Malonyl-CoA synthase

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Malonyl-CoA synthase


Malonyl-CoA synthase or ACSF3 protein is a mitochondrial fatty-acyl-CoA synthase found in mammals. Traditionally, malonyl-CoA is formed from acetyl-CoA by the action of acetyl-CoA carboxylase. However, Witkowski et al (2011) showed that mammals express malonyl-CoA Synthase (ACSF3) with enzymatic activity in the presence of malonate (Complex II inhibitor) and methylmalonate.

Reference: Witkowski 2011 J Biol Chem

MitoPedia topics: Enzyme