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O2k-Publications alert - 2023
- Mitochondria and Cell Research - the Oroboros Ecosystem
- » Listed in Oroboros Ecosystem Agenda
Sep 2023
- Sep- 15 Fr - World Lymphoma Awareness Day
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"Respirometry assays confirmed that OXPHOShigh Richter transformation cells had a 3.5-fold higher oxygen consumption at ROUTINE respiration and fivefold higher electron transfer system capacity compared to chronic lymphocytic leukemia"
- Nadeu F, Royo R, Massoni-Badosa R, Playa-Albinyana H, Garcia-Torre B, et al (2022) Detection of early seeding of Richter transformation in chronic lymphocytic leukemia. »Bioblast link«
- from the O2k-Network »ES Barcelona Garcia-Roves PM« and »ES Barcelona IDIBAPS Hospital Clinic«
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"The higher ROS release rates observed in both the muscle and liver of older individuals may suggest that increased ROS release is evidence of mitochondrial dysfunction during ageing in finches."
- Salmón P, Millet C, Selman C, Monaghan P, Dawson NJ (2023) Tissue-specific reductions in mitochondrial efficiency and increased ROS release rates during ageing in zebra finches, Taeniopygia guttata. »Bioblast link«
- from the O2k-Network »DE Wilhelmshaven Salmon P«, »UK Glasgow Metcalfe NB«
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"...enhancing mitochondrial function by either overexpressing parkin or bypassing defective mitochondrial complexes has significant beneficial effects in a fly model of HD [Huntington's disease], rescuing neurodegeneration and enhancing viability and lifespan."
- Campesan S, Del Popolo I, Marcou K, Straatman-Iwanowska A, Repici M, Boytcheva KV, Cotton VE, Allcock N, Rosato E, Kyriacou CP, Giorgini F (2023) Bypassing mitochondrial defects rescues Huntington's phenotypes in Drosophila. »Bioblast link«
- from the O2k-Network »UK Leicester Giorgini F«
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Aug 2023
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"Our study showed that salinity modulates the mitochondrial responses to long-term and acute hypoxia exposure in an euryhaline intertidal bivalve C. gigas."
- Steffen JBM, Sokolov EP, Sokolova IM (2023) Combined effects of salinity and intermittent hypoxia on mitochondrial capacity and reactive oxygen species efflux in the Pacific oyster, Crassostrea gigas »Bioblast link«
- from the O2k-Network »DE Rostock Sokolova I«
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"Altogether, our results show that chronic hypoxia optimizes the efficiency of mitochondrial ATP synthesis in the retrosplenial cortex of mice. Contrastingly, rats sustain the production of ATP only by increasing mitochondrial content and altering mitochondrial dynamics, suggesting drastic mitochondrial malfunctions."
- Arias-Reyes C, Aliaga-Raduán F, Pinto-Aparicio R, Joseph V, Soliz J (2023) Mitochondrial plasticity in the retrosplenial cortex enhances ATP synthesis during acclimatization to hypoxia in mice but not in rats. MitoFit Preprints 2023.6. https://doi.org/10.26124/mitofit:2023-0006
- from the O2k-Network »CA Quebec Soliz J«
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"Understanding acylcarnitine metabolic and signaling pathways provides a better rationale for selecting targets for therapeutic interventions."
- Dambrova M, Makrecka-Kuka M, Kuka J, Vilskersts R, Nordberg D, Attwood MM, Smesny S, Sen ZD, Guo AC, Oler E, Tian S, Zheng J, Wishart DS, Liepinsh E, Schioth HB. (2022) Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials. »Bioblast link«
- from the O2k-Network »LV Riga Liepins E«
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"... species-specific differences in cardiac metabolic capacity [...] may influence the acclimation potential of notothenioid fishes to changing environmental conditions."
- Mandic M, Frazier AJ, Naslund AW, Todgham AE (2022) A comparative and ontogenetic examination of mitochondrial function in antarctic notothenioid species. »Bioblast link«
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"Reducing lipid hydroxides by GPX4 overexpression ameliorates the majority of muscle atrophy and weakness phenotypes present in mouse models of sarcopenia"
- Czyżowska A, Brown J, Xu H, Sataranatarajan K, Kinter M, Tyrell VJ, O'Donnell VB, Van Remmen H (2023) Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness. »Bioblast link«
- from the O2k-Network »US OK Oklahoma City Van Remmen H«
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An overview of the “do’s and don’ts” when it comes to assessing mitochondrial function in Drosophila
- Rodríguez E, Bettinazzi S, Inwongwan S, Camus MF, Lane N (2023) Harmonizing protocols to measure Drosophila respiratory function in mitochondrial preparations. Bioenerg Commun 2023.3. https://doi.org/10.26124/bec:2023-0003
- from the O2k-Network »UK London Lane N«
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"Hepatocyte-derived cells maintain cellular and mitochondrial Ca2+ concentrations within strictly controlled ranges, maximizing electron transport capacity by promoting the Goldilocks Ca2+ “sweet spot” for oxidative phosphorylation activity: neither too much nor too little, but just right."
- Vilas-Boas EA, Cabral-Costa JV, Ramos VM, Caldeira da Silva CC, Kowaltowski AJ (2023) Goldilocks calcium concentrations and the regulation of oxidative phosphorylation: too much, too little, or just right. »Bioblast link«
- from the O2k-Network »BR Sao Paulo Kowaltowski AJ«
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Jul 2023
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Mitochondrial function abnormalities in patients with heart failure with preserved ejection fraction are associated with exercise intolerance and represent novel therapeutic targets.
- Scandalis L, Kitzman DW, Nicklas BJ, Lyles M, Brubaker P, Nelson MB, Gordon M, Stone J, Bergstrom J, Neufer PD, Gnaiger E, Molina AJA (2023) Skeletal muscle mitochondrial respiration and exercise intolerance in patients with heart failure with preserved ejection fraction. »Bioblast link«
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"A cancer-selective Na+ increase correlated with HCC [hepatocellular carcinoma] cell killing, and a slower growth rate of HCC xenograft tumors."
- Clemente N, Baroni S, Fiorilla S, Tasso F, Reano S, Borsotti C, Ruggiero MR, Alchera E, Corrazzari M, Walker G, Follenzi A, Crich SG, Carini R (2023) Boosting intracellular sodium selectively kills hepatocarcinoma cells and induces hepatocellular carcinoma tumor shrinkage in mice. »Bioblast link«
- from the O2k-Network »IT Novara Filigheddu N«
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Triplefin fish species have different ROS production and electron leakage according to their tolerance to hypoxia.
- Devaux JBL, Hedges CP, Birch N, Herbert N, Renshaw GMC, Hickey AJR (2023) Electron transfer and ROS production in brain mitochondria of intertidal and subtidal triplefin fish (Tripterygiidae). »Bioblast link«
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"G3 MB [Group 3 medulloblastoma] cells demonstrate exquisite sensitivity towards inhibitors of complex-I in the electron transport [system (ETS)] but not to other metabolism-targeting agents, including glycolytic inhibitors."
- Martell E, Kuzmychova H, Kaul E, Senthil H, Chowdhury SR, Morrison LC, Fresnoza A, Zagozewski J, Venugopal C, Anderson CM, Singh SK, Banerji V, Werbowetski-Ogilvie TE, Sharif T (2023) Metabolism-based targeting of MYC via MPC-SOD2 axis-mediated oxidation promotes cellular differentiation in group 3 medulloblastoma. »Bioblast link«
- from the O2k-Network »CA Winnipeg Banerji V«
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Jun 2023
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"This study reinforces the strict aerobic status of M. tuberculosis and indicates that the therapeutic value of inhibiting the terminal oxidases is relevant even under nano-oxic conditions found in TB [tuberculosis] lung granulomas."
- Kalia NP, Singh S, Hards K, Cheung CY, Sviriaeva E, Banaei-Esfahani A, Aebersold R, Berney M, Cook GM, Pethe K (2023) M. tuberculosis relies on trace oxygen to maintain energy homeostasis and survive in hypoxic environments. »Bioblast link«
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"BAM15 is a tolerable and efficacious protonophore that protects against diet‐induced obesity."
- Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP (2021) BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. »Bioblast link«
- from the O2k-Network »US LA Baton Rouge Noland RC« and »US OH Cleveland Hoppel CL«
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"Obesity has an opposing association with mitochondrial respiration in adipose- and liver tissue with no overall association with NAFLD (nonalcoholic fatty liver disease) severity."
- Pedersen JS, Rygg MO, Chrøis K, Sustarsic EG, Gerhart-Hines Z, Wever Albrechtsen NJ, Serizawa RR, Kristiansen VB, Basse AL, Boilesen AEB, Olsen BH, Hansen T, Gluud LL, Madsbad S, Larsen S, Bendtsen F, Dela F (2022) Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration. »Bioblast link«
- from the O2k-Network »DK Copenhagen Gerhart-Hines Z« and »DK Copenhagen Larsen S«
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May 2023
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"Such markers [of mitochondrial function] could help to identify metabolic changes before the disease becomes irreversible and at a stage where therapeutic and lifestyle intervention could be more effective, thus reducing the burden of the health and economic costs of this epidemic."
- Calabria E, Muollo V, Cavedon V, Capovin T, Saccenti L, Passarotti F, Ghiotto L, Milanese C, Gelati M, Rudi D, Salvagno GL, Lippi G, Tam E, Schena F, Pogliaghi S (2023) Type 2 diabetes related mitochondrial defects in peripheral mononucleated blood cells from overweight postmenopausal women. »Bioblast link«
- from the O2k-Network »IT Verona Venturelli M«
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"Mitochondria–nucleus communication and its integration within the maintenance of cellular homeostasis constitute key determinants of cellular fate and organism health in the context of cellular stress, homeostasis perturbation, and disease"
- Temelie M, Talpur R, Dominguez-Prieto M, Dantas Silva A, Cenusa C, Craciun L, Savu DI, Moisoi N (2023) Impaired integrated stress response and mitochondrial integrity modulate genotoxic stress impact and lower the threshold for immune signalling. »Bioblast link«
- from the O2k-Network »UK Leicester Moisoi N«
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Apr 2023
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“The variety of approaches to studying Drosophila mitochondrial function in the circa 60 studies surveyed over a 12-year period calls for a more careful consideration of the methodological approach tailored to the research questions.”
- Rodríguez E, Bettinazzi S, Inwongwan S, Camus MF, Lane N (2023) Harmonising protocols to measure Drosophila respiratory function in mitochondrial preparations. MitoFit Preprints 2023.4. https://doi.org/10.26124/mitofit:2023-0004
- from the O2k-Network »UK London Lane N«
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“The ambiguities surrounding Complex II in the literature call for quality control, to secure scientific standards in current communications on bioenergetics and support adequate clinical applications.”
- from the O2k-Network »AT Innsbruck Oroboros«
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"Our findings suggest that O2 control of mitochondrial oxidative phosphorylation can relay changes in respiration and reduce mitochondrial Ca2+ uptake... [which] may influence how muscle mitochondria adapt after contractions in conditions of hypoxia."
- Donnelly C, Komlódi T, Cecatto C, Cardoso LHD, Compagnion AC, Matera A, Tavernari D, Zanou N, Kayser B, Gnaiger E, Place N (2023) Functional hypoxia reduces mitochondrial calcium uptake. MitoFit Preprints 2023.2. https://doi.org/10.26124/mitofit:2023-0002
- from the O2k-Network »AT Innsbruck Oroboros«, »CH Lausanne Place N«, »HU Budapest Tretter L«
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Oliveira and Couto-Lima provide evidence for the importance of local stock centers in sustaining the substantial increase in the output of Drosophila mitochondrial research worldwide in recent decades.
- from the O2k-Network »BR Jaboticabal Oliveira MT«
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Mar 20223
- Mar- 24 Fr - World Tuberculosis Day-
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"The molecular structure of the bd oxidase from M. tuberculosis provides the long-sought atomic framework for the design of highly specific drugs to target this respiratory enzyme"
- Safarian S, Opel-Reading HK, Wu D, Mehdipour AR, Hards K, Harold LK, Radloff M, Stewart I, Welsch S, Hummer G, Cook GM, Krause KL, Michel H (2021) The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB. »Bioblast link«
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- Mar- 10 Fr - World Kidney Day
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"...subcapsular administration of MSC-derived EVs [extracellular vesicles secreted by adipose tissue mesenchymal cells] at the moment of reperfusion after ischemia totally recovers the normal ROS formation by mitochondria from renal proximal tubule cells in all functional respiratory states"
- Lopes JA, Collino F, Rodrigues-Ferreira C, Sampaio LDS, Costa-Sarmento G, Wendt CHC, Almeida FP, Miranda KR, Kasai-Brunswick TH, Lindoso RS, Vieyra A (2022) Early effects of extracellular vesicles secreted by adipose tissue mesenchymal cells in renal ischemia followed by reperfusion: mechanisms rely on a decrease in mitochondrial anion superoxide production »Bioblast link«
- from the O2k-Network »BR Rio de Janeiro Vieyra A«
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Natural cycling of ADP with ATP attenuates mitochondrial permeability transition in permeabilized muscle fibres: can repeating mtPT assessments with and without adenylates provide new insights?
- Bellissimo CA, Soendergaard S, Hughes MC, Ramos SV, Larsen S, Perry CGR (2022) The influence of adenylate cycling on mitochondrial calcium-induced permeability transition in permeabilized skeletal muscle fibers. Bioenerg Commun 2023.1. https://doi.org/10.26124/bec:2023-0001
- from the O2k-Network »CA Toronto Perry CG« and »DK Copenhagen Larsen S«
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- Mar- 03 Fr - World Wildlife Day
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"[...]adaptive changes in the physiology of specific mitochondrial fractions can help overcome the metabolic challenges of life in the harsh environment at high altitude."
- Dawson NJ, Scott GR (2022) Adaptive increases in respiratory capacity and O2 affinity of subsarcolemmal mitochondria from skeletal muscle of high-altitude deer mice. »Bioblast link«
- from the O2k-Network »CA Hamilton Scott GR«
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Feb 20223
- Feb- 28 Tu - Rare Disease Day
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Balbaisi and Stiban review the current knowledge on Barth Syndrome, a rare disease affecting the production of cardiolipin, the only phospholipid specific to mitochondria.
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- Feb- 15 We - International Childhood Cancer Day
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Mitochondrial respiratory dysfunction present in platelets from 10- to 11-year-old children with acute lymphoblastic leukemia
- Lelcu T, Bînă AM, Dănilă MD, Popoiu CM, Aburel OM, Arghirescu ST, Borza C, Muntean DM (2021) Assessment of platelet mitochondrial respiration in a pediatric population: A pilot study in healthy children and children with acute lymphoblastic leukemia. »Bioblast link«
- from the O2k-Network »RO Timisoara Muntean DM«
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- Feb- 13 Mo - International Epilepsy Day
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"NAC [N-acetylcysteine] modulates neuronal excitability and the appearance or propagation of seizures through its antioxidant capacity and ability to reduce glycolytic/lactic metabolism in WAR [Wistar Audiogenic Rat – a genetic model of epilepsy]"
- Dechandt CRP, Ferrari GD, Dos Santos JR, de Oliveira JAC, da Silva-Jr RMP, Cunha AOS, Garcia-Cairasco N, Alberici LC (2019) Energy metabolism and redox state in brains of wistar audiogenic rats, a genetic model of epilepsy. Front Neurol 10:1007. »Bioblast link«
- from the O2k-Network »BR Ribeirao Preto Alberici LC«
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- Feb- 11 Sa - International Day of Women and Girls in Science
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“While progress has been made, women (particularly women of color) remain underrepresented in many scientific, engineering, and medical fields, and at many levels in education and career stages.”
Read this report for actionable recommendations to promote participation of females in STEM fields:
- National Academies of Sciences, Engineering, and Medicine (2020) Promising practices for addressing the underrepresentation of women in science, engineering, and medicine: opening doors. The National Academies Press, Washington DC . »Bioblast link«
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Antitumoral properties of triterpenic acid functionalized gold nanoparticles arise from decreasing mitochondrial respiration
- Mioc M, Mioc A, Racoviceanu R, Ghiulai R, Prodea A, Milan A, Barbu Tudoran L, Oprean C, Ivan V, Șoica C (2023) The antimelanoma biological assessment of triterpenic acid functionalized gold nanoparticles. »Bioblast link«
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Jan 2023
- Jan- 24 Tu - International Day of Education
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Restricted access to academic research produces problems of social inequality in education: A re-evaluation of scientific communication and value of science is needed. Open access to research is essential, together with a bigger demand on quality control to ensure reproducibility of the results and prevent an avalanche of new publications that may go into oblivion.
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Bionenerg Commun 2022.20
Bombaça and Menna-Barreto discuss data on mitochondrial susceptibility and adaptative processes obtained by their group in the last 17 years.
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Stay alert
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