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Mottahedin 2017 J Cereb Blood Flow Metab

From Bioblast
Publications in the MiPMap
Mottahedin A, Svedin P, Nair S, Mohn CJ, Wang X, Hagberg H, Ek J, Mallard C (2017) Systemic activation of Toll-like receptor 2 suppresses mitochondrial respiration and exacerbates hypoxic-ischemic injury in the developing brain. J Cereb Blood Flow Metab 37:1192-8.

Β» PMID: 28139935 Open Access

Mottahedin A, Svedin P, Nair S, Mohn CJ, Wang Xi, Hagberg H, Ek J, Mallard C (2017) J Cereb Blood Flow Metab

Abstract: Infection and inflammation are known risk factors for neonatal brain injury. Mycoplasma and Gram-positive bacteria, for which Toll-like receptor 2 (TLR2) plays a key role in recognition and inflammatory response, are among the most common pathogens in the perinatal period. Here, we report that systemic activation of TLR2 by Pam3CSK4 (P3C) increases neural tissue loss and demyelination induced by subsequent hypoxia-ischemia (HI) in neonatal mice. High-resolution respirometry of brain isolated mitochondria revealed that P3C suppresses ADP-induced oxidative phosphorylation, the main pathway of cellular energy production. The results suggest that infection and inflammation might contribute to HI-induced energy failure. β€’ Keywords: Cerebral palsy, Birth asphyxia, Metabolism, Perinatal brain injury β€’ Bioblast editor: Kandolf G β€’ O2k-Network Lab: SE Gothenburg Hagberg H


Labels: MiParea: Respiration  Pathology: Other  Stress:Ischemia-reperfusion  Organism: Mouse  Tissue;cell: Nervous system  Preparation: Isolated mitochondria 


Coupling state: LEAK, OXPHOS, ET  Pathway:HRR: Oxygraph-2k