Bajpeyi 2015 Abstract MiPschool Cape Town 2015
|Twelve weeks of pioglitazone treatment improves insulin sensitivity, lipid utilization and metabolic flexibility - but not maximal ATP synthesis rates.|
Bajpeyi S (2015)
Event: MiPschool Cape Town 2015
Pioglitazone (Pio) is known to improve insulin sensitivity in skeletal muscle. However, the role of Pio on skeletal muscle lipid metabolism and skeletal muscle oxidative capacity is not clear.
The purpose of this study was to determine the effects of 12 weeks of pioglitazone treatment on insulin sensitivity measured by hyperinsulinemic euglycemic clamp, intramyocellular lipid content (IMCL) measured by proton magnetic resonance spectroscopy, metabolic flexibility measured by calculating delta RQ during the steady state of the clamp and muscle maximal ATP synthesis capacity (ATPmax) measured by 31P Magnetic Resonance Spectroscopy. Twenty-four participants with type 2 diabetes (13M/11F 53.38 2.1 years; BMI 36.471.1) were randomized to either a placebo (n=8) or a Pio (n=16) group. After 12 weeks of Pio treatment, there was an increase in insulin sensitivity (Placebo 2.2% vs. Pio 90.1% increase; p=< 0.05) and an increase in metabolic flexibility (delta RQ; Placebo 0.0630.01 to 0.0330.01; p=0.02 vs. Pio 0.0610.01 to 0.0880.02; p=0.03). Pio treatment decreased plasma free fatty acids (Placebo vs. Pio 16% increase vs. -7.7% decrease; p=0.04) and IMCL content in Gastrocnemius (Placebo -1.1% vs. Pio -56.5% decrease, p=0.005), Soleus (Placebo -0.4% vs. Pio -21.8% decrease, p<0.05) and Tibialis anterior muscle (Placebo -1.1% vs. Pio -39.5% decrease, p=0.003). There was no change in ATPmax after Pio treatment (Placebo 15.8% vs. Pio 6.1%, p=0.6). These results suggest that 12 weeks of pioglitazone treatment improves insulin sensitivity, metabolic flexibility and lipid utilization independent of any improvement in maximal ATP synthesis capacity in skeletal muscle.
• O2k-Network Lab: US TX El Paso Bajpeyi S
Labels: MiParea: Respiration, mt-Medicine, Patients Pathology: Diabetes
Organism: Human Tissue;cell: Skeletal muscle
College Health Sc, Univ Texas El Paso, USA. - [email protected]