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Template:SUIT-020 Fluo mt D033

From Bioblast
MitoPedia: SUIT

Steps and respiratory states

1PM;2D;3G;4S;5Rot;6Omy;7U;8Ama.png

Step State Pathway Q-junction Comment - Events (E) and Marks (M)
1PM PML(n) N CI 1PM
2D PMP N CI 1PM;2D
3G PGMP N CI 1PM;2D;3G
4S PGMSP NS CI&II 1PM;2D;3G;4S
  • Respiratory stimulation by simultaneous action of type N substrates & succinate, with convergent electron flow in the NS-pathway for reconstitution of TCA cycle function.
  • OXPHOS capacity P (with saturating [ADP]), active OXPHOS state.
5Rot SP S CII 1PM;2D;3G;4S;5Rot
6Omy SL(Omy) 1PM;2D;3G;4S;5Rot;6Omy
  • Non-phosphorylating resting state (LEAK state); LEAK-respiration, L(Omy), after blocking the ATP synthase with oligomycin.
7U* SE S CII 1PM;2D;3G;4S;5Rot;6Omy;7S
8Ama ROX 1PM;2D;3G;4S;5Rot;6Omy;7S;8Ama
  • Rox is the residual oxygen consumption in the ROX state, due to oxidative side reactions, estimated after addition of antimycin A (inhibitor of CIII). Rox is subtracted from oxygen flux as a baseline for all respiratory states, to obtain mitochondrial respiration (mt).


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