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Andric 2019b MiP2019 - Revision history
2024-03-29T14:22:14Z
Revision history for this page on the wiki
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https://wiki.oroboros.at/index.php?title=Andric_2019b_MiP2019&diff=185740&oldid=prev
Plangger Mario at 12:32, 26 September 2019
2019-09-26T12:32:48Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 12:32, 26 September 2019</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Labeling</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Labeling</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|area=mt-Biogenesis;mt-density</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|area=mt-Biogenesis;mt-density<ins style="font-weight: bold; text-decoration: none;">, Comparative MiP;environmental MiP</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|organism=Rat</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|organism=Rat</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations and support ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations and support ==</div></td></tr>
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Plangger Mario
https://wiki.oroboros.at/index.php?title=Andric_2019b_MiP2019&diff=185738&oldid=prev
Plangger Mario at 12:25, 26 September 2019
2019-09-26T12:25:30Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 12:25, 26 September 2019</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|area=mt-Biogenesis;mt-density</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|area=mt-Biogenesis;mt-density</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|organism=Rat</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|organism=Rat</div></td></tr>
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Plangger Mario
https://wiki.oroboros.at/index.php?title=Andric_2019b_MiP2019&diff=185737&oldid=prev
Plangger Mario at 12:25, 26 September 2019
2019-09-26T12:25:23Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 12:25, 26 September 2019</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Adaptability to stress is fundamental prerequisites for survival. Mitochondria are a key component of the stress response in all cells. For steroid-hormones-producing cells, including also Leydig cells of testes, the mitochondria are a key control point for the steroid biosynthesis and regulation. However, the mitochondrial biogenesis in steroidogenic cells has never been explored.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Adaptability to stress is fundamental prerequisites for survival. Mitochondria are a key component of the stress response in all cells. For steroid-hormones-producing cells, including also Leydig cells of testes, the mitochondria are a key control point for the steroid biosynthesis and regulation. However, the mitochondrial biogenesis in steroidogenic cells has never been explored.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Here we show that increased mitochondrial biogenesis is the adaptive response of testosterone-producing Leydig cells from stressed rats. All markers of mitochondrial biogenesis together with transcription factors and related kinases are up-regulated in Leydig cells from rats exposed to repeated psychophysical stress. This is followed with increased mitochondrial mass. The expression of PGC1, master regulator of mitochondrial biogenesis and integrator of environmental signals, is stimulated by cAMP-PRKA, cGMP and <del style="font-weight: bold; text-decoration: none;"></del>-adrenergic receptors. Accordingly, stress-triggered mitochondrial biogenesis represents an adaptive mechanism and does not only correlate-with but also is an essential for testosterone production, being both events depend on the same regulators.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Here we show that increased mitochondrial biogenesis is the adaptive response of testosterone-producing Leydig cells from stressed rats. All markers of mitochondrial biogenesis together with transcription factors and related kinases are up-regulated in Leydig cells from rats exposed to repeated psychophysical stress. This is followed with increased mitochondrial mass. The expression of PGC1, master regulator of mitochondrial biogenesis and integrator of environmental signals, is stimulated by cAMP-PRKA, cGMP and <ins style="font-weight: bold; text-decoration: none;">β</ins>-adrenergic receptors. Accordingly, stress-triggered mitochondrial biogenesis represents an adaptive mechanism and does not only correlate-with but also is an essential for testosterone production, being both events depend on the same regulators.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Here we propose that all events induced by acute stress, the most common stress in human society, provoke adaptive response of testosterone-producing Leydig cells and activate PGC1, a protein required to make new mitochondria but also protector against the oxidative damage.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Here we propose that all events induced by acute stress, the most common stress in human society, provoke adaptive response of testosterone-producing Leydig cells and activate PGC1, a protein required to make new mitochondria but also protector against the oxidative damage.</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Labeling</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Labeling</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|area=mt-Biogenesis;mt-density<del style="font-weight: bold; text-decoration: none;">, mt-Structure;fission;fusion, mtDNA;mt-genetics</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|area=mt-Biogenesis;mt-density</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">|diseases=Other</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|organism=<ins style="font-weight: bold; text-decoration: none;">Rat</ins></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|organism=<del style="font-weight: bold; text-decoration: none;">Human</del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">|tissues=Blood cells</del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|additional=PBMCs,</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|additional=PBMCs,</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations and support ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations and support ==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Gak IR*, Radovic SM*, Starovlah IM, Kostic TS, Andric SA</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">::::</ins>Gak IR*, Radovic SM*, Starovlah IM, Kostic TS, Andric SA</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>*These authors contributed equally to this work.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">:::: </ins>*These authors contributed equally to this work.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Laboratory for </del>Reproductive Endocrinology <del style="font-weight: bold; text-decoration: none;">and </del>Signaling, <del style="font-weight: bold; text-decoration: none;">Laboratory for </del>Chronobiology <del style="font-weight: bold; text-decoration: none;">and </del>Aging, Centre <del style="font-weight: bold; text-decoration: none;">of </del>Excellence CeRES, <del style="font-weight: bold; text-decoration: none;">Faculty of </del>Sciences, <del style="font-weight: bold; text-decoration: none;">University of </del>Novi Sad, Novi Sad, Serbia – silvana.andric@dbe.uns.ac.rs</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">::::Lab </ins>Reproductive Endocrinology Signaling, <ins style="font-weight: bold; text-decoration: none;">Lab </ins>Chronobiology Aging, Centre Excellence CeRES, <ins style="font-weight: bold; text-decoration: none;">Fac </ins>Sciences, <ins style="font-weight: bold; text-decoration: none;">Univ </ins>Novi Sad, Novi Sad, Serbia<ins style="font-weight: bold; text-decoration: none;">. </ins>– silvana.andric@dbe.uns.ac.rs</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>This work was supported by the grant no. 173057 and grant no. 451-0302807 Centre of Excellence CeRES from the Ministry of Education, Science and Technological Development, Republic of Serbia, as well as grant no. 2130 from the Autonomous Province of Vojvodina</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">::::</ins>This work was supported by the grant no. 173057 and grant no. 451-0302807 Centre of Excellence CeRES from the Ministry of Education, Science and Technological Development, Republic of Serbia, as well as grant no. 2130 from the Autonomous Province of Vojvodina</div></td></tr>
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Plangger Mario
https://wiki.oroboros.at/index.php?title=Andric_2019b_MiP2019&diff=185726&oldid=prev
Plangger Mario at 11:45, 26 September 2019
2019-09-26T11:45:49Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 11:45, 26 September 2019</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|title=[[Image:MiPsocietyLOGO.JPG|left|90px|Mitochondrial Physiology Society|MiPsociety]] <del style="font-weight: bold; text-decoration: none;">Markers of </del>mitochondrial biogenesis<del style="font-weight: bold; text-decoration: none;">, fusion and architecture </del>are <del style="font-weight: bold; text-decoration: none;">disturbed </del>in <del style="font-weight: bold; text-decoration: none;">PBMC </del>from <del style="font-weight: bold; text-decoration: none;">war veterans with posttraumatic stress disorder (PTSD)</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|title=[[Image:MiPsocietyLOGO.JPG|left|90px|Mitochondrial Physiology Society|MiPsociety]] <ins style="font-weight: bold; text-decoration: none;">Mitochondrial morphology and </ins>mitochondrial biogenesis are <ins style="font-weight: bold; text-decoration: none;">altered </ins>in <ins style="font-weight: bold; text-decoration: none;">Leydig cells </ins>from <ins style="font-weight: bold; text-decoration: none;">stressed adult rats</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MiP2019]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MiP2019]]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|authors=<del style="font-weight: bold; text-decoration: none;">Markovic AZ, Milosevic MM</del>, Radovic SM, Starovlah IM<del style="font-weight: bold; text-decoration: none;">, Brkljacic J, Vojnovic Milutinovic D, Matic G</del>, Kostic TS, Andric SA</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|authors=<ins style="font-weight: bold; text-decoration: none;">Gak IR</ins>, Radovic SM, Starovlah IM, Kostic TS, Andric SA</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2019</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2019</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiP2019</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiP2019</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MitoEAGLE]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MitoEAGLE]]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">The aim of this study was </del>to <del style="font-weight: bold; text-decoration: none;">define the transcription profiles </del>of the <del style="font-weight: bold; text-decoration: none;">molecular markers </del>of <del style="font-weight: bold; text-decoration: none;">mitochondrial biogenesis and fusion/architecture</del>, <del style="font-weight: bold; text-decoration: none;">as well as </del>the <del style="font-weight: bold; text-decoration: none;">markers of mtDNA copy numbers in </del>the <del style="font-weight: bold; text-decoration: none;">peripheral blood mononuclear cells (PBMCs) from war veterans with/without post-traumatic stress disorder (PTSD)</del>. <del style="font-weight: bold; text-decoration: none;">Also</del>, in <del style="font-weight: bold; text-decoration: none;">order to define signaling molecules involved in changes of transcription profiles immortalized human males monocytes were exposed ''in vitro'' to hormonal markers of PTSD</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Adaptability </ins>to <ins style="font-weight: bold; text-decoration: none;">stress is fundamental prerequisites for survival. Mitochondria are a key component </ins>of the <ins style="font-weight: bold; text-decoration: none;">stress response in all cells. For steroid-hormones-producing cells, including also Leydig cells </ins>of <ins style="font-weight: bold; text-decoration: none;">testes</ins>, the <ins style="font-weight: bold; text-decoration: none;">mitochondria are a key control point for </ins>the <ins style="font-weight: bold; text-decoration: none;">steroid biosynthesis and regulation</ins>. <ins style="font-weight: bold; text-decoration: none;">However</ins>, <ins style="font-weight: bold; text-decoration: none;">the mitochondrial biogenesis </ins>in <ins style="font-weight: bold; text-decoration: none;">steroidogenic cells has never been explored</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">RQ-PCR-results showed </del>that the <del style="font-weight: bold; text-decoration: none;">transcription profiles </del>of <del style="font-weight: bold; text-decoration: none;">above mentioned </del>markers <del style="font-weight: bold; text-decoration: none;">were disturbed, with high individual variability within the groups. A significant increase in the expression </del>of <del style="font-weight: bold; text-decoration: none;">the PPARGC1A transcript was observed in a group of subjects who currently have PTSD, as well as in the subjects </del>with <del style="font-weight: bold; text-decoration: none;">“life</del>-<del style="font-weight: bold; text-decoration: none;">time" PTSD, compared </del>to <del style="font-weight: bold; text-decoration: none;">healthy controls</del>. <del style="font-weight: bold; text-decoration: none;">PPARGC1B</del>, <del style="font-weight: bold; text-decoration: none;">NRF2 </del>and <del style="font-weight: bold; text-decoration: none;">MFN2 transcripts increased only in PBMCs </del>of <del style="font-weight: bold; text-decoration: none;">“life-time"</del>-<del style="font-weight: bold; text-decoration: none;">PTSD</del>, <del style="font-weight: bold; text-decoration: none;">while the level of transcripts for other investigated genes </del>and <del style="font-weight: bold; text-decoration: none;">the ratio of markers of mtDNA copy numbers showed no significant difference between groups</del>. <del style="font-weight: bold; text-decoration: none;">The in vitro results showed parallelism in the transcription profile of molecular markers of </del>mitochondrial biogenesis with <del style="font-weight: bold; text-decoration: none;">results obtained using the PBMCs of </del>the <del style="font-weight: bold; text-decoration: none;">PTSD study</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Here we show </ins>that <ins style="font-weight: bold; text-decoration: none;">increased mitochondrial biogenesis is </ins>the <ins style="font-weight: bold; text-decoration: none;">adaptive response </ins>of <ins style="font-weight: bold; text-decoration: none;">testosterone-producing Leydig cells from stressed rats. All </ins>markers of <ins style="font-weight: bold; text-decoration: none;">mitochondrial biogenesis together </ins>with <ins style="font-weight: bold; text-decoration: none;">transcription factors and related kinases are up</ins>-<ins style="font-weight: bold; text-decoration: none;">regulated in Leydig cells from rats exposed </ins>to <ins style="font-weight: bold; text-decoration: none;">repeated psychophysical stress. This is followed with increased mitochondrial mass</ins>. <ins style="font-weight: bold; text-decoration: none;">The expression of PGC1</ins>, <ins style="font-weight: bold; text-decoration: none;">master regulator of mitochondrial biogenesis </ins>and <ins style="font-weight: bold; text-decoration: none;">integrator </ins>of <ins style="font-weight: bold; text-decoration: none;">environmental signals, is stimulated by cAMP</ins>-<ins style="font-weight: bold; text-decoration: none;">PRKA</ins>, <ins style="font-weight: bold; text-decoration: none;">cGMP </ins>and <ins style="font-weight: bold; text-decoration: none;">-adrenergic receptors</ins>. <ins style="font-weight: bold; text-decoration: none;">Accordingly, stress-triggered </ins>mitochondrial biogenesis <ins style="font-weight: bold; text-decoration: none;">represents an adaptive mechanism and does not only correlate-</ins>with <ins style="font-weight: bold; text-decoration: none;">but also is an essential for testosterone production, being both events depend on </ins>the <ins style="font-weight: bold; text-decoration: none;">same regulators</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">It should be emphasized </del>that all <del style="font-weight: bold; text-decoration: none;">results should be considered as preliminary because </del>the <del style="font-weight: bold; text-decoration: none;">technical/time constraints did not allow the analysis </del>of a <del style="font-weight: bold; text-decoration: none;">larger number </del>of <del style="font-weight: bold; text-decoration: none;">PTSD subjects. However</del>, the <del style="font-weight: bold; text-decoration: none;">results are first findings </del>in <del style="font-weight: bold; text-decoration: none;">the field </del>and <del style="font-weight: bold; text-decoration: none;">can </del>be <del style="font-weight: bold; text-decoration: none;">used as </del>a <del style="font-weight: bold; text-decoration: none;">solid base </del>for <del style="font-weight: bold; text-decoration: none;">further extensive multidisciplinary research </del>in <del style="font-weight: bold; text-decoration: none;">order to clarify the molecular mechanisms for the prevention </del>and <del style="font-weight: bold; text-decoration: none;">treatment </del>of <del style="font-weight: bold; text-decoration: none;">trauma-induced pathological conditions</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Here we propose </ins>that all <ins style="font-weight: bold; text-decoration: none;">events induced by acute stress, </ins>the <ins style="font-weight: bold; text-decoration: none;">most common stress in human society, provoke adaptive response </ins>of <ins style="font-weight: bold; text-decoration: none;">testosterone-producing Leydig cells and activate PGC1, </ins>a <ins style="font-weight: bold; text-decoration: none;">protein required to make new mitochondria but also protector against the oxidative damage.</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Giving the importance </ins>of <ins style="font-weight: bold; text-decoration: none;">mitochondria for steroid hormones production and stress response</ins>, <ins style="font-weight: bold; text-decoration: none;">as well as </ins>the <ins style="font-weight: bold; text-decoration: none;">role of steroid hormones </ins>in <ins style="font-weight: bold; text-decoration: none;">stress response </ins>and <ins style="font-weight: bold; text-decoration: none;">metabolic syndrome, we anticipate our result to </ins>be a <ins style="font-weight: bold; text-decoration: none;">starting point </ins>for <ins style="font-weight: bold; text-decoration: none;">more investigations since stress is a constant factor </ins>in <ins style="font-weight: bold; text-decoration: none;">life </ins>and <ins style="font-weight: bold; text-decoration: none;">has become one </ins>of <ins style="font-weight: bold; text-decoration: none;">the most significant health problems in modern societies</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|editor=[[Plangger M]], [[Tindle-Solomon L]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|editor=[[Plangger M]], [[Tindle-Solomon L]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations and support ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations and support ==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">::::Markovic AZ(1)*, Milosevic MM(1)</del>*, Radovic SM<del style="font-weight: bold; text-decoration: none;">(1)</del>, Starovlah IM<del style="font-weight: bold; text-decoration: none;">(1), Brkljacic J(2), Vojnovic Milutinovic D(2), Matic G(2)</del>, Kostic TS<del style="font-weight: bold; text-decoration: none;">(1)</del>, Andric SA<del style="font-weight: bold; text-decoration: none;">(1)</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Gak IR</ins>*, Radovic SM<ins style="font-weight: bold; text-decoration: none;">*</ins>, Starovlah IM, Kostic TS, Andric SA</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">:::: </del>*These authors contributed equally to this work.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>*These authors contributed equally to this work.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">::::#Lab </del>Reproductive Endocrinology Signaling, <del style="font-weight: bold; text-decoration: none;">Lab </del>Chronobiology Aging, Centre Excellence CeRES, <del style="font-weight: bold; text-decoration: none;">Fac </del>Sciences, <del style="font-weight: bold; text-decoration: none;">Univ </del>Novi Sad, Novi Sad, Serbia</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Laboratory for </ins>Reproductive Endocrinology <ins style="font-weight: bold; text-decoration: none;">and </ins>Signaling, <ins style="font-weight: bold; text-decoration: none;">Laboratory for </ins>Chronobiology <ins style="font-weight: bold; text-decoration: none;">and </ins>Aging, Centre <ins style="font-weight: bold; text-decoration: none;">of </ins>Excellence CeRES, <ins style="font-weight: bold; text-decoration: none;">Faculty of </ins>Sciences, <ins style="font-weight: bold; text-decoration: none;">University of </ins>Novi Sad, Novi Sad, Serbia – silvana.andric@dbe.uns.ac.rs</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">::::#Dept Biochemistry, Inst Biological Research "Siniša Stankovic", Univ Belgrade, Belgrade, Serbia. - </del>– silvana.andric@dbe.uns.ac.rs</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>This work was supported by the grant no. 173057 and grant no. 451-0302807 Centre of Excellence CeRES from the Ministry of Education, Science and Technological Development, Republic of Serbia, as well as grant no. 2130 from the Autonomous Province of Vojvodina</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">::::</del>This work was supported by the grant no. 173057 and grant no. 451-0302807 Centre of Excellence CeRES from the Ministry of Education, Science and Technological Development, Republic of Serbia, as well as grant no. 2130 from the Autonomous Province of Vojvodina<del style="font-weight: bold; text-decoration: none;">.</del></div></td><td colspan="2"></td></tr>
</table>
Plangger Mario
https://wiki.oroboros.at/index.php?title=Andric_2019b_MiP2019&diff=185724&oldid=prev
Plangger Mario: Created page with "{{Abstract |title=MiPsociety Markers of mitochondrial biogenesis, fusion and architecture are disturbed..."
2019-09-26T11:37:40Z
<p>Created page with "{{Abstract |title=<a href="/index.php/File:MiPsocietyLOGO.JPG" title="File:MiPsocietyLOGO.JPG">left|90px|Mitochondrial Physiology Society|MiPsociety</a> Markers of mitochondrial biogenesis, fusion and architecture are disturbed..."</p>
<p><b>New page</b></p><div>{{Abstract<br />
|title=[[Image:MiPsocietyLOGO.JPG|left|90px|Mitochondrial Physiology Society|MiPsociety]] Markers of mitochondrial biogenesis, fusion and architecture are disturbed in PBMC from war veterans with posttraumatic stress disorder (PTSD).<br />
|info=[[MiP2019]]<br />
|authors=Markovic AZ, Milosevic MM, Radovic SM, Starovlah IM, Brkljacic J, Vojnovic Milutinovic D, Matic G, Kostic TS, Andric SA<br />
|year=2019<br />
|event=MiP2019<br />
|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MitoEAGLE]]<br />
The aim of this study was to define the transcription profiles of the molecular markers of mitochondrial biogenesis and fusion/architecture, as well as the markers of mtDNA copy numbers in the peripheral blood mononuclear cells (PBMCs) from war veterans with/without post-traumatic stress disorder (PTSD). Also, in order to define signaling molecules involved in changes of transcription profiles immortalized human males monocytes were exposed ''in vitro'' to hormonal markers of PTSD.<br />
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RQ-PCR-results showed that the transcription profiles of above mentioned markers were disturbed, with high individual variability within the groups. A significant increase in the expression of the PPARGC1A transcript was observed in a group of subjects who currently have PTSD, as well as in the subjects with “life-time" PTSD, compared to healthy controls. PPARGC1B, NRF2 and MFN2 transcripts increased only in PBMCs of “life-time"-PTSD, while the level of transcripts for other investigated genes and the ratio of markers of mtDNA copy numbers showed no significant difference between groups. The in vitro results showed parallelism in the transcription profile of molecular markers of mitochondrial biogenesis with results obtained using the PBMCs of the PTSD study.<br />
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It should be emphasized that all results should be considered as preliminary because the technical/time constraints did not allow the analysis of a larger number of PTSD subjects. However, the results are first findings in the field and can be used as a solid base for further extensive multidisciplinary research in order to clarify the molecular mechanisms for the prevention and treatment of trauma-induced pathological conditions.<br />
|editor=[[Plangger M]], [[Tindle-Solomon L]]<br />
}}<br />
{{Labeling<br />
|area=mt-Biogenesis;mt-density, mt-Structure;fission;fusion, mtDNA;mt-genetics<br />
|diseases=Other<br />
|organism=Human<br />
|tissues=Blood cells<br />
|additional=PBMCs,<br />
}}<br />
== Affiliations and support ==<br />
::::Markovic AZ(1)*, Milosevic MM(1)*, Radovic SM(1), Starovlah IM(1), Brkljacic J(2), Vojnovic Milutinovic D(2), Matic G(2), Kostic TS(1), Andric SA(1)<br />
:::: *These authors contributed equally to this work.<br />
::::#Lab Reproductive Endocrinology Signaling, Lab Chronobiology Aging, Centre Excellence CeRES, Fac Sciences, Univ Novi Sad, Novi Sad, Serbia<br />
::::#Dept Biochemistry, Inst Biological Research "Siniša Stankovic", Univ Belgrade, Belgrade, Serbia. - – silvana.andric@dbe.uns.ac.rs<br />
<br />
::::This work was supported by the grant no. 173057 and grant no. 451-0302807 Centre of Excellence CeRES from the Ministry of Education, Science and Technological Development, Republic of Serbia, as well as grant no. 2130 from the Autonomous Province of Vojvodina.</div>
Plangger Mario