Malate dehydrogenase

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Malate dehydrogenase

Description

Mitochondrial malate dehydrogenase is localized in the mitochondrial matrix and oxidizes malate, generated from fumarate by fumarase, to oxaloacetate, reducing NAD+ to NADH+H+ in the TCA cycle. Malate is added as a substrate in most N-pathway control states.

Abbreviation: mtMDH

Reference: Gnaiger 2020 BEC MitoPathways


  • Dasika SK, Vinnakota KC, Beard DA (2015) Determination of the catalytic mechanism for mitochondrial malate dehydrogenase. Biophys J 108:408-19. - »Bioblast link«



MitoPedia topics: Enzyme