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Difference between revisions of "Dawson 2020 Exp Gerontol"

From Bioblast
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|keywords=Aging, Birds, Citrate synthase, Mitochondrial dysfunction, Senescence
|keywords=Aging, Birds, Citrate synthase, Mitochondrial dysfunction, Senescence
|editor=[[Plangger M]],
|editor=[[Plangger M]],
|mipnetlab=DE Wilhelmshaven Salmon P
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Revision as of 15:18, 11 April 2023

Publications in the MiPMap
Dawson NJ, Salmón P (2020) Age-related increase in mitochondrial quantity may mitigate a decline in mitochondrial quality in red blood cells from zebra finches (Taeniopygia guttata). Exp Gerontol 133:110883.

» PMID: 32084534 Open Access

Dawson NJ, Salmon P (2020) Exp Gerontol

Abstract: Aging is typically associated with a decline in whole animal performance that ultimately contributes to death. It is suspected that a decline in ATP production leads to dysfunction in cellular processes, contributing to the decline in performance. Birds require large amounts of ATP to support physiological process, especially flight, which is one of the most energetically expensive forms of locomotion in the animal kingdom to sustain. Since the bulk of ATP production is coordinated through mitochondrial activity, we set out to explore mitochondrial function in young (~8 months) and old (~73 months) zebra finches (Taeniopygia guttata). We exploited the fact that avian red blood cells (RBCs) are nucleated and have functional mitochondria to explore the phenomenon of age-related decline in mitochondrial function without the need for terminal sampling. We found that RBCs from old zebra finches have lower flux control ratios (mitochondrial O2 consumption attributed to ATP production; 0.29-0.36-fold), exhibit higher respiration (1.4-fold), and significantly higher citrate synthase activity (1.4-fold) than young birds. Respiration rates normalized to citrate synthase activity suggest that mitochondrial quality is changing, as leak state is significantly lower (0.39-fold) in old zebra finches in comparison to young animals. Overall, our findings indicate a possible change in the function of mitochondria in older zebra finches, which may be associated with a corresponding increase in mitochondrial quantity, possibly to offset a decline in mitochondrial quality.

Copyright © 2018. Published by Elsevier Inc. Keywords: Aging, Birds, Citrate synthase, Mitochondrial dysfunction, Senescence Bioblast editor: Plangger M O2k-Network Lab: DE Wilhelmshaven Salmon P


Labels: MiParea: Respiration  Pathology: Aging;senescence 

Organism: Birds  Tissue;cell: Blood cells  Preparation: Intact cells 


Coupling state: LEAK, ROUTINE, ET  Pathway: ROX  HRR: Oxygraph-2k 

2020-2