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Metformin

From Bioblast
Revision as of 11:56, 20 January 2020 by Gnaiger Erich (talk | contribs)


high-resolution terminology - matching measurements at high-resolution


Metformin

Description

Metformin is mainly known as an important antidiabetic drug which is effective, however, in a wide spectrum of degenerative diseases. It is an inhibitor of Complex I.


Reference: Brunmair 2004 Diabetes

Metformin and mitObesity

Work in progress by Gnaiger E 2020-01-20 linked to a preprint in preparation on BME and mitObesity.
  1. Brunmair B, Staniek K, Gras F, Scharf N, Althaym A, Clara R, Roden M, Gnaiger E, Nohl H, Waldhäusl W, Fürnsinn C (2004) Thiazolidinediones, like metformin, inhibit respiratory Complex I: a common mechanism contributing to their antidiabetic actions?. Diabetes 53:1052-9. - »Bioblast link«
  2. Dantas-Ferreira RF, Raingard H, Dumont S, Schuster-Klein C, Guardiola-Lemaitre B, Pevet P, Challet E (2018) Melatonin potentiates the effects of metformin on glucose metabolism and food intake in high-fat-fed rats. Endocrinol Diabetes Metab 1:e00039. - https://www.ncbi.nlm.nih.gov/pubmed/30815567
  3. Alshahrani A, AlDubayee M, Zahra M, Alsebayel FM, Alammari N, Alsudairy F, Almajed M, Aljada A (2019) Differential expression of human N-alpha-acetyltransferase 40 (hNAA40), nicotinamide phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) pathway in obesity and T2DM: modulation by metformin and macronutrient intake. Diabetes Metab Syndr Obes 12:2765-74. - https://www.ncbi.nlm.nih.gov/pubmed/31920356
  4. Sanches-Silva A, Testai L, Nabavi SF, Battino M, Devi KP, Tejada S, Sureda A, Xu S, Yousefi B, Majidinia M, Russo GL, Efferth T, Nabavi SM, Farzaei MH (2020) Therapeutic potential of polyphenols in cardiovascular diseases: regulation of mTOR signaling pathway. Pharmacol Res 2020 Jan 2:104626. - https://www.ncbi.nlm.nih.gov/pubmed/31904507
  5. Srivastava SB (2019) Is there a prescription to treat pediatric obesity? Am J Lifestyle Med 14:36-9. - https://www.ncbi.nlm.nih.gov/pubmed/31903078
  6. McCrimmon RJ, Catarig AM, Frias JP, Lausvig NL, le Roux CW, Thielke D, Lingvay I (2020) Effects of once-weekly semaglutide vs once-daily canagliflozin on body composition in type 2 diabetes: a substudy of the SUSTAIN 8 randomised controlled clinical trial. Diabetologia 2020 Jan 2. doi: 10.1007/s00125-019-05065-8. - https://www.ncbi.nlm.nih.gov/pubmed/31897524
  7. Kothari S, Dhami-Shah H, Shah SR (2019) Antidiabetic drugs and statins in nonalcoholic fatty liver disease. J Clin Exp Hepatol 9:723-30. - https://www.ncbi.nlm.nih.gov/pubmed/31889754
  8. Hiluy JC, Nazar BP, Gonçalves WS, Coutinho W, Appolinario JC (2019) Effectiveness of pharmacologic interventions in the management of weight gain in patients with severe mental illness: a systematic review and meta-analysis. Prim Care Companion CNS Disord 21 pii: 19r02483. - https://www.ncbi.nlm.nih.gov/pubmed/31856432
  9. Crocker CL, Baumgarner BL, Kinsey ST (2019) β-guanidinopropionic acid and metformin differentially impact autophagy, mitochondria and cellular morphology in developing C2C12 muscle cells. J Muscle Res Cell Motil. 2019 Dec 13. doi: 10.1007/s10974-019-09568-0. - https://www.ncbi.nlm.nih.gov/pubmed/31836952
  10. Guo H, Kong W, Zhang L, Han J, Clark LH, Yin Y, Fang Z, Sun W, Wang J, Gilliam TP, Lee D, Makowski L, Zhou C, Bae-Jump VL (2019) Reversal of obesity-driven aggressiveness of endometrial cancer by metformin. Am J Cancer Res 9:2170-93. - https://www.ncbi.nlm.nih.gov/pubmed/31720081
  11. Wang Y, An H, Liu T, Qin C, Sesaki H, Guo S, Radovick S, Hussain M, Maheshwari A, Wondisford FE, O'Rourke B, He L (2019) Metformin improves mitochondrial respiratory activity through activation of AMPK. Cell Rep 29:1511-23.e5. - https://www.ncbi.nlm.nih.gov/pubmed/31693892
  12. MacNeil LT, Schertzer JD, Steinberg GR (2020) Bacteria transmit metformin-associated lifespan extension. Nat Rev Endocrinol 16:9-10. - https://www.ncbi.nlm.nih.gov/pubmed/31645681
  13. El-Sayed SM, Ibrahim HM (2019) Effect of high-fat diet-induced obesity on thyroid gland structure in female rats and the possible ameliorating effect of metformin therapy. Folia Morphol (Warsz). 2019 Sep 6. doi: 10.5603/FM.a2019.0100. - https://www.ncbi.nlm.nih.gov/pubmed/31489607
  14. Hartman SJ, Nelson SH, Marinac CR, Natarajan L, Parker BA, Patterson RE (2019) The effects of weight loss and metformin on cognition among breast cancer survivors: Evidence from the Reach for Health study. Psychooncology 28:1640-46. - https://www.ncbi.nlm.nih.gov/pubmed/31140202
  15. Rotermund C, Machetanz G, Fitzgerald JC (2018) The therapeutic potential of metformin in neurodegenerative diseases. Front Endocrinol (Lausanne) 9:400. - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060268/
  16. Glossmann HH, Lutz OMD (2019) Metformin and aging: a review. Gerontology 65:581-90. - https://www.karger.com/Article/FullText/502257#
  17. Saraei P, Asadi I, Kakar MA, Moradi-Kor N (2019) The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances. Cancer Manag Res 11:3295-313. - https://www.ncbi.nlm.nih.gov/pubmed/31114366