Edit Publication: Sheldon 2018 Nature

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Abstract:	Thousands of papers are submitted every month to the platforms arXiv and bioRxiv, which make manuscripts available before they have been peer reviewed and accepted by a journal. Scientists applaud preprints because they enable researchers to claim priority and make their findings available more quickly, unshackled from sluggish and tyrannical journals. This might make sense within the scientific community, but as someone who has worked for years with researchers and journalists to ensure responsible coverage of science in the media, I fear that this method of publication holds substantial risks for the broader community — risks that are not being given proper consideration by the champions of preprint. Weak work that hasn’t been reviewed could get overblown in the media. Conversely, better work could be ignored.
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MiPareas:	Gender Respiration Instruments;methods mt-Biogenesis;mt-density mt-Structure;fission;fusion mt-Membrane mtDNA;mt-genetics nDNA;cell genetics Genetic knockout;overexpression Comparative MiP;environmental MiP Developmental biology Exercise physiology;nutrition;life style mt-Medicine Patients Pharmacology;toxicology mt-Awareness
Pathological states:	COPD Aging;senescence Alzheimer's Autism Cancer Cardiovascular Diabetes Inherited Infectious Myopathy Neurodegenerative Obesity Parkinson's Sepsis Other
Stress conditions:	Hypoxia Cell death Cryopreservation Ischemia-reperfusion Permeability transition Oxidative stress;RONS Temperature Mitochondrial disease
Organism:	Pig Human Mouse Rat Guinea pig Bovines Horse Dog Rabbit Cat Other mammals Chicken Zebrafish Drosophila Artemia Caenorhabditis elegans Saccharomyces cerevisiae Birds Reptiles Amphibians Fishes Chelicerates Crustaceans Hexapods Myriapods Annelids Molluscs Nematodes Other invertebrates Fungi Plants Protists Eubacteria Archea Algae
Tissues;cells:	Fat Heart Skeletal muscle Nervous system Liver Kidney Lung;gill Islet cell;pancreas;thymus Endothelial;epithelial;mesothelial cell Blood cells Genital Other cell lines CHO HEK HeLa Neuroblastoma Fibroblast HUVEC Macrophage-derived Lymphocyte Platelet Stem cells
Preparations:	SMP Intact organism Intact organ Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria Chloroplasts Enzyme Oxidase;biochemical oxidation Intact cells
Enzyme:	Complex I Adenine nucleotide translocase Complex II;succinate dehydrogenase Complex III Complex IV;cytochrome c oxidase Complex V;ATP synthase Inner mt-membrane transporter Marker enzyme Supercomplex TCA cycle and matrix dehydrogenases Uncoupling protein
Regulation; kinetics:	pH Aerobic glycolysis ADP ATP ATP production AMP Calcium Coupling efficiency;uncoupling Cyt c Flux control Inhibitor Ion;substrate transport mt-Membrane potential Oxygen kinetics PCr;Cr Phosphate Redox state Substrate Temperature Threshold;excess capacity Uncoupler Fatty acid Amino acid Q-junction effect
Coupling:	ET LEAK ROUTINE OXPHOS
Pathways:	F N S Gp DQ CIV NS Other combinations ROX
High-resolution respirometry:	pH Oxygraph-2k TIP2k O2k-Fluorometer NO TPP Ca O2k-Spectrophotometer O2k-Manual O2k-Protocol Theory NextGen-O2k
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Free text: If the abstract is longer than 500 words, please enter additional information here. {{MitoFit page name}} == Comments == ::::» Fraser J, Polka J (2018) Together scientists and journalists can spot poor preprints. Nature 560:553. - [[Fraser 2018 Nature |»Bioblast link«]] ::::» Sarabipour S (2018) Preprints are good for science and good for the public. Nature 560:553. - [[Sarabipour 2018 Nature |»Bioblast link«]] ::::» Tennant J, Gatto L, Logan C (2018) Preprints help journalism, not hinder it. Nature 560:553. - [[Tennant 2018 Nature |»Bioblast link«]]

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