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Hosler 2023 Mitochondrion

From Bioblast
Publications in the MiPMap
Hosler J, Hoang N, Shirey Edwards K (2023) The cyclic lipopeptide micafungin induces rupture of isolated mitochondria by reprograming the mitochondrial inner membrane anion channel.

Β» Mitochondrion [Epub ahead of print]. PMID: 37201620 Open Access

Hosler Jonathan, Hoang Ngoc, Shirey Edwards Kristine (2023) Mitochondrion

Abstract: The antifungal activity of the drug micafungin, a cyclic lipopeptide that interacts with membrane proteins, may involve inhibition of fungal mitochondria. In humans, mitochondria are spared by the inability of micafungin to cross the cytoplasmic membrane. Using isolated mitochondria, we find that micafungin initiates the uptake of salts, causing rapid swelling and rupture of mitochondria with release of cytochrome c. The inner membrane anion channel (IMAC) is altered by micafungin to transfer both cations and anions. We propose that binding of anionic micafungin to IMAC attracts cations into the ion pore for the rapid transfer of ion pairs. β€’ Keywords: Anion transport, Cyclic lipopeptides, Inner mitochondrial anion channel, Ion channel, Micafungin, Mitochondrial respiratory chain complex, Mitochondrial transport β€’ Bioblast editor: Plangger M β€’ O2k-Network Lab: US MS Jackson Hosler J

Labels: MiParea: Respiration, Pharmacology;toxicology 

Organism: Rat  Tissue;cell: Liver  Preparation: Isolated mitochondria 

Regulation: Ion;substrate transport 

Pathway: CIV  HRR: Oxygraph-2k