Complex II-linked substrate state

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MitoPedia

Complex II-linked substrate state

Description

The Complex II-linked substrate state is induced in mt-preparations by addition of succinate+rotenone (Complex I inhibitor). Succinate is the direct substrate of Complex II (succinate dehydrogenase). In CII-linked respiration, only Complex III and Complex IV are involved in pumping protons from the matrix (P-phase) to the N-phase with a P/O ratio of 1.75 (P/O2 = 3.5).

Abbreviation: CII-linked

Reference: Gnaiger 2014 MitoPathways, Gnaiger 2000 Proc Natl Acad Sci U S A



MitoPedia topics: "Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. Respiratory state"Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property., Substrate and metabolite 

List of publications: CII-linked substrate state