Difference between revisions of "Belosludtseva 2021 Bull Exp Biol Med"
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{{Publication | {{Publication | ||
|title=Belosludtseva NV, Starinets VS, Belosludtsev KN (2021) Effect of dapagliflozin on the functioning of rat liver mitochondria ''in vitro''. Bull Exp Biol Med | |title=Belosludtseva NV, Starinets VS, Belosludtsev KN (2021) Effect of dapagliflozin on the functioning of rat liver mitochondria ''in vitro''. Bull Exp Biol Med 171:601-05. | ||
|info=[https://www.ncbi.nlm.nih.gov/pubmed/34617185 PMID: 34617185 Open Access] | |info=[https://www.ncbi.nlm.nih.gov/pubmed/34617185 PMID: 34617185 Open Access] | ||
|authors=Belosludtseva NV, Starinets VS, Belosludtsev KN | |authors=Belosludtseva NV, Starinets VS, Belosludtsev KN |
Latest revision as of 14:46, 19 October 2021
Belosludtseva NV, Starinets VS, Belosludtsev KN (2021) Effect of dapagliflozin on the functioning of rat liver mitochondria in vitro. Bull Exp Biol Med 171:601-05. |
Belosludtseva NV, Starinets VS, Belosludtsev KN (2021) Bull Exp Biol Med
Abstract: We studied the effect of a new hypoglycemic compound dapagliflozin on the functioning of rat liver mitochondria. Dapagliflozin in concentrations of 10-20 μM had no effect on the parameters of respiration and oxidative phosphorylation of rat liver mitochondria. Increasing dapagliflozin concentration to 50 μM led to a significant inhibition of mitochondrial respiration in states 3 and 3UDNP. Dapagliflozin in this concentration significantly reduced calcium retention capacity of rat liver mitochondria. These findings indicate a decline in the resistance of rat liver mitochondria to induction of Ca2+-dependent mitochondrial permeability transition pore. In a concentration of 10 μM, dapagliflozin significantly decreases the rate of H2O2 formation in rat liver mitochondria, which attested to an antioxidant effect of this compound. Possible mitochondrion-related mechanisms of the protective action of dapagliflozin on liver cells are discussed.
• Bioblast editor: Plangger M
Labels: MiParea: Respiration
HRR: Oxygraph-2k
2021-10