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Tretter 2013 Abstract MiP2013 - Revision history
2024-03-28T21:55:08Z
Revision history for this page on the wiki
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Beno Marija at 09:25, 28 April 2017
2017-04-28T09:25:02Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Tretter L, Komlódi T, Ádám-Vizi V (2013) The effects of methylmalonic acid on alpha-ketoglutarate supported oxidation in isolated brain, heart and liver mitochondria. Mitochondr Physiol Network 18.08.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Tretter L, Komlódi T, Ádám-Vizi V (2013) The effects of methylmalonic acid on alpha-ketoglutarate supported oxidation in isolated brain, heart and liver mitochondria. Mitochondr Physiol Network 18.08.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|info=[[File:Logo MiP2013.jpg|150px|right|MiPsociety]][<del style="font-weight: bold; text-decoration: none;">http://www.mitophysiology.org/?MiP2013 </del>MiP2013], [[Laner 2013 Mitochondr Physiol Network MiP2013|Book of Abstracts Open Access]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|info=[[File:Logo MiP2013.jpg|150px|right|MiPsociety]][<ins style="font-weight: bold; text-decoration: none;">[</ins>MiP2013<ins style="font-weight: bold; text-decoration: none;">]</ins>], [[Laner 2013 Mitochondr Physiol Network MiP2013|Book of Abstracts Open Access]]</div></td></tr>
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Beno Marija
https://wiki.oroboros.at/index.php?title=Tretter_2013_Abstract_MiP2013&diff=124224&oldid=prev
Beno Marija at 08:29, 8 November 2016
2016-11-08T08:29:16Z
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Beno Marija
https://wiki.oroboros.at/index.php?title=Tretter_2013_Abstract_MiP2013&diff=92295&oldid=prev
Went Nora at 11:21, 9 June 2015
2015-06-09T11:21:26Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2013</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2013</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|event=<del style="font-weight: bold; text-decoration: none;">MiP2013 Programme</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|event=<ins style="font-weight: bold; text-decoration: none;">MiPNet18.08_MiP2013</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=[[Methylmalonic acid]] (Mma) is a common intermediate in many catabolic processes. Its accumulation is associated with neurological symptoms. In methylmalonic acidemia mitochondrial dysfunction can be observed. In this study the effects of Mma were tested in isolated brain, heart and liver mitochondria. Oxygen consumption of isolated mitochondria was measured by Clark electrode, ATP synthesis was estimated by coupled enzyme assay, mitochondrial membrane potential was measured by safranin fluorescence. It was found that in the presence of Mma alpha-ketoglutarate (aKG) oxidation was significantly increased in isolated mitochondria. The oxidation of Mma is reflected in the increased ATP production and membrane hyperpolarization. This phenomenon could be explained by: (i) The mitochondrial transport of aKG was increased by Mma; (ii) The added Mma was itself activated and oxidized; (iii) alpha-ketoglutarate dehydrogenase (aKGDH) activity was increased by Mma. The effect of Mma on isolated aKGDH was tested and found that the enzyme activity was inhibited by Mma. Our results are in good agreement with that of Melo et al (2012). According to their interpretation the stimulating effect of Mma can be attributed to the stimulation of aKG transport. Our recent experiments however showed that this stimulation does not occur in liver mitochondria but it is pronounced in mitochondria isolated from the brain and heart, respectively. One of the differences between these types of mitochondria is that heart and brain are tissues able to oxidize ketone bodies. We interpret our results that a reaction analogous to the ketone body activation may activate methylmalonate to methylmalonyl-CoA. This reaction occurs in the heart and brain, but not in the liver mitochondria, respectively. This hypothesis is supported by the Mma-induced changes in P/O ratio. In brain and heart mitochondria in the presence of Mma, P/O ratio of aKG oxidation decreases. This finding is in agreement with the hypothesis that acetoacetate:succinyl-CoA transferase can transfer CoA and activates Mma to Mma-CoA.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=[[Methylmalonic acid]] (Mma) is a common intermediate in many catabolic processes. Its accumulation is associated with neurological symptoms. In methylmalonic acidemia mitochondrial dysfunction can be observed. In this study the effects of Mma were tested in isolated brain, heart and liver mitochondria. Oxygen consumption of isolated mitochondria was measured by Clark electrode, ATP synthesis was estimated by coupled enzyme assay, mitochondrial membrane potential was measured by safranin fluorescence. It was found that in the presence of Mma alpha-ketoglutarate (aKG) oxidation was significantly increased in isolated mitochondria. The oxidation of Mma is reflected in the increased ATP production and membrane hyperpolarization. This phenomenon could be explained by: (i) The mitochondrial transport of aKG was increased by Mma; (ii) The added Mma was itself activated and oxidized; (iii) alpha-ketoglutarate dehydrogenase (aKGDH) activity was increased by Mma. The effect of Mma on isolated aKGDH was tested and found that the enzyme activity was inhibited by Mma. Our results are in good agreement with that of Melo et al (2012). According to their interpretation the stimulating effect of Mma can be attributed to the stimulation of aKG transport. Our recent experiments however showed that this stimulation does not occur in liver mitochondria but it is pronounced in mitochondria isolated from the brain and heart, respectively. One of the differences between these types of mitochondria is that heart and brain are tissues able to oxidize ketone bodies. We interpret our results that a reaction analogous to the ketone body activation may activate methylmalonate to methylmalonyl-CoA. This reaction occurs in the heart and brain, but not in the liver mitochondria, respectively. This hypothesis is supported by the Mma-induced changes in P/O ratio. In brain and heart mitochondria in the presence of Mma, P/O ratio of aKG oxidation decreases. This finding is in agreement with the hypothesis that acetoacetate:succinyl-CoA transferase can transfer CoA and activates Mma to Mma-CoA.</div></td></tr>
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Went Nora
https://wiki.oroboros.at/index.php?title=Tretter_2013_Abstract_MiP2013&diff=82570&oldid=prev
Bader Helga at 09:26, 26 February 2015
2015-02-26T09:26:44Z
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Bader Helga
https://wiki.oroboros.at/index.php?title=Tretter_2013_Abstract_MiP2013&diff=52070&oldid=prev
Bidaurratzaga Eider at 11:53, 17 September 2013
2013-09-17T11:53:06Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Tretter L, Komlódi T, Ádám-Vizi V (2013) The effects of methylmalonic acid on alpha-ketoglutarate supported oxidation in isolated brain, heart and liver mitochondria. Mitochondr Physiol Network 18.08.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Tretter L, Komlódi T, Ádám-Vizi V (2013) The effects of methylmalonic acid on alpha-ketoglutarate supported oxidation in isolated brain, heart and liver mitochondria. Mitochondr Physiol Network 18.08.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|info=[http://www.mitophysiology.org/?MiP2013 MiP2013], [[Laner 2013 Mitochondr Physiol Network MiP2013|Book of Abstracts Open Access]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|info=<ins style="font-weight: bold; text-decoration: none;">[[File:Logo MiP2013.jpg|150px|right|MiPsociety]]</ins>[http://www.mitophysiology.org/?MiP2013 MiP2013], [[Laner 2013 Mitochondr Physiol Network MiP2013|Book of Abstracts Open Access]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Tretter L, Komlodi T, Adam-Vizi V</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Tretter L, Komlodi T, Adam-Vizi V</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2013</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2013</div></td></tr>
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Bidaurratzaga Eider
https://wiki.oroboros.at/index.php?title=Tretter_2013_Abstract_MiP2013&diff=51974&oldid=prev
Gnaiger Erich at 07:38, 15 September 2013
2013-09-15T07:38:22Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations and author contributions ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations and author contributions ==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Semmelweis University, Dept of Medical Biochemistry and Hungarian Academy of Science, Laboratory for Neurobiochemistry and Molecular Physiology, Budapest, Hungary.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Semmelweis University, Dept of Medical Biochemistry and Hungarian Academy of Science, Laboratory for Neurobiochemistry and Molecular Physiology, Budapest, Hungary. <ins style="font-weight: bold; text-decoration: none;">- </ins>Email: tretter@eok.sote.hu</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Email: tretter@eok.sote.hu</div></td><td colspan="2"></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Supported by OTKA (NK 81983), TAMOP (4.2.2./B-09/1), MTA (MTA TKI 2006 TKI88) to V.A-V.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Supported by OTKA (NK 81983), TAMOP (4.2.2./B-09/1), MTA (MTA TKI 2006 TKI88) to V.A-V.</div></td></tr>
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Tretter_2013_Abstract_MiP2013&diff=51833&oldid=prev
Gnaiger Erich at 07:55, 14 September 2013
2013-09-14T07:55:30Z
<p></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Tretter L, Komlódi T, Ádám-Vizi V (2013) The effects of methylmalonic acid on alpha-ketoglutarate supported oxidation in isolated brain, heart and liver mitochondria. Mitochondr Physiol Network 18.08.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Tretter L, Komlódi T, Ádám-Vizi V (2013) The effects of methylmalonic acid on alpha-ketoglutarate supported oxidation in isolated brain, heart and liver mitochondria. Mitochondr Physiol Network 18.08.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|info=[http://www.mitophysiology.org/?MiP2013 MiP2013]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|info=[http://www.mitophysiology.org/?MiP2013 MiP2013<ins style="font-weight: bold; text-decoration: none;">], [[Laner 2013 Mitochondr Physiol Network MiP2013|Book of Abstracts Open Access]</ins>]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Tretter L, Komlodi T, Adam-Vizi V</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Tretter L, Komlodi T, Adam-Vizi V</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2013</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2013</div></td></tr>
</table>
Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Tretter_2013_Abstract_MiP2013&diff=51652&oldid=prev
Gnaiger Erich at 17:38, 10 September 2013
2013-09-10T17:38:51Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Tretter L, Komlódi T, Ádám-Vizi V (2013) The effects of methylmalonic acid on alpha-ketoglutarate supported oxidation in isolated brain, heart and liver mitochondria. Mitochondr Physiol Network 18.08.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Tretter L, Komlódi T, Ádám-Vizi V (2013) The effects of methylmalonic acid on alpha-ketoglutarate supported oxidation in isolated brain, heart and liver mitochondria. Mitochondr Physiol Network 18.08.</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|info=[http://www.mitophysiology.org/?MiP2013 MiP2013]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Tretter L, Komlodi T, Adam-Vizi V</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Tretter L, Komlodi T, Adam-Vizi V</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2013</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2013</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|event=MiP2013</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|event=MiP2013 <ins style="font-weight: bold; text-decoration: none;">Programme</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=[[Methylmalonic acid]] (Mma) is a common intermediate in many catabolic processes. Its accumulation is associated with neurological symptoms. In methylmalonic acidemia mitochondrial dysfunction can be observed. In this study the effects of Mma were tested in isolated brain, heart and liver mitochondria. Oxygen consumption of isolated mitochondria was measured by Clark electrode, ATP synthesis was estimated by coupled enzyme assay, mitochondrial membrane potential was measured by safranin fluorescence. It was found that in the presence of Mma alpha-ketoglutarate (aKG) oxidation was significantly increased in isolated mitochondria. The oxidation of Mma is reflected in the increased ATP production and membrane hyperpolarization. This phenomenon could be explained by: (i) The mitochondrial transport of aKG was increased by Mma; (ii) The added Mma was itself activated and oxidized; (iii) alpha-ketoglutarate dehydrogenase (aKGDH) activity was increased by Mma. The effect of Mma on isolated aKGDH was tested and found that the enzyme activity was inhibited by Mma. Our results are in good agreement with that of Melo et al (2012). According to their interpretation the stimulating effect of Mma can be attributed to the stimulation of aKG transport. Our recent experiments however showed that this stimulation does not occur in liver mitochondria but it is pronounced in mitochondria isolated from the brain and heart, respectively. One of the differences between these types of mitochondria is that heart and brain are tissues able to oxidize ketone bodies. We interpret our results that a reaction analogous to the ketone body activation may activate methylmalonate to methylmalonyl-CoA. This reaction occurs in the heart and brain, but not in the liver mitochondria, respectively. This hypothesis is supported by the Mma-induced changes in P/O ratio. In brain and heart mitochondria in the presence of Mma, P/O ratio of aKG oxidation decreases. This finding is in agreement with the hypothesis that acetoacetate:succinyl-CoA transferase can transfer CoA and activates Mma to Mma-CoA.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=[[Methylmalonic acid]] (Mma) is a common intermediate in many catabolic processes. Its accumulation is associated with neurological symptoms. In methylmalonic acidemia mitochondrial dysfunction can be observed. In this study the effects of Mma were tested in isolated brain, heart and liver mitochondria. Oxygen consumption of isolated mitochondria was measured by Clark electrode, ATP synthesis was estimated by coupled enzyme assay, mitochondrial membrane potential was measured by safranin fluorescence. It was found that in the presence of Mma alpha-ketoglutarate (aKG) oxidation was significantly increased in isolated mitochondria. The oxidation of Mma is reflected in the increased ATP production and membrane hyperpolarization. This phenomenon could be explained by: (i) The mitochondrial transport of aKG was increased by Mma; (ii) The added Mma was itself activated and oxidized; (iii) alpha-ketoglutarate dehydrogenase (aKGDH) activity was increased by Mma. The effect of Mma on isolated aKGDH was tested and found that the enzyme activity was inhibited by Mma. Our results are in good agreement with that of Melo et al (2012). According to their interpretation the stimulating effect of Mma can be attributed to the stimulation of aKG transport. Our recent experiments however showed that this stimulation does not occur in liver mitochondria but it is pronounced in mitochondria isolated from the brain and heart, respectively. One of the differences between these types of mitochondria is that heart and brain are tissues able to oxidize ketone bodies. We interpret our results that a reaction analogous to the ketone body activation may activate methylmalonate to methylmalonyl-CoA. This reaction occurs in the heart and brain, but not in the liver mitochondria, respectively. This hypothesis is supported by the Mma-induced changes in P/O ratio. In brain and heart mitochondria in the presence of Mma, P/O ratio of aKG oxidation decreases. This finding is in agreement with the hypothesis that acetoacetate:succinyl-CoA transferase can transfer CoA and activates Mma to Mma-CoA.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|keywords=Methylmalonic acid, Safranine</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|keywords=Methylmalonic acid, Safranine</div></td></tr>
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Tretter_2013_Abstract_MiP2013&diff=50946&oldid=prev
Gnaiger Erich at 16:06, 19 August 2013
2013-08-19T16:06:05Z
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Tretter_2013_Abstract_MiP2013&diff=50075&oldid=prev
Bidaurratzaga Eider at 14:05, 13 August 2013
2013-08-13T14:05:22Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 14:05, 13 August 2013</td>
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Bidaurratzaga Eider