Difference between revisions of "Electron leak"
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{{MitoPedia | {{MitoPedia | ||
|description= | |description=Electrons that escape the [[electron transfer pathway]] without completing the reduction of oxygen to water at cytochrome ''c'' oxidase, causing the production of [[Reactive_oxygen_species |ROS]]. The rate of electron leak depends on the topology of the complex, the redox state of the moiety responsible of electron leakiness and usually on the protonmotive force ([[Protonmotive force|Δ''p'']]). In some cases, the [[Protonmotive force|Δ''p'']] dependance relies more on the ∆pH component than in the ∆''Ψ''. | ||
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[[File:Questions.jpg|left|40px]] | [[File:Questions.jpg|left|40px]] | ||
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[[File:Expand.png|right|45px |Click to expand or collaps]] | [[File:Expand.png|right|45px |Click to expand or collaps]] | ||
<div class="toccolours mw-collapsible mw-collapsed"> | <div class="toccolours mw-collapsible mw-collapsed"> | ||
::: <span style="font-size:105%; color:##424242">'''» Keywords: leak'''</span> | ::: <span style="font-size:105%; color:##424242">'''» Keywords: electron leak'''</span> | ||
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::: '''Specific''' | ::: '''Specific''' | ||
::::» [[Reactive_oxygen_species]] | ::::» [[Reactive_oxygen_species]] | ||
::::» [[LEAK | ::::» [[LEAK respiration]] | ||
::::» [[LEAK state with ATP]] | ::::» [[LEAK state with ATP]] | ||
::::» [[LEAK state with Omy|LEAK state with oligomycin]] | ::::» [[LEAK state with Omy|LEAK state with oligomycin]] | ||
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== References == | |||
# Jastroch M, Divakaruni AS, MookerjeecS, Treberg JR, Brand MD (2010) Mitochondrial proton and electron leaks. Essays Biochemistry 47: 53–67 pp. | |||
{{MitoPedia concepts | {{MitoPedia concepts | ||
|mitopedia concept= | |mitopedia concept=MiP concept | ||
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{{MitoPedia methods | {{MitoPedia methods | ||
|mitopedia method=Respirometry | |mitopedia method=Respirometry, Fluorometry | ||
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{{MitoPedia O2k and high-resolution respirometry}} | |||
{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=EAGLE | |mitopedia topic=EAGLE | ||
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Latest revision as of 09:35, 8 June 2020
Description
Electrons that escape the electron transfer pathway without completing the reduction of oxygen to water at cytochrome c oxidase, causing the production of ROS. The rate of electron leak depends on the topology of the complex, the redox state of the moiety responsible of electron leakiness and usually on the protonmotive force (Δp). In some cases, the Δp dependance relies more on the ∆pH component than in the ∆Ψ.
- » Keywords: electron leak
References
- Jastroch M, Divakaruni AS, MookerjeecS, Treberg JR, Brand MD (2010) Mitochondrial proton and electron leaks. Essays Biochemistry 47: 53–67 pp.
MitoPedia concepts:
MiP concept
MitoPedia methods:
Respirometry,
Fluorometry
MitoPedia topics: EAGLE