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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
Holloway Graham P
MitoPedia topics: EAGLE
| Name | Holloway Graham P, PhD, Assistant Prof. |
|---|---|
| Institution |  University of Guelph, CA |
| Address | 50 Stone Rd., N1G2W1 |
| City | Guelph |
| State/Province | Ontario (ON) |
| Country | Canada |
| [email protected] | |
| Weblink | |
| O2k-Network Lab | CA Guelph Holloway GP |
Labels:
Publications
| Published | Reference | |
|---|---|---|
| Holwerda 2024 J Cachexia Sarcopenia Muscle | 2024 | Holwerda AM, Dirks ML, Barbeau PA, Goessens J, Gijsen A, van Loon LJC, Holloway GP (2024) Mitochondrial bioenergetics are not associated with myofibrillar protein synthesis rates. J Cachexia Sarcopenia Muscle [Epub ahead of print]. https://doi.org/10.1002/jcsm.13532 |
| Brunetta 2024 BEC | 2024 | Brunetta HS, Holloway GP (2024) Methodological considerations for the determination of mitochondrial ADP sensitivity in skeletal muscle. Bioenerg Commun 2024.4. https://doi.org/10.26124/bec:2024-0004 |
| Brunetta 2024 MitoFit | 2024 | Brunetta HS, Holloway GP (2024) Methodological considerations for the determination of mitochondrial ADP sensitivity in skeletal muscle. MitoFit Preprints 2024. 1. https://doi.org/10.26124/mitofit:2024-0001 |
| Frangos 2023 J Biol Chem | 2023 | Frangos SM, DesOrmeaux GJ, Holloway GP (2023) Acidosis attenuates CPT-I supported bioenergetics as a potential mechanism limiting lipid oxidation. https://doi.org/10.1016/j.jbc.2023.105079 |
| Wang 2023 Nature | 2023 | Wang D, Townsend LK, DesOrmeaux GJ, Frangos SM, Batchuluun B, Dumont L, Kuhre RE, Ahmadi E, Hu S, Rebalka IA, Gautam J, Jabile MJT, Pileggi CA, Rehal S, Desjardins EM, Tsakiridis EE, Lally JSV, Juracic ES, Tupling AR, Gerstein HC, ParΓ© G, Tsakiridis T, Harper ME, Hawke TJ, Speakman JR, Blondin DP, Holloway GP, JΓΈrgensen SB, Steinberg GR (2023) GDF15 promotes weight loss by enhancing energy expenditure in muscle. https://doi.org/10.1038/s41586-023-06249-4 |
| Brunetta 2022 Redox Biol | 2022 | Brunetta HS, Petrick HL, Momken I, Handy RM, Pignanelli C, Nunes EA, Piquereau J, Mericskay M, Holloway GP (2022) Nitrate consumption preserves HFD-induced skeletal muscle mitochondrial ADP sensitivity and lysine acetylation: A potential role for SIRT1. https://doi.org/10.1016/j.redox.2022.102307 |
| Goudie 2022 Sci Rep | 2022 | Goudie L, Mancini NL, Shutt TE, Holloway GP, Mu C, Wang A, McKay DM, Shearer J (2022) Impact of experimental colitis on mitochondrial bioenergetics in intestinal epithelial cells. https://doi.org/10.1038/s41598-022-11123-w |
| BEC 2020.1 doi10.26124bec2020-0001.v1 | 2020 | Gnaiger E et al β MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1 |
| Dirks 2020 J Physiol | 2020 | Dirks ML, Miotto PM, Goossens GH, Senden JM, Petrick HL, van Kranenburg J, van Loon LJC, Holloway GP (2020) Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H2O2 emission. J Physiol 598:123-37. |
| Brunetta 2020 J Physiol | 2020 | Brunetta HS, Politis-Barber V, Petrick HL, Dennis KMJH, Kirsh AJ, Barbeau PA, Nunes EA, Holloway GP (2020) Nitrate attenuates HFD-induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial ROS emission. J Physiol 598:3357-71. |
| Politis-Barber 2020 Am J Physiol Endocrinol Metab | 2020 | Politis-Barber V, Brunetta HS, Paglialunga S, Petrick HL, Holloway GP (2020) Long-term high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration. Am J Physiol Endocrinol Metab 319:E376-87. |
| Miotto 2020 Am J Physiol Endocrinol Metab | 2020 | Miotto PM, Petrick HL, Holloway GP (2020) Acute insulin deprivation results in altered mitochondrial substrate sensitivity conducive to greater fatty acid transport. Am J Physiol Endocrinol Metab 319:E345-53. |
| Pignanelli 2019 Am J Physiol Regul Integr Comp Physiol | 2019 | Pignanelli C, Petrick HL, Keyvani F, Heigenhauser GJF, Quadrilatero J, Holloway GP, Burr JF (2019) Low-load resistance training to task-failure with and without blood flow restriction: muscular functional and structural adaptations. Am J Physiol Regul Integr Comp Physiol 318:R284-95. |
| Petrick 2019 J Physiol | 2019 | Petrick HL, Pignanelli C, Barbeau PA, Churchward-Venne TA, Dennis KMJH, van Loon LJC, Burr JF, Goossens GH, Holloway GP (2019) Blood flow restricted resistance exercise and reductions in oxygen tension attenuate mitochondrial H2O2 emission rates in human skeletal muscle. J Physiol 597:3985-97. |
| Miotto 2019 FASEB J | 2019 | Miotto PM, McGlory C, Bahniwal R, Kamal M, Phillips SM, Holloway GP (2019) Supplementation with dietary Ο-3 mitigates immobilization-induced reductions in skeletal muscle mitochondrial respiration in young women. FASEB J 33:8232-40. |
| Petrick 2019 Biochem J | 2019 | Petrick HL, Holloway GP (2019) High intensity exercise inhibits carnitine palmitoyltransferase-I sensitivity to L-carnitine. Biochem J 476:547-58. |
| Monaco 2018 Am J Physiol Regul Integr Comp Physiol | 2018 | Monaco CMF, Miotto PM, Huber JS, van Loon LJC, Simpson JA, Holloway GP (2018) Sodium nitrate supplementation alters mitochondrial H2O2 emission but does not improve mitochondrial oxidative metabolism in the heart of healthy rats. Am J Physiol Regul Integr Comp Physiol 315:R191-R204. |
| Barbeau 2018 Biochem J | 2018 | Barbeau PA, Miotto PM, Holloway GP (2018) Mitochondrial derived reactive oxygen species influence ADP sensitivity, but not CPT-I substrate sensitivity. Biochem J 475:2997-3008. |
| Monaco 2018 Diabetologia | 2018 | Monaco CMF, Proudfoot R, Miotto PM, Herbst EAF, MacPherson REK, Holloway GP (2018) Ξ±-linolenic acid supplementation prevents exercise-induced improvements in white adipose tissue mitochondrial bioenergetics and whole-body glucose homeostasis in obese Zucker rats. Diabetologia 61:433-44. |
| Baaten 2018 Haematologica | 2018 | Baaten CCFMJ, Moenen FCJI, Henskens YMC, Swieringa F, Wetzels RJH, van Oerle R, Heijnen HFG, Ten Cate H, Holloway GP, Beckers EAM, Heemskerk JWM, van der Meijden PEJ (2018) Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy. Haematologica 103:1557-67. |
| Holloway 2018 Cell Rep | 2018 | Holloway GP, Holwerda AM, Miotto PM, Dirks ML, Verdijk LB, van Loon LJC (2018) Age-associated impairments in mitochondrial ADP sensitivity contribute to redox stress in senescent human skeletal muscle. Cell Rep 22:2837β48. |
| Herbst 2017 Appl Physiol Nutr Metab | 2017 | Herbst EAF, George MAJ, Brebner K, Holloway GP, Kane DA (2017) Lactate is oxidized outside of the mitochondrial matrix in rodent brain. Appl Physiol Nutr Metab 43:467-74. |
| Chorner 2016 Am J Physiol Regul Integr Comp Physiol | 2016 | Chorner Z, Barbeau PA, Castellani L, Wright DC, Chabowski A, Holloway GP (2016) Dietary Ξ±-linolenic acid supplementation alters skeletal muscle plasma membrane lipid composition, sarcolemmal FAT/CD36 abundance, and palmitate transport rates. Am J Physiol Regul Integr Comp Physiol 311:R1234-42. |
| Miotto 2016 Biochem J | 2016 | Miotto PM, Holloway GP (2016) In the absence of phosphate shuttling, exercise reveals the in vivo importance of creatine-independent mitochondrial ADP transport. Biochem J 473:2831-43. |
| Herbst 2016 Appl Physiol Nutr Metab | 2016 | Herbst EA, Holloway GP (2016) Exercise increases mitochondrial glutamate oxidation in the mouse cerebral cortex. Appl Physiol Nutr Metab 41:799-801. |
| Snook 2016 Am J Physiol Regul Integr Comp Physiol | 2016 | Snook LA, MacPherson RE, Monaco CM, Frendo-Cumbo S, Castellani L, Peppler WT, Anderson ZG, Buzelle SL, LeBlanc PJ, Holloway GP, Wright DC (2016) Prior exercise training blunts short term highfat diet induced weight gain. Am J Physiol Regul Integr Comp Physiol 311:R315-24. |
| Paglialunga 2015 Diabetologia | 2015 | Paglialunga S, Ludzki A, Root-McCaig J, Holloway GP (2015) In adipose tissue, increased mitochondrial emission of reactive oxygen species is important for short-term high-fat diet-induced insulin resistance in mice. Diabetologia 58:1071-80. |
| Herbst 2015 J Physiol | 2015 | Herbst EA, Holloway GP (2015) Permeabilization of brain tissue in situ enables multi-region analysis of mitochondrial function in a single mouse brain. J Physiol 593:787-801. |
| Ludzki 2015 Diabetes | 2015 | Ludzki A, Paglialunga S, Smith BK, Herbst EA, Allison MK, Heigenhauser GJ, Neufer PD, Holloway GP (2015) Rapid repression of ADP transport by palmitoyl-CoA is attenuated by exercise training in humans; a potential mechanism to decrease oxidative stress and improve skeletal muscle insulin signaling. Diabetes 64:2769-79. |
| Whitfield 2015 J Physiol | 2015 | Whitfield J, Ludzki A, Heigenhauser GJ, Senden JM, Verdijk LB, van Loon LJ, Spriet LL, Holloway GP (2015) Beetroot juice supplementation reduces whole body oxygen consumption but does not improve indices of mitochondrial efficiency in human skeletal muscle. J Physiol 594:421-35. |
| Herbst 2015 Neuroscience | 2015 | Herbst EA, Holloway GP (2015) Exercise training normalizes mitochondrial respiratory capacity within the striatum of the R6/1 model of Huntington's disease. Neuroscience 303:515-23. |
| Herbst 2015 Metabolism | 2015 | Herbst EA, Roussakis C, Matravadia S, Holloway GP (2015) Chronic treadmill running does not enhance mitochondrial oxidative capacity in the cortex or striatum. Metabolism 64:1419-25. |
| Herbst 2014 J Physiol | 2014 | Herbst EA, Paglialunga S, Gerling C, Whitfield J, Mukai K, Chabowski A, Heigenhauser GJ, Spriet LL, Holloway GP (2014) Omega-3 supplementation alters mitochondrial membrane composition and respiration kinetics in human skeletal muscle. J Physiol 592:1341-52. |
| Beaudoin 2014 J Physiol | 2014 | Beaudoin MS, Perry CC, Arkell A, Chabowski A, Simpson JA, Wright DC, Holloway GP (2014) In the ZDF rat, impairments in mitochondrial palmitoyl-CoA respiratory kinetics that precede the development of diabetic cardiomyopathy are prevented by resveratrol supplementation. J Physiol 592:2519-33. |
| Beaudoin 2013 Am J Physiol Regul Integr Comp Physiol | 2013 | Beaudoin MS, Snook LA, Arkell AM, Simpson JA, Holloway GP, Wright DC (2013) Resveratrol supplementation improves white adipose tissue function in a depot-specific manner in Zucker diabetic fatty rats. Am J Physiol Regul Integr Comp Physiol 305:542-51. |
| Smith 2013 J Physiol | 2013 | Smith BK, Perry CG, Herbst EA, Ritchie IR, Beaudoin MS, Smith JC, Neufer PD, Wright DC, Holloway GP (2013) Submaximal ADP-stimulated respiration is impaired in ZDF rats and recovered by resveratrol. J Physiol 591:6089-101. |
| Lally 2013 PLoS One | 2013 | Lally JS, Herbst EA, Matravadia S, Maher AC, Perry CG, Ventura-Clapier R, Holloway GP (2013) Over-expressing mitofusin-2 in healthy mature mammalian skeletal muscle does not alter mitochondrial bioenergetics. PLoS One 8:e55660. |
| Smith 2012 Biochem J | 2012 | Smith BK, Perry CG, Koves TR, Wright DC, Smith JC, Neufer PD, Muoio DM, Holloway GP (2012) Identification of a novel malonyl-CoA IC50 for CPT-I: implications for predicting in vivo fatty acid oxidation rates. Biochem J 448:13-20. |
| Perry 2012 J Physiol | 2012 | Perry CG, Kane DA, Herbst EA, Mukai K, Lark DS, Wright DC, Heigenhauser GJ, Neufer PD, Spriet LL, Holloway GP (2012) Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle. J Physiol 590: 5475-5486. |
| McFarlan 2012 J Biol Chem | 2012 | McFarlan JT, Yoshida Y, Jain SS, Han XX, Snook LA, Lally J, Smith BK, Glatz JF, Luiken JJ, Sayer RA, Tupling AR, Chabowski A, Holloway GP, Bonen A (2012) In vivo, fatty acid translocase (CD36) critically regulates skeletal muscle fuel selection, exercise performance and training-induced adaptation of fatty acid oxidation. J Biol Chem 287:23502-16. |
| Smith 2011 Biochem J | 2011 | Smith BK, Jain SS, Rimbaud S, Dam A, Quadrilatero J, Ventura-Clapier R, Bonen A, Holloway GP (2011) FAT/CD36 is located on the outer mitochondrial membrane, upstream of long-chain acyl-CoA synthetase, and regulates palmitate oxidation. Biochem J 437:125-34. |
Abstracts
| Published | Reference | |
|---|---|---|
| Holloway 2023 MiP2023 | 2023 | |
| George 2015 Abstract MiPschool Greenville 2015 | 2015 | Mitochondria do not directly oxidize lactate within the cerebral cortex or hippocampus. |
| Holloway 2014 Abstract MiP2014 | 2014 | Acute diet-induced insulin resistance is associated with increased adipose tissue mitochondrial ROS emissions. |
| Herbst 2014 Abstract MiP2014 | 2014 | Analysis of mitochondrial function in multiple brain regions through in situ permeabilization. |
| Holloway 2013 Abstract MiP2013 | 2013 | Holloway GP (2013) Tissue specific changes in respiratory substrate kinetics in the ZDF rat and in response to resveratrol supplementation. Mitochondr Physiol Network 18.08. |
| Holloway 2012 Abstract Bioblast | 2012 | Holloway GP (2012) Over-expressing mitofusin-2 in healthy mature mammalian skeletal muscle does not alter mitochondrial bioenergetics. Mitochondr Physiol Network 17.12. |
