Duplaquet 2020 Elife

From Bioblast
Publications in the MiPMap
Duplaquet L, Leroy C, Vinchent A, Paget S, Lefebvre J, Vanden Abeele F, Lancel S, Giffard F, Paumelle R, Bidaux G, Heliot L, Poulain L, Furlan A, Tulasne D (2020) Control of cell death/survival balance by the MET dependence receptor. Elife 9:e50041.

Β» PMID: 32091387 Open Access

Duplaquet L, Leroy C, Vinchent A, Paget S, Lefebvre J, Vanden Abeele F, Lancel S, Giffard F, Paumelle R, Bidaux G, Heliot L, Poulain L, Furlan A, Tulasne D (2020) Elife

Abstract: Control of cell death/survival balance is an important feature to maintain tissue homeostasis. Dependence receptors are able to induce either survival or cell death in presence or absence of their ligand, respectively. However, their precise mechanism of action and their physiological importance are still elusive for most of them including the MET receptor. We evidence that pro-apoptotic fragment generated by caspase cleavage of MET localizes to the mitochondria-associated membrane region. This fragment triggers a calcium transfer from endoplasmic reticulum to mitochondria, which is instrumental for the apoptotic action of the receptor. Knock-in mice bearing a mutation of MET caspase cleavage site highlighted that p40MET production is important for FAS-driven hepatocyte apoptosis, and demonstrate that MET acts as a dependence receptor in vivo. Our data shed light on new signaling mechanisms for dependence receptors' control of cell survival/death balance, which may offer new clues for the pathophysiology of epithelial structures.

Β© 2020, Duplaquet et al. β€’ Keywords: Apoptosis, Calcium, Cell biology, Hepatocyte, Mouse, Receptor tyrosine kinase β€’ Bioblast editor: Plangger M β€’ O2k-Network Lab: FR Lille Duez H, FR Lille Lancel Steve


Labels:

Stress:Cell death  Organism: Human  Tissue;cell: HEK  Preparation: Permeabilized cells 



HRR: O2k-Fluorometer 

2020-03, CaG 

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