Difference between revisions of "Oxidative phosphorylation"

Revision as of 13:09, 14 June 2019

high-resolution terminology - matching measurements at high-resolution

Oxidative phosphorylation

Description

Oxidative phosphorylation (OXPHOS) is the oxidation of reduced fuel substrates by electron transfer to oxygen, chemiosmotically coupled to the phosphorylation of ADP to ATP (P») and accompanied by an intrinsically uncoupled component of respiration. The OXPHOS state of respiration provides a measure of OXPHOS-capacity (P), which is frequently corrected for residual oxygen consumption (ROX).

Abbreviation: OXPHOS

Reference: OXPHOS capacity

MitoPedia concepts: Respiratory state, Recommended

MitoPedia methods: Respirometry

MitoPedia topics: EAGLE

Contributed by Gnaiger E 2010-09-10, edited 2014-11-02.

Energy transformation in coupled fluxes, J, and forces, F and Δp, of oxidative phosphorylation. 2[H] indicates the reduced hydrogen equivalents of CHO fuel substrates and electron transfer to oxygen. J_H⁺out is coupled output flux. Proton leaks dissipate energy of translocated protons from low pH in the positive to the negative compartment (Gnaiger 2019 MitoPathways).

OXPHOS

Figure: Energy transformation in coupled fluxes, J, and forces, F and Δp, of oxidative phosphorylation. 2[H] indicates the reduced hydrogen equivalents of CHO fuel substrates and electron transfer to oxygen. J_H+out is coupled output flux. Proton leaks dissipate energy of translocated protons from low pH in the positive to the negative compartment (from Gnaiger 2014).

Related terms in Bioblast

OXPHOS; P

ROUTINE; R

ET-capacity; E

LEAK; L

ROX; Rox

SUITbrowser question: OXPHOS respiration

» OXPHOS-capacity

@@ Line 1: / Line 1: @@
 {{MitoPedia
 |abbr=OXPHOS
-|description=[[File:P.jpg |link=OXPHOS capacity]] '''Oxidative phosphorylation''' (OXPHOS) is the oxidation of reduced fuel substrates by electron transfer to oxygen, chemiosmotically coupled to the phosphorylation of [[ADP]] to [[ATP]] (P») and accompanied by an intrinsically uncoupled component of respiration. The OXPHOS state of respiration provides a measure of [[OXPHOS capacity]] (''P''), which is frequently corrected for [[residual oxygen consumption]] (ROX).
+|description=[[File:P.jpg |link=OXPHOS-capacity]] '''Oxidative phosphorylation''' (OXPHOS) is the oxidation of reduced fuel substrates by electron transfer to oxygen, chemiosmotically coupled to the phosphorylation of [[ADP]] to [[ATP]] (P») and accompanied by an intrinsically uncoupled component of respiration. The OXPHOS state of respiration provides a measure of [[OXPHOS-capacity]] (''P''), which is frequently corrected for [[residual oxygen consumption]] (ROX).
 |info=[[OXPHOS capacity]]
 }}
@@ Line 17: / Line 17: @@
 __TOC__
-[[Image:OXPHOS-coupled energy cycles.jpg|400px|link=Gnaiger 2012 MitoPathways|thumb|Energy transformation in coupled fluxes, ''J'', and forces, ''F'' and Δ''p'', of oxidative phosphorylation. 2[H] indicates the reduced hydrogen equivalents of CHO fuel substrates and electron transfer to oxygen. ''J''<sub>H<sup>+</sup>out</sub> is coupled output flux. Proton leaks dissipate energy of translocated protons from low pH in the positive to the negative compartment ([[Gnaiger 2014 MitoPathways]]).]]
+[[Image:OXPHOS-coupled energy cycles.jpg|400px|link=Gnaiger 2019 MitoPathways|thumb|Energy transformation in coupled fluxes, ''J'', and forces, ''F'' and Δ''p'', of oxidative phosphorylation. 2[H] indicates the reduced hydrogen equivalents of CHO fuel substrates and electron transfer to oxygen. ''J''<sub>H<sup>+</sup>out</sub> is coupled output flux. Proton leaks dissipate energy of translocated protons from low pH in the positive to the negative compartment ([[Gnaiger 2019 MitoPathways]]).]]
 == OXPHOS ==
@@ Line 38: / Line 38: @@
 == [[SUITbrowser]] question: OXPHOS respiration ==
- Work in progress
+::::» [[OXPHOS-capacity]]
-Physiological pathway control: protocols with substrates under the OXPHOS state, assessing mitochondrial respiration in conditions that approximate the physiological.