Search results

...rload than SSM. The differences in respiratory capacity of cardiac IFM and SSM in healthy hearts are eliminated with pressure overload-induced heart failu |keywords=Subsarcolemmal mitochondria (SSM), Interfibrillar mitochondria (IFM),

...of a continuous mitochondrial reticulum challenges the view of distinctive SSM and IFM bioenergetics. Here, a comprehensive approach is developed to ident ...creased dispase content and homogenization speed; (b) trypsin treatment of SSM fractions; (c) recentrifugation of mitochondrial fractions at low speed to

390 Towne Building SSM

...dent of other pathologies, mitochondrial dysfunction is present in cardiac SSM of patients with type 2 diabetes and the degree of dysfunction is consisten

...of a continuous mitochondrial reticulum challenges the view of distinctive SSM and IFM bioenergetics. Here, a comprehensive approach is developed to ident ...creased dispase content and homogenization speed; (b) trypsin treatment of SSM fractions; (c) recentrifugation of mitochondrial fractions at low speed to

390 Towne Building SSM

390 Towne Building SSM, 19104

...tially distinct mitochondrial subpopulations, subsarcolemmal mitochondria (SSM) and intermyofibrillar mitochondria (IFM). These approaches can easily be t ...al oxygen consumption, Mouse heart, Oxygraph, Subsarcolemmal mitochondria (SSM)

390 Towne Building SSM

...ore recent dog skeletal muscle study [5] used a new isolation protocol for SSM and IFM in which RCR were higher than those obtained in rat studies; the mi ...protease was used to disperse the myofibrils and facilitate the release of SSM during homogenization. The myofibrillar pellet was treated with a combinati

...⁻ emission was measured spectrofluorometrically, and H₂O₂ was increased in SSM, IFM, and liver mitochondria (∼2.3-, ∼2.5-, and ∼2.3-fold, respective

...chanisms. Overall, these data indicate that dystrophin-deficiency disrupts SSM localization, promotes mitochondrial inefficiency and restricts maximal mit

...ficant decrease in state 3 and an increase in state 4 respiration, in both SSM and IFM. However, PostC but not CsA treatment reduced total heart oxidative

...oled together, in order to isolate interfibrillar (IFM) or subsarcolemmal (SSM) LV or RV mitochondria [3]. Mitochondrial oxidative phosphorylation (OXPHOS Both in SSM and IFM, enzymatic activity of fatty acid import enzymes (CPT1+CPT2) was st

...ponin-permeabilized rat heart muscle fibres and isolated subsarcolemmal ([[SSM]]) and interfibrillar ([[IFM]]) cardiac mitochondria. ...a dramatic decrease in the ADP-dependent respiratory rates in both cardiac SSM and IFM. The improvement of respiratory rates by collapsing the mitochondri

...d the brain and the heart and isolated brain mitochondria, subsarcolemmal (SSM) and interfibrillar (IFM) heart mitochondria [3]. Mitochondrial bioenergeti Among female heart mitochondria, SSM only showed a decrease in state 3 of complex II after acute hypoxia.

::::* SSM was converted to SSmt

::::* SSM was converted to SSmt

...ion, P/E ratio, PC, PDHB, PDK4, PGC1α, PHTN, PM, PPARα, PPIA, RCR, RT-PCR, SSM, Succ, acyl-CoA dehydrogenase, long chain, acyl-CoA dehydrogenase, medium c

...a become spheroid their cristae were 77% lamelliform, as were those in the SSM in in situ fibers.54 In a heart muscle study, the respiratory capacity in i