Difference between revisions of "Tricarboxylic acid cycle"
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The tricarboxylic acid (TCA) cycle is a system of enzymes in the mitochondrial matrix (and [[succinate dehydrogenase]] in the inner mt-membrane) arranged in a cyclic metabolic structure, including dehydrogenases that converge in the NADH pool and succinate dehydrogenase for entry into the [[ETS]]. [[Citrate synthase]] is a marker enzyme of the TCA cycle, at the gateway into the cycle from pyruvate via acteyl-CoA. Sections of TCA cycle are required for [[β-oxidation]]. [[Anaplerotic reactions]] fuel the TCA cycle with other intermediary metabolites. In the cell, the TCA cycle serves biosynthetic functions by metabolite export from the matrix into the cytosol. | The tricarboxylic acid (TCA) cycle is a system of enzymes in the mitochondrial matrix (and [[succinate dehydrogenase]] in the inner mt-membrane) arranged in a cyclic metabolic structure, including dehydrogenases that converge in the NADH pool and succinate dehydrogenase for entry into the [[ETS]]. [[Citrate synthase]] is a marker enzyme of the TCA cycle, at the gateway into the cycle from pyruvate via acteyl-CoA. Sections of TCA cycle are required for [[β-oxidation]]. [[Anaplerotic reactions]] fuel the TCA cycle with other intermediary metabolites. In the cell, the TCA cycle serves biosynthetic functions by metabolite export from the matrix into the cytosol. | ||
==References== | |||
*Gnaiger E (2009) Mitochondrial pathways through Complexes I+II: Convergent electron transport at the Q-junction and additive effect of substrate combinations. [http://www.oroboros.at/index.php?compl-12-convergent Mitochondr. Physiol. Network 12.12: 1-20]. | |||
[[Category:MitoPedia]] | |||
Revision as of 17:29, 15 August 2010
The tricarboxylic acid (TCA) cycle is a system of enzymes in the mitochondrial matrix (and succinate dehydrogenase in the inner mt-membrane) arranged in a cyclic metabolic structure, including dehydrogenases that converge in the NADH pool and succinate dehydrogenase for entry into the ETS. Citrate synthase is a marker enzyme of the TCA cycle, at the gateway into the cycle from pyruvate via acteyl-CoA. Sections of TCA cycle are required for β-oxidation. Anaplerotic reactions fuel the TCA cycle with other intermediary metabolites. In the cell, the TCA cycle serves biosynthetic functions by metabolite export from the matrix into the cytosol.
References
- Gnaiger E (2009) Mitochondrial pathways through Complexes I+II: Convergent electron transport at the Q-junction and additive effect of substrate combinations. Mitochondr. Physiol. Network 12.12: 1-20.
