Kraehenbuehl Stephan
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Name | KrĂ€henbĂŒhl Stephan, Prof. Dr. |
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Institution | UniversitÀtsspital Basel
Department Biomedizin Labor 410, Klinische Pharmakologie und Toxikologie |
Address | Hebelstrasse 20, 4031 |
City | Basel |
State/Province | |
Country | Switzerland |
[email protected] | |
Weblink | |
O2k-Network Lab | CH Basel Kraehenbuehl S |
Labels:
Publications
Published | Reference | |
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Abegg 2024 Toxicol Lett | 2024 | Abegg VF, Panajatovic MV, Mancuso RV, Allard JA, Duthaler U, Odermatt A, KrĂ€henbĂŒhl S, Bouitbir J (2024) Mechanisms of hepatocellular toxicity associated with the components of St. John's Wort extract hypericin and hyperforin in HepG2 and HepaRG cells. https://doi.org/10.1016/j.toxlet.2024.01.008 |
Bouitbir 2022 Int J Mol Sci | 2022 | Bouitbir J, Panajatovic MV, KrĂ€henbĂŒhl S (2022) Mitochondrial toxicity associated with imatinib and sorafenib in isolated rat heart fibers and the cardiomyoblast H9c2 cell line. Int J Mol Sci 23:2282. https://doi.org/10.3390/ijms23042282 |
Gruenig 2020 Biochem Pharmacol | 2020 | GrĂŒnig D, Szabo L, Marbet M, KrĂ€henbĂŒhl S (2020) Valproic acid affects fatty acid and triglyceride metabolism in HepaRG cells exposed to fatty acids by different mechanisms. Biochem Pharmacol 177:113860. |
Bouitbir 2019 Toxicology | 2019 | Bouitbir J, Alshaikhali A, Panajatovic MV, Abegg VF, Paech F, KrĂ€henbĂŒhl S (2019) Mitochondrial oxidative stress plays a critical role in the cardiotoxicity of sunitinib. Toxicology 426:152281. |
Zhou 2019 Int J Mol Sci | 2019 | Zhou X, Luethi D, Sanvee GM, Bouitbir J, Liechti ME, KrĂ€henbĂŒhl S (2019) Molecular toxicological mechanisms of synthetic cathinones on C2C12 myoblasts. Int J Mol Sci 20:E1561. |
Paech 2018a Toxicology | 2018 | Paech F, Mingard C, GrĂŒnig D, Abegg VF, Bouitbir J, KrĂ€henbĂŒhl S (2018) Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells. Toxicology 395:34-44. |
Paech 2018b Toxicology | 2018 | Paech F, Abegg VF, Duthaler U, Terracciano L, Bouitbir J, KrĂ€henbĂŒhl S (2018) Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice. Toxicology 409:13-23. |
Singh 2018 Arch Toxicol | 2018 | Singh F, Zoll J, Duthaler U, Charles AL, Panajatovic MV, Laverny G, McWilliams TG, Metzger D, Geny B, KrĂ€henbĂŒhl S, Bouitbir J (2018) PGC-1ÎČ modulates statin-associated myotoxicity in mice. Arch Toxicol 93:487-504. |
Paech 2017 Arch Toxicol | 2017 | Paech F, Messner S, Spickermann J, Wind M, Schmitt-Hoffmann AH, Witschi AT, Howell BA, Church RJ, Woodhead J, Engelhardt M, KrĂ€henbĂŒhl S, Maurer M (2017) Mechanisms of hepatotoxicity associated with the monocyclic ÎČ-lactam antibiotic BAL30072. Arch Toxicol 91:3647-62. |
Luethi 2017 Toxicology | 2017 | Luethi D, Liechti ME, KrĂ€henbĂŒhl S (2017) Mechanisms of hepatocellular toxicity associated with new psychoactive synthetic cathinones. Toxicology 387:57-66. |
Haegler 2017 PLOS ONE | 2017 | Haegler P, GrĂŒnig D, Berger B, Terracciano L, KrĂ€henbĂŒhl S, Bouitbir J (2017) Hepatic effects of pharmacological doses of hydroxy-cobalamin[c-lactam] in mice. PLOS ONE 12:e0171026. |
Gruenig 2017 Toxicol In Vitro | 2017 | GrĂŒnig D, Felser A, Bouitbir J, KrĂ€henbĂŒhl S (2017) The catechol-O-methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cells. Toxicol In Vitro 42:337-47. |
Brecht 2016 Toxicol In Vitro | 2016 | Brecht K, Riebel V, Couttet P, Paech F, Wolf A, Chibout SD, Pognan F, KrĂ€henbĂŒhl S, Uteng M (2016) Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin. Toxicol In Vitro 40:55-65. |
Bonifacio 2016 Arch Toxicol | 2016 | Bonifacio A, Mullen PJ, Mityko IS, Navegantes LC, Bouitbir J, KrĂ€henbĂŒhl S (2016) Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo. Arch Toxicol 90:203-15. doi: 10.1007/s00204-014-1378-4 |
Bouitbir 2016 Antioxid Redox Signal | 2016 | Bouitbir J, Singh F, Charles AL, Schlagowski AI, Bonifacio A, Echaniz-Laguna A, Geny B, KrĂ€henbĂŒhl S, Zoll J (2016) Statins trigger mitochondrial ROS-induced apoptosis in glycolytic skeletal muscle. Antioxid Redox Signal 24:84-98. |
Singh 2015 Biochim Biophys Acta | 2015 | Singh F, Charles AL, Schlagowski AI, Bouitbir J, Bonifacio A, Piquard F, KrĂ€henbĂŒhl S, Geny B, Zoll J (2015) Reductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesis. Biochim Biophys Acta 1853:1574-85. |
Haegler 2015 Toxicology | 2015 | Haegler P, GrĂŒnig D, Berger B, KrĂ€henbĂŒhl S, Bouitbir J (2015) Impaired mitochondrial function in HepG2 cells treated with hydroxy-cobalamin[c-lactam]: A cell model for idiosyncratic toxicity. Toxicology 336:48-58. |
Felser 2014 Toxicology I | 2014 | Felser A, Stoller A, Morand R, Schnell D, Donzelli M, Terracciano L, Bouitbir J, KrĂ€henbĂŒhl S (2014) Hepatic toxicity of dronedarone in mice: role of mitochondrial ÎČ-oxidation. Toxicology 323:1-9. |
Felser 2014 Toxicology II | 2014 | Felser A, Lindinger PW, Schnell D, Kratschmar DV, Odermatt A, Mies S, Jenö P, KrĂ€henbĂŒhl S (2014) Hepatocellular toxicity of benzbromarone: effects on mitochondrial function and structure. Toxicology 324:136-46. |
Morand 2014 Eur J Nutr | 2014 | Morand R, Bouitbir J, Felser A, Hench J, Handschin C, Frank S, KrĂ€henbĂŒhl S (2014) Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice. Eur J Nutr 53:1313-25. |
Hirzel 2013 J Recept Signal Transduct Res | 2013 | Hirzel E, Lindinger PW, Maseneni S, Giese M, Rhein VV, Eckert A, Hoch M, KrĂ€henbĂŒhl S, Eberle AN (2013) Differential modulation of ROS signals and other mitochondrial parameters by the antioxidants MitoQ, resveratrol and curcumin in human adipocytes. J Recept Signal Transduct Res 33:304-12. |
Felser 2013 Toxicol Sci | 2013 | Felser A, Blum K, Lindinger PW, Bouitbir J, Kraehenbuehl S (2013) Mechanisms of hepatocellular toxicity associated with dronedarone - a comparison to amiodarone. Toxicol Sci 131:480-90. |
Abstracts
Published | Reference | |
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Panajatovic 2017 IOC124 | 2017 | Role of PGC-1α associated mitochondrial biogenesis in statin-induced myotoxicity. |