Labajova 2006 Gen Physiol Biophys

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LΓ‘bajovΓ‘ A, KofrΓ‘nek J, KrivΓ‘kovΓ‘ P, CervinkovΓ‘ Z, Drahota Z (2006) Tetraphenylphosphonium-Selective Electrode as a Tool for Evaluating Mitochondrial Permeability Transition Pore Function in Isolated Rat Hepatocytes. Gen Physiol Biophys 25:325-31.

Β» PMID: 17197730 Open Access

Labajova Anna, Kofranek J, Stankova Pavla, Cervinkova Zuzana, Drahota Zdenek (2006) Gen Physiol Biophys

Abstract: The changes in mitochondrial membrane potential (Ξ”Οˆm) were used as an indicator for evaluating the mitochondrial permeability transition pore (MPTP) function. We found that in situ mitochondria in digitonin-permeabilized hepatocytes were coupled and responded to the addition of substrates, inhibitors and uncouplers. Ca2+-induced Ξ”Οˆm dissipation was caused by MPTP opening because this process was inhibited by cyclosporin A. MPTP opening was enhanced by the pro-oxidant tert-butyl hydroperoxide. β€’ Keywords: Tetraphenylphosphonium-selective electrode, Mitochondrial permeability transition pore, Hepatocytes

β€’ O2k-Network Lab: CZ Hradec Kralove Cervinkova Z


Organism: Rat  Tissue;cell: Liver  Preparation: Permeabilized cells 

HRR: Oxygraph-2k 

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