| Saturday, 7th July Arrival |
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17:00 | Registration (Bridgetower room) |
19:00 | Buffet Dinner (Graham Storey Room) |
20:00 - 20:15 | Welcome to Cambridge (Lecture theatre) |
20:15 - 21:15 | Chuck Hoppel (Cleveland) |
| Mitochondrial physiology and functional testing in diagnosis of mitochondrial disease (Lecture theatre) |
21:15 | Reception (Terrace room) |
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| Sunday, 8th July |
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09:00 | Mitochondrial structure and respiratory function session (Graham Storey room) |
09:00 - 09:30 | Erich Gnaiger (Innsbruck) |
| Mitochondrial respiration: in vitro to in vivo |
09:30 - 10:00 | Rodrigue Rossignol (Bordeaux) |
| Mitochondrial structure, fission and networks |
10:00 - 10:15 | Steve Hand (Baton Rouge) |
| Protein targeting and translocation into mitochondria |
10:15 - 10:30 | Discussion |
10:30 | Coffee break (Dining Hall) |
11:00 - 11:15 | Shijun Xu (Gothenburg) |
| Mitochondrial dynamics at single cell level |
11:15 - 11:30 | Kel Sheldon (NIH) |
| VDAC blockage by tubulin is the missing link of mitochondrial respiration control |
11:30 - 11:45 | Marleen Forkink (Nijmegen) |
| Inhibiting mitochondrial Complex I or Complex III differentially affects mitochondrial physiology |
11:45 - 12:00 | Laura García Corzo (Granada) |
| A new insight about molecular aspects of CoQ deficiency |
12:00 - 12:15 | Marta Luna-Sánchez (Granada) |
| CoQ deficiency: molecular and pathophysiology consequences |
12:15 - 12:30 | Discussion |
12:30 | Lunch (Dining Hall) |
13:30 | Experimental methods session (Graham Storey room) |
13:30 - 13:50 | Vilmante Borutaite (Kaunas) |
| How to isolate mitochondria |
13:50 - 14:10 | Rodrigue Rossignol (Bordeaux) |
| How to measure morphology, fusion/fission |
14:10 - 14:30 | Kathrin Renner (Regensburg) |
| How to measure respiration & membrane potential |
14:30 - 14:50 | Erich Gnaiger (Innsbruck) |
| How to express respiratory states - www.bioblast.at |
14:50 - 15:10 | Chuck Hoppel (Cleveland) |
| How to diagnose mitochondrial disease |
15:10 - 15:30 | Aviva Tolkovsky (Cambridge) |
| How to measure cell death and mitophagy |
15:30 - 15:50 | Mike Murphy (Cambridge) |
| How to measure ROS |
15:50 - 16:00 | Discussion |
16:00 | Tea break (Dining Hall) |
16:30 | Mitochondrial coupling, thermogenesis & obesity session (Graham Storey room) |
16:30 - 16:45 | Guy Brown (Cambridge) |
| Mitochondrial energy production |
16:45 - 17:00 | Mary Ellen Harper (Ottawa) |
| Variable mitochondrial oxidative phosphorylation efficiency and its implications for obesity |
17:00 - 17:15 | Maria Holmström (Stockholm) |
| Tissue-specific effects of leptin treatment on mitochondrial function in obese leptin-deficient (ob/ob) mice |
17:15 - 17:30 | Thierry Arnould (Namur) |
| Mitochondrial uncoupling induces modifications of glucose metabolism and microRNA expression in 3T3-L1 adipocytes |
17:30 - 17:45 | Erika Cortez (Rio de Janeiro) |
| Mitochondrial oxidative metabolism impairment in bone marrow mononuclear cells of obese mice |
17:45 - 18:00 | Anastasia Kalinovich (Stockholm) |
| The effects of the mitochondria-targeted cationic uncoupler C12TPP on brown adipose tissue mitochondria, cells & mice |
18:00 - 19:00 | Discussion |
19:00 | Dinner (Dining Hall) |
21:00 | Evening tour of Cambridge & its pubs |
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| Monday, 9th July |
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09:00 | Mitophagy, neurons and neurodegenerative disease session (Graham Storey room) |
09:00 - 09:30 | Aviva Tolkovsky (Cambridge) |
| Mitophagy and neurodegeneration |
09:30 - 10:00 | Vilmante Borutaite (Kaunas) |
| Mitochondria in ischaemic & neurodegenerative disease |
10:00 - 10:15 | Subir Roy Chowdhury (Canada) |
| Neurodegeneration in diabetes is linked to impaired AMPK signaling and mitochondrial dysfunction |
10:15 - 10:30 | Discussion |
10:30 | Coffee (Dining Hall) |
11:00 - 11:15 | Ana Carina Costa (Leicester) |
| Mitochondrial chaperone Trap1 interacts genetically with Pink1 in Drosophila |
11:15 - 11:30 | Carola Schiller (Frankfurt) |
| Mitochondrial dysfunction in SY5Y cells moderately expressing human ß-amyloid |
11:30 - 11:45 | Joanna Poulton (Oxford) |
| Severe OPA1 mutations dysregulate mitophagy and disorganise the location of mitochondria in patients with OPA1 plus |
11:45 - 12:15 | Discussion |
12:30 | Lunch (Dining Hall) or MiP Society Board Meeting (Bridgetower room) |
13:30 - 15:00 | Walk to Grantchester (meet outside Graham Storey room) |
15:00 - 16:00 | Special interest discussion sessions in Orchard Tea Gardens or The Green Man |
| Structure & dynamics or Mitophagy & Neurodegeneration or Obesity & Coupling or Respiratory function |
16:00 - 17:00 | Walk back to Cambridge |
17:30 | Reactive oxygen species session (Graham Storey room) |
17:30 - 18:00 | Michael Murphy (Cambridge MBU) |
| Targeting bioactive molecules to mitochondria |
18:00 - 18:15 | Heather Wilkins (Denver) |
| Dicarboxylate carrier-mediated transport of glutathione into mitochondria determines neuronal susceptibility to oxidative and nitrosative stress |
18:15 - 18:30 | Maria Chiara Magnifico (Rome) |
| Cell bioenergetics, nitric oxide and melatonin |
18:30 - 18:45 | Stephanie Hagl (Frankfurt) |
| Herbal antioxidants induce mitogenesis and improve mitochondrial function in PC12 cells |
18:45 - 19:00 | Ryan Mailloux (Ottawa) |
| Glutaredoxin-2 and glutathionylation in the regulation of mitochondrial energetics in mice |
19:00 - 19:30 | Discussion |
19:30 | Dinner (Dining Hall) |
21:00 - 22:00 | Poster session (Bar & Crescent room) |
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| Tuesday, 10th July |
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09:00 | MRC Mitochondrial Biology Unit (Graham Storey room) |
09:00 - 09:40 | Sir John Walker (Cambridge MBU) |
| The ATP synthase |
09:40 - 10:20 | Leonid Sazonov (Cambridge MBU) |
| Mitochondrial Complex I |
10:20 | Coffee break (Dining Hall) |
10:50 - 11:30 | Edmund Kunji (Cambridge MBU) |
| Mitochondrial transport proteins |
11:30 - 12:10 | Michal Minczuk (Cambridge MBU) |
| Posttranscriptional regulation of mtDNA expression |
12:10 - 12:50 | Antonella Spinazzola (Cambridge MBU) |
| Mitochondrial nucleiods and biogenesis |
13:00 | Lunch (Dining Hall) |
14:00 | Hypoxia, stress and exercise session (Graham Storey room) |
14:00 - 14:30 | Steve Hand (Baton Rouge) |
| Mitochondrial function in an invertebrate extremophile |
14:30 - 15:00 | Andrew Murray (Cambridge) |
| Mitochondria in hypoxia, exercise and altitude |
15:00 - 15:15 | Matthias Elstner (Munich) |
| Life is not a sprint, it's a marathon: the metabolic gene expression footprint of human muscle fibres |
15:15 - 15:30 | Cesare Granata (Melbourne) |
| Mitochondrial adaptations to different training stimuli: the remarkable plasticity of skeletal muscle oxidative capacity |
15:30 - 15:45 | Dita Kasparova (Prague) |
| Expression of mitochondrial creatine kinase and hexokinase is amplified in the rat heart adapted to chronic hypoxia |
15:45 - 16:15 | Discussion |
16:15 | Tea break (Dining Hall) |
17:15 - 19:15 | Meet the PI session (Graham Storey room) 10 min 1 to 1 with the PIs of your choice |
19:30 | Dinner (Dining Hall) |
21:00 - 22:00 | Poster session (Bar & Crescent room) |
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| Wednesday, 11th July |
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09:00 | Cancer, Sepsis & Immunity session (Graham Storey room) |
09:00 - 09:30 | Rodrigue Rossignol (Bordeaux) |
| Mitochondria and cancer |
09:30 - 10:00 | Elizabeth Murchison (Cambridge) |
| The devil's mitochondria: biology and evolution of transmissible cancers |
10:00 - 10:15 | Martina Bajzíková (Prague) |
| Mitochondrial targeting of vitamin E succinate enhances its anti-cancer activity via mitochondrial Complex II |
10:15 - 10:30 | Discussion |
10:30 | Coffee break (Dining Hall) |
11:00 - 11:30 | Mervyn Singer (London) |
| Mitochondria and sepsis |
11:30 - 11:45 | Marco Fischer (Basel) |
| Metabolic profiles of human naďve and memory CD8+ T cells |
11:45 - 12:15 | Discussion |
12:30 | Lunch (Dining Hall) |
13:30 - 14:30 | Special interest group discussion sessions (meet Graham Storey room) |
| Modelling & regulation or Pathology or Reactive Oxygen Species or Hypoxia & Exercise & Mitochondrial DNA & disease or Cell death & the heart |
14:30 - 15:30 | Punting session |
15:30 | Tea break (Dining Hall) |
16:00 | Mitochondrial modelling & regulation of energy metabolism session (Graham Storey room) |
16:00 - 16:30 | Bernard Korzeniewski (Krakow) |
| Computer modelling of metabolic systems |
16:30 - 17:00 | Alan Robinson (Cambridge MBU) |
| Modelling the metabolism of the mitochondrion |
17:00 - 17:30 | Chris Cooper (Essex) |
| Cytochrome oxidase and its modelling |
17:30 - 17:45 | Vitaly Selivanov (Barcelona) |
| Multistationary and oscillatory modes of free radicals generation by the mitochondrial respiratory chain revealed by a bifurcation analysis |
17:45 - 18:00 | Chong Kiat Goo (Singapore) |
| PI3K/Akt signaling enhances mitochondrial respiratory capacity through 4E-BP1 |
18:00 - 18:15 | Robert Boushel (Copenhagen) |
| Inhibition of skeletal muscle ATPase activity alters mitochondrial substrate and adenylate control of OXPHOS, uncoupling |
18:15 - 18:30 | Philippe Diolez (Bordeaux) |
| From in vivo to in vitro: top-down control analyses of mitochondrial bioenergetics impairment in aged rat gastrocnemius muscle |
18:30 - 19:00 | Discussion |
19:30 | Dinner (Dining Hall) |
21:00 - 22:00 | Poster session (Bar & Crescent room) |
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| Thursday, 12th July |
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09:00 | Mitochondrial cell death, pathology & the heart session (Graham Storey room) |
09:00 - 09:15 | Guy Brown (Cambridge) |
| Cell death pathways |
09:15 - 09:45 | Michael Duchen (London) |
| Mitochondrial pathology |
09:45 - 10:15 | Andrew Halestrap (Bristol) |
| Mechanisms regulating ROS production and the permeability transition pore in ischaemia/reperfusion injury of the heart |
10:15 - 10:45 | Discussion |
10:45 | Coffee break |
11:15 - 11:30 | Marina Makrecka (Riga, Latvia) |
| Reduced availability of L-carnitine protects cardiac mitochondria against fatty acid-induced stress |
11:30 - 11:45 | Magdaléna Vondrusová (Prague, Czeck) |
| The role of mitochondrial supercomplexes in apoptosis induction by mitochondria-targeted agents |
11:45 - 12:00 | Petra Arnostova (Prague) |
| Comparison of hexokinase expression in the left and right ventricle of male Wistar rats |
12:10 - 12:30 | Discussion |
12:30 | Lunch (Dining Hall) |
13:30 - 14:30 | Punting session |
14:30 - 15:30 | The Great Debate session (Graham Storey room) The future of mitochondrial research |
15:30 | Tea break (Dining Hall) |
16:00 | Mitochondrial evolution, DNA & disease session (Graham Storey room) |
16:00 - 16:30 | Nick Lane (London) |
| Mitochondria in the evolution of complex life |
16:30 - 17:00 | Masashi Tanaka (Tokyo) |
| Rapid genetic diagnosis and pyruvate therapy for mitochondrial diseases |
17:00 - 17:15 | Chin San Liu (Taiwan) |
| Functional recovery in human cells harboring MERRF A8344G mutation of mitochondrial DNA via peptide-mediated mitochondrial delivery |
17:15 - 17:30 | Sarah Miles (Bristol) |
| Effect of DNA lesions on transcription by human mitochondrial RNA polymerase |
17:30 - 18:00 | Discussion |
18:00 - 18:30 | Summary - feedback - evaluation (Graham Storey room) |
18:30 - 19:30 | Reception & MiPArt exhibition (Graham Storey room &/or outside) |
19:30 | MiP Summer Dinner (Dining Hall) |
21:00 | MiP special lecture: Chris Cooper |
| The Mitochondrial Olympics (Dining Hall) |
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| Friday, 13th July Departure |
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