El-Bacha 2012 Int J Biochem Cell Biol
|El-Bacha T, Da Poian AT (2012) Virus-induced changes in mitochondrial bioenergetics as potential targets for therapy. Int J Biochem Cell Biol 45:41-6.|
Abstract: Infectious diseases such as those caused by virus, account for a vast proportion of deaths worldwide. Re-emerging aspects of host-virus interactions in recent literature include the vital role played by host metabolism on viral replication and the pro-active participation of mitochondria in this process. Different viruses use distinctive strategies to modulate mitochondrial bioenergetics and enhance viral replication. As a result, energy yielding metabolic pathways are programmed to provide both energy and biosynthetic resources to drive viral protein synthesis and produce infectious particles. Therefore, metabolic antagonists may prove important not only to outline efficient therapy strategies but also to shed light on the pathogenesis of viral infections.
• Keywords: Viral infections, Mitochondrial bioenergetics, Host metabolism, Metabolic antagonists
• O2k-Network Lab: BR Rio de Janeiro Da Poian AT
Stress:Oxidative stress;RONS Organism: Human, Mouse Tissue;cell: Nervous system, Liver, Fibroblast Preparation: Intact cells