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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
Neuzil Jiri
MitoPedia topics: EAGLE
COST: Member
| Name | Neuzil Jiri, Prof. Dr. |
|---|---|
| Institution |  Molecular Therapy Group, Institute of Biotechnology, Czech Academy of Sciences, CZ ____ Apoptosis Research Group, School of Medical Science, Griffith Health Institute, Griffith University, AU |
| Address | Videnska 1083
Prague 4, 142 20 |
| City | Prague and Southport |
| State/Province | |
| Country | Czech Republic and Australia |
| [email protected] | |
| Weblink | |
| O2k-Network Lab | AU Queensland Neuzil J, CZ Prague Neuzil J |
Labels: Field of research: Basic
Publications
| Published | Reference | |
|---|---|---|
| Vacurova 2022 Nat Commun | 2022 | Vacurova E, Trnovska J, Svoboda P, Skop V, Novosadova V, Reguera DP, Petrezselyová S, Piavaux B, Endaya B, Spoutil F, Zudova D, Stursa J, Melcova M, Bielcikova Z, Werner L, Prochazka J, Sedlacek R, Huttl M, Hubackova SS, Haluzik M, Neuzil J (2022) Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice. https://doi.org/10.1038/s41467-022-29486-z |
| Fialova 2022 Biomed Pharmacother | 2022 | Fialova JL, Hönigova K, Raudenska M, Miksatkova L, Zobalova R, Navratil J, Šmigová J, Moturu TR, Vicar T, Balvan J, Vesela K, Abramenko N, Kejik Z, Kaplanek R, Gumulec J, Rosel D, Martasek P, Brábek J, Jakubek M, Neuzil J, Masarik M (2022) Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration. https://doi.org/10.1016/j.biopha.2022.113582 |
| Arbon 2022 Antimicrob Agents Chemother | 2022 | Arbon D, Ženíšková K, Šubrtová K, Mach J, Štursa J, Machado M, Zahedifard F, Leštinová T, Hierro-Yap C, Neuzil J, Volf P, Ganter M, Zoltner M, Zíková A, Werner L, Sutak R (2022) Repurposing of MitoTam: Novel anti-cancer drug candidate exhibits potent activity against major protozoan and fungal pathogens. https://doi.org/10.1128/aac.00727-22 |
| Vidimce 2021 Front Pharmacol | 2021 | Vidimce J, Pillay J, Shrestha N, Dong LF, Neuzil J, Wagner KH, Holland OJ, Bulmer AC (2021) Mitochondrial function, fatty acid metabolism, and body composition in the hyperbilirubinemic gunn rat. Front Pharmacol 12:586715. |
| Sandoval-Acuna 2021 Cancer Res | 2021 | Sandoval-Acuña C, Torrealba N, Tomkova V, Jadhav SB, Blazkova K, Merta L, Lettlova S, Adamcová MK, Rosel D, Brábek J, Neuzil J, Stursa J, Werner L, Truksa J (2021) Targeting mitochondrial iron metabolism suppresses tumor growth and metastasis by inducing mitochondrial dysfunction and mitophagy. Cancer Res 81:2289-303. |
| Boukalova 2020 Biochim Biophys Acta Mol Basis Dis | 2020 | Boukalova S, Hubackova S, Milosevic M, Ezrova Z, Neuzil J, Rohlena J (2020) Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer. Biochim Biophys Acta Mol Basis Dis 1866:165759. https://doi.org/10.1016/j.bbadis.2020.165759 |
| BEC 2020.1 doi10.26124bec2020-0001.v1 | 2020 | Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1 |
| 6th Biannual Meeting on Mitochondria Apoptosis & Cancer 2019 Prague CZ | 2019-09-17 | Prague, CZ, 2019 September 17-20. 6th Biannual Meeting on Mitochondria Apoptosis & Cancer |
| Bajzikova 2019 Cell Metab | 2019 | Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman Werner JH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J (2019) Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab 29:399-416. 10.1016/j.cmet.2018.10.014 |
| Blecha 2017 Free Radic Biol Med | 2017 | Blecha J, Novais SM, Rohlenova K, Novotna E, Lettlova S, Schmitt S, Zischka H, Neuzil J, Rohlena J (2017) Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death. Free Radic Biol Med 112:253-66. |
| Rohlenova 2016 Antioxid Redox Signal | 2016 | Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alisadeh E, Yan B, Nguyen M, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong L, Neuzil J (2016) Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2high breast cancer. Antioxid Redox Signal 26:84-103. |
| Khera 2015 Placenta | 2015 | Khera A, Dong LF, Holland OJ, Vanderlelie J, Pasdar EA, Neuzil J, Perkins AV (2015) Selenium supplementation induces mitochondrial biogenesis in trophoblasts. Placenta 36:863-9. |
| Yan 2015 BMC Cancer | 2015 | Yan B, Stantic M, Zobalova R, Bezawork-Geleta A, Stapelberg M, Stursa J, Prokopova K, Dong L, Neuzil J (2015) Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner. BMC Cancer 15:401. |
| Kluckova 2015 Cell Death Dis | 2015 | Kluckova K, Sticha M, Cerny J, Mracek T, Dong L, Drahota Z, Gottlieb E, Neuzil J, Rohlena J (2015) Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation. Cell Death Dis 6:e1749. |
| Pasdar 2015 PLoS One | 2015 | Pasdar EA, Smits M, Stapelberg M, Bajzikova M, Stantic M, Goodwin J, Yan B, Stursa J, Kovarova J, Sachaphibulkij K, Bezawork-Geleta A, Sobol M, Filimonenko A, Tomasetti M, Zobalova R, Hozak P, Dong LF, Neuzil J (2015) Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents. PLoS One 10:e0119549. |
| Kluckova 2015 Methods Mol Biol | 2015 | Kluckova K, Dong L, Bajzikova M, Rohlena J, Neuzil J (2015) Evaluation of respiration of mitochondria in cancer cells exposed to mitochondria-targeted agents. Methods Mol Biol 1265:181-94. |
| Truksa 2015 Antioxid Redox Signal | 2015 | Truksa J, Dong L, Rohlena J, Stursa J, Vondrusova M, Goodwin J, Nguyen M, Kluckova K, Rychtarcikova Z, Lettlova S, Spacilova J, Stapelberg M, Zoratti M, Neuzil J (2015) Mitochondrially targeted vitamin E succinate modulates expression of mitochondrial DNA transcripts and mitochondrial biogenesis. Antioxid Redox Signal 22:883-900. |
| Tan 2015 Cell Metab | 2015 | Tan AS, Baty JW, Dong L, Bezawork-Geleta A, Endaya B, Goodwin J, Bajzikova M, Kovarova J, Peterka M, Yan B, Pesdar EA, Sobol M, Filimonenko A, Stuart S, Vondrusova M, Kluckova K, Sachaphibulkij K, Rohlena J, Hozak P, Truksa J, Eccles D, Haupt LM, Griffiths LR, Neuzil J, Berridge MV (2015) Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA. Cell Metab 21:81-94. |
| Moreno-Sanchez 2013 FEBS J | 2013 | Moreno-Sánchez R, Hernández-Esquivel L, Rivero-Segura NA, Marín-Hernández A, Neuzil J, Ralph SJ, Rodríguez-Enríquez S (2013) Reactive oxygen species are generated by the respiratory Complex II - evidence for lack of contribution of the reverse electron flow in Complex I. FEBS J 280:927-38. |
Abstracts
| Published | Reference | |
|---|---|---|
| Neuzil 2022 Abstract Bioblast | 2022 | 6.4. «10+5» |
| Rohlena 2017 MiP2017 | 2017 |  |
| Blecha 2015 Abstract MiP2015 | 2015 | Modulation of mitochondrial electron transport chain activity differentially regulates cell death in proliferating and quiescent cells. |
| Lettlova 2015 Abstract MiP2015 | 2015 | Role of the microRNA-301a in the regulation of mitochondrial function in cancer cells. |
| Rohlena 2015 Abstract MiP2015 | 2015 | Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation. |
| Rohlenova 2015 Abstract MiP2015 | 2015 | Mitochondrial targeting of tamoxifen enhances its activity against Her2high breast cancer. |
| Kluckova 2014 Abstract MiP2014 | 2014 | Proximal ubiquinone binding site in mitochondrial respiratory Complex II is a target for vitamin E analog MitoVES, an experimental anti-cancer agent. Mitochondr Physiol Network 19.13. |
| Bajzikova 2013 Abstract IOC79 | 2013 | Bajzikova M (2013) Mitochondrially targeted vitamin E succinate and its effects on mitochondrial oxidative phosphorylation system. Mitochondr Physiol Network 18.07. |
