Forgan 2012 J Comp Physiol B
| Forgan LG, Forster ME (2012) Oxygen dependence of metabolism and cellular adaptation in vertebrate muscles: a review. J Comp Physiol B 182:177-88. |
Forgan LG, Forster ME (2012) J Comp Physiol B
Abstract: The key roles the cardiovascular system play in the complex distribution of blood, and consequently oxygen, have been extensively studied in vertebrates. Numerous studies have also revealed the complex and varied ways in which tissues cope with compromised oxygen supply. The links between these two processes are the subject of much current research. This article aims to review how blood supply influences tissue oxygenation and affects metabolism, and how this might have played a role in the evolution of the complex muscle arrangements which characterise vertebrates. Muscle tissue is the greatest proportion of body mass in most vertebrates and undergoes dramatic alterations in metabolism and associated oxygen flux. Special attention is given to the myotome of fishes, in which the partitioning of the fibre types contrasts with the mosaic arrangement of tetrapods. This gives us the opportunity to study pure whole vascularised muscle blocks, rather than single fibres, and further explore the interrelationship between oxygen supply and tissue energetics. • Keywords: Oxygen dependence, Metabolism, Muscle
Labels: MiParea: Respiration
Tissue;cell: Skeletal muscle
