Difference between revisions of "Lemieux 2010 J Gerontol A Biol Sci Med Sci"
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|title=Lemieux H, Vazquez EJ, Fujioka H, Hoppel CL (2010) Decrease in mitochondrial function in rat cardiac permeabilized fibers correlates with the aging phenotype. J. Gerontol. A. Biol. Sci. Med. Sci. 65(11):1157-1164. | |title=Lemieux H, Vazquez EJ, Fujioka H, Hoppel CL (2010) Decrease in mitochondrial function in rat cardiac permeabilized fibers correlates with the aging phenotype. J. Gerontol. A. Biol. Sci. Med. Sci. 65(11):1157-1164. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/20801909 PMID:20801909] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/20801909 PMID:20801909] | ||
|authors=Lemieux H, Vazquez EJ, Fujioka H, Hoppel CL | |authors=Lemieux H, Vazquez EJ, Fujioka H, Hoppel CL | ||
|year=2010 | |year=2010 | ||
|journal=J Gerontol A Biol Sci Med Sci | |journal=J Gerontol A Biol Sci Med Sci | ||
Revision as of 11:50, 30 August 2011
| Lemieux H, Vazquez EJ, Fujioka H, Hoppel CL (2010) Decrease in mitochondrial function in rat cardiac permeabilized fibers correlates with the aging phenotype. J. Gerontol. A. Biol. Sci. Med. Sci. 65(11):1157-1164. |
Lemieux H, Vazquez EJ, Fujioka H, Hoppel CL (2010) J Gerontol A Biol Sci Med Sci
Abstract: We measured the loss of cardiac mitochondrial function related to aging in males of three rat strains presenting with different longevity and aging phenotypes: the Fischer 344 (F344), the Brown Norway (BN), and the hybrid F344×BN. The F344 rat has a short life span and a ∼45% decrease in coupled mitochondrial oxidation in the cardiac permeabilized fibers from the old rats compared with the young rats. Citrate synthase activity in the permeabilized fibers (mitochondrial content) did not change significantly with aging. The BN live longer compared with the F344 and have a 15%-18% loss of mitochondrial respiration in the aged rats compared with the young rats. The differences are not significant. In hybrids, more resistant to aging than are the BN and the F344, mitochondrial function is preserved during aging. The difference in longevity of the different strains is correlated with mitochondrial dysfunction in the heart, suggesting the importance of mitochondria in cardiac aging. • Keywords: aging, mitochondrial, oxidative phosphorylation, rat, strains
• O2k-Network Lab: CA_Edmonton_Lemieux H
Labels:
Organism: Rat
Tissue;cell: Cardiac Muscle"Cardiac Muscle" is not in the list (Heart, Skeletal muscle, Nervous system, Liver, Kidney, Lung;gill, Islet cell;pancreas;thymus, Endothelial;epithelial;mesothelial cell, Blood cells, Fat, ...) of allowed values for the "Tissue and cell" property., Fibroblast
Preparation: Isolated Mitochondria"Isolated Mitochondria" is not in the list (Intact organism, Intact organ, Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria, SMP, Chloroplasts, Enzyme, Oxidase;biochemical oxidation, ...) of allowed values for the "Preparation" property.
HRR: Oxygraph-2k
