Additive effect of convergent electron flow: Difference between revisions
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Electron flow converges at the [[Q-junction]] from respiratory Complexes I and II ([[CI+II e-input]]), [[glycerophosphate dehydrogenase]] and [[electron-transferring flavoprotein]]. Convergent electron flow corresponds to the operation of the [[TCA cycle]] and mitochondrial substrate supply in vivo. Due to the | Electron flow converges at the [[Q-junction]] from respiratory Complexes I and II ([[CI+II e-input]]), [[glycerophosphate dehydrogenase]] and [[electron-transferring flavoprotein]]. Convergent electron flow corresponds to the operation of the [[TCA cycle]] and mitochondrial substrate supply in vivo. | ||
==Additive effect== | |||
Due to the additive effect of convergent CI+II electron flow on respiratory flux, respiration is increased up to 2-fold relative to flux supported only by Complex I substrates. | |||
==References== | ==References== | ||
*Gnaiger E (2009) Mitochondrial pathways through Complexes I+II: Convergent electron transport at the Q-junction and additive effect of substrate combinations. [http://www.oroboros.at/index.php?compl-12-convergent Mitochondr. Physiol. Network 12.12: 1-20]. | |||
*Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCH-4W04KR1-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a6456620daa0d8cca022b5f934f2cf30 Int. J. Biochem. Cell Biol. 41: 1837–1845]. | |||
[[Category:MitoPedia]] | |||
Revision as of 14:53, 15 August 2010
Electron flow converges at the Q-junction from respiratory Complexes I and II (CI+II e-input), glycerophosphate dehydrogenase and electron-transferring flavoprotein. Convergent electron flow corresponds to the operation of the TCA cycle and mitochondrial substrate supply in vivo.
Additive effect
Due to the additive effect of convergent CI+II electron flow on respiratory flux, respiration is increased up to 2-fold relative to flux supported only by Complex I substrates.
References
- Gnaiger E (2009) Mitochondrial pathways through Complexes I+II: Convergent electron transport at the Q-junction and additive effect of substrate combinations. Mitochondr. Physiol. Network 12.12: 1-20.
- Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int. J. Biochem. Cell Biol. 41: 1837–1845.
