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Difference between revisions of "Oxidative phosphorylation"

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{{MitoPedia
{{MitoPedia
|abbr=OXPHOS
|abbr=OXPHOS
|description='''Oxidative phosphorylation''' (OXPHOS) is the oxidation of reduced substrates with electron transfer to oxygen, incompletely coupled to the phosphorylation of [[ADP]] to [[ATP]]. The OXPHOS state (''P'') of respiration provides a measure of [[OXPHOS capacity]].
|description=[[File:P.jpg |link=OXPHOS capacity]] '''Oxidative phosphorylation''' (OXPHOS) is the oxidation of reduced fuel substrates by electron transfer to oxygen, chemiosmotically coupled to the phosphorylation of [[ADP]] to [[ATP]] (P») and accompanied by an intrinsically uncoupled component of respiration. The OXPHOS state of respiration provides a measure of [[OXPHOS capacity]] (''P''), which is frequently corrected for [[residual oxygen consumption]] (ROX).
|info=[[MiPNet12.15]]; [[List of respiratory states]]
|info=[[OXPHOS capacity]]
|type=Respiration
}}
__TOC__
Contributed by [[Gnaiger E]] 2010-09-10, edited 2014-11-02.
 
[[Image:OXPHOS-coupled energy cycles.jpg|400px|link=BEC 2020.1|thumb|Energy transformation in coupled fluxes, ''J'', and forces, ''F'' and Δ''p'', of oxidative phosphorylation. 2[H] indicates the reduced hydrogen equivalents of CHO fuel substrates and electron transfer to oxygen. ''J''<sub>H<sup>+</sup>out</sub> is coupled output flux. Proton leaks dissipate energy of translocated protons from low pH in the positive to the negative compartment ([[BEC 2020.1]]).]]
 
== OXPHOS ==
 
'''Figure''': Energy transformation in coupled fluxes, ''J'', and forces, ''F'' and Δ''p'', of oxidative phosphorylation. 2[H] indicates the reduced hydrogen equivalents of CHO fuel substrates and electron transfer to oxygen. ''J''<sub>H+out</sub> is coupled output flux. Proton leaks dissipate energy of translocated protons from low pH in the positive to the negative compartment (from [[Gnaiger 2020 BEC MitoPathways]]).
 
 
 
== Related terms in Bioblast ==
:::: [[File:P.jpg |link=OXPHOS capacity]] [[OXPHOS capacity |OXPHOS]]; ''P''
 
:::: [[File:R.jpg |link=ROUTINE respiration]] [[ROUTINE respiration |ROUTINE]]; ''R''
 
:::: [[File:E.jpg |link=ET capacity]] [[ET capacity]]; ''E''
 
:::: [[File:L.jpg |link=LEAK respiration]] [[LEAK respiration |LEAK]]; ''L''
 
:::: [[File:ROX.jpg]] [[Residual oxygen consumption |ROX]]; ''Rox''
 
 
== [[SUITbrowser]] question: OXPHOS respiration ==
::::» [[OXPHOS capacity]]
:::: OXPHOS respiration is the focus of several [[SUIT]] protocols. The [https://suitbrowser.oroboros.at/ SUITbrowser] can be used to find SUIT protocols for this and other research questions.
 
 
== References ==
 
{{#ask:[[Additional label::Oxidative phosphorylation]]
| mainlabel=Bioblast link
|?Has title=Reference
|?Was published in year=Year
|format=broadtable
|limit=5000
|offset=0
|sort=Has title
|order=ascending
}}
 
{{MitoPedia concepts
|mitopedia concept=Respiratory state, Recommended
}}
{{MitoPedia methods
|mitopedia method=Respirometry
}}
}}
{{MitoPedia topics
{{MitoPedia topics
|mitopedia topic=Respiratory state
|mitopedia topic=EAGLE
|type=Respiration
}}
}}

Revision as of 17:56, 1 January 2021


high-resolution terminology - matching measurements at high-resolution


Oxidative phosphorylation

Description

P.jpg Oxidative phosphorylation (OXPHOS) is the oxidation of reduced fuel substrates by electron transfer to oxygen, chemiosmotically coupled to the phosphorylation of ADP to ATP (P») and accompanied by an intrinsically uncoupled component of respiration. The OXPHOS state of respiration provides a measure of OXPHOS capacity (P), which is frequently corrected for residual oxygen consumption (ROX).

Abbreviation: OXPHOS

Reference: OXPHOS capacity

Contributed by Gnaiger E 2010-09-10, edited 2014-11-02.
Energy transformation in coupled fluxes, J, and forces, F and Δp, of oxidative phosphorylation. 2[H] indicates the reduced hydrogen equivalents of CHO fuel substrates and electron transfer to oxygen. JH+out is coupled output flux. Proton leaks dissipate energy of translocated protons from low pH in the positive to the negative compartment (BEC 2020.1).

OXPHOS

Figure: Energy transformation in coupled fluxes, J, and forces, F and Δp, of oxidative phosphorylation. 2[H] indicates the reduced hydrogen equivalents of CHO fuel substrates and electron transfer to oxygen. JH+out is coupled output flux. Proton leaks dissipate energy of translocated protons from low pH in the positive to the negative compartment (from Gnaiger 2020 BEC MitoPathways).


Related terms in Bioblast

P.jpg OXPHOS; P
R.jpg ROUTINE; R
E.jpg ET capacity; E
L.jpg LEAK; L
ROX.jpg ROX; Rox


SUITbrowser question: OXPHOS respiration

» OXPHOS capacity
OXPHOS respiration is the focus of several SUIT protocols. The SUITbrowser can be used to find SUIT protocols for this and other research questions.


References

Bioblast linkReferenceYear
Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. https://doi.org/10.1016/j.biocel.2009.03.0132009
Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v12020


MitoPedia concepts: Respiratory state, Recommended 


MitoPedia methods: Respirometry 


MitoPedia topics: EAGLE