Rana 2017 Nat Commun

From Bioblast
Publications in the MiPMap
Rana A, Oliveira MP, Khamoui AV, Aparicio R, Rera M, Rossiter HB, Walker DW (2017) Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster. https://doi.org/10.1038/s41467-017-00525-4

Β» Nat Commun 8:448. PMID: 28878259 Open Access

Rana Anil, Oliveira Matheus P, Khamoui Andy V, Aparicio Ricardo, Rera Michael, Rossiter Harry B, Walker David W (2017) Nat Commun

Abstract: The accumulation of dysfunctional mitochondria has been implicated in aging, but a deeper understanding of mitochondrial dynamics and mitophagy during aging is missing. Here, we show that upregulating Drp1-a Dynamin-related protein that promotes mitochondrial fission-in midlife, prolongs Drosophila lifespan and healthspan. We find that short-term induction of Drp1, in midlife, is sufficient to improve organismal health and prolong lifespan, and observe a midlife shift toward a more elongated mitochondrial morphology, which is linked to the accumulation of dysfunctional mitochondria in aged flight muscle. Promoting Drp1-mediated mitochondrial fission, in midlife, facilitates mitophagy and improves both mitochondrial respiratory function and proteostasis in aged flies. Finally, we show that autophagy is required for the anti-aging effects of midlife Drp1-mediated mitochondrial fission. Our findings indicate that interventions that promote mitochondrial fission could delay the onset of pathology and mortality in mammals when applied in midlife.Mitochondrial fission and fusion are important mechanisms to maintain mitochondrial function. Here, the authors report that middle-aged flies have more elongated, or 'hyper-fused' mitochondria, and show that induction of mitochondrial fission in midlife, but not in early life, extends the health and life of flies.

β€’ Bioblast editor: Plangger M β€’ O2k-Network Lab: BR Rio de Janeiro Oliveira MF, US FL Boca Raton Khamoui AV, US CA Torrance Rossiter HB

Labels: MiParea: Respiration 

Organism: Drosophila 

Coupling state: OXPHOS  Pathway: N, Gp, NS  HRR: Oxygraph-2k 


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