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2-mercaptoacetate
Description
2-mercaptoacetate is an inhibitor of medium-chain acyl-CoA dehydrogenase, MCAD , the rate-limiting enzyme of octanoylcarnitine oxidation. As such, 2-mercaptoacetate has been used as an inhibitor of fatty acid oxidation. In permeabilized rat Soleus muscle fibers pre-incubation with 1 mM 2-mercaptoacetate for 45 min resulted in 58% inhibition of MCAD and decreased malate+octanoylcarnitine stimulated respiration by approximately 60% (Osiki 2016 FASEB J).
Reference: Bauché 1981 Biochem J, Osiki 2016 FASEB J
MitoPedia topics: Inhibitor
