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Vendelin Marko

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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping


Vendelin Marko


MitoPedia topics: EAGLE 

COST: Member COST WG1: WG1 COST WG2: WG2


COST Mentor: Mentor

WG1 Leader - Management Committee MitoEAGLE


Name Vendelin Marko, Dr.
Institution
Vendelin Marko
Laboratory of Systems Biology,

Institute of Cybernetics, EE

Address Akadeemia 21, 12618
City Tallinn
State/Province
Country Estonia
Email [email protected]
Weblink http://sysbio.ioc.ee
O2k-Network Lab


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Publications

Abstracts

 PublishedReference
Vendelin 2109 MiP20192019
Marko Vendelin
No abstract, Co-autor of Karro 2019 MiP2019.
Karro 2019 MiP20192019
Niina Karro
Respiration of permeabilized cardiomyocytes from mice: no sex differences, but substrate-dependent changes in the apparent ADPaffinity.
Vendelin 2018 MiPschool Tromso D22018
Marko Vendelin
Modeling actomyosin contraction in the heart muscle.
Vendelin 2018 MiPschool Tromso E12018
Marko Vendelin
Introducing a platform for primary kinetics data analysis.
Laasmaa 2018 MiP20182018
MiPsociety
Introducing open source platform for primary kinetics data analysis. Laasmaa_Presentation
Vendelin 2018 MiPschool Tromso B12018
Marko Vendelin
Restrictions to intracellular diffusion of ATP and ADP in cardiomyocytes.
Vendelin 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
Most of mitochondrial voltage-dependent anion channels are closed in rat cardiomyocytes


MitoEAGLE

        • Benefits for COST and for the COST Action MitoEAGLE
WG1: I think that we could contribute via participation in the evaluation of the protocols, and helping to develop them further. In addition, we have been working on the establishing a database that would allow us to keep protocol details, cell isolation and several other aspects. There is nothing very advanced, but we could contribute to establishing such data collection practice. In addition, we, as opposed to many others, happen to use Strathkelvin respirometer. This alternative hardware would allow us to verify whether the protocols work on them as well.
WG2: Our main research subject is the heart muscle cells. So, we could contribute in datasets for several animals (rat, trout, mice [WT and KOs]). In collaboration with WG1, it would be possible to report data in standardized format.


MitoEAGLE Short-Term Scientific Mission

Work Plan summary
The aims of this STSM are:
[1] establishing new collaboration between the laboratories of Prof. Uwe Schlattner and Dr. Marko Vendelin in the field of research tightly coupled to mitochondrial physiology in the context of aging, gender differences, and environment;
[2] establishing user expectations on data collection and management in experiments linked to mitochondrial physiology.
During STSM, we plan
* to discuss the latest results obtained in the laboratories;
* write a prototype mathematical model to calculate movement of molecules of interest between mitochondrial periphery and intermembrane space taking into account novel developments in ATP/AMP ratio sensing developed by Prof Uwe Schlattner;
* follow the workflow established during experiments and the data analysis in Prof. Uwe Schlattner with the perspective of taking it into account in data processing and collection software.
The discussions are planned to be done formally, through two seminars (one for a group and one for the whole laboratory), and informally through discussion with the group and the laboratory members. In the seminars, I plan to present our latest results on comparison of respiration kinetics performed on male and female mice and an overview of the database software developed in our laboratory. If ready for presentation, some other results will be presented as well.
STSM is planned to be started on Monday (early flight from Tallinn) with the seminar on Monday afternoon in Grenoble, and finished on Friday.


Participated at