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From Bioblast

Bioblast 2022


Tyrolean Government grant
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  • The project O2k-Innovation (officially NextGen-O2k project) was supported by the "Technologieförderungsprogramm - Tiroler Innovationsförderung" of the Tyrolean Government.
  • Project duration: 2015-02-01 to 2017-01-31
  • Partners in the Oroboros Ecosystem: WGT Elektronik, Software Security Networks
  • Application: 2015-01-30; Granted: 2015-03-24 (total budget € 350.000)
  • Funding: € 140,000 plus a bonus of € 5,000 for the implementation of gender sensitive actions

O2k-Innovation publication

  • Harrison DK, Fasching M, Fontana-Ayoub M, Gnaiger E (2015) Cytochrome redox states and respiratory control in mouse and beef heart mitochondria at steady-state levels of hypoxia. J Appl Physiol Aug 6:jap.00146.2015. doi: 10.1152/japplphysiol.00146.2015. - »Bioblast link«

The fourth dimension of respiratory control

  1. On the "line": one dimension is insufficient.
  2. Coupling and pathway control are two necessarily connected dimensions defining the “area” of respiratory control.
  3. Adding kinetics (including substrate kinetics of O2, CHO, adenylates, Pi, and flux-force kinetics) is the third dimension bringing “volume” into the picture of classical mitochondrial respiratory control.
  4. The O2k-Innovation on top of O2k-MultiSensor modules and the O2k-FluoRespirometer represent the fourth dimension of respiratory control, by adding analysis of functional variables (such as ROS production, mt-membrane potential, Ca2+, proton flux, cytochrome and NADH redox states, ATP production) to the measurement of O2 and O2-flux in the same chamber.

Development of the O2k-Innovation prototype: a look inside

Different stages of prototype development: The O2k-Innovation is becoming more and more packed with two spectrofluorometers, two spectrophotometers, light guides, Peltier temperatue control with new heat pipes, microelectronics.