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| {{MitoPedia | | {{MitoPedia |
| |abbr=''CCC'' | | |abbr= |
| |description='''Coupling control capacities''', ''CCC'', are [[flux control capacity|flux control capacities]], ''FCC'', at a constant [[ETS-competent substrate state]]. In mitochondrial preparations, there are three well-defined coupling states of respiration, ''L'', ''P'', ''E'' ([[LEAK]], [[OXPHOS]], [[ETS]]). In intact cells, state ''P'' cannot be induced, but a [[ROUTINE]] state of respiration, ''R'', can be measured. | | |description='''Coupling-control efficiencies''' are [[flux control efficiency |flux control efficiencies]] ''j<sub>Z-Y</sub>'' at a constant [[ET-pathway competent state]]. |
| | |info=[[Flux control efficiency]] |
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| 1. If the [[metabolic control variable]], ''X'', is an [[uncoupler]], the reference state ''Z'' is ''E''. Then two [[background state]]s, ''Y'', of coupling control are possible: The uncoupler may act on the ''L'' or ''P'' state in mt-preparations, and on the ''L'' or ''R'' state in intact cells. The corresponding coupling control capacities are:
| | == Compare == |
| * [[E-L coupling control capacity|''E-L'' coupling control capacity]], Δ''j<sub>E-L</sub>'' = (''E-L'')/''E'' = 1-''L/E'' (mt-preparations and intact cells)
| | ::::* [[Coupling-control ratio]] |
| * [[E-P coupling control capacity|''E-P'' coupling control capacity]], Δ''j<sub>E-P</sub>'' = (''E-P'')/''E'' = 1-''P/E'' (mt-preparations)
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| * [[E-R coupling control capacity|''E-R'' coupling control capacity]], Δ''j<sub>E-P</sub>'' = (''E-R'')/''E'' = 1-''R/E'' (intact cells) | |
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| 2. If the metablic control variable is stimulation by [[ADP]], D, or release of an inhibitor of phosphorylation of ADP to ATP ([[DT-phosphorylation]]; e.g. -Omy), the reference state ''Z'' is ''P'' in mt-preparations at saturating [[[ADP]]], or ''R'' in intact cells at physiologically controlled steady states of [ADP] and ATP-turnover. The background state ''Y'' is ''L'', and the corresponding coupling control capacities are:
| | {{MitoPedia concepts |
| * [[P-L coupling control capacity|''P-L'' coupling control capacity]], Δ''j<sub>P-L</sub>'' = (''P-L'')/''P'' = 1-''L/P'' (mt-preparations)
| | |mitopedia concept=Respiratory control ratio |
| * [[R-L coupling control capacity|''R-L'' coupling control capacity]], Δ''j<sub>R-L</sub>'' = (''R-L'')/''R'' = 1-''L/R'' (intact cells)
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| |info=[[Gnaiger 2013 Abstract MiP2013]]
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| {{MitoPedia methods | | {{MitoPedia methods |
| |mitopedia method=Respirometry | | |mitopedia method=Respirometry |
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| {{MitoPedia topics
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| |mitopedia topic=Respiratory control ratio
| | [[Category:Coupling control]] |
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| == Compare ==
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| * [[Coupling control ratio]]
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