- high-resolution terminology - matching measurements at high-resolution
N/NS pathway control ratio
Description
The CI/CI+II substrate control ratio is obtained when succinate is added to CI-linked respiration in a defined coupling state. CI and CII are abbreviations for Complex I and Complex II, but indicate here CI-linked respiration (with pyruvate, glutamate, malate, or other ETS competent CI-linked substrate combinations) and CII-linked (with succinate) respiration. CI+II indicates respiration with a CI- and CII-linked substrate cocktail. The nomenclature using subscripts helps to distinguish CI+CII as the calculated sum of CI- plus CII-linked respiration measured separately, versus CI+II as the measured flux in the presence of both CI- plus CII-linked substrates.
Abbreviation: CI/CI+II
Reference: Gnaiger 2009 Int J Biochem Cell Biol
MitoPedia methods:
Respirometry
MitoPedia topics: "Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory control ratio"Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
