Ojuka 2014 Abstract IOC96

From Bioblast
Ojuka E (2014) Excess fructose consumption: effects on mitochondrial function and insulin resistance. Mitochondr Physiol Network 19.11.


Ojuka E (2014)

Event: IOC96

Fructose is the master of all foods in its ability to cause fat accumulation and insulin resistance. The lecture discusses how these properties of fructose are exploited by some mammals and birds to survive periods of food scarcity and also why these same properties have contributed to the alarming increase in the incidence of type II diabetes in man today. Mechanisms to explain why small amounts of fructose enhance glucose metabolism but excess consumption leads to de novo lipogenesis, ectopic lipid deposition, and insulin resistance are explored in detail. The acute effects of fructose overload on the mitochondrial function along with the adaptive responses of the organelle to prolonged exposure are also examined. Lastly the thrifty gene hypothesis is presented as a possible mechanism to explain why humans are so prone to fructose-induced obesity and diabetes.

β€’ O2k-Network Lab: ZA Cape Town Ojuka EO

Labels: Pathology: Diabetes, Obesity 

Organism: Human 


Institute of South Africa Newlands ESSM UCT Dept of Human Biology Sports Science University of Cape Town

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