Difference between revisions of "N/NS pathway control ratio"
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|description=The '''CI/CI<small>&</small>II [[substrate control ratio]]''' is obtained when succinate is added to CI-linked respiration in a defined coupling state. CI and CII are abbreviations for Complex I and Complex II, but indicate here CI-linked respiration (with pyruvate, glutamate, malate, or other ETS competent CI-linked substrate combinations) and CII-linked (with succinate) respiration. CI<small>&</small>II indicates respiration with a CI- and CII-linked substrate cocktail. The symbol '&' in CI<small>&</small>II helps to distinguish CI<small>&</small>II as the measured flux in the presence of both CI- '''and''' CII-linked substrates from CI+CII as the operation of a mathematical addition when calculating the sum of CI- plus CII-linked respiration measured separately. | |description=The '''CI/CI<small>&</small>II [[substrate control ratio]]''' is obtained when succinate is added to CI-linked respiration in a defined coupling state. CI and CII are abbreviations for Complex I and Complex II, but indicate here CI-linked respiration (with pyruvate, glutamate, malate, or other ETS competent CI-linked substrate combinations) and CII-linked (with succinate) respiration. CI<small>&</small>II indicates respiration with a CI- and CII-linked substrate cocktail. The symbol '&' in CI<small>&</small>II helps to distinguish CI<small>&</small>II as the measured flux in the presence of both CI- '''and''' CII-linked substrates from CI+CII as the operation of a mathematical addition when calculating the sum of CI- plus CII-linked respiration measured separately. | ||
|info=[[Gnaiger 2009 Int J Biochem Cell Biol]] | |info=[[Gnaiger 2009 Int J Biochem Cell Biol]] | ||
}} | |||
{{MitoPedia concepts | |||
|mitopedia concept=Respiratory control ratio | |||
}} | }} | ||
{{MitoPedia methods}} | {{MitoPedia methods}} | ||
{{MitoPedia topics | {{MitoPedia O2k and high-resolution respirometry}} | ||
{{MitoPedia topics}} | |||
}} | |||
= List of publications: CI and CI<small>+</small>II = | = List of publications: CI and CI<small>+</small>II = | ||
{{#ask:[[Category:Publications]] [[Substrate states::CI]] [[Substrate states::CI+II]] | {{#ask:[[Category:Publications]] [[Substrate states::CI]] [[Substrate states::CI+II]] |
Revision as of 14:06, 8 February 2016
Description
The CI/CI&II substrate control ratio is obtained when succinate is added to CI-linked respiration in a defined coupling state. CI and CII are abbreviations for Complex I and Complex II, but indicate here CI-linked respiration (with pyruvate, glutamate, malate, or other ETS competent CI-linked substrate combinations) and CII-linked (with succinate) respiration. CI&II indicates respiration with a CI- and CII-linked substrate cocktail. The symbol '&' in CI&II helps to distinguish CI&II as the measured flux in the presence of both CI- and CII-linked substrates from CI+CII as the operation of a mathematical addition when calculating the sum of CI- plus CII-linked respiration measured separately.
Abbreviation: CI/CI&II
Reference: Gnaiger 2009 Int J Biochem Cell Biol
MitoPedia concepts:
Respiratory control ratio