Malate-aspartate shuttle

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Malate-aspartate shuttle

Description

The malate-aspartate shuttle involves the glutamate-aspartate carrier and the 2-oxoglutarate carrier exchanging malate2- for 2-oxoglutarate2-. Cytosolic and mitochondrial malate dehydrogenase and transaminase complete the shuttle for the transport of cytosolic NADH into the mitochondrial matrix. It is most important in heart, liver and kidney.


Reference: Gnaiger 2020 BEC MitoPathways


  • Scaduto RC Jr (1994) Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria. Eur J Biochem 223:751-8. - »Bioblast link«


MitoPedia methods: Respirometry 


MitoPedia topics: Enzyme