Difference between revisions of "2-mercaptoacetate"
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|description='''2-mercaptoacetate''' is an inhibitor of medium-chain acyl-CoA dehydrogenase, MCAD , the rate-limiting enzyme of [[ | |description='''2-mercaptoacetate''' is an inhibitor of medium-chain acyl-CoA dehydrogenase, MCAD, the rate-limiting enzyme of [[octanoylcarnitine]] oxidation. 2-mercaptoacetate has been used as an inhibitor of [[fatty acid oxidation]] ([[F-pathway control state]]). In permeabilized rat soleus muscle fibers, pre-incubation with 1 mM 2-mercaptoacetate for 45 min resulted in 58% inhibition of MCAD and decreased [[octanoylcarnitine]]&[[malate]] stimulated respiration by approximately 60% ([[Osiki 2016 FASEB J]]). | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/7317017 Bauché 1981 Biochem J], [[ | |info=[http://www.ncbi.nlm.nih.gov/pubmed/7317017 Bauché 1981 Biochem J], [[Osiki 2016 FASEB J]] | ||
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{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=Inhibitor | |mitopedia topic=Inhibitor | ||
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Revision as of 12:47, 8 November 2016
- high-resolution terminology - matching measurements at high-resolution
2-mercaptoacetate
Description
2-mercaptoacetate is an inhibitor of medium-chain acyl-CoA dehydrogenase, MCAD, the rate-limiting enzyme of octanoylcarnitine oxidation. 2-mercaptoacetate has been used as an inhibitor of fatty acid oxidation (F-pathway control state). In permeabilized rat soleus muscle fibers, pre-incubation with 1 mM 2-mercaptoacetate for 45 min resulted in 58% inhibition of MCAD and decreased octanoylcarnitine&malate stimulated respiration by approximately 60% (Osiki 2016 FASEB J).
Reference: Bauché 1981 Biochem J, Osiki 2016 FASEB J
MitoPedia topics:
Inhibitor
