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Difference between revisions of "Electron leak"

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{{MitoPedia
|description=The flux of electrons that exit the electron transfer system without completing the reduction of oxygen to water at cytochrome ''c'', causing the production of ROS. The rate of electron leak depends on the topology of the complex, the redox state of the moiety responsible of electron leakiness and usually on the Δp. In some cases, the Δp dependance relies more on the ΔpH component than in the ΔΨ.
|description=Electrons that escape the [[electron transfer pathway]] without completing the reduction of oxygen to water at cytochrome ''c'' oxidase, causing the production of [[Reactive_oxygen_species |ROS]]. The rate of electron leak depends on the topology of the complex, the redox state of the moiety responsible of electron leakiness and usually on the protonmotive force ([[Protonmotive force|Δ''p'']]). In some cases, the [[Protonmotive force|Δ''p'']] dependance relies more on the ∆pH component than in the ∆''Ψ''.
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::: '''Specific'''
::: '''Specific'''
::::» [[Reactive_oxygen_species]]
::::» [[Reactive_oxygen_species]]
::::» [[LEAK-respiration]]
::::» [[LEAK respiration]]
::::» [[LEAK state with ATP]]
::::» [[LEAK state with ATP]]
::::» [[LEAK state with Omy|LEAK state with oligomycin]]
::::» [[LEAK state with Omy|LEAK state with oligomycin]]
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== References ==


 
# Jastroch M, Divakaruni AS, MookerjeecS, Treberg JR, Brand MD (2010) Mitochondrial proton and electron leaks. Essays Biochemistry 47: 53–67 pp.
 


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|mitopedia concept=MiP concept
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{{MitoPedia methods
|mitopedia method=Respirometry
|mitopedia method=Respirometry, Fluorometry
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{{MitoPedia O2k and high-resolution respirometry}}
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{{MitoPedia topics
|mitopedia topic=EAGLE
|mitopedia topic=EAGLE
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Latest revision as of 09:35, 8 June 2020


high-resolution terminology - matching measurements at high-resolution


Electron leak

Description

Electrons that escape the electron transfer pathway without completing the reduction of oxygen to water at cytochrome c oxidase, causing the production of ROS. The rate of electron leak depends on the topology of the complex, the redox state of the moiety responsible of electron leakiness and usually on the protonmotive force (Δp). In some cases, the Δp dependance relies more on the ∆pH component than in the ∆Ψ.


Questions.jpg


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References

  1. Jastroch M, Divakaruni AS, MookerjeecS, Treberg JR, Brand MD (2010) Mitochondrial proton and electron leaks. Essays Biochemistry 47: 53–67 pp.


MitoPedia concepts: MiP concept 


MitoPedia methods: Respirometry, Fluorometry 



MitoPedia topics: EAGLE