Silva 2021 MitoFit Etomoxir
From Bioblast
| Silva FSG, Komlódi T, Duarte A, Garcia-Souza L, Bento G, Grilo L, Makrecka-Kuka M, Doerrier C, Oliveira PJ, Gnaiger E (2021) Off-target effect of etomoxir on mitochondrial Complex I. MitoFit Preprints 2021 (in prep). |
Abstract:
Labels:
References
| Link | Reference | View | Year |
|---|---|---|---|
| Agius 1991 Biochem Pharmacol | Agius L, Meredith EJ, Sherratt HS (1991) Stereospecificity of the inhibition by etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes. Biochem Pharmacol 42:1717-20. | PMID:1930298 | 1991 |
| Auger 2015 Front Cell Dev Biol | Auger C, Alhasawi A, Contavadoo M, Appanna VD (2015) Dysfunctional mitochondrial bioenergetics and the pathogenesis of hepatic disorders. Front Cell Dev Biol 3:40. | PMID:26161384 Open Access | 2015 |
| Bartlett 2004 Eur J Biochem | Bartlett K, Eaton S (2004) Mitochondrial beta-oxidation. Eur J Biochem 271:462-9. | PMID:14728673 | 2004 |
| Bastos 2019 Clin Mol Hepatol | Bastos KLM, Quaio CR, Lima FR, Araújo IM, Araújo CAT, Piazzon FB, Silva IDCG, Benevides GN, Tannuri AC, Tannuri U, Azevedo RA, Kim CA (2019) Biochemical profile in an infant with neonatal hemochromatosis shows evidence of impairment of mitochondrial long-chain fatty acid oxidation. Clin Mol Hepatol 25:86-91. | PMID:30149691 Open Access | 2019 |
| Bentebibel 2006 Biochemistry | Bentebibel A, Sebastián D, Herrero L, López-Viñas E, Serra D, Asins G, Gómez-Puertas P, Hegardt FG (2006) Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation. Biochemistry 45:4339-50. | PMID:16584169 | 2006 |
| Cabrero 1999 Biochem Biophys Res Commun | Cabrero A, Alegret M, Sánchez R, Adzet T, Laguna JC, Vázquez M (1999) Etomoxir, sodium 2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate, up-regulates uncoupling protein-3 mRNA levels in primary culture of rat preadipocytes. Biochem Biophys Res Commun 263:87-93. | PMID:10486258 Open Access | 1999 |
| Clara 2016 Metabolism | Clara R, Langhans W, Mansouri A (2016) Oleic acid stimulates glucagon-like peptide-1 release from enteroendocrine cells by modulating cell respiration and glycolysis. Metabolism 65:8-17. | PMID: 26892511 | 2016 |
| Declercq 1987 J Biol Chem | Declercq PE, Falck JR, Kuwajima M, Tyminski H, Foster DW, McGarry JD (1987) Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. I. Use of inhibitors. J Biol Chem 262:9812-21. | PMID:3597441 | 1987 |
| Divakaruni 2018 Cell Metab | Divakaruni AS, Hsieh WY, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, Murphy AN (2018) Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis. Cell Metab 28:490-503. | PMID:30043752 Open Access | 2018 |
| Eaton 2002 Prog Lipid Res | Eaton S (2002) Control of mitochondrial beta-oxidation flux. Prog Lipid Res 41:197-239. | PMID:11814524 | 2002 |
| Eaton 1996 Biochem J | Eaton S, K Bartlett K, Pourfarzam M (1996) Mammalian mitochondrial beta-oxidation. Biochem J 320:345-57. | PMID:8973539 Open Access | 1996 |
| Egnatchik 2014 Metabolism | Egnatchik RA, Leamy AK, Noguchi Y, Shiota M, Young JD (2014) Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes. Metabolism 63:283-95. | PMID:24286856 Open Access | 2014 |
| Gaca-Tabaszewska 2022 Cancers (Basel) | Gaca-Tabaszewska M, Bogusiewicz J, and Bojko B (2022) Metabolomic and Lipidomic Profiling of Gliomas—A New Direction in Personalized Therapies. Cancers (Basel) 14:5041. | PMID: 36291824 Open Access | 2022 |
| Huang 2016 Immunity | Huang SC, Smith AM, Everts B, Colonna M, Pearce EL, Schilling JD, Pearce EJ (2016) Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation. Immunity 45:817-830. | PMID:27760338 Open Access | 2016 |
| Kerner 2000 Biochim Biophys Acta | Kerner J, Hoppel C (2000) Fatty acid import into mitochondria. Biochim Biophys Acta 1486:1-17. | PMID:10856709 | 2000 |
| Kiorpes 2021 J Biol Chem | Kiorpes TC, Hoerr D, Ho W, Weaner LE, Inman MG, Tutwiler GF (2021) Identification of 2-tetradecylglycidyl coenzyme A as the active form of methyl 2-tetradecylglycidate (methyl palmoxirate) and its characterization as an irreversible, active site-directed inhibitor of carnitine palmitoyltransferase A in isolated rat liver mitochondria. J Biol Chem 259:9750-5. | PMID:6547720 | 2021 |
| Lambertucci 2008 J Cell Physiol | Lambertucci RH, Hirabara SM, Silveira Ldos R, Levada-Pires AC,Curi R,Pithon-Curi TC (2008) Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells. J Cell Physiol 216:796-804. | PMID:18446788 | 2008 |
| Liepinsh 2020 Physiol Rep | Liepinsh E, Makarova E, Plakane L, Konrade I, Liepins K, Videja M, Sevostjanovs E, Grinberga S, Makrecka-Kuka M, Dambrova M (2020) Low-intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults. Physiol Rep 8:e14489. | PMID: 32562386 Open Access | 2020 |
| Lilly 1992 Biochem Pharmacol | Lilly K, Chung C, Kerner J, Van Renterghem R, Bieber LL (1992) Effect of etomoxiryl-CoA on different carnitine acyltransferases. Biochem Pharmacol 43:353-61. | PMID:1739421 | 1992 |
| Lin 2017 Neuro Oncol | Lin H, Patel S, Affleck VS, Wilson I, Turnbull DM, Joshi AR, Maxwell R, Stoll EA (2017) Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells. Neuro Oncol 19:43-54. | PMID:27365097 Open Access | 2017 |
| Lou 2014 PLoS One | Lou PH, Lucchinetti E, Zhang L, Affolter A, Schaub MC, Gandhi M, Hersberger M, Warren BE, Lemieux H, Sobhi HF, Clanachan AS, Zaugg M (2014) The mechanism of intralipid®-mediated cardioprotection Complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases. PLoS One 9:e87205. | PMID:24498043 | 2014 |
| Ma 2020 Sci Rep | Ma Y, Wang W, Devarakonda T, Zhou H, Wang XY, Salloum FN, Spiegel S, Fang X (2020) Functional analysis of molecular and pharmacological modulators of mitochondrial fatty acid oxidation. Sci Rep 10:1450. | PMID:31996743/ Open Access | 2020 |
| Makrecka-Kuka 2017 Sci Rep | Makrecka-Kuka M, Sevostjanovs E, Vilks K, Volska K, Antone U, Kuka J, Makarova E, Pugovics O, Dambrova M, Liepinsh E (2017) Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues. Sci Rep 7:17528. | PMID:29235526 Open Access | 2017 |
| McGarry 1997 Eur J Biochem | McGarry JD, Brown NF (1997) The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur J Biochem 244:1-14. | PMID:9063439 Open Access | 1997 |
| Morillas 2000 Biochem J | Morillas M, Clotet J, Rubí B, Serra D, Ariño J, Hegardt FG, Asins G (2000) Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues. Biochem J 351:495-502. | PMID:11023836/ Open Access | 2000 |
| Namgaladze 2014 Biochim Biophys Acta | Namgaladze D, Brüne B (2014) Fatty acid oxidation is dispensable for human macrophage IL-4-induced polarization. Biochim Biophys Acta 1841:1329-35. | PMID:24960101 | 2014 |
| Nomura 2016 Nat Immunol | Nomura M, Liu J, Rovira II, Gonzalez-Hurtado E, Lee J, Wolfgang MJ, Finkel T (2016) Fatty acid oxidation in macrophage polarization. Nat Immunol 17:216-7. | PMID:26882249 Open Access | 2016 |
| O'Connor 2018 Sci Rep | O'Connor RS, Guo L, Ghassemi S, Snyder NW, Worth AJ, Weng L, Yoonseok Kam Y, Philipson B, Trefely S, Nunez-Cruz S, Blair IA, June CH, Milone MC (2018) The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations. Sci Rep 8:6289. | PMID:29674640 Open Access | 2018 |
| Ojuka 2016 Am J Physiol Endocrinol Metab | Ojuka E, Andrew B, Bezuidenhout N, George S, Maarman G, Madlala HP, Mendham A, Osiki PO (2016) Measurement of β-oxidation capacity of biological samples by respirometry: a review of principles and substrates. Am J Physiol Endocrinol Metab 310:E715-23. https://doi.org/10.1152/ajpendo.00475.2015 | PMID: 26908505 Open Access | 2016 |
| Pereyra 2021 J Lipid Res | Pereyra AS, Harris KL, Soepriatna AH, Waterbury QA, Bharathi SS, Zhang Y, Fisher-Wellman KH, Goergen CJ, Goetzman ES, Ellis JM (2021) Octanoate is differentially metabolized in liver and muscle and fails to rescue cardiomyopathy in CPT2 deficiency. J Lipid Res 62:100069. | PMID: 33757734 Open Access | 2021 |
| Pike 2011 Biochim Biophys Acta | Pike LS, Smift AL, Croteau NJ, Ferrick DA, Wu M (2011) Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. https://doi.org/10.1016/j.bbabio.2010.10.022 | Biochim Biophys Acta 1807:726-34. PMID: 21692241 Open Access | 2011 |
| Raud 2016 Cell Metab | Raud B, Roy DG, Divakaruni AS, Tarasenko TN, Franke R, Ma EH, Samborska B, Hsieh WY, Wong AH, Stüve P, Arnold-Schrauf C, Guderian M, Lochner M, Rampertaap S, Romito K, Monsale J, Brönstrup M, Bensinger SJ, Murphy AN, McGuire PJ, Jones RG, Sparwasser T, Berod L (2016) Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation. Cell Metab 28:504-515. | PMID:30043753 Open Access | 2016 |
| Rector 2010 J Hepatol | Rector RS, Thyfault JP, Uptergrove GM, Morris EM, Naples SP, Borengasser SJ, Mikus CR, Laye MJ, Laughlin MH, Booth FW, Ibdah JA (2010) Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model. J Hepatol 52:727-36. | PMID:20347174 Open Access | 2010 |
| Rogers 2013 Free Radic Biol Med | Rogers C, Davis B, Neufer PD, Murphy MP, Anderson EJ, Robidoux J (2013) A transient increase in lipid peroxidation primes preadipocytes for delayed mitochondrial inner membrane permeabilization and ATP depletion during prolonged exposure to fatty acids. Free Radic Biol Med 67:330-41. | PMID:24269897 | 2013 |
| Sainero-Alcolado 2022 Cell Death Differ | Sainero-Alcolado L, Liaño-Pons J, Ruiz-Pérez MV, Arsenian-Henriksson M (2022) Targeting mitochondrial metabolism for precision medicine in cancer. Cell Death Differ 29:1304-17. https://doi.org/10.1038/s41418-022-01022-y | PMID: 35831624 Open Access | 2022 |
| Schlaepfer 2014 Mol Cancer Ther | Schlaepfer IR, Rider L, Rodrigues LU, Gijón MA, Pac CT, Romero L, Cimic A, Sirintrapun SJ, Glodé LM, Eckel RH, Cramer SD (2014) Lipid catabolism via CPT1 as a therapeutic target for prostate cancer. Mol Cancer Ther 13:2361-71. | PMID:25122071 Open Access | 2014 |
| Schönfeld 2013 J Cereb Blood Flow Metab | Schönfeld P, Reiser G (2013) Why does brain metabolism not favor burning of fatty acids to provide energy? Reflections on disadvantages of the use of free fatty acids as fuel for brain. J Cereb Blood Flow Metab 33:1493-9. | PMID:23921897 Open Access | 2013 |
| Schönfeld 2016 J Lipid Res | Schönfeld P, Wojtczak L (2016) Short- and medium-chain fatty acids in energy metabolism: the cellular perspective. J Lipid Res 57:943-54. | PMID:27080715 Open Access | 2016 |
| Selby 1989 Trends Pharmacol Sci | Selby PL, Sherratt HS (1989) Substituted 2-oxiranecarboxylic acids: a new group of candidate hypoglycaemic drugs. Trends Pharmacol Sci 10:495-500. | PMID:2694542 | 1989 |
| Serafim 2021 Eur J Clin Invest | Serafim TL, Cunha-Oliveira T, Deus CM, Sardão VA, Cardoso IM, Yang S, Odhiambo JF, Ghnenis AB, Smith AM, Li J, Nathanielsz PW, Ford SP, Oliveira PJ (2021) Maternal obesity in sheep impairs foetal hepatic mitochondrial respiratory chain capacity. Eur J Clin Invest 51:e13375. | PMID:32780417 | 2021 |
| Shim 2022 Cancer Cell Int | Shim JK, Choi S, Yoon SJ, Choi RJ, Park J, Lee EH, Cho HJ, Lee S, Teo WY, Moon JH, Kim HS, Kim EH, Cheong JH, Chang JH, Yook JI, Kang SG. (2022) Etomoxir, a carnitine palmitoyltransferase 1 inhibitor, combined with temozolomide reduces stemness and invasiveness in patient-derived glioblastoma tumorspheres. Cancer Cell Int 22:309. | PMID:36221088 Open Access | 2022 |
| Spinazzi 2012 Nat Protoc | Spinazzi M, Casarin A, Pertegato V, Salviati L, Angelini C (2012) Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells. Nat Protoc 7:1235-46. | PMID:22653162 | 2012 |
| Spurway 1997 FEBS Letters | Spurway TD, Pogson CI, Sherratt HS, Agius L (1997) Etomoxir, sodium 2-[6-(4-chlorophenoxy)hexyl] oxirane-2-carboxylate, inhibits triacylglycerol depletion in hepatocytes and lipolysis in adipocytes. FEBS Letters 404:111-4. | PMID:9074648 Open Access | 1997 |
| Spurway 1997 Biochem J | Spurway TD, Sherratt HA, Pogson CI, Agius L (1997) The flux control coefficient of carnitine palmitoyltransferase I on palmitate beta-oxidation in rat hepatocyte cultures. Biochem J 323:119-22. | PMID:9173869 Open Access | 1997 |
| Tan 2015 J Immunol | Tan Z, Xie N, Cui H, Moellering DR, Abraham E, Thannickal VJ, Liu G (2015) Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism. J Immunol 194:6082-9. | PMID:25964487 Open Access | 2015 |
| Tarasenko 2015 Biochim Biophys Acta | Tarasenko TN, Singh LN, Chatterji-Len M, Zerfas PM, Cusmano-Ozog K, McGuire PJ (2015) Kupffer cells modulate hepatic fatty acid oxidation during infection with PR8 influenza. Biochim Biophys Acta 1852:2391-401. | PMID:26319418 Open Access | 2015 |
| Van den Bossche 2016 Cell Rep | Van den Bossche J, Baardman J, Otto NA, van der Velden S, Neele AE, van den Berg SM, Luque-Martin R, Chen HJ, Boshuizen MCS, Ahmed M, Hoeksema MA, de Vos AF, de Winther MP (2016) Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages. Cell Rep 17:684-696. | PMID:27732846 Open Access | 2016 |
| Van der Windt 2012 Immunity | Van der Windt GJ, Bart Everts B, Chih-Hao Chang CH, Jonathan D Curtis JD, Tori C Freitas TC, Eyal Amiel E, Edward J Pearce EJ, Pearce EL (2012) Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity 36:68-78. | PMID:22206904 Open Access | 2012 |
| Vats 2006 Cell Metab | Vats D, Mukundan L, Odegaard JI, Zhang L,Smith KL, Morel CR, Wagner RA, Greaves DR, Murray PJ, Chawla A (2006) Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab 4:13-24. | PMID:16814729 Open Access | 2006 |
| Wang 2022 Front Oncol | Wang CY, Wang CH, Mai RT, Chen TW, Li CW, Chao CH (2022) Mutant p53-microRNA-200c-ZEB2-Axis-Induced CPT1C Elevation Contributes to Metabolic Reprogramming and Tumor Progression in Basal-Like Breast Cancers. Front Oncol 12:940402. | PMID:35936710 Open Access | 2022 |
| Wu 2022 Chem Sci | Wu Y, Li Y, Lv G, Bu W (2022) Redox dyshomeostasis strategy for tumor therapy based on nanomaterials chemistry. Chem Sci 13:2202-2217. | PMID:35310479 Open Access | 2022 |
| Xu 2003 J Lipid Res | Xu FY, Taylor WA, Hurd JA, Hatch GM (2003) Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J Lipid Res 44:415-23. | PMID:12576524 Open Access | 2003 |
| Yang 1987 J Biol Chem | Yang SY, He XY, Schulz H (1987) Fatty acid oxidation in rat brain is limited by the low activity of 3-ketoacyl-coenzyme A thiolase. J Biol Chem 262:13027-32. | PMID:3654601 Open Access | 1987 |
| Yao 2018 PLoS Biol | Yao CH, Liu GY, Wang R, Moon SH, Gross RW, Patti GJ (2018) Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation. PLoS Biol 16:e2003782. | PMID:29596410 Open Access | 2018 |
