aging;senescence Alzheimer's | |
| Russell 2020 Nutrients | 2020 | Russell JS, Griffith TA, Naghipour S, Vider J, Du Toit EF, Patel HH, Peart JN, Headrick JP (2020) Dietary α-linolenic acid counters cardioprotective dysfunction in diabetic mice: unconventional PUFA protection. Nutrients 12:E2679. | Mouse | Heart | Ischemia-reperfusion | Diabetes |
| Risiglione 2020 Int J Mol Sci | 2020 | Risiglione P, Leggio L, Cubisino SAM, Reina S, Paternò G, Marchetti B, Magrì A, Iraci N, Messina A (2020) High-resolution respirometry reveals MPP+ mitochondrial toxicity mechanism in a cellular model of parkinson's disease. Int J Mol Sci 21:E7809. | Human | Neuroblastoma | ||
| Irion 2020 Stem Cells Int | 2020 | Irion CI, Martins EL, Christie MLA, de Andrade CBV, de Moraes ACN, Ferreira RP, Pimentel CF, Suhett GD, Campos de Carvalho AC, Lindoso RS, Vieyra A, Galina A, Goldenberg RCS (2020) Acute myocardial infarction reduces respiration in rat cardiac fibers, despite adipose tissue mesenchymal stromal cell transplant. Stem Cells Int 2020:4327965 . | Rat | Heart | Cardiovascular | |
| Pena 2020 Int J Chronic Dis | 2020 | Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Dis 2020:Article ID 5919501. | Mouse | Nervous system | Alzheimer's | |
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| Silaidos 2020 Mitochondrion | 2020 | Silaidos C, Grube J, Muley C, Eckert GP (2020) Time-dependent melatonin secretion is associated with mitochondrial function in peripheral blood mononuclear cells (PBMC) of male volunteers. Mitochondrion 53:21-29. | Human | Blood cells | ||
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| Magnesa 2020 Thesis | 2020 | Magnesa B (2020) Skeletal muscle mitochondrial oxidative phosphorylation plasticity in two studies on humans: exercise training effect in obese subjects and bed rest effect in healthy subjects. PhD Thesis 81. | Human | Skeletal muscle | Obesity | |
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| Li 2019 Int Urol Nephrol | 2019 | Li Z, Zhou J, Li Y, Yang F, Lian X, Liu W (2019) Mitochondrial TRPC3 promotes cell proliferation by regulating the mitochondrial calcium and metabolism in renal polycystin-2 knockdown cells. Int Urol Nephrol 51:1059-70. | Human | Endothelial;epithelial;mesothelial cell | Inherited | |
| Penniman 2019 Mol Metab | 2019 | Penniman CM, Suarez Beltran PA, Bhardwaj G, Junck TL, Jena J, Poro K, Hirshman MF, Goodyear LJ, O'Neill BT (2019) Loss of FoxOs in muscle reveals sex-based differences in insulin sensitivity but mitigates diet-induced obesity. Mol Metab 30:203-220. | Mouse | Skeletal muscle | Obesity | |
| Bittel 2019 Diabetologia | 2019 | Bittel AJ, Bittel DC, Mittendorfer B, Patterson BW, Okunade AL, Yoshino J, Porter LC, Abumrad NA, Reeds DN, Cade WT (2019) A single bout of resistance exercise improves postprandial lipid metabolism in overweight/obese men with prediabetes. Diabetologia 63:611-23. | Human | Skeletal muscle | Diabetes Obesity | |
| Gregg 2019 J Biol Chem | 2019 | Gregg T, Sdao SM, Dhillon RS, Rensvold JW, Lewandowski SL, Pagliarini DJ, Denu JM, Merrins MJ (2019) Obesity-dependent CDK1 signaling stimulates mitochondrial respiration at Complex I in pancreatic β-cells. J Biol Chem 294:4656-66. | Mouse | Islet cell;pancreas;thymus | Obesity Diabetes | |
| Campos 2019 Thesis | 2019 | Campos DF (2019) Os peixes amazônicos vivem perto dos seus limites térmicos? O efeito das mudanças climáticas sobre a ecofisiologia de peixes de Igarapé da Amazônia Central. PhD Thesis 106. | Fishes | Lung;gill | Temperature | |
| Doig 2019 bioRxiv | 2019 | Doig CD, Zelinska AE, Oakey LA, Fletcher RS, El Hassan Y, Garten A, Cartwright D, Heising S, Tennant DA, Watson D, Adamski J, Lavery GG (2019) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in skeletal muscle of H6PDH KO mice. bioRxiv doi: https://doi.org/10.1101/567297 . | Mouse | Skeletal muscle | ||
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| Aubin 2019 Thesis | 2019 | Aubin M (2019) Glucocorticoids and acute lymphoid leukemia: a proteomic approach. Doctoral Dissertation 99. | Human | Lymphocyte | Cancer | |
| Latham 2019 J Anim Sci | 2019 | Latham CM, Fenger CK, White SH (2019) Rapid Communication: Differential skeletal muscle mitochondrial characteristics of weanling racing-bred horses. J Anim Sci [Epub ahead of print]. | Horse | Skeletal muscle | ||
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| Hirschi 2019 Biol Reprod | 2019 | Hirschi KM, Tsai KYF, Davis T, Clark JC, Knowlton MN, Bikman BT, Reynolds PR, Arroyo JA (2019) Growth arrest specific protein (Gas)-6/AXL signaling induces preeclampsia (PE) in rats. Biol Reprod 102:199-210. | Rat | Genital | Other | |
| Kumar 2019 Free Radic Biol Med | 2019 | Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S (2019) Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy. Free Radic Biol Med 145:284-99. | Mouse | Skeletal muscle | Oxidative stress;RONS | |
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| Chang 2019 Br J Anaesth | 2019 | Chang L, Daly C, Miller DM, Allen PD, Boyle JP, Hopkins PM, Shaw MA (2019) Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals. Br J Anaesth 122:613-21. | Human | Skeletal muscle | Temperature | |
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| Sundstroem 2019 Acta Neuropathol Commun | 2019 | Sundstrøm T, Prestegarden L, Azuaje F, Aasen SN, Røsland GV, Varughese JK, Bahador M, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Ingham ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M, Beschorner R, Bjerkvig R, Thorsen F (2019) Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathol Commun 7:55. | Human | Endothelial;epithelial;mesothelial cell | Cancer | |
| Tomasic 2019 Biochim Biophys Acta Mol Basis Dis | 2019 | Tomašić N, Kotarsky H, de Oliveira Figueiredo R, Hansson E, Mörgelin M, Tomašić I, Kallijärvi J, Elmér E, Jauhiainen M, Eklund EA, Fellman V (2019) Fasting reveals largely intact systemic lipid mobilization mechanisms in respiratory chain complex III deficient mice. Biochim Biophys Acta Mol Basis Dis 1866:165573. | Mouse | Liver | ||
| Ma 2019 Biochem Biophys Res Commun | 2019 | Ma T, Lin S, Wang B, Wang Q, Xia W, Zhang H, Cui Y, He C, Wu H, Sun F, Zhao Z, Gao P, Zhu Z, Liu D (2019) TRPC3 deficiency attenuates high salt-induced cardiac hypertrophy by alleviating cardiac mitochondrial dysfunction. Biochem Biophys Res Commun 519:674-81. | Mouse | Heart | ||
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| Cesnekova 2019 Thesis | 2019 | Cesnekova J (2019) Functional characterization of LACE1 APTase and mitochondrial AAA proteases YME1L and AFG3L2 in mitochondrial protein homeostasis. PhD Thesis 133. | Human | HEK | ||
| Crescenzo 2019 Mol Neurobiol | 2019 | Crescenzo R, Spagnuolo MS, Cancelliere R, Iannotta L, Mazzoli A, Gatto C, Iossa S, Cigliano L (2019) Effect of initial aging and high-fat/high-fructose diet on mitochondrial bioenergetics and oxidative status in rat brain. Mol Neurobiol 56:7651-63. | Rat | Nervous system | Aging;senescence | |
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| Zhao 2019 Basic Res Cardiol | 2019 | Zhao J, Gao JL, Zhu JX, Zhu HB, Peng X, Jiang M, Fu Y, Xu J, Mao XH, Hu N, Ma MH, Dong DL (2019) The different response of cardiomyocytes and cardiac fibroblasts to mitochondria inhibition and the underlying role of STAT3. Basic Res Cardiol 114:12. | Rat | Heart Fibroblast | Ischemia-reperfusion | |
| Papadimitriou 2019 Sci Rep | 2019 | Papadimitriou ID, Eynon N, Yan X, Munson F, Jacques M, Kuang J, Voisin S, North KN, Bishop DJ (2019) A "human knockout" model to investigate the influence of the α-actinin-3 protein on exercise-induced mitochondrial adaptations. Sci Rep 9:12688. | Human | Skeletal muscle | ||
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| Esselun 2019 Oxid Med Cell Longev | 2019 | Esselun C, Bruns B, Hagl S, Grewal R, Eckert GP (2019) Differential effects of silibinin A on mitochondrial function in neuronal PC12 and HepG2 liver cells. Oxid Med Cell Longev 2019:1652609. | Human Rat | Nervous system Liver | ||
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| Monteiro 2019 J Bioenerg Biomembr | 2019 | Monteiro J, Assis-de-Lemos G, de-Souza-Ferreira E, Marques AM, Neves GA, Silveira MS, Galina A (2019) Energization by multiple substrates and calcium challenge reveal dysfunctions in brain mitochondria in a model related to acute psychosis. J Bioenerg Biomembr 52:1-15. | Mouse | Nervous system | Oxidative stress;RONS | Other |
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| Gururaja Rao 2019 Cells | 2019 | Gururaja Rao S, Bednarczyk P, Towheed A, Shah K, Karekar P, Ponnalagu D, Jensen HN, Addya S, Reyes BAS, Van Bockstaele EJ, Szewczyk A, Wallace DC, Singh H (2019) BKCa (Slo) channel regulates mitochondrial function and lifespan in Drosophila melanogaster. Cells 8:E945. | Drosophila | Aging;senescence | ||
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| Miranda-Silva 2019 Acta Physiologica | 2019 | Miranda-Silva D, Wüst RCI, Conceição G, Gonçalves-Rodrigues P, Gonçalves N, Gonçalves A, Kuster DWD, Leite-Moreira AF, van der Velden J, de Sousa Beleza JM, Magalhães J, Stienen GJM, Falcão-Pires I (2019) Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction. Acta Physiol e13378. | Rat | Heart | Cardiovascular Obesity | |
| Ng 2019 J Biol Chem | 2019 | Ng J, Kaur H, Collier T, Chang K, Brooks AES, Allison JR, Brimble MA, Hickey A, Birch NP (2019) Site-specific glycations of Aβ1-42 affect fibril formation and are neurotoxic. J Biol Chem 294:8806-18. | Human | Neuroblastoma | Alzheimer's | |
| Dollerup 2019 J Physiol | 2019 | Dollerup OL, Chubanava S, Agerholm M, Søndergård SD, Altıntaş A, Møller AB, Høyer KF, Ringgaard S, Stødkilde-Jørgensen H, Lavery GG, Barres R, Larsen S, Prats C, Jessen N, Treebak JT (2019) Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men. J Physiol 598:731-54. | Human | Skeletal muscle | ||
| Lemieux 2019 bioRxiv | 2019 | Lemieux H, Subarsky P, Doblander C, Wurm M, Troppmair J, Gnaiger E (2019) Mitochondrial respiratory function as an early biomarker of apoptosis induced by growth factor removal. bioRxiv doi: https://doi.org/10.1101/151480 . | Mouse | Blood cells | Cell death | Cancer |
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| Chabi 2018 J Bioenerg Biomembr | 2018 | Chabi B, Fouret G, Lecomte J, Cortade F, Pessemesse L, Baati N, Coudray C, Lin L, Tong Q, Wrutniak-Cabello C, Casas F, Feillet-Coudray C (2018) Skeletal muscle overexpression of short isoform Sirt3 altered mitochondrial cardiolipin content and fatty acid composition. J Bioenerg Biomembr 50:131-42. | Mouse | Skeletal muscle | ||
| Angebault 2018 Sci Signal | 2018 | Angebault C, Fauconnier J, Patergnani S, Rieusset J, Danese A, Affortit CA, Jagodzinska J, Mégy C, Quiles M, Cazevieille C, Korchagina J, Bonnet-Wersinger D, Milea D, Hamel C, Pinton P, Thiry M, Lacampagne A, Delprat B, Delettre C (2018) ER-mitochondria cross-talk is regulated by the Ca2+ sensor NCS1 and is impaired in Wolfram syndrome. Sci Signal 11:eaaq1380. | Human | Fibroblast | Neurodegenerative Inherited | |
| Sirsat 2018 Comp Biochem Physiol A Mol Integr Physiol | 2018 | Sirsat SKG, Dzialowski EM (2018) Ontogeny of skeletal and cardiac muscle mitochondria oxygen fluxes in two breeds of chicken. Comp Biochem Physiol A Mol Integr Physiol 215:20-7. | Birds | Heart Skeletal muscle | ||
| Vatner 2018 Aging Cell | 2018 | Vatner DE, Zhang J, Oydanich M, Guers J, Katsyuba E, Yan L, Sinclair D, Auwerx J, Vatner SF (2018) Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14. Aging Cell 17:e12751. | Mouse | Fat | Aging;senescence | |
| Lobo-Jarne 2018 Cell Rep | 2018 | Lobo-Jarne T, Nývltová E, Pérez-Pérez R, Timón-Gómez A, Molinié T, Choi A, Mourier A, Fontanesi F, Ugalde C, Barrientos A (2018) Human COX7A2L regulates complex III biogenesis and promotes supercomplex organization remodeling without affecting mitochondrial bioenergetics. Cell Rep 25:1786-99. | Human | HEK Other cell lines | ||
| Barca 2018 Hum Mol Genet | 2018 | Barca E, Ganetzky RD, Potluri P, Juanola-Falgarona M, Gai X, Li D, Jalas C, Hirsch Y, Emmanuele V, Tadesse S, Ziosi M, Akman HO, Chung WK, Tanji K, McCormick E, Place E, Consugar M, Pierce EA, Hakonarson H, Wallace DC, Hirano M, Falk MJ (2018) USMG5 Ashkenazi Jewish founder mutation impairs mitochondrial complex V dimerization and ATP synthesis. Hum Mol Genet 27:3305-12. | Human | Fibroblast | Other Neurodegenerative | |
| Smenes 2018 Interact Cardiovasc Thorac Surg | 2018 | Smenes BT, Bækkerud FH, Slagsvold KH, Hassel E, Wohlwend M, Pinho M, Høydal M, Wisløff U, Rognmo Ø, Wahba A (2018) Acute exercise is not cardioprotective and may induce apoptotic signalling in heart surgery: a randomized controlled trial. Interact Cardiovasc Thorac Surg 27:95-101. | Human | Heart | Ischemia-reperfusion | Aging;senescence Cardiovascular |
| Burtscher 2018 Front Mol Neurosci | 2018 | Burtscher J, Bean C, Zangrandi L, Kmiec I, Agostinho A, Scorrano L, Gnaiger E, Schwarzer C (2018) Proenkephalin derived peptides are involved in the modulation of mitochondrial respiratory control during epileptogenesis. Front Mol Neurosci doi:10.3389/fnmol.2018.00351. | Mouse | Nervous system | Neurodegenerative | |
| Hsiao 2018 Anal Biochem | 2018 | Hsiao CP, Hoppel C (2018) Analyzing mitochondrial function in human peripheral blood mononuclear cells. Anal Biochem 549:12-20. | Human | Blood cells | ||
| Aparicio-Trejo 2018 Free Radic Biol Med | 2018 | Aparicio-Trejo OE, Reyes-Fermín LM, Briones-Herrera A, Tapia E, León-Contreras JC, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2018) Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, oxidative stress, dynamics and S-glutathionylation alterations in acute kidney damage induced by folic acid. Free Radic Biol Med 130:379-96. | Rat | Kidney | Oxidative stress;RONS | Other |
| Petiz 2018 Chem Biol Interact | 2018 | Petiz LL, Pires ADRA, Echevarria A, Rodrigues-Santos CE, Eliane Merlin Rocha M, Acco A, Cadena SMSC (2018) Effects of a new antiprotozoal drug, N,N'-diphenyl-4-methoxy-benzamidine, on energy-linked functions of rat liver mitochondria. Chem Biol Interact 279:34-42. | Rat | Liver | ||
| Logan 2018 Thesis | 2018 | Logan C (2018) Nitrate and nitrite differentially affect respiration in zebrafish during exercise. Honors Baccalaureate of Science in Nutrition p44. | Zebrafish | Skeletal muscle | ||
| Reutzel 2018 Oxid Med Cell Longev | 2018 | Reutzel M, Grewal R, Silaidos C, Zotzel J, Marx S, Tretzel J, Eckert GP (2018) Effects of long-term treatment with a blend of highly purified olive secoiridoids on cognition and brain ATP levels in aged NMRI mice. Oxid Med Cell Longev 2018:4070935. | Mouse | Nervous system | Aging;senescence | |
| Mavroudis 2018 Eur J Cardiothorac Surg | 2018 | Mavroudis CD, Karlsson M, Ko T, Hefti M, Gentile JI, Morgan RW, Plyler R, Mensah-Brown KG, Boorady TW, Melchior RW, Rosenthal TM, Shade BC, Schiavo KL, Nicolson SC, Spray TL, Sutton RM, Berg RA, Licht DJ, Gaynor JW, Kilbaugh TJ (2018) Cerebral mitochondrial dysfunction associated with deep hypothermic circulatory arrest in neonatal swine. Eur J Cardiothorac Surg 54:162-68. | Pig | Nervous system | Ischemia-reperfusion Temperature | |
| Karlsson 2018 J Neurotrauma | 2018 | Karlsson M, Pukenas B, Chawla S, Ehinger JK, Plyler R, Stolow M, Gabello M, Hugerth M, Elmér E, Hansson MJ, Margulies S, Kilbaugh T (2018) Neuroprotective effects of cyclosporine in a porcine pre-clinical trial of focal traumatic brain injury. J Neurotrauma [Epub ahead of print]. | Pig | Nervous system | Other | |
| Urazov 2018 Sovrem Tekhnologii Med | 2018 | Urazov MD, Astrakhanova TA, Usenko AV, Mishchenko TA, Schelchkova NA, Kravchenko GA, Vedunova MV, Mitroshina EV (2018) New aspects of central nervous system adaptation to prenatal hypoxia. Sovrem Tekhnologii Med 10:60-68. | Mouse | Nervous system | Hypoxia | |
| Arena 2018 Mol Cell | 2018 | Arena G, Cissé MY, Pyrdziak S, Chatre L, Riscal R, Fuentes M, Arnold JJ, Kastner M, Gayte L, Bertrand-Gaday C, Nay K, Angebault-Prouteau C, Murray K, Chabi B, Koechlin-Ramonatxo C, Orsetti B, Vincent C, Casas F, Marine JC, Etienne-Manneville S, Bernex F, Lombès A, Cameron CE, Dubouchaud H, Ricchetti M, Linares LK, Le Cam L (2018) Mitochondrial MDM2 regulates respiratory complex I activity independently of p53. Mol Cell 69:594-609. | Human | Lung;gill Other cell lines | Cancer | |
| Tillmans 2018 Thesis | 2018 | Tillmans F (2018) Effect of normobaric hypoxia on leukemic vell lines in vitro. Dissertation p92. | Human | Other cell lines Lymphocyte | Oxidative stress;RONS | Cancer |
| Souza 2018 Sci Rep | 2018 | Souza RWA, Alves CRR, Medeiros A, Rolim N, Silva GJJ, Moreira JBN, Alves MN, Wohlwend M, Gebriel M, Hagen L, Sharma A, Koch LG, Britton SL, Slupphaug G, Wisløff U, Brum PC (2018) Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity. Sci Rep 8:17772. | Rat | Heart Skeletal muscle | ||
| Christen 2018 Free Radic Biol Med | 2018 | Christen F, Desrosiers V, Dupont-Cyr BA, Vandenberg GW, Le François NR, Tardif JC, Dufresne F, Lamarre SG, Blier PU (2018) Thermal tolerance and thermal sensitivity of heart mitochondria: Mitochondrial integrity and ROS production. Free Radic Biol Med 116:11-8. | Fishes | Heart | Temperature | Cardiovascular |
| Lu 2018 Cell Rep | 2018 | Lu Z, Cui Y, Wei X, Gao P, Zhang H, Wei X, Li Q, Sun F, Yan Z, Zheng H, Yang G, Liu D, Zhu Z (2018) Deficiency of PKD2L1 (TRPP3) exacerbates pathological cardiac hypertrophy by augmenting NCX1-mediated mitochondrial calcium overload. Cell Rep 24:1639-52. | Mouse | Heart | Cardiovascular | |
| Efimova 2018 Thesis | 2018 | Efimova I (2018) Structural composition and functional properties of mitochondrial FoF1 ATP synthase on models of specific subunits deficiencies. PhD Thesis 94. | Human | HEK | ||
| Bhaskaran 2018 EMBO Rep | 2018 | Bhaskaran S, Pharaoh G, Ranjit R, Murphy A, Matsuzaki S, Nair BC, Forbes B, Gispert S, Auburger G, Humphries KM, Kinter M, Griffin TM, Deepa SS (2018) Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance. EMBO Rep 19. pii: e45009. | Mouse | Fat | Diabetes Obesity | |
| Becker 2018 EMBO Rep | 2018 | Becker C, Kukat A, Szczepanowska K, Hermans S, Senft K, Brandscheid CP, Maiti P, Trifunovic A (2018) CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis. EMBO Rep 19. pii: e45126. | Mouse | Liver Fat | Temperature Mitochondrial disease | |
| Arnoux 2018 Elife | 2018 | Arnoux I, Willam M, Griesche N, Krummeich J, Watari H, Offermann N, Weber S, Narayan Dey P, Chen C, Monteiro O, Buettner S, Meyer K, Bano D, Radyushkin K, Langston R, Lambert JJ, Wanker E, Methner A, Krauss S, Schweiger S, Stroh A (2018) Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease. Elife 7:e38744. | Mouse | Nervous system | Inherited Neurodegenerative | |
| Monaco 2018b Diabetologia | 2018 | Monaco CMF, Hughes MC, Ramos SV, Varah NE, Lamberz C, Rahman FA, McGlory C, Tarnopolsky MA, Krause MP, Laham R, Hawke TJ, Perry CGR (2018) Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes. Diabetologia 61:1411-23. | Human | Skeletal muscle | Diabetes | |
| Du 2018 Environ Sci Technol | 2018 | Du SNN, McCallum ES, Vaseghi-Shanjani M, Choi JA, Warriner TR, Balshine S, Scott GR (2018) Metabolic costs of exposure to wastewater effluent lead to compensatory adjustments in respiratory physiology in bluegill sunfish. Environ Sci Technol 52:801-11. | Fishes | Liver | ||
| Gam 2018 Acta Diabetol | 2018 | Gam CMBF, Mortensen OH, Larsen LH, Poulsen SS, Qvortrup K, Mathiesen ER, Damm P, Quistorff B (2018) Diabetes, myometrium, and mitochondria in pregnant women at term. Acta Diabetol 55:999-1010. | Human | Genital | Diabetes | |
| Boutoual 2018 Sci Rep | 2018 | Boutoual R, Meseguer S, Villarroya M, Martín-Hernández E, Errami M, Martín MA, Casado M, Armengod ME (2018) Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARγ-UCP2-AMPK axis. Sci Rep 8:1163. | Human | Fibroblast | Hypoxia | |
| Brouwers 2018 Front Physiol | 2018 | Brouwers B, Stephens NA, Costford SR, Hopf ME, Ayala JE, Yi F, Xie H, Li JL, Gardell SJ, Sparks LM, Smith SR (2018) Elevated nicotinamide phosphoribosyl transferase in skeletal muscle augments exercise performance and mitochondrial respiratory capacity following exercise training. Front Physiol 9:704. | Mouse | Skeletal muscle | ||
| Van Erp 2018 Sci Rep | 2018 | Van Erp AC, Rebolledo RA, Hoeksma D, Jespersen NR, Ottens PJ, Nørregaard R, Pedersen M, Laustsen C, Burgerhof JGM, Wolters JC, Ciapaite J, Bøtker HE, Leuvenink HGD, Jespersen B (2018) Organ-specific responses during brain death: increased aerobic metabolism in the liver and anaerobic metabolism with decreased perfusion in the kidneys. Sci Rep 8:4405. | Rat | Liver Kidney | ||
| Holland 2018 Cell Death Dis | 2018 | Holland OJ, Cuffe JSM, Dekker Nitert M, Callaway L, Kwan Cheung KA, Radenkovic F, Perkins AV (2018) Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery. Cell Death Dis 9:1150. | Human | Genital | Ischemia-reperfusion | Other |
| Silaidos 2018 Biol Sex Differ | 2018 | Silaidos C, Pilatus U, Grewal R, Matura S, Lienerth B, Pantel J, Eckert GP (2018) Sex-associated differences in mitochondrial function in human peripheral blood mononuclear cells (PBMCs) and brain. Biol Sex Differ 9:34. | Human | Nervous system Blood cells | Alzheimer's | |
| Martins 2018 Oxid Med Cell Longev | 2018 | Martins IK, de Carvalho NR, Macedo GE, Rodrigues NR, Ziech CC, Vinadé L, Filho VMB, Menezes IA, Franco J, Posser T (2018) Anacardium microcarpum promotes neuroprotection dependently of AKT and ERK phosphorylation but does not prevent mitochondrial damage by 6-OHDA. Oxid Med Cell Longev 2018:2131895. | Chicken | Nervous system | Parkinson's | |
| Silva 2018 Nat Cell Biol | 2018 | Silva J, Aivio S, Knobel PA, Bailey LJ, Casali A, Vinaixa M, Garcia-Cao I, Coyaud É, Jourdain AA, Pérez-Ferreros P, Rojas AM, Antolin-Fontes A, Samino-Gené S, Raught B, González-Reyes A, Ribas de Pouplana L, Doherty AJ, Yanes O, Stracker TH (2018) EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation. Nat Cell Biol 20:162-74. | Islet cell;pancreas;thymus | Aging;senescence | ||
| Musi 2018 Aging Cell | 2018 | Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME (2018) Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell 17:e12840. | Mouse | Nervous system | Aging;senescence | |
| Sokolov 2018 Mitochondrion | 2018 | Sokolov EP, Sokolova IM (2018) Compatible osmolytes modulate mitochondrial function in a marine osmoconformer Crassostrea gigas (Thunberg, 1793). Mitochondrion 45:29-37. | Molluscs | Lung;gill | ||
| Trewin 2018 Am J Physiol Regul Integr Comp Physiol | 2018 | Trewin AJ, Parker L, Shaw CS, Hiam D, Garnham AP, Levinger I, McConell GK, Stepto NK (2018) Acute HIIE elicits similar changes in human skeletal muscle mitochondrial H2O2 release, respiration and cell signaling as endurance exercise even with less work. Am J Physiol Regul Integr Comp Physiol 315:R1003-R1016. | Human | Skeletal muscle | ||
| Weisz 2018 Hum Mol Genet | 2018 | Weisz ED, Towheed A, Monyak RE, Toth MS, Wallace DC, Jongens TA (2018) Loss of Drosophila FMRP leads to alterations in energy metabolism and mitochondrial function. Hum Mol Genet 27:95-106. | Drosophila | Skeletal muscle | Autism Neurodegenerative | |
| Yang 2018 Cell Death Dis | 2018 | Yang F, Wu R, Jiang Z, Chen J, Nan J, Su S, Zhang N, Wang C, Zhao J, Ni C, Wang Y, Hu W, Zeng Z, Zhu K, Liu X, Hu X, Zhu W, Yu H, Huang J, Wang J (2018) Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation. Cell Death Dis 9:556. | Mouse | Cardiovascular | ||
| Niu 2018 Cancer Metab | 2018 | Niu X, Chen YJ, Crawford PA, Patti GJ (2018) Transport-exclusion pharmacology to localize lactate dehydrogenase activity within cells. Cancer Metab 6:19. | Human | HeLa | ||
| Sumbalova 2018 Recent Advances Mitochondr Med Coenzyme Q10 | 2018 | Sumbalová Z, Garcia-Souza LF, Cizmarova B, Volani C, Gnaiger E (2018) Analysis of mitochondrial function in human blood cells. In: Recent advances in mitochondrial medicine and Coenzyme Q10. Gvozdjáková A, Cornelissen G, Singh RB eds, Nova Sciences:255-68. | Human | Blood cells | ||
| Paech 2018b Toxicology | 2018 | Paech F, Abegg VF, Duthaler U, Terracciano L, Bouitbir J, Krähenbühl S (2018) Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice. Toxicology 409:13-23. | Mouse | Liver | Cell death Cryopreservation | |
| Papadimitriou 2018 Thesis | 2018 | Papadimitriou ID (2018) The influence of ACTN3 R577X genotype on performance and muscle adaptations to a single bout of exercise . PhD Thesis 125. | Human | Skeletal muscle | ||
| Coleman 2018 Sci Rep | 2018 | Coleman V, Sa-Nguanmoo P, Koenig J, Schulz TJ, Grune T, Klaus S, Kipp AP, Ost M (2018) Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling. Sci Rep 8:2446. | Mouse | Skeletal muscle | ||
| Monzio Compagnoni 2018 Biochim Biophys Acta Mol Basis Dis | 2018 | Monzio Compagnoni G, Kleiner G, Bordoni A, Fortunato F, Ronchi D, Salani S, Guida M, Corti C, Pichler I, Bergamini C, Fato R, Pellecchia MT, Vallelunga A, Del Sorbo F, Elia A, Reale C, Garavaglia B, Mora G, Albanese A, Cogiamanian F, Ardolino G, Bresolin N, Corti S, Comi GP, Quinzii CM, Di Fonzo A (2018) Mitochondrial dysfunction in fibroblasts of multiple system atrophy. Biochim Biophys Acta Mol Basis Dis 1864:3588-97. | Human | Fibroblast | Neurodegenerative | |
| Matsumoto 2018 Circulation | 2018 | Matsumoto J, Takada S, Kinugawa S, Furihata T, Nambu H, Kakutani N, Tsuda M, Fukushima A, Yokota T, Tanaka S, Takahashi H, Watanabe M, Hatakeyama S, Matsumoto M, Nakayama KI, Otsuka Y, Sabe H, Tsutsui H, Anzai T (2018) Brain-derived neurotrophic factor improves limited exercise capacity in mice with heart failure. Circulation 138:2064-66. | Mouse | Skeletal muscle | Cardiovascular | |
| Zhang 2018 J Mol Cell Cardiol | 2018 | Zhang G, Sheng M, Wang J, Teng T, Sun Y, Yang Q, Xu Z (2018) Zinc improves mitochondrial respiratory function and prevents mitochondrial ROS generation at reperfusion by phosphorylating STAT3 at Ser727. J Mol Cell Cardiol 118:169-82. | Mouse | Heart | Ischemia-reperfusion Hypoxia | |
| De Moura Alvorcem 2018 Mitochondrion | 2018 | De Moura Alvorcem L, Britto R, Parmeggiani B, Glanzel NM, Da Rosa-Junior NT, Cecatto C, Bobermin LD, Amaral AU, Wajner M, Leipnitz G (2018) Evidence that thiol group modification and reactive oxygen species are involved in hydrogen sulfide-induced mitochondrial permeability transition pore opening in rat cerebellum. Mitochondrion 47:141-50. | Rat | Nervous system | Permeability transition Oxidative stress;RONS | |
| Komlodi 2018 Methods Mol Biol | 2018 | Komlodi T, Sobotka O, Krumschnabel G, Bezuidenhout N, Hiller E, Doerrier C, Gnaiger E (2018) Comparison of mitochondrial incubation media for measurement of respiration and hydrogen peroxide production. Methods Mol Biol 1782:137-55. | Human Mouse | Skeletal muscle HEK | ||
| Friederich 2018 Nat Commun | 2018 | Friederich MW, Timal S, Powell CA, Dallabona C, Kurolap A, Palacios-Zambrano S, Bratkovic D, Derks TGJ, Bick D, Bouman K, Chatfield KC, Damouny-Naoum N, Dishop MK, Falik-Zaccai TC, Fares F, Fedida A, Ferrero I, Gallagher RC, Garesse R, Gilberti M, González C, Gowan K, Habib C, Halligan RK, Kalfon L, Knight K, Lefeber D, Mamblona L, Mandel H, Mory A, Ottoson J, Paperna T, Pruijn GJM, Rebelo-Guiomar PF, Saada A, Sainz B Jr, Salvemini H, Schoots MH, Smeitink JA, Szukszto MJ, Ter Horst HJ, van den Brandt F, van Spronsen FJ, Veltman JA, Wartchow E, Wintjes LT, Zohar Y, Fernández-Moreno MA, Baris HN, Donnini C, Minczuk M, Rodenburg RJ, Van Hove JLK (2018) Pathogenic variants in glutamyl-tRNAGln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder. Nat Commun 9:4065. | Human Fungi | Fibroblast | Myopathy | |
| Hafen 2018 J Appl Physiol (1985) | 2018 | Hafen PS, Preece CN, Sorensen JR, Hancock CR, Hyldahl RD (2018) Repeated exposure to heat stress induces mitochondrial adaptation in human skeletal muscle. J Appl Physiol (1985) 125:1447-55. | Human | Skeletal muscle | Temperature | |
| Leckey 2018 FASEB J | 2018 | Leckey JJ, Hoffman NJ, Parr EB, Devlin BL, Trewin AJ, Stepto NK, Morton JP, Burke LM, Hawley JA (2018) High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans. FASEB J 32:2979-91. | Human | Skeletal muscle | ||
| Mayer 2018 Endocrinology | 2018 | Mayer AL, Zhang Y, Feng EH, Higgins CB, Adenekan O, Pietka TA, Beatty WL, DeBosch BJ (2018) Enhanced hepatic PPARα activity links GLUT8 deficiency to augmented peripheral fasting responses in male mice. Endocrinology 159:2110-26. | Mouse | Skeletal muscle Liver | ||
| Chen 2018 Hum Mol Genet | 2018 | Chen A, Tiosano D, Guran T, Baris HN, Bayram Y, Mory A, Shapiro-Kulnane L, Hodges CA, Coban Akdemir Z, Turan S, Jhangiani SN, van den Akker F, Hoppel CL, Salz HK, Lupski JR, Buchner DA (2018) Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency. Hum Mol Genet 27:1913-26. | Human | Endothelial;epithelial;mesothelial cell Fibroblast | Inherited | |
| Van Den Brink 2018 PLoS Genet | 2018 | Van Den Brink DM, Cubizolle A, Chatelain G, Davoust N, Girard V, Johansen S, Napoletano F, Dourlen P, Guillou L, Angebault-Prouteau C, Bernoud-Hubac N, Guichardant M, Brabet P, Mollereau B (2018) Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina. PLoS Genet 14:e1007627. | Mouse | Endothelial;epithelial;mesothelial cell | Neurodegenerative | |
| Razak 2018 RUMeS | 2018 | Razak SHA, Hassan H, Hakimi NH, Rani NA, Ibrahim NF, Ngah WZW, Makpol S, Damanhuri MHA, Karim NA, Tan JK (2018) Isolation of mitochondria and measurement of oxygen consumption rate by high-resolution respirometry in rat hippocampus. RUMeS 6:11-18. | Rat | Nervous system | ||
| Dejos 2018 Sci Rep | 2018 | Dejos C, Kuny S, Han WH, Capel H, Lemieux H, Sauvé Y (2018) Photoreceptor-induced RPE phagolysosomal maturation defects in Stargardt-like Maculopathy (STGD3). Sci Rep 8:5944. | Mouse | Endothelial;epithelial;mesothelial cell | Neurodegenerative | |
| Fink 2018 J Biol Chem | 2018 | Fink BD, Bai F, Yu L, Sheldon RD, Sharma A, Taylor EB, Sivitz WI (2018) Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II-driven respiration. J Biol Chem 293:19932-41. | Mouse | Skeletal muscle | ||
| Weber 2018 Int J Mol Sci | 2018 | Weber A, Klocker H, Oberacher H, Gnaiger E, Neuwirt H, Sampson N, Eder IE (2018) Succinate accumulation is associated with a shift of mitochondrial respiratory control and HIF-1α upregulation in PTEN negative prostate cancer cells. Int J Mol Sci 19:2129. | Human | Genital | Cancer | |
| Goncalves 2018 Neurotoxicology | 2018 | Gonçalves DF, Courtes AA, Hartmann DD, da Rosa PC, Oliveira DM, Soares FAA, Dalla Corte CL (2018) 6-Hydroxydopamine induces different mitochondrial bioenergetics response in brain regions of rat. Neurotoxicology 70:1-11. | Rat | Nervous system | Parkinson's Neurodegenerative | |
| Burney 2018 Thesis | 2018 | Burney E (2018) Characterization of mitochondrial metabolism in L6 rat myoblasts. Bachelor's Thesis p50. | Rat | Other cell lines | ||
| Nielsen 2018 Neurosci Lett | 2018 | Nielsen B, Cejvanovic V, Wörtwein G, Hansen AR, Marstal KK, Weimann A, Bjerring PN, Dela F, Poulsen HE, Jørgensen MB (2018) Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue. Neurosci Lett 690:1-5. | Rat | Nervous system | Other | |
| Fischer 2018 BMC Musculoskelet Disord | 2018 | Fischer MJ, Horvath G, Krismer M, Gnaiger E, Goebel G, Pesta DH (2018) Evaluation of mitochondrial function in chronic myofascial trigger points - a prospective cohort pilot study using high-resolution respirometry. BMC Musculoskelet Disord 19:388. | Human | Skeletal muscle | ||
| Wen 2018 PLOS Pathog | 2018 | Wen JJ, Yin YW, Garg NJ (2018) PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance. PLOS Pathog 14:e1007065. | Mouse | Heart Other cell lines | Infectious | |
| Gorgey 2018 Eur J Appl Physiol | 2018 | Gorgey AS, Witt O, O'Brien L, Cardozo C, Chen Q, Lesnefsky EJ, Graham ZA (2018) Mitochondrial health and muscle plasticity after spinal cord injury. Eur J Appl Physiol 119:315-31. | Human | Skeletal muscle | Oxidative stress;RONS | |
| Setz 2018 Hear Res | 2018 | Setz C, Benischke AS, Pinho Ferreira Bento AC, Brand Y, Levano S, Paech F, Leitmeyer K, Bodmer D (2018) Induction of mitophagy in the HEI-OC1 auditory cell line and activation of the Atg12/LC3 pathway in the organ of Corti. Hear Res 361:52-65. | Mouse | Other cell lines | ||
| Nacarelli 2018 Geroscience | 2018 | Nacarelli T, Azar A, Altinok O, Orynbayeva Z, Sell C (2018) Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts. Geroscience 40:243-56. | Human | Heart Fibroblast | Aging;senescence | |
| Doerrier 2018 Methods Mol Biol | 2018 | Doerrier C, Garcia-Souza LF, Krumschnabel G, Wohlfarter Y, Mészáros AT, Gnaiger E (2018) High-Resolution FluoRespirometry and OXPHOS protocols for human cells, permeabilized fibers from small biopsies of muscle, and isolated mitochondria. Methods Mol Biol 1782:31-70. | Human Mouse Rat Saccharomyces cerevisiae | Heart Skeletal muscle Endothelial;epithelial;mesothelial cell Blood cells HEK Platelet | ||
| Kjeld 2018 PLoS One | 2018 | Kjeld T, Stride N, Gudiksen A, Hansen EG, Arendrup HC, Horstmann PF, Zerahn B, Jensen LT, Nordsborg N, Bejder J, Halling JF (2018) Oxygen conserving mitochondrial adaptations in the skeletal muscles of breath hold divers. PLoS One 13:e0201401. | Human | Skeletal muscle | ||
| Ahn 2018 Redox Biol | 2018 | Ahn B, Pharaoh G, Premkumar P, Huseman K, Ranjit R, Kinter M, Szweda L, Kiss T, Fulop G, Tarantini S, Csiszar A, Ungvari Z, Van Remmen H (2018) Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass. Redox Biol 17:47-58. | Mouse | Skeletal muscle | Aging;senescence | |
| Allard 2018 J Clin Endocrinol Metab | 2018 | Allard NAE, Schirris TJJ, Verheggen RJ, Russel FGM, Rodenburg RJ, Smeitink JAM, Thompson PD, Hopman MTE, Timmers S (2018) Statins affect skeletal muscle performance: evidence for disturbances in energy metabolism. J Clin Endocrinol Metab 103:75-84. | Human | Skeletal muscle | Myopathy | |
| Tarpey 2018 Skelet Muscle | 2018 | Tarpey MD, Amorese AJ, Balestrieri NP, Ryan TE, Schmidt CA, McClung JM, Spangenburg EE (2018) Characterization and utilization of the flexor digitorum brevis for assessing skeletal muscle function. Skelet Muscle 8:14. | Mouse | Skeletal muscle | ||
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| Briones-Herrera 2018 Food Chem Toxicol | 2018 | Briones-Herrera A, Avila-Rojas SH, Aparicio-Trejo OE, Cristóbal M, León-Contreras JC, Hernández-Pando R, Pinzón E, Pedraza-Chaverri J, Sánchez-Lozada LG, Tapia E (2018) Sulforaphane prevents maleic acid-induced nephropathy by modulating renal hemodynamics, mitochondrial bioenergetics and oxidative stress. Food Chem Toxicol 115:185-97. | Rat | Kidney | Other | |
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| Rodrigues 2018 Free Radic Biol Med | 2018 | Rodrigues NR, Macedo GE, Martins IK, Gomes KK, de Carvalho NR, Posser T, Franco JL (2018) Short-term sleep deprivation with exposure to nocturnal light alters mitochondrial bioenergetics in Drosophila. Free Radic Biol Med 120:395-406. | Drosophila | Oxidative stress;RONS | ||
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| Kappler 2018 Thesis | 2018 | Kappler L (2018) Method development for valid high‐resolution profiling of mitochondria and Omics investigation of mitochondrial adaptions to excess energy intake and physical exercise. Dissertation p181. | Human Mouse | Skeletal muscle Liver Other cell lines | Diabetes | |
| Konopka 2018 Aging Cell | 2018 | Konopka AR, Laurin JL, Schoenberg HM, Reid JJ, Castor WM, Wolff CA, Musci RV, Safairad OD, Linden MA, Biela LM, Bailey SM, Hamilton KL, Miller BF (2018) Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. Aging Cell 18:e12880. | Human | Skeletal muscle | Aging;senescence Diabetes | |
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| Holloway 2018 Cell Rep | 2018 | Holloway GP, Holwerda AM, Miotto PM, Dirks ML, Verdijk LB, van Loon LJC (2018) Age-associated impairments in mitochondrial ADP sensitivity contribute to redox stress in senescent human skeletal muscle. Cell Rep 22:2837–48. | Human | Skeletal muscle | Oxidative stress;RONS | Aging;senescence |
| Lee 2018 Neurol Genet | 2018 | Lee RG, Sedghi M, Salari M, Shearwood AJ, Stentenbach M, Kariminejad A, Goullee H, Rackham O, Laing NG, Tajsharghi H, Filipovska A (2018) Early-onset Parkinson disease caused by a mutation in CHCHD2 and mitochondrial dysfunction. Neurol Genet 4:e276. | Human | Fibroblast | Parkinson's | |
| Jang 2018 Intensive Care Med Exp | 2018 | Jang DH, MD, Khatri UG, Shortal BP, Kelly M, Lambert DS, Hardy K, Eckmann DM (2018) Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen. Intensive Care Med Exp 6:4. | Human | Blood cells | Oxidative stress;RONS | |
| Chung 2018 J Exp Biol | 2018 | Chung DJ, Sparagna GC, Chicco AJ, Schulte PM (2018) Patterns of mitochondrial membrane remodeling parallel functional adaptations to thermal stress. J Exp Biol 221. pii: jeb174458. | Fishes | Liver | Temperature | |
| Champigny 2018 Mar Drugs | 2018 | Champigny CM, Cormier RPJ, Simard CJ, St-Coeur PD, Fortin S, Pichaud N (2018) Omega-3 monoacylglyceride effects on longevity, mitochondrial metabolism and oxidative stress: insights from Drosophila melanogaster. Mar Drugs 16:E453. | Drosophila | Aging;senescence | ||
| Seite 2018 Sci Rep | 2018 | Seite S, Mourier A, Camougrand N, Salin B, Figueiredo-Silva AC, Fontagne-Dicharry S, Panserat S, Seiliez I (2018) Dietary methionine deficiency affects oxidative status, mitochondrial integrity and mitophagy in the liver of rainbow trout (Oncorhynchus mykiss). Sci Rep 8:10151. | Fishes | Liver | ||
| Woodman 2018 FASEB J | 2018 | Woodman AG, Mah R, Keddie D, Noble RMN, Panahi S, Gragasin FS, Lemieux H, Bourque SL (2018) Prenatal iron deficiency causes sex-dependent mitochondrial dysfunction and oxidative stress in fetal rat kidneys and liver. FASEB J 32:3254-63. | Rat | Liver Kidney | ||
| Audia 2018 Basic Res Cardiol | 2018 | Audia JP, Yang XM, Crockett ES, Housley N, Haq EU, O'Donnell K, Cohen MV, Downey JM, Alvarez DF (2018) Caspase‑1 inhibition by VX‑765 administered at reperfusion in P2Y12 receptor antagonist‑treated rats provides long‑term reduction in myocardial infarct size and preservation of ventricular function. Basic Res Cardiol 113:32. | Rat | Heart | Ischemia-reperfusion | Cardiovascular |
| Corrochano 2018 Hum Mol Genet | 2018 | Corrochano S, Blanco G, Williams D, Wettstein J, Simon M, Kumar S, Moir L, Agnew T, Stewart M, Landman A, Kotiadis VN, Duchen MR, Wackerhage H, Rubinsztein DC, Brown SDM, Acevedo-Arozena A (2018) A genetic modifier suggests that endurance exercise exacerbates Huntington's disease. Hum Mol Genet 27:1723-31. | Mouse | Skeletal muscle | Neurodegenerative | |
| Manoharan 2018 Thesis | 2018 | Manoharan N (2018) Characterization of mitochondrial respiration in atlantic salmon (Salmo salar) fed with glutamate and succinate enhanced diet. Master's Thesis 52. | Fishes | Heart Liver | ||
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| Van den Berg 2017 Am J Respir Crit Care Med | 2017 | van den Berg M, Hooijman PE, Beishuizen A, de Waard MC, Paul MA, Hartemink KJ, van Hees HWH, Lawlor MW, Brocca L, Bottinelli R, Pellegrino MA, Stienen GJM, Heunks LMA, Wüst RCI, Ottenheijm CAC (2017) Diaphragm atrophy and weakness in the absence of mitochondrial dysfunction in the critically ill. Am J Respir Crit Care Med 196:1544-58. | Human | Skeletal muscle | Other | |
| Zholobenko 2017 PLOS ONE | 2017 | Zholobenko AV, Mouithys-Mickalad A, Dostal Z, Serteyn D, Modriansky M (2017) On the causes and consequences of the uncoupler-like effects of quercetin and dehydrosilybin in H9c2 cells. PLOS ONE 12:e0185691. | Rat | Heart | Hypoxia | |
| Horscroft 2017 Proc Natl Acad Sci U S A | 2017 | Horscroft JA, Kotwica AO, Laner V, West JA, Hennis PJ, Levett DZH, Howard DJ, Fernandez BO, Burgess SL, Ament Z, Gilbert-Kawai ET, Vercueil A, Landis BD, Mitchell K, Mythen MG, Branco C, Johnson RS, Feelisch M, Montgomery HE, Griffin JL, Grocott MPW, Gnaiger E, Martin DS, Murray AJ (2017) Metabolic basis to Sherpa altitude adaptation. Proc Natl Acad Sci U S A 114:6382–7. | Human | Skeletal muscle | Oxidative stress;RONS Hypoxia | |
| Grassi 2017 J Appl Physiol (1985) | 2017 | Grassi B, Majerczak J, Bardi E, Buso A, Comelli M, Chlopicki S, Guzik M, Mavelli I, Nieckarz Z, Salvadego D, Tyrankiewicz U, Skórka T, Bottinelli R, Zoladz JA, Pellegrino MA (2017) Exercise training in Tgαq*44 mice during the progression of chronic heart failure: cardiac vs. peripheral (soleus muscle) impairments to oxidative metabolism. J Appl Physiol (1985) 123:326-36. | Mouse | Skeletal muscle | Cardiovascular | |
| Asseburg 2017 Thesis | 2017 | Asseburg H (2017) Untersuchungen zur nutritiven Prävention der Neurodegeneration – Wirkungen von Trauben- und Olivenpolyphenolen auf die mitochondriale und kognitive Dysfunktion bei der Gehirnalterung und Alzheimer-Erkrankung. Dissertation p296. | Mouse Rat | Nervous system Other cell lines | Aging;senescence Alzheimer's | |
| Lopez 2017 PLOS ONE | 2017 | López A, Ortiz F, Doerrier C, Venegas C, Fernández-Ortiz M, Aranda P, Díaz-Casado ME, Fernández-Gil B, Barriocanal-Casado E, Escames G, López L, Acuña-Castroviejo D (2017) Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases. PLOS ONE 12:e0183090. | Mouse | Parkinson's | ||
| Permer 2017 Bachelor Thesis | 2017 | Permer M (2017) Respirometrische Charakterisierung kryopräservierter HEK 239T Zellen. Bachelor Thesis 1-56. | Human | Other cell lines HEK | Cryopreservation | |
| Miller 2017 PLOS ONE | 2017 | Miller B, Hamilton K, Boushel R, Williamson K, Laner V, Gnaiger E, Davis M (2017) Mitochondrial respiration in highly aerobic canines in the non-raced state and after a 1600-km sled dog race. PLOS ONE 12:e0174874. | Dog | Skeletal muscle | ||
| Koning 2017 J Cereb Blood Flow Metab | 2017 | Koning G, Leverin AL, Nair S, Schwendimann L, Ek J, Carlsson Y, Gressens P, Thornton C, Wang X, Mallard C, Hagberg H (2017) Magnesium induces preconditioning of the neonatal brain via profound mitochondrial protection. J Cereb Blood Flow Metab 39:1038-55. | Rat | Ischemia-reperfusion Hypoxia | ||
| Luethi 2017 Toxicology | 2017 | Luethi D, Liechti ME, Krähenbühl S (2017) Mechanisms of hepatocellular toxicity associated with new psychoactive synthetic cathinones. Toxicology 387:57-66. | Human | Liver | ||
| De Moura 2017 Neurotox Res | 2017 | de Moura Alvorcem L, da Rosa MS, Glänzel NM, Parmeggiani B, Grings M, Schmitz F, Wyse ATS, Wajner M, Leipnitz G (2017) Disruption of energy transfer and redox status by sulfite in hippocampus, striatum, and cerebellum of developing rats. Neurotox Res 32:264-75. | Rat | Nervous system | ||
| Van Schaardenburgh 2017 J Transl Med | 2017 | van Schaardenburgh M, Wohlwend M, Rognmo Ø, Mattsson EJR (2017) Exercise in claudicants increase or decrease walking ability and the response relates to mitochondrial function. J Transl Med 15:130. | Human | Skeletal muscle | Ischemia-reperfusion | |
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| Khalifa 2017 Physiol Rep | 2017 | Khalifa AR, Abdel-Rahman EA, Mahmoud AM, Ali MH, Noureldin M, Saber SH, Mohsen M, Ali SS (2017) Sex-specific differences in mitochondria biogenesis, morphology, respiratory function, and ROS homeostasis in young mouse heart and brain. Physiol Rep 5. pii: e13125. | Mouse | Heart Nervous system | Aging;senescence Cardiovascular Other | |
| Wollenman 2017 PLOS ONE | 2017 | Wollenman LC, Vander Ploeg MR, Miller ML, Zhang Y, Bazil JN (2017) The effect of respiration buffer composition on mitochondrial metabolism and function. PLOS ONE 12:e0187523. | Guinea pig | Heart Liver | ||
| Lemieux 2017 Sci Rep | 2017 | Lemieux H, Blier PU, Gnaiger E (2017) Remodeling pathway control of mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840, DOI:10.1038/s41598-017-02789-8. | Mouse | Heart | ||
| Fourcade 2017 Aging Cell | 2017 | Fourcade S, Morató L, Parameswaran J, Ruiz M, Ruiz-Cortés T, Jové M, Naudí A, Martínez-Redondo P, Dierssen M, Ferrer I, Villarroya F, Pamplona R, Vaquero A, Portero-Otín M, Pujol A (2017) Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance. Aging Cell 16:1404-13. | Mouse | Aging;senescence Neurodegenerative | ||
| Buso 2017 Thesis | 2017 | Buso A (2017) Mitochondrial oxidative phosphorylation plasticity/adaptation triggered by disturbances and stresses and targeted by therapies. PhD Thesis p110. | Mouse | Skeletal muscle | Aging;senescence | |
| Jackson 2017 Cancer Res | 2017 | Jackson LE, Kulkarni S, Wang H, Lu J, Dolezal JM, Bharathi SS, Ranganathan S, Patel MS, Deshpande R, Alencastro F, Wendell SG, Goetzman ES, Duncan AW, Prochownik EV (2017) Genetic dissociation of glycolysis and the TCA cycle affects neither normal nor neoplastic proliferation. Cancer Res 77:5795-807. | Mouse | Liver | Cancer | |
| Huang 2017 Sci Rep | 2017 | Huang L, Zhang K, Guo Y, Huang F, Yang K, Chen L, Huang K, Zhang F, Long Q, Yang Q (2017) Honokiol protects against doxorubicin cardiotoxicity via improving mitochondrial function in mouse hearts. Sci Rep 7:11989. | Mouse | Heart | Cancer | |
| Briston 2017 Sci Rep | 2017 | Briston T, Roberts M, Lewis S, Powney B, M Staddon J, Szabadkai G, Duchen MR (2017) Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability. Sci Rep 7:10492. | Rat | Liver | Permeability transition | |
| Ljones 2017 PLOS ONE | 2017 | Ljones K, Ness HO, Solvang-Garten K, Gaustad SE, Andre Høydal M (2017) Acute exhaustive aerobic exercise training impair cardiomyocyte function and calcium handling in Sprague-Dawley rats. PLOS ONE 12:e0173449. | Rat | Heart | ||
| Krylova 2017 Biomed Khim | 2017 | Krylova TD, Tsygankova PG, Itkis YS, Sheremet NL, Nevinitsyna TA, Mikhaylova SV, Zakharova EY (2017) High resolution respirometry in diagnostic of mitochondrial disorders caused by mitochondrial complex I deficiency. Biomed Khim 63:327-33. | Human | Endothelial;epithelial;mesothelial cell Fibroblast | Mitochondrial disease | Neurodegenerative |
| Friederich 2017 Hum Mol Genet | 2017 | Friederich MW, Erdogan AJ, Coughlin CR 2nd, Elos MT, Jiang H, O'Rourke CP, Lovell MA, Wartchow E, Gowan K, Chatfield KC, Chick WS, Spector EB, Van Hove JLK, Riemer J (2017) Mutations in the accessory subunit NDUFB10 result in isolated complex I deficiency and illustrate the critical role of intermembrane space import for complex I holoenzyme assembly. Hum Mol Genet 26:702-16. | Human | Fibroblast | Myopathy | |
| Boutant 2017 EMBO J | 2017 | Boutant M, Kulkarni SS, Joffraud M, Ratajczak J, Valera-Alberni M, Combe R, Zorzano A, Cantó C (2017) Mfn2 is critical for brown adipose tissue thermogenic function. EMBO J 36:1543-58. | Mouse | Fat Fibroblast | ||
| Sharaf 2017 Biochim Biophys Acta | 2017 | Sharaf MS, Stevens D, Kamunde C (2017) Mitochondrial transition ROS spike (mTRS) results from coordinated activities of complex I and nicotinamide nucleotide transhydrogenase. Biochim Biophys Acta 1858:955-65. | Mouse Fishes | Heart Liver | Oxidative stress;RONS | |
| Rowley 2017 J Nutr Biochem | 2017 | Rowley TJ, Bitner BF, Ray JD, Lathen DR, Smithson AT, Dallon BW, Plowman CJ, Bikman BT, Hansen JM, Dorenkott MR, Goodrich KM, Ye L, O'Keefe SF, Neilson AP, Tessem JS (2017) Monomeric cocoa catechins enhance β-cell function by increasing mitochondrial respiration. J Nutr Biochem 49:30-41. | Rat | Islet cell;pancreas;thymus | Diabetes | |
| Fisar 2017 Indian J Biochem Biophys | 2017 | Fišar Z, Hroudová J, Namrata S, Macečková D, Kopřivová A (2017) Protocols for high-resolution respirometry experiments to test the activity of electron transfer system of pig brain mitochondria. Indian J Biochem Biophys 54:258-72. | Pig | Nervous system | ||
| Du 2017 Evolution | 2017 | Du SNN, Khajali F, Dawson NJ, Scott GR (2017) Hybridization increases mitochondrial production of reactive oxygen species in sunfish. Evolution 71:1643-52. | Fishes | Liver | Oxidative stress;RONS Ischemia-reperfusion | |
| Yan 2017 BMC Genomics | 2017 | Yan X, Eynon N, Papadimitriou ID, Kuang J, Munson F, Tirosh O, O’Keefe L, Griffiths LR, Ashton KJ, Byrne N, Pitsiladis YP, Bishop DJ (2017) The gene SMART study: method, study design, and preliminary findings. BMC Genomics 18:821. | Human | Skeletal muscle | ||
| Pecinova 2017 Oxid Med Cell Longev | 2017 | Pecinova A, Drahota Z, Kovalcikova J, Kovarova N, Pecina P, Alan L, Zima M, Houstek J, Mracek T (2017) Pleiotropic effects of biguanides on mitochondrial reactive oxygen species production. Oxid Med Cell Longev 7038603. | Rat | Fat | Oxidative stress;RONS | Diabetes |
| Duicu 2017 Can J Physiol Pharmacol | 2017 | Duicu OM, Privistirescu A, Wolf A, Petruş A, Dănilă MD, Raţiu CD, Muntean DM, Sturza A (2017) Methylene blue improves mitochondrial respiration and decreases oxidative stress in a substrate-dependent manner in diabetic rat hearts. Can J Physiol Pharmacol 95:1376-82. | Rat | Heart | Diabetes Myopathy | |
| Cockova 2017 Thesis | 2017 | Čočková Z (2017) Modulation of RNA demethylase FTO function in SH-SY5Y cells: the effect on insulin signaling and mitochondrial respiration. Diploma Thesis p70. | Human | Nervous system | Cancer | |
| Rekuviene 2017 Neurosci Lett | 2017 | Rekuviene E, Ivanoviene L, Borutaite V, Morkuniene R (2017) Rotenone decreases ischemia-induced injury by inhibiting mitochondrial permeability transition in mature brains. Neurosci Lett 653:45-50. | Rat | Nervous system | Ischemia-reperfusion Permeability transition | |
| Dolezal 2017 J Biol Chem | 2017 | Dolezal JM, Wang H, Kulkarni S, Jackson L, Lu J, Ranganathan S, Goetzman ES, Bharathi SS, Beezhold K, Byersdorfer CA, Prochownik EV (2017) Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma. J Biol Chem 292:10068-86. | Mouse | Liver | Cancer | |
| Nan 2017 Circ Res | 2017 | Nan J, Hu H, Sun Y, Zhu L, Wang Y, Zhong Z, Zhao J, Zhang N, Wang Y, Wang Y, Ye J, Zhang L, Hu X, Zhu W, Wang J (2017) TNFR2 stimulation promotes mitochondrial fusion via Stat3- and NF-kB-dependent activation of OPA1 expression. Circ Res 121:392-410. | Mouse | Heart | ||
| Van Schaardenburgh 2017 J Vasc Surg | 2017 | Van Schaardenburgh M, Wohlwend M, Rognmo Ø, Mattsson E (2017) Calf raise exercise increases walking performance in patients with intermittent claudication. J Vasc Surg 65:1473-82. | Human | Skeletal muscle | ||
| Dent 2017 Mol Metab | 2017 | Dent JR, Martins VF, Svensson K, LaBarge SA, Schlenk NC, Esparza MC, Buckner EH, Meyer GA, Hamilton DL, Schenk S, Philp A (2017) Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation. Mol Metab 6:1574-84. | Mouse | Skeletal muscle | ||
| De Carvalho 2017 Toxicol Research | 2017 | de Carvalho NR, Rodrigues NR, Macedo GE, Boligon AA, de Campos MM, Posser T, Cunha FAB, Coutinho HD, Klamt F, Bristot IJ, Merritt TJS, Franco JL (2017) Eugenia uniflora leaves essential oil promotes mitochondrial dysfunction in Drosophila melanogaster through the inhibition of oxidative phosphorylation. Toxicol Research 6:526-34 . | Drosophila | |||
| Knuppertz 2017 Aging Cell | 2017 | Knuppertz L, Osiewacz HD (2017) Autophagy compensates impaired energy metabolism in CLPXP-deficient Podospora anserina strains and extends healthspan. Aging Cell 16:704-15. | Fungi | Aging;senescence | ||
| Irgebay 2017 Breast | 2017 | Irgebay Z, Yeszhan B, Sen B, Tuleukhanov S, Brooks AD, Sensenig R, Orynbayeva Z (2017) Danazol alters mitochondria metabolism of fibrocystic breast Mcf10A cells. Breast 35:55-62. | Human | Genital | Other | |
| Han 2017 Invest Ophthalmol Vis Sci | 2017 | Han WH, Gotzmann J, Kuny S, Huang H, Chan CB, Lemieux H, Sauvé Y (2017) Modifications in retinal mitochondrial respiration precede type 2 diabetes and protracted microvascular retinopathy. Invest Ophthalmol Vis Sci 58:3826-39. | Rat | Nervous system | Diabetes | |
| Torres 2017 Cell Metab | 2017 | Torres MJ, Kew KA, Ryan TE, Pennington ER, Lin CT, Buddo KA, Fix AM, Smith CA, Gilliam LA, Karvinen S, Lowe DA, Spangenburg EE, Zeczycki TN, Shaikh SR, Neufer PD (2017) 17β-estradiol directly lowers mitochondrial membrane microviscosity and improves bioenergetic function in skeletal muscle. Cell Metab 27:167-79. | Mouse | Skeletal muscle | Diabetes | |
| Kyhl 2017 Peptides | 2017 | Kyhl K, Lønborg J, Hartmann B, Kissow H, Poulsen SS, Ali HE, Kjær A, Dela F, Engstrøm T, Treiman M (2017) Lack of effect of prolonged treatment with liraglutide on cardiac remodeling in rats after acute myocardial infarction. Peptides 93:1-12. | Rat | Heart | Cardiovascular Myopathy | |
| Lau 2017 Dissertation | 2017 | Lau G (2017) Adaptive variation of mitochondrial function in response to oxygen variability in intertidal sculpins (Cottidae, Actinopterygii). Dissertation p148. | Fishes | Nervous system | Hypoxia | |
| Merz 2017 Intensive Care Med Exp | 2017 | Merz T, Vogt JA, Wachter U, Calzia E, Szabo C, Wang R, Radermacher P, McCook O (2017) Impact of hyperglycemia on cystathionine-γ-lyase expression during resuscitated murine septic shock. Intensive Care Med Exp 5:30. | Mouse | Liver | Sepsis | |
| Gifford 2017 J Appl Physiol (1985) | 2017 | Gifford JR, Trinity JD, Kwon OS, Layec G, Garten RS, Park SY, Nelson AD, Richardson RS (2017) Altered skeletal muscle mitochondrial phenotype in COPD: disease versus disuse. J Appl Physiol (1985) 124:1045-53. | Human | Skeletal muscle | COPD | |
| Djafarzadeh 2017b J Vis Exp | 2017 | Djafarzadeh S, Jakob SM (2017) Isolation of intact mitochondria from skeletal muscle by differential centrifugation for High-Resolution Respirometry measurements. J Vis Exp doi: 10.3791/55251. | Skeletal muscle | |||
| Yang 2017 Cell Death Dis | 2017 | Yang N, Weinfeld M, Lemieux H, Montpetit B, Goping IS (2017) Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis. Cell Death Dis 8:e2587. | Saccharomyces cerevisiae Human | Lymphocyte | Cell death | Cancer |
| Dahlke 2017 Glob Chang Biol | 2017 | Dahlke FT, Leo E, Mark FC, Pörtner HO, Bickmeyer U, Frickenhaus S, Storch D (2017) Effects of ocean acidification increase embryonic sensitivity to thermal extremes in Atlantic cod, Gadus morhua. Glob Chang Biol 23(4):1499-1510. | Fishes | Temperature | ||
| Goedecke 2017 JMIR Res Protoc | 2017 | Goedecke JH, Mendham AE, Clamp L, Nono Nankam PA, Fortuin-de Smidt MC, Phiri L, Micklesfield LK, Keswell D, Woudberg NJ, Lecour S, Alhamud A, Kaba M, Lutomia FM, van Jaarsveld PJ, de Villiers A, Kahn SE, Chorell E, Hauksson J, Olsson T (2017) An exercise intervention to unravel the mechanisms underlying insulin resistance in a cohort of black South African women: Protocol for a randomized controlled trial. JMIR Res Protoc 03/10/2017:9098. | Human | Skeletal muscle Fat | Diabetes Obesity | |
| Kake 2017 J Therm Biol | 2017 | Kake Guena SA, Touisse K, Warren BE, Scott KY, Dufresne F, Blier PU, Lemieux H (2017) Temperature-related differences in mitochondrial function among clones of the cladoceran Daphnia pulex. J Therm Biol 69:23-31. | Crustaceans | Temperature | ||
| Jang 2017 Biol Open | 2017 | Jang DH, Seeger SC, Grady ME, Shofer FC, Eckmann DM (2017) Mitochondrial dynamics and respiration within cells with increased open pore cytoskeletal meshes. Biol Open 6:1831-9. | Human | Endothelial;epithelial;mesothelial cell Fibroblast | Oxidative stress;RONS | Cancer |
| Schmidt 2017 J Vasc Surg | 2017 | Schmidt CA, Ryan TE, Lin CT, Inigo MM, Green TD, Brault JJ, Spangenburg EE, McClung JM (2017) Diminished force production and mitochondrial respiratory deficits are strain-dependent myopathies of subacute limb ischemia. J Vasc Surg 65:1504-1514. | Mouse | Skeletal muscle | Hypoxia | Myopathy Other |
| Hu 2017 Proc Natl Acad Sci U S A | 2017 | Hu H, Nan J, Sun Y, Zhu D, Xiao C, Wang Y, Zhu L, Wu Y, Zhao J, Wu R, Chen J, Yu H, Hu X, Zhu W, Wang J (2017) Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-reperfusion injury via dimerized STAT3. Proc Natl Acad Sci U S A 114:11908-13. | Mouse | Cell death Ischemia-reperfusion Oxidative stress;RONS | ||
| Ravasz 2017 Neurochem Int | 2017 | Ravasz D, Kacso G, Fodor V, Horvath K, Adam-Vizi V, Chinopoulos C (2017) Catabolism of GABA, succinic semialdehyde or gamma-hydroxybutyrate through the GABA shunt impair mitochondrial substrate-level phosphorylation. Neurochem Int 109:41-53. | Mouse | Nervous system Liver | ||
| Newsom 2017 Am J Physiol Endocrinol Metab | 2017 | Newsom SA, Miller BF, Hamilton KL, Ehrlicher SE, Stierwalt HD, Robinson MM (2017) Long-term rates of mitochondrial protein synthesis are increased in mouse skeletal muscle with high fat feeding regardless of insulin sensitizing treatment. Am J Physiol Endocrinol Metab 313:552-62. | Mouse | Skeletal muscle | Diabetes Obesity | |
| Tegelberg 2017 Orphanet J Rare Dis | 2017 | Tegelberg S, Tomašić N, Kallijärvi J, Purhonen J, Elmér E, Lindberg E, Nord DG, Soller M, Lesko N, Wedell A, Bruhn H, Freyer C, Stranneheim H, Wibom R, Nennesmo I, Wredenberg A, Eklund EA, Fellman V (2017) Respiratory chain complex III deficiency due to mutated BCS1L: a novel phenotype with encephalomyopathy, partially phenocopied in a Bcs1l mutant mouse model. Orphanet J Rare Dis 12:73. | Human Mouse | Blood cells Platelet | Other | |
| Zhou 2017 Biochim Biophys Acta | 2017 | Zhou L, Wang W, Hoppel C, Liu J, Zhu X (2017) Parkinson's disease-associated pathogenic VPS35 mutation causes complex I deficits. Biochim Biophys Acta 1863:2791-5. | Human | Fibroblast | Parkinson's | |
| Cardoso 2017 Biochim Biophys Acta | 2017 | Cardoso GMF, Pletsch JT, Parmeggiani B, Grings M, Glanzel NM, Bobermin LD, Amaral AU, Wajner M, Leipnitz G (2017) Bioenergetics dysfunction, mitochondrial permeability transition pore opening and lipid peroxidation induced by hydrogen sulfide as relevant pathomechanisms underlying the neurological dysfunction characteristic of ethylmalonic encephalopathy. Biochim Biophys Acta 1863:2192-2201. | Rat | Nervous system | Permeability transition | Other |
| Asping 2017 Eur J Clin Pharmacol | 2017 | Asping M, Stride N, Søgaard D, Dohlmann TL, Helge JW, Dela F, Larsen S (2017) The effects of 2 weeks of statin treatment on mitochondrial respiratory capacity in middle-aged males: the LIFESTAT study. Eur J Clin Pharmacol 73:679-87. | Human | |||
| Edgett 2017 Thesis | 2017 | Edgett B (2017) Regulation of SIRT1, SIRT3, PGC-1α, and LRP130 in response to energetic stress in human skeletal muscle. Doctoral Dissertation p145. | Human | Skeletal muscle | ||
| Lalia 2017 Aging (Albany NY) | 2017 | Lalia AZ, Dasari S, Robinson MM, Abid H, Morse DM, Klaus KA, Lanza IR (2017) Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults. Aging (Albany NY) 9:1096-1129. | Human | Skeletal muscle | Aging;senescence | |
| Radenkovic 2017 Biochem Pharmacol | 2017 | Radenkovic F, Holland OJ, Vanderlelie JJ, Perkins AV (2017) Selective inhibition of endogenous antioxidants with Auranofin causes mitochondrial oxidative stress which can be countered by selenium supplementation. Biochem Pharmacol 146:42-52. | Human | Other cell lines | Oxidative stress;RONS | |
| Svensson 2017 Acta Physiol (Oxf) | 2017 | Svensson K, LaBarge SA, Martins VF, Schenk S (2017) Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis. Acta Physiol (Oxf) 221:193-203. | Mouse | Skeletal muscle | Diabetes | |
| Jespersen 2017 J Physiol | 2017 | Jespersen NR, Yokota T, Støttrup NB, Bergdahl A, Paelestik KB, Povlsen JA, Dela F, Bøtker HE (2017) Pre-ischaemic mitochondrial substrate constraint by inhibition of malate-aspartate shuttle preserves mitochondrial function after ischaemia-reperfusion. J Physiol 595:3765-80. | Rat | Heart | Ischemia-reperfusion Oxidative stress;RONS | |
| Mueller 2017 Orphanet J Rare Dis | 2017 | Mueller SM, Gehrig SM, Petersen JA, Frese S, Mihaylova V, Ligon-Auer M, Khmara N, Nuoffer JM, Schaller A, Lundby C, Toigo M, Jung HH (2017) Effects of endurance training on skeletal muscle mitochondrial function in Huntington disease patients. Orphanet J Rare Dis 12:184. | Human | Skeletal muscle | Neurodegenerative | |
| Chavanelle 2017 Sci Rep | 2017 | Chavanelle V, Boisseau N, Otero YF, Combaret L, Dardevet D, Montaurier C, Delcros G, Peltier SL, Sirvent P (2017) Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice. Sci Rep 7:204. | Mouse | Skeletal muscle | Diabetes | |
| Ho 2017 Thesis | 2017 | Ho DH (2017) The role of MLQ protein in structure and function of mammalian ATP synthase. Master's Thesis p84. | Human | Kidney | ||
| Kenny 2017 Diabetologia | 2017 | Kenny HC, Rudwill F, Breen L, Salanova M, Blottner D, Heise T, Heer M, Blanc S, O'Gorman DJ (2017) Bed rest and resistive vibration exercise unveil novel links between skeletal muscle mitochondrial function and insulin resistance. Diabetologia 60:1491-501. | Human | Skeletal muscle | Diabetes | |
| Volani 2017 Metallomics | 2017 | Volani C, Doerrier C, Demetz E, Haschka D, Paglia G, Lavdas AA, Gnaiger E, Weiss G (2017) Dietary iron loading negatively affects liver mitochondrial function. Metallomics 9:1634-44. | Mouse | Liver | ||
| Xiong 2017 J Am Heart Assoc | 2017 | Xiong S, Wang B, Lin S, Zhang H, Li Y, Wei X, Cui Y, Wei X, Lu Z, Gao P, Li L, Zhao Z, Liu D, Zhu Z (2017) Activation of transient receptor potential melastatin subtype 8 attenuates cold-induced hypertension through ameliorating vascular mitochondrial dysfunction. J Am Heart Assoc 6. pii: e005495. | Mouse | Endothelial;epithelial;mesothelial cell | Temperature | |
| Nelskylae 2017 Resuscitation | 2017 | Nelskylä A, Nurmi J, Jousi M, Schramko A, Mervaala E, Ristagno G, Skrifvars MB (2017) The effect of 50% compared to 100% inspired oxygen fraction on brain oxygenation and post cardiac arrest mitochondrial function in experimental cardiac arrest. Resuscitation 116:1-7. | Pig | Heart | Cardiovascular | |
| Varga 2017 Inflammopharmacology | 2017 | Varga G, Ugocsai M, Hartmann P, Lajkó N, Molnár R, Szűcs S, Jász DK, Érces D, Ghyczy M, Tóth G, Boros M (2017) Acetylsalicylic acid-tris-hydroxymethyl-aminomethane reduces colon mucosal damage without causing gastric side effects in a rat model of colitis. Inflammopharmacology 26:261-71. | Rat | Liver | Infectious Other | |
| Yeh 2017 Aquat Toxicol | 2017 | Yeh A, Marcinek DJ, Meador JP, Gallagher EP (2017) Effect of contaminants of emerging concern on liver mitochondrial function in Chinook salmon. Aquat Toxicol 190:21-31. | Fishes | Liver | ||
| Koit 2017 Oxid Med Cell Longev | 2017 | Koit A, Shevchuk I, Ounpuu L, Klepinin A, Chekulayev V, Timohhina N, Tepp K, Puurand M,Truu L, Heck K, Valvere V, Guzun R, Kaambre T (2017) Mitochondrial respiration in human colorectal and breast cancer clinical material is regulated differently. Oxid Med Cell Longev 2017:1372640. | Human | Endothelial;epithelial;mesothelial cell | Cancer | |
| Westerlund 2017 Pediatr Res | 2017 | Westerlund E, Marelsson SE, Ehinger JK, Sjövall F, Morota S, Åsander Frostner E, Oldfors A, Darin N, Lundgren J, Hansson MJ, Fellman V, Elmér E (2017) Oxygen consumption in platelets as an adjunct diagnostic method for pediatric mitochondrial disease. Pediatr Res 83:455-65. | Human | Platelet Blood cells | Mitochondrial disease | |
| Makrecka-Kuka 2017 Toxicol Lett | 2017 | Makrecka-Kuka M, Volska K, Antone U, Vilskersts R, Grinberga S, Bandere D, Liepinsh E, Dambrova M (2017) Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria. Toxicol Lett 267:32-8. | Mouse | Heart | ||
| MiPNet21.14 Reference sample HRR | 2016-10-19 | | Human | HEK | Cryopreservation | |
| MiPNet21.13 Comparison mt-preparations | 2016-10-18 | | Mouse | Heart | ||
| MiPNet21.12 Comparison mt respiration media | 2016-10-18 | | Human | HEK | ||
| Sheremet 2016 Biochemistry (Moscow) | 2016 | Sheremet NL, Nevinitsyna TA, Zhorzholadze NV, Ronzina IA, Itkis YS, Krylova TD, Tsygankova PG, Malakhova VA, Zakharova EY, Tokarchuk AV, Panteleeva AA, Karger EM, Lyamzaev KG, Avetisov SE (2016) Previously unclassified mutation of mtDNA m.3472T>C: evidence of pathogenicity in Leber’s hereditary optic neuropathy. Biochemistry (Moscow) BM16-078. | Human | Endothelial;epithelial;mesothelial cell Fibroblast Platelet | ||
| Vevera 2016 Physiol Res | 2016 | Vevera J, Fišar Z, Nekovářová T, Vrablík M, Zlatohlávek L, Hroudová J, Singh N, Raboch J, Valeš K (2016) Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia. Physiol Res 65:777-88. | Human Rat | Blood cells Platelet | ||
| McCurdy 2016 JCI Insight | 2016 | McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE (2016) Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. JCI Insight 1:e86612. | Other mammals | Skeletal muscle | Inherited Obesity Other | |
| Alvarez-Mora 2016 Mol Neurobiol | 2016 | Alvarez-Mora MI, Rodriguez-Revenga L, Madrigal I, Guitart-Mampel M, Garrabou G, Milà M (2016) Impaired mitochondrial function and dynamics in the pathogenesis of FXTAS. Mol Neurobiol 54:6896-902. | Human | Fibroblast | Neurodegenerative | |
| Fisar 2016a Folia Biol (Praha) | 2016 | Fisar Z, Hroudova J (2016) Pig brain mitochondria as a biological model for study of mitochondrial respiration. Folia Biol (Praha) 62:15-25. | Pig | Nervous system | ||
| Shirey 2016 Biochemistry | 2016 | Shirey K, Stover KR, Cleary J, Hoang N, Hosler J (2016) Membrane-anchored cyclic peptides as effectors of mitochondrial oxidative phosphorylation. Biochemistry 55:2100-11. | Rat | Heart Liver | ||
| Assmann 2016 Cell Rep | 2016 | Assmann N, Dettmer K, Simbuerger JM, Broeker C, Nuernberger N, Renner K, Courtneidge H, Klootwijk ED, Duerkop A, Hall A, Kleta R, Oefner PJ, Reichold M, Reinders J (2016) Renal fanconi syndrome is caused by a mistargeting-based mitochondriopathy. Cell Rep 15:1423-9. | Pig | Kidney Other cell lines | Other | |
| Barth 2016 Thesis | 2016 | Barth C (2016) Effekte einer intermittierenden Hyperoxie auf die mitochondriale Atmung in Alveolarmakrophagen. Dissertation p69. | Mouse | Lung;gill Macrophage-derived | Oxidative stress;RONS | |
| Nissinen 2016 Sci Rep | 2016 | Nissinen TA, Degerman J, Räsänen M, Poikonen AR, Koskinen S, Mervaala E, Pasternack A, Ritvos O, Kivelä R, Hulmi JJ (2016) Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes. Sci Rep 6:32695. | Mouse | Skeletal muscle | Cancer | |
| Maarman 2016 J Appl Physiol (1985) | 2016 | Maarman GJ, Andrew BM, Blackhurst DM, Ojuka EO (2016) Melatonin protects against uric acid-induced mitochondrial dysfunction, oxidative stress, and triglyceride accumulation in C2C12 myotubes. J Appl Physiol (1985) 122:1003-10. | Mouse | Skeletal muscle | ||
| Cannon 2016 Lung | 2016 | Cannon DT, Liu J, Sakurai R, Rossiter HB, Rehan VK (2016) Impaired lung mitochondrial respiration following perinatal nicotine exposure in rats. Lung 194:325-8. | Rat | Lung;gill | ||
| Roy 2016 Free Radic Biol Med | 2016 | Roy J, Fauconnier J, Oger C, Farah C, Angebault-Prouteau C, Thireau J, Bideaux P, Scheuermann V, Bultel-Poncé V, Demion M, Galano JM, Durand T, Lee JC, Le Guennec JY (2016) Non-enzymatic oxidized metabolite of DHA, 4(RS)-4-F4t-neuroprostane protects the heart against reperfusion injury. Free Radic Biol Med 102:229-39. | Rat | Heart | Ischemia-reperfusion Permeability transition Oxidative stress;RONS | Cardiovascular |
| Gregg 2016 Diabetes | 2016 | Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW, Merrins MJ (2016) Pancreatic β cells from mice offset age-associated mitochondrial deficiency with reduced KATP channel activity. Diabetes 65:2700-10. | Human Mouse | Islet cell;pancreas;thymus Other cell lines | Aging;senescence | |
| Tsai 2016 Sci Rep | 2016 | Tsai HH, Chang SC, Chou CH, Weng TP, Hsu CC, Wang JS (2016) Exercise training alleviates hypoxia-induced mitochondrial dysfunction in the lymphocytes of sedentary males. Sci Rep 6:35170. | Human | Lymphocyte Blood cells | Oxidative stress;RONS | |
| Strifler 2016b PLOS ONE | 2016 | Strifler G, Tuboly E, Görbe A, Boros M, Pécz D, Hartmann P (2016) Targeting mitochondrial dysfunction with L-alpha glycerylphosphorylcholine. PLOS ONE 11:e0166682. | Rat | Liver | Ischemia-reperfusion | |
| Berressem 2016 PLOS ONE | 2016 | Berressem D, Koch K, Franke N, Klein J, Eckert GP (2016) Intravenous treatment with a long-chain omega-3 lipid emulsion provides neuroprotection in a murine model of ischemic stroke - a pilot study. PLOS ONE 11:e0167329. | Mouse | Nervous system | Ischemia-reperfusion | |
| Lund 2016 J Physiol | 2016 | Lund MT, Kristensen M, Hansen M, Tveskov L, Floyd AK, Støckel M, Vainer B, Poulsen SS, Helge JW, Prats C, Dela F (2016) Hepatic mitochondrial oxidative phosphorylation is normal in obese patients with and without type 2 diabetes. J Physiol 594:4351-8. | Human | Liver | Diabetes Obesity | |
| Reich 2016 Thesis | 2016 | Reich V (2016) Pathophysiologie und Verfahrensentwicklung: Mechanismen der Metabolisierung von Schwefelwasserstoff im mitochondrialen Atmungskreislauf von Lungenalveolarmakrophagen. Dissertation p91. | Mouse | Macrophage-derived | Temperature | |
| Kontro 2016 Thesis | 2016 | Kontro H (2016) Mitochondrial function and sirtuin expression in hippocampus of young and old high and low-capacity runner rats. Master's Thesis p35. | Rat | Nervous system | Aging;senescence | |
| Moon 2016 J Biol Chem | 2016 | Moon SH, Mancuso DJ, Sims HF, Liu X, Nguyen AL, Yang K, Guan S, Dilthey BG, Jenkins CM, Weinheimer CJ, Kovacs A, Abendschein D, Gross RW (2016) Cardiac myocyte-specific knock-out of calcium-independent phospholipase A2γ (iPLA2γ) decreases oxidized fatty acids during ischemia/reperfusion and reduces infarct size. J Biol Chem 291:19687-700. | Mouse | Heart | Ischemia-reperfusion | |
| Van Schaardenburgh 2016 PLOS ONE | 2016 | van Schaardenburgh M, Wohlwend M, Rognmo Ø, Mattsson EJ (2016) Mitochondrial respiration after one session of calf raise exercise in patients with peripheral vascular disease and healthy older adults. PLOS ONE 11:e0165038. | Human | Skeletal muscle | Cardiovascular | |
| Raesaenen 2016 Proc Natl Acad Sci U S A | 2016 | Räsänen M, Degerman J, Nissinen TA, Miinalainen I, Kerkelä R, Siltanen A, Backman JT, Mervaala E, Hulmi JJ, Kivelä R, Alitalo K (2016) VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection. Proc Natl Acad Sci U S A 113:13144-49. | Mouse | Heart | Cancer Cardiovascular | |
| Salin 2016 J Exp Biol | 2016 | Salin K, Auer SK, Anderson GJ, Selman C, Metcalfe NB (2016) Inadequate food intake at high temperatures is related to depressed mitochondrial respiratory capacity. J Exp Biol 219:1356-62. | Fishes | Skeletal muscle Liver | Temperature | |
| Radovic 2016 Diabetologia | 2016 | Radović B, Vujić N, Leopold C, Schlager S, Goeritzer M, Patankar JV, Korbelius M, Kolb D, Reindl J, Wegscheider M, Tomin T, Birner-Gruenberger R, Schittmayer M, Groschner L, Magnes C, Diwoky C, Frank S, Steyrer E, Du H, Graier WF, Madl T, Kratky D (2016) Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice. Diabetologia 59:1743-52. | Mouse | Liver | ||
| Jacobs 2016 J Physiol | 2016 | Jacobs RA, Lundby AM, Fenk S, Gehrig S, Siebenmann C, Flück D, Kirk N, Hilty MP, Lundby C (2016) Twenty-eight days of exposure to 3,454 m increases mitochondrial volume density in human skeletal muscle. J Physiol 594:1151-66. | Human | Skeletal muscle | Oxidative stress;RONS | |
| Christensen 2016 J Appl Physiol (1985) | 2016 | Christensen PM, Jacobs RA, Bonne T, Flück D, Bangsbo J, Lundby C (2016) A short period of high-intensity interval training improves skeletal muscle mitochondrial function and pulmonary oxygen uptake kinetics. J Appl Physiol (1985) 120:1319-27. | Human | Skeletal muscle | ||
| Asseburg 2016 Neuromolecular Med | 2016 | Asseburg H, Schäfer C, Müller M, Hagl S, Pohland M, Berressem D, Borchiellini M, Plank C, Eckert GP (2016) Effects of grape skin extract on age-related mitochondrial dysfunction, memory and life span in C57BL/6J mice. Neuromolecular Med 18:378-95. | Mouse | Nervous system | Aging;senescence | |
| Fisar 2016b Folia Biol (Praha) | 2016 | Fisar Z, Hroudova J, Singh N, Koprivova A, Maceckova D (2016) Effect of simvastatin, coenzyme Q10, resveratrol, acetylcysteine and acetylcarnitine on mitochondrial respiration. Folia Biol (Praha) 62:53-66. | Pig | Nervous system | ||
| Wang 2016 Toxicol Sci | 2016 | Wang L, Espinoza HM, MacDonald JW, Bammler TK, Williams CR, Yeh A, Louie KW, Marcinek DJ, Gallagher EP (2016) Olfactory Transcriptional Analysis of Salmon Exposed to Mixtures of Chlorpyrifos and Malathion Reveal Novel Molecular Pathways of Neurobehavioral Injury. Toxicol Sci 149:145-57. | Fishes | Endothelial;epithelial;mesothelial cell | ||
| Lemieux 2016 Mitochondrion | 2016 | Lemieux H, Boemer F, van Galen G, Serteyn D, Amory H, Baise E, Cassart D, van Loon G, Marcillaud-Pitel C, Votion DM (2016) Mitochondrial function is altered in horse atypical myopathy. Mitochondrion 30:35-41. | Horse | Skeletal muscle | Myopathy | |
| Kilbaugh 2016 Mitochondrion | 2016 | Kilbaugh TJ, Karlsson M, Duhaime AC, Hansson MJ, Elmer E, Margulies SS (2016) Mitochondrial response in a toddler-aged swine model following diffuse non-impact traumatic brain injury. Mitochondrion 26:19-25. | Pig | Nervous system | Other | |
| Amaral 2016 J Neurochem | 2016 | Amaral AU, Cecatto C, Castilho RF, Wajner M (2016) 2-methylcitric acid impairs glutamate metabolism and induces permeability transition in brain mitochondria. J Neurochem 137:62-75. | Rat | Nervous system | Permeability transition | Neurodegenerative |
| Timpani 2016 Neurotherapeutics | 2016 | Timpani CA, Trewin AJ, Stojanovska V, Robinson A, Goodman CA, Nurgali K, Betik AC, Stepto N, Hayes A, McConell GK, Rybalka E (2016) Attempting to compensate for reduced neuronal nitric oxide synthase protein with nitrate supplementation cannot overcome metabolic dysfunction but rather has detrimental effects in Dystrophin-deficient mdx muscle. Neurotherapeutics 14:429-46. | Mouse | Skeletal muscle | Other | |
| Kimball 2016 Thesis | 2016 | Kimball RL (2016) The role of hypoxia on pyruvate kinase M2, mammalian target of rapamycin, mitochondrial function, and cell invasion in the trophoblast. Master Thesis p55. | Human | Genital Other cell lines | Oxidative stress;RONS | Other |
| Iglesias-Gonzalez 2016 Mol Neurobiol | 2016 | Iglesias-González J, Sánchez-Iglesias S, Beiras-Iglesias A, Méndez-Álvarez E, Soto-Otero R (2016) Effects of aluminium on rat brain mitochondria bioenergetics: an in vitro and in vivo study. Mol Neurobiol 54:563-70. | Rat | Nervous system | Alzheimer's Neurodegenerative Parkinson's | |
| Johnson 2016 Diabetes | 2016 | Johnson ML, Distelmaier K, Lanza IR, Irving BA, Robinson MM, Konopka AR, Shulman GI, Nair KS (2016) Mechanism by which caloric restriction improves insulin sensitivity in sedentary obese adults. Diabetes 65:74-84. | Human | Skeletal muscle | Diabetes Obesity | |
| Duteil 2016 Cell Rep | 2016 | Duteil D, Tosic M, Lausecker F, Nenseth HZ, Müller JM, Urban S, Willmann D, Petroll K, Messaddeq N, Arrigoni L, Manke T, Kornfeld JW, Brüning JC, Zagoriy V, Meret M, Dengjel J, Kanouni T, Schüle R (2016) Lsd1 ablation triggers metabolic reprogramming of brown adipose tissue. Cell Rep 17:1008-21. | Mouse | Fat | ||
| Zabielski 2016 Diabetes | 2016 | Zabielski P, Lanza IR, Gopala S, Holtz Heppelmann CJ, Bergen HR 3rd, Dasari S, Nair KS (2016) Altered skeletal muscle mitochondrial proteome as the basis of disruption of mitochondrial function in diabetic mice. Diabetes 65:561-73. | Mouse | Skeletal muscle | Oxidative stress;RONS | Diabetes |
| Chakraborty 2016 Pancreatology | 2016 | Chakraborty M, Hickey AJ, Petrov MS, Macdonald JR, Thompson N, Newby L, Sim D, Windsor JA, Phillips AR (2016) Mitochondrial dysfunction in peripheral blood mononuclear cells in early experimental and clinical acute pancreatitis. Pancreatology 16:739-47. | Human Rat | Blood cells | Other | |
| Wijermars 2016 Kidney Int | 2016 | Wijermars LG, Schaapherder AF, de Vries DK, Verschuren L, Wuest RC, Kostidis S, Mayboroda OA, Prins F, Ringers J, Bierau J, Bakker JA, Kooistra T, Lindeman JH (2016) Defective postreperfusion metabolic recovery directly associates with incident delayed graft function. Kidney Int 90:181-91. | Human | Kidney | Ischemia-reperfusion | |
| Schoenenberger 2016 Cancer Res | 2016 | Schönenberger D, Harlander S, Rajski M, Jacobs RA, Lundby AK, Adlesic M, Hejhal T, Wild PJ, Lundby C, Frew IJ (2016) Formation of renal cysts and tumors in Vhl/Trp53-deficient mice requires HIF1α and HIF2α. Cancer Res 76:2025-36. | Mouse | Nervous system | Cancer | |
| Doerrier 2016 Mitochondrion | 2016 | Doerrier C, García JA, Volt H, Díaz-Casado ME, Luna-Sánchez M, Fernández-Gil B, Escames G, López LC, Acuña-Castroviejo D (2016) Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network. Mitochondrion 27:56-63. | Mouse | Heart | Sepsis | |
| Pohland 2016 Neurochem Res | 2016 | Pohland M, Hagl S, Pellowska M, Wurglics M, Schubert-Zsilavecz M, Eckert GP (2016) MH84: a novel γ-secretase modulator/PPARγ agonist-improves mitochondrial dysfunction in a cellular model of Alzheimer's disease. Neurochem Res 41:231-42. | Human | Kidney HEK | Alzheimer's | |
| Fisar 2016 Curr Alzheimer Res | 2016 | Fišar Z, Hroudová J, Hansíková H, Spáčilová J, Lelková P, Wenchich L, Jirák R, Zvěřová M, Zeman J, Martásek P, Raboch J (2016) Mitochondrial respiration in the platelets of patients with Alzheimer's disease. Curr Alzheimer Res 13:930-41. | Human | Blood cells Platelet | Alzheimer's | |
| Lim 2016 FASEB J | 2016 | Lim SC, Hroudová J, Van Bergen NJ, Lopez Sanchez MI, Trounce IA, McKenzie M (2016) Loss of mitochondrial DNA-encoded protein ND1 results in disruption of complex I biogenesis during early stages of assembly. FASEB J 30:2236-48. | Human | Other cell lines | Cancer | |
| Grundmanova 2016 Physiol Res | 2016 | Grundmanová M, Jarkovská D, Süß A, Tůma Z, Marková M, Grundman Z, El-Kadi A, Čedíková M, Štengl M, Kuncová J (2016) Propofol-induced mitochondrial and contractile dysfunction of the rat ventricular myocardium. Physiol Res 65:S601-9. | Rat | Heart | Cardiovascular | |
| Distefano 2016 J Gerontol A Biol Sci Med Sci | 2016 | Distefano G, Standley RA, Dubé JJ, Carnero EA, Ritov VB, Stefanovic-Racic M, Toledo FG, Piva SR, Goodpaster BH, Coen PM (2016) Chronological age does not influence ex-vivo mitochondrial respiration and quality control in skeletal muscle. J Gerontol A Biol Sci Med Sci 72:535-42. | Human | Skeletal muscle | Aging;senescence | |
| Price 2016 J Thermal Biol | 2016 | Price ER, Sirsat TS, Sirsat SKG, Kang G, Keereetaweep J, Aziz M, Chapman KD, Dzialowski EM (2016) Thermal acclimation in American alligators: Effects of temperature regime on growth rate, mitochondrial function, and membrane composition. J Thermal Biol p11. | Reptiles | Heart Skeletal muscle | Temperature | |
| Rackham 2016 Cell Rep | 2016 | Rackham O, Busch JD, Matic S, Siira SJ, Kuznetsova I, Atanassov I, Ermer JA, Shearwood AM, Richman TR, Stewart JB, Mourier A, Milenkovic D, Larsson NG, Filipovska A (2016) Hierarchical RNA processing is required for mitochondrial ribosome assembly. Cell Rep 16:1874-90. | Mouse | Heart | ||
| Ehinger 2016 Mov Disord | 2016 | Ehinger JK, Morota S, Hansson MJ, Gesine P, Elmér E (2016) Mitochondrial respiratory function in peripheral blood cells from Huntington’s disease patients. Mov Disord doi:10.1002/mdc3.12308. | Human | Blood cells Lymphocyte Platelet | Neurodegenerative | |
| Hagl 2016 Nutr Neurosci | 2016 | Hagl S, Berressem D, Grewal R, Grebenstein N, Frank J, Eckert GP (2016) Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice. Nutr Neurosci 19:1-10. | Mouse | Nervous system | Aging;senescence Neurodegenerative | |
| Wijermars 2016 Am J Transplant | 2016 | Wijermars LG, Schaapherder AF, Kostidis S, Wüst RC, Lindeman JH (2016) Succinate accumulation and ischemia reperfusion injury: of mice but not men - A study in renal ischemia reperfusion. Am J Transplant 16:2741-6. | Human Pig Mouse Rat | Kidney | Ischemia-reperfusion Oxidative stress;RONS | |
| Gehrig 2016 Orphanet J Rare Dis | 2016 | Gehrig SM, Mihaylova V, Frese S, Mueller SM, Ligon-Auer M, Spengler CM, Petersen JA, Lundby C, Jung HH (2016) Altered skeletal muscle (mitochondrial) properties in patients with mitochondrial DNA single deletion myopath. Orphanet J Rare Dis 11:105. | Human | Skeletal muscle | Myopathy | |
| Strifler 2016 Magyar Sebeszet | 2016 | Strifler G, Meszaros A, Pecz D, Ficzere A, Barath B, Mihaly B, Hartmann P (2016) A májfunkció vizsgálata respirometriával - Examination of liver mitochondria with respirometry. Magyar Sebészet 69:194–8. | Rat | Liver | Ischemia-reperfusion | |
| Koncsos 2016 Am J Physiol Heart Circ Physiol | 2016 | Koncsos G, Varga ZV, Baranyai T, Boengler K, Rohrbach S, Li L, Schlüter KD, Schreckenberg R, Radovits T, Oláh A, Mátyás C, Lux Á, Al-Khrasani M, Komlódi T, Bukosza N, Máthé D, Deres L, Barteková M, Rajtík T, Adameová A, Szigeti K, Hamar P, Helyes Z, Tretter L, Pacher P, Merkely B, Giricz Z, Schulz R, Ferdinandy P (2016) Diastolic dysfunction in prediabetic male rats: role of mitochondrial oxidative stress. Am J Physiol Heart Circ Physiol 311:H927-43. | Rat | Heart | Oxidative stress;RONS | Cardiovascular Diabetes |
| Tam 2016 Eur J Appl Physiol | 2016 | Tam E, Bruseghini P, Calabria E, Sacco LD, Doria C, Grassi B, Pietrangelo T, Pogliaghi S, Reggiani C, Salvadego D, Schena F, Toniolo L, Verratti V, Vernillo G, Capelli C (2016) Gokyo Khumbu/Ama Dablam Trek 2012: effects of physical training and high-altitude exposure on oxidative metabolism, muscle composition, and metabolic cost of walking in women. Eur J Appl Physiol 116:129-44. | Human | Skeletal muscle | ||
| Hagl 2016 Neuromolecular Med | 2016 | Hagl S, Asseburg H, Heinrich M, Sus N, Blumrich EM, Dringen R, Frank J, Eckert GP (2016) Effects of long-term rice bran extract supplementation on survival, cognition and brain mitochondrial function in aged NMRI mice. Neuromolecular Med 18:347-63. | Mouse | Nervous system | Aging;senescence Alzheimer's Neurodegenerative | |
| Tretter 2016 Biochim Biophys Acta | 2016 | Tretter L, Patocs A, Chinopoulos C (2016) Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis. Biochim Biophys Acta 1857:1086-101. | Oxidative stress;RONS | Cancer | ||
| Schoepf 2016 FEBS J | 2016 | Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. FEBS J 283:2181-96. | Human | Endothelial;epithelial;mesothelial cell Genital Other cell lines Fibroblast | Cancer | |
| Morad 2016 J Lipid Res | 2016 | Morad SA, Ryan TE, Neufer PD, Zeczycki TN, Davis TS, MacDougall MR, Fox TE, Tan SF, Feith DJ, Loughran TP Jr, Kester M, Claxton DF, Barth BM, Deering TG, Cabot MC (2016) Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia. J Lipid Res 57:1231-42. | Human | Blood cells Other cell lines | Cell death | Cancer |
| Edgett 2016 Exp Physiol | 2016 | Edgett BA, Hughes MC, Matusiak JB, Perry CG, Simpson CA, Gurd BJ (2016) SIRT3 gene expression but not SIRT3 subcellular localization is altered in response to fasting and exercise in human skeletal muscle. Exp Physiol 101:1101-13. | Human | Skeletal muscle | ||
| Chowdhury 2015 Biosci Rep | 2016 | Chowdhury SK, Djordjevic J, Albensi B, Fernyhough P (2015) Simultaneous evaluation of substrate-dependent oxygen consumption rates and mitochondrial membrane potential by TMRM and safranin in cortical mitochondria. Biosci Rep 36:e00286. | Mouse | Nervous system | Alzheimer's | |
| Granata 2016 FASEB J | 2016 | Granata C, Oliveira RS, Little JP, Renner K, Bishop DJ (2016) Mitochondrial adaptations to high-volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle. FASEB J 30:3413-23. | Human | Skeletal muscle | ||
| Du 2016 J Exp Biol | 2016 | Du SN, Mahalingam S, Borowiec BG, Scott GR (2016) Mitochondrial physiology and reactive oxygen species production are altered by hypoxia acclimation in killifish (Fundulus heteroclitus). J Exp Biol 219:1130-8. | Fishes | Liver | Oxidative stress;RONS | |
| Witt 2016 Metab Brain Dis | 2016 | Witt AM, Larsen FS, Bjerring PN (2016) Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity. Metab Brain Dis 32:461-70. | Rat | Nervous system | Other | |
| Heinonen 2016 Hum Exp Toxicol | 2016 | Heinonen JA, Schramko AA, Skrifvars MB, Litonius E, Backman JT, Mervaala E, Rosenberg PH (2016) The effects of intravenous lipid emulsion on hemodynamic recovery and myocardial cell mitochondrial function after bupivacaine toxicity in anesthetized pigs. Hum Exp Toxicol 36:365-75. | Pig | Heart | Cardiovascular | |
| Du 2016 Thesis | 2016 | Du X (2016) Anthropogenic pollution effects on mitochondrial energy metabolism, gene expression, and genotypes of natural Fundulus heteroclitus populations. Dissertation p175. | Fishes | Liver | ||
| Strifler 2016 PLOS ONE | 2016 | Strifler G, Tuboly E, Szél E, Kaszonyi E, Cao C, Kaszaki J, Mészáros A, Boros M, Hartmann P (2016) Inhaled methane limits the mitochondrial electron transport chain dysfunction during experimental liver ischemia-reperfusion injury. PLOS ONE 11:e0146363. | Rat | Liver | Ischemia-reperfusion | |
| Mills 2016 Cell Metab | 2016 | Mills KF, Yoshida S, Stein LR, Uchida K, Yoshino J, Imai SI (2016) Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab 24:1–12. | Mouse | Skeletal muscle | Aging;senescence | |
| Teulier 2016 Proc Biol Sci | 2016 | Teulier L, Weber JM, Crevier J, Darveau CA (2016) Proline as a fuel for insect flight: enhancing carbohydrate oxidation in hymenopterans. Proc Biol Sci 283: 20160333. | Hexapods | Skeletal muscle | ||
| Cacabelos 2016 Acta Neuropathol Commun | 2016 | Cacabelos D, Ramírez-Núñez O, Granado-Serrano AB, Torres P, Ayala V, Moiseeva V, Povedano M, Ferrer I, Pamplona R, Portero-Otin M, Boada J (2016) Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS. Acta Neuropathol Commun 4:3. | Mouse | Nervous system Other cell lines | Neurodegenerative | |
| Wang 2016 J Biol Chem | 2016 | Wang H, Lu J, Edmunds LR, Kulkarni S, Dolezal J, Tao J, Ranganathan S, Jackson L, Fromherz M, Stolz DB, Uppala R, Bharathi S, Monga SP, Goetzman ES, Prochownik EV (2016) Coordinated activities of multiple Myc-dependent and Myc-independent biosynthetic pathways in Hepatoblastoma. J Biol Chem 291:26241-51. | Mouse | Liver | Cancer | |
| Frey 2016 Biochim Biophys Acta | 2016 | Frey S, Geffroy G, Desquiret-Dumas V, Gueguen N, Bris C, Belal S, Amati-Bonneau P, Chevrollier A, Barth M, Henrion D, Lenaers G, Bonneau D, Reynier P, Procaccio V (2016) The addition of ketone bodies alleviates mitochondrial dysfunction by restoring complex I assembly in a MELAS cellular model. Biochim Biophys Acta 1863:284-91. | Human | Nervous system | Other | |
| Ferguson 2016 J Bioenerg Biomembr | 2016 | Ferguson MA, Sutton RM, Karlsson M, Sjövall F, Becker LB, Berg RA, Margulies SS, Kilbaugh TJ (2016) Increased platelet mitochondrial respiration after cardiac arrest and resuscitation as a potential peripheral biosignature of cerebral bioenergetic dysfunction. J Bioenerg Biomembr 48:269-79. | Pig | Nervous system Platelet | Cardiovascular | |
| Chu 2016 World J Gastroenterol | 2016 | Chu MJ, Premkumar R, Hickey AJ, Jiang Y, Delahunt B, Phillips AR, Bartlett A (2016) Steatotic livers are susceptible to normothermic ischemia-reperfusion injury from mitochondrial Complex-I dysfunction. World J Gastroenterol 22:4673-84. | Rat | Liver | Ischemia-reperfusion | Obesity Other |
| Bai 2016 PLOS ONE | 2016 | Bai F, Fink BD, Yu L, Sivitz WI (2016) Voltage-dependent regulation of Complex II energized mitochondrial oxygen flux. PLOS ONE 11:e0154982. | Mouse | Heart Skeletal muscle Nervous system Liver | Oxidative stress;RONS | |
| Gariani 2016 J Hepatol | 2016 | Gariani K, Ryu D, Menzies KJ, Yi HS, Stein S, Zhang H, Perino A, Lemos V, Katsyuba E, Jha P, Vijgen S, Rubbia-Brandt L, Kim YK, Kim JT, Kim KS, Shong M, Schoonjans K, Auwerx J (2016) Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease. J Hepatol 66:132-41. | Mouse | Liver | Other | |
| Hartmannova 2016 Hum Mol Genet | 2016 | Hartmannová H, Piherová L, Tauchmannová K, Kidd K, Acott PD, Crocker JF, Oussedik Y, Mallet M, Hodaňová K, Stránecký V, Přistoupilová A, Barešová V, Jedličková I, Živná M, Sovová J, Hůlková H, Robins V, Vrbacký M, Pecina P, Kaplanová V, Houštěk J, Mráček T, Thibeault Y, Bleyer AJ, Kmoch S (2016) Acadian variant of Fanconi syndrome is caused by mitochondrial respiratory chain complex I deficiency due to a non-coding mutation in complex I assembly factor NDUFAF6. Hum Mol Genet 25:4062-79. | Human | Fibroblast | Inherited | |
| Hamilton 2016 Am J Physiol Heart Circ Physiol | 2016 | Hamilton DJ, Zhang A, Li S, Cao TN, Smith JA, Vedula I, Cordero-Reyes AM, Youker KA, Torre-Amione G, Gupte AA (2016) Combination of angiotensin II and l-NG-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure. Am J Physiol Heart Circ Physiol 310:H667-80. | Mouse | Heart | Oxidative stress;RONS | Cardiovascular |
| ... further results | ||||||
List of publications: N and S and NS and Gp(CI and CII and CI&II and CGpDH)
MitoPedia methods: Respirometry
MitoPedia topics:
Substrate and metabolite
