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Difference between revisions of "Sliwa 2012 Acta Biochim Pol"

From Bioblast
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|instruments=Oxygraph-2k
|instruments=Oxygraph-2k
|injuries=RONS; Oxidative Stress
|injuries=RONS; Oxidative Stress
|diseases=Diabetes
|organism=Human
|organism=Human
|tissues=Fat
|tissues=Fat

Revision as of 15:58, 14 March 2013

Publications in the MiPMap
Sliwa A, Goralska J, Czech U, Gruca A, Polus A, Zapala B, Dembinska-Kiec A (2012) Modulation of the human preadipocyte mitochondrial activity by beta-carotene. Acta Biochim Pol 59: 39-41.

» PMID: 22428124 Open Access

Sliwa A, Goralska J, Czech U, Gruca A, Polus A, Zapała B, Dembinska-Kiec A (2012) Acta Biochim Pol

Abstract: Increased ROS generation by the overload by metabolic substrates mitochondria paralleled by decrease of antioxidant activity are typical events found in metabolic syndrome and diabetes type 2. Metabolites of beta-carotene (BC) such as retinoic acid (RA), as well as low concentration of reactive oxygen species (ROS) modify the mitochondrial bioenergetic function. The aim of the study was to investigate the effect of beta-carotene on mitochondrial activity in human preadipocytes. BC used in concentrations, 10 or 30 µM, decreased mitochondrial membrane potential, inhibited mitochondrial respiration and decreased cellular ATP content. We conclude, that BC, the known antioxidant may decrease oxidative phosphorylation capacity of mitochondria. Keywords: Metabolic syndrome, diabetes, beta-carotene, retinoic acid, Chub-S7, preadipocytes


Labels: Pathology: Diabetes  Stress:RONS; Oxidative Stress"RONS; Oxidative Stress" is not in the list (Cell death, Cryopreservation, Ischemia-reperfusion, Permeability transition, Oxidative stress;RONS, Temperature, Hypoxia, Mitochondrial disease) of allowed values for the "Stress" property.  Organism: Human  Tissue;cell: Fat  Preparation: Intact Cell; Cultured; Primary"Intact Cell; Cultured; Primary" is not in the list (Intact organism, Intact organ, Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria, SMP, Chloroplasts, Enzyme, Oxidase;biochemical oxidation, ...) of allowed values for the "Preparation" property.  Enzyme: Complex V; ATP Synthase"Complex V; ATP Synthase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property. 


HRR: Oxygraph-2k