Takahashi 2016 Exp Gerontol

From Bioblast
Jump to: navigation, search
Publications in the MiPMap
Takahashi K, Ohsawa I, Shirasawa T, Takahashi M (2016) Early-onset motor impairment and increased accumulation of phosphorylated α-synuclein in the motor cortex of normal aging mice are ameliorated by coenzyme Q. Exp Gerontol 81:65-75.

» PMID: 27143639

Takahashi K, Ohsawa I, Shirasawa T, Takahashi M (2016) Exp Gerontol

Abstract: Brain mitochondrial function declines with age; however, the accompanying behavioral and histological alterations that are characteristic of Parkinson's disease (PD) are poorly understood. We found that the mitochondrial oxygen consumption rate (OCR) and coenzyme Q (CoQ) content were reduced in aged (15-month-old) male mice compared to those in young (6-month-old) male mice. Concomitantly, motor functions, including the rate of movement and exploratory and voluntary motor activities, were significantly reduced in the aged mice compared to the young mice. In the motor cortex of the aged mouse brain, the accumulation of α-synuclein (α-syn) phosphorylated at serine129 (Ser129) significantly increased, and the level of vesicular glutamate transporter 1 (VGluT1) decreased compared with that in the young mouse brain. The administration of exogenous water-soluble CoQ10 to aged mice via drinking water restored the mitochondrial OCR, motor function, and phosphorylated α-syn and VGluT1 levels in the motor cortex. These results suggest that early-onset motor impairment and the increased accumulation of Ser129-phosphorylated α-syn in the motor cortex are ameliorated by the exogenous administration of CoQ10.

Copyright © 2016 Elsevier Inc. All rights reserved.

Keywords: Coenzyme Q, Mitochondria, Motor cortex, Motor impairment, Normal aging, α-Synuclein

O2k-Network Lab: JP Tokyo Tanaka M


Labels: MiParea: Respiration  Pathology: Aging;senescence, Parkinson's 

Organism: Mouse  Tissue;cell: Nervous system  Preparation: Isolated mitochondria 


Coupling state: OXPHOS  Pathway: N, S, ROX  HRR: Oxygraph-2k 

2016-07, JP