|
Β |
(14 intermediate revisions by 6 users not shown) |
Line 1: |
Line 1: |
| {{MitoPedia
| | #REDIRECT [[MitoKit-CII]] |
| |abbr=MitoKit-CII
| |
| |description='''Cell permeable prodrugs''', composed of [[NV161/MitoKit-CII]] and [[NV118/MitoKit-CII]], of the Complex II substrate succinate increase ATP-linked mitochondrial respiration in CI-deficient human blood cells, fibroblasts and heart fibres.
| |
| |info=[[MitoKit-CII]], [[Ehinger 2016 Nat Commun]]
| |
| }}
| |
| {{MitoPedia topics
| |
| |mitopedia topic=Medium
| |
| }}
| |
| * For preparation, see [[MitoKit-CII]].
| |
| Β | |
| Β | |
| == Application in [[HRR]] ==
| |
| Β | |
| Β | |
| === Preparation ===
| |
| Β | |
| :::: Both compounds are dissolved in DMSO and stored in aliquots at -20 Β°C.
| |
| :::: We recommend the following dilutions for reaching the desired concentration in the experiments:
| |
| Β | |
| Β | |
| ::::* NV118/MitoKit-CII: 100 mM stock solution
| |
| ::::* NV161/MitoKit-CII: 10 mM stock solution
| |