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Difference between revisions of "Tricarboxylic acid cycle"

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The tricarboxylic acid (TCA) cycle is a system of enzymes in the mitochondrial matrix (and [[succinate dehydrogenase]] in the inner mt-membrane) arranged in a cyclic metabolic structure, including dehydrogenases that converge in the NADH pool and succinate dehydrogenase for entry into the [[ETS]]. [[Citrate synthase]] is a marker enzyme of the TCA cycle, at the gateway into the cycle from pyruvate via acteyl-CoA. Sections of TCA cycle are required for [[ฮฒ-oxidation]]. [[Anaplerotic reactions]] fuel the TCA cycle with other intermediary metabolites. In the cell, the TCA cycle serves biosynthetic functions by metabolite export from the matrix into the cytosol.
{{MitoPedia
|abbr=TCA cycle
|description=The '''tricarboxylic acid (TCA) cycle''' is a system of enzymes in the mitochondrial matrix arranged in a cyclic metabolic structure, including dehydrogenases that converge in the NADH pool and [[succinate dehydrogenase]] (on the inner side of the inner mt-membrane) for entry into the membrane-bound ET pathway [[Membrane-bound ET pathway|mET pathway]]. [[Citrate synthase]] is a marker enzyme of the TCA cycle, at the gateway into the cycle from [[pyruvate]] via [[acetyl-CoA]]. It is thus the major module of the [[Electron transfer pathway]], upstream of the inner [[Membrane-bound ET pathway|Membrane-bound ET pathway]] (mET-pathway) and downstream of the [[Mitochondrial outer membrane|outer mt-membrane]]. Sections of TCA cycle are required for [[fatty acid oxidation]] (FAO, ฮฒ-oxidation). [[Anaplerosis|Anaplerotic reactions]] fuel the TCA cycle with other intermediary metabolites. In the cell, the TCA cycle serves also biosynthetic functions by metabolite export from the matrix into the cytosol.
|info=[[Gnaiger 2020 BEC MitoPathways]]
|type=Enzyme
}}
{{MitoPedia methods|type=Enzyme
}}
{{MitoPedia topics|type=Enzyme
}}

Latest revision as of 17:47, 1 January 2021


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Tricarboxylic acid cycle

Description

The tricarboxylic acid (TCA) cycle is a system of enzymes in the mitochondrial matrix arranged in a cyclic metabolic structure, including dehydrogenases that converge in the NADH pool and succinate dehydrogenase (on the inner side of the inner mt-membrane) for entry into the membrane-bound ET pathway mET pathway. Citrate synthase is a marker enzyme of the TCA cycle, at the gateway into the cycle from pyruvate via acetyl-CoA. It is thus the major module of the Electron transfer pathway, upstream of the inner Membrane-bound ET pathway (mET-pathway) and downstream of the outer mt-membrane. Sections of TCA cycle are required for fatty acid oxidation (FAO, ฮฒ-oxidation). Anaplerotic reactions fuel the TCA cycle with other intermediary metabolites. In the cell, the TCA cycle serves also biosynthetic functions by metabolite export from the matrix into the cytosol.

Abbreviation: TCA cycle

Reference: Gnaiger 2020 BEC MitoPathways