Seppet EK

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Name Seppet Enn K., Prof. Dr. MD, PhD**
Institution Faculty of Medicine

Pathophysiology

University of Tartu

Address 18 Ulikooli St., EE2400
City Tartu
State/Province
Country Estonia
Email
Weblink
O2k-Network Lab EE Tartu Seppet EK


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Publications

 PublishedReference
Paeaesuke 2015 Oxid Med Cell Longev2015Pääsuke R, Eimre M, Piirsoo A, Peet N, Laada L, Kadaja L, Roosimaa M, Pääsuke M, Märtson A, Seppet E, Paju K (2015) Proliferation of human primary myoblasts is associated with altered energy metabolism in dependence of ageing in vivo and in vitro. Oxid Med Cell Longev 8296150:10p.
Trumbeckaite 2013 Mitochondrion2013Trumbeckaite S, Gizatullina Z, Arandarcikaite O, Röhnert P, Vielhaber S, Malesevic M, Fischer G, Seppet E, Striggow F, Gellerich FN (2013) Oxygen glucose deprivation causes mitochondrial dysfunction in cultivated rat hippocampal slices: Protective effects of CsA, its immunosuppressive congener [D-Ser](8)CsA, the novel non-immunosuppressive cyclosporin derivative Cs9, and the NMDA receptor antagonist MK 801. Mitochondrion 13:539–47.
Gellerich 2012 Biochem J2012Gellerich FN, Gizatullina Z, Trumbeckaite S, Korzeniewski B, Gaynutdinov T, Seppet E, Vielhaber S, Heinze HJ, Striggow F (2012) Cytosolic Ca2+ regulates the energisation of isolated brain mitochondria by formation of pyruvate through the malate-aspartate shuttle. Biochem J 443:747-55.
Kadaja 2010 Exp Clin Cardiol2010Kadaja L, Eimre M, Paju K, Roosimaa M, Podramaegi T, Kaasik P, Pehme A, Orlova E, Mudist M, Peet N, Piirsoo A, Seene T, Gellerich FN, Seppet EK (2010) Impaired oxidative phosphorylation in overtrained rat myocardium. Exp Clin Cardiol 15:116-27.
Gellerich 2010 Biochim Biophys Acta2010Gellerich FN, Gizatullina Z, Trumbeckaite S, Nguyen HP, Pallas T, Arandarcikaite O, Vielhaber S, Seppet E, Striggow F (2010) The regulation of OXPHOS by extramitochondrial calcium. Biochim Biophys Acta 1797:1018-27.
Guerrero 2010 Mol Cell Biochem2010Guerrero K, Monge C, Brückner A, Puurand U, Kadaja L, Käämbre T, Seppet E, Saks V (2010) Study of possible interactions of tubulin, microtubular network, and STOP protein with mitochondria in muscle cells. Mol Cell Biochem 337:239-49.
Monge 2009 Can J Physiol Pharmacol 87:318-326.2009Monge C, Beraud N, Tepp K, Pelloux S, Chahboun S, Kaambre T, Kadaja L, Roosimaa M, Piirsoo A, Tourneur Y, Kuznetsov AV, Saks V, Seppet E (2009) Comparative analysis of the bioenergetics of adult cardiomyocytes and nonbeating HL-1 cells: respiratory chain activities, glycolytic enzyme profiles, and metabolic fluxes. Can J Physiol Pharmacol 87:318-26.
Gellerich 2009 PLoS One2009Gellerich FN, Gizatullina Z, Arandarcikaite O, Jerzembek D, Vielhaber S, Seppet E, Striggow F (2009) Extramitochondrial Ca2+ in the nanomolar range regulates glutamate-dependent oxidative phosphorylation on demand. PloS One 4:e8181.
Eimre 2008 Biochim Biophys Acta2008Eimre M, Paju K, Pelloux S, Beraud N, Roosimaa M, Kadaja L, Gruno M, Peet N, Orlova E, Remmelkoor R, Piirsoo A, Saks V, Seppet E (2008) Distinct organization of energy metabolism in HL-1 cardiac cell line and cardiomyocytes. Biochim Biophys Acta 1777:514-24.
Gellerich 2008 J Biol Chem2008Gellerich FN, Gizatullina Z, Nguyen HP, Trumbeckaite S, Vielhaber S, Seppet E, Zierz S, Landwehrmeyer B, Riess O, von Hörsten S, Striggow F (2008) Impaired regulation of brain mitochondria by extramitochondrial Ca2+ in transgenic huntington disease rats. J Biol Chem 283:30715-24.
Gruno 2008 J Gastroenterol2008Gruno M, Peet N, Tein A, Salupere R, Sirotkina M, Valle J, Peetsalu A, Seppet EK (2008) Atrophic gastritis: deficient complex I of the respiratory chain in the mitochondria of corpus mucosal cells. J Gastroenterol 43:780-8.
Safiulina 2006 Toxicol Sci2006Safiulina D, Peet N, Seppet E, Zharkovsky A, Kaasik A (2006) Dehydroepiandrosterone inhibits Complex I of the mitochondrial respiratory chain and is neurotoxic in vitro and in vivo at high concentrations. Toxicol Sci 93:348-56.
Seppet 2005 Mol Cell Biochem2005Seppet E, Eimre M, Peet N, Paju K, Orlova E, Ress M, Kovask S, Piirsoo A, Saks VA, Gellerich FN, Zierz S, Seppet EK (2005) Compartmentation of energy metabolism in atrial myocardium of patients undergoing cardiac surgery. Mol Cell Biochem 270:49-61.
Anmann 2005 FEBS J2005Anmann T, Eimre M, Kuznetsov AV, Andrienko T, Kaambre T, Sikk P, Seppet E, Tiivel T, Vendelin M, Seppet EK, Saks VA (2005) Calcium-induced contraction of sarcomeres changes the regulation of mitochondrial respiration in permeabilized cardiac cells. FEBS J 272:3145-61.
Safiulina 2004 J Neurosci Methods2004Safiulina D, Kaasik A, Seppet E, Peet N, Zharkovsky A, Seppet EK (2004) Method for in situ detection of the mitochondrial function in neurons. J Neurosci Methods 137:87-95.
Seppet 2003 Cardiac Remodeling and Failure2003Seppet E, Peet N, Paju K, Ress M, Saks V, Gellerich FN, Chen Y, Trumbeckaite S, Prondzinsky R, Silber R, Werdan K, Zierz S, Seppet EK (2003) Mitochondrial function in failing human myocardium in vitro: atrioventricular differences. In: Cardiac Remodeling and Failure (Singal P, Dixon I, Lorrie A. Kirshenbaum L, Dhalla N eds. Kiuwer Academic Publishers, Boston: 459-470.
Saks 2001 Biochem J2001Saks VA, Kaambre T, Sikk P, Eimre M, Orlova E, Paju K, Piirsoo A, Appaix F, Kay L, Regitz-Zagrosek V, Fleck E, Seppet E (2001) Intracellular energetic units in red muscle cells. Biochem J 356:643-57.
Seppet 2001 Biochim Biophys Acta2001Seppet EK, Kaambre T, Sikk P, Tiivel T, Vija H, Tonkonogi M, Sahlin K, Kay L, Appaix F, Braun U, Eimre M, Saks VA (2001) Functional complexes of mitochondria with Ca,Mg ATPases of myofibrils and sarcoplasmic reticulum in muscle cells. Biochim Biophys Acta 1504:379-95.
Braun 2001 Biochim Biophys Acta2001Braun U, Paju K, Eimre M, Seppet E, Orlova E, Kadaja L, Trumbeckaite S, Gellerich FN, Zierz S, Jockusch H, Seppet EK (2001) Lack of dystrophin is associated with altered integration of the mitochondria and ATPases in slow-twitch muscle cells of MDX mice. Biochim Biophys Acta 1505:258-70.
Menin 2001 Mol Cell Biochem2001Menin L, Panchichkina M, Keriel C, Olivares J, Braun U, Seppet EK, Saks VA (2001) Macrocompartmentation of total creatine in cardiomyocytes revisited. Mol Cell Biochem 220:149-59.

Abstracts

 PublishedReference
Paju 2014 Abstract MiP20142014Characterization of the effects of pro-inflammatory cytokines on energy metabolism in human myoblasts.

(**We must very sorrowfully inform that our dear colleague, Prof. Dr. Enn K Seppet, passed away.)