Proline dehydrogenase

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Proline dehydrogenase

Description

Proline dehydrogenase (ProDH), L-proline:quinone oxidoreductase, is located on the inner side of the mtIM, oxidizing proline to delta-1-pyrroline-5-carboxylate, with reduction of FAD to FADH2 and direct entry into the Q-junction, exerting an additive effect of convergent pathways. ProDH is widely distributed in a variety of organisms, is a source of ROS, and may play a role in carcinogenesis.

Abbreviation: ProDH

Reference: Teulier 2016 Proc Biol Sci, Kononczuk et al 2015, Soares 2015 PLoS One






MitoPedia topics: Enzyme 

Communicated by Garcia-Souza LF and Gnaiger E 2019-04-29

References

  1. Kononczuk J, Czyzewska U, Moczydlowska J, Surażyński A, Palka J, Miltyk W (2015) Proline oxidase (POX) as a target for cancer therapy. Curr Drug Targets 16:1464-9. - »PubMed 26553010«
  2. Teulier L, Weber JM, Crevier J, Darveau CA (2016) Proline as a fuel for insect flight: enhancing carbohydrate oxidation in hymenopterans. Proc Biol Sci 283: 20160333. - »Bioblast link«