Silva Ramos 2016 Biochim Biophys Acta

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Silva Ramos E, Larsson NG, Mourier A (2016) Bioenergetic roles of mitochondrial fusion. Biochim Biophys Acta 1857:1277-83.

» PMID: 27060252

Silva Ramos E, Larsson NG, Mourier A (2016) Biochim Biophys Acta

Abstract: Mitochondria are bioenergetic hotspots, producing the bulk of ATP by the oxidative phosphorylation process. Mitochondria are also structurally dynamic and undergo coordinated fusion and fission to maintain their function. Recent studies of the mitochondrial fusion machinery have provided new evidence in detailing their role in mitochondrial metabolism. Remarkably, mitofusin 2, in addition to its role in fusion, is important for maintaining coenzyme Q levels and may be an integral player in the mevalonate synthesis pathway. Here, we review the bioenergetic roles of mitochondrial dynamics and emphasize the importance of the in vitro growth conditions when evaluating mitochondrial respiration. This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016,' edited by Prof. Paolo Bernardi.

Copyright © 2016. Published by Elsevier B.V.

Keywords: Bioenergetics, Coenzyme Q, Mevalonate pathway, Mitochondrial dynamics, Mitofusin 2

O2k-Network Lab: FR Bordeaux Devin A, DE Cologne Larsson NG

Labels: MiParea: Respiration, mt-Structure;fission;fusion, Genetic knockout;overexpression 

Organism: Mouse  Tissue;cell: Fibroblast  Preparation: Permeabilized cells 

Coupling state: LEAK, OXPHOS, ET  Pathway: S, Gp  HRR: Oxygraph-2k